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A bidirectional brain-computer interface for effective epilepsy control

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第10期15卷 839-847页

作者： Yu QI fei-qiang ma Ting-ting GE Yue-ming WANG Jun-ming ZHU Jian-min ZHANG Xiao-xiang ZHENG Zhao-hui WU Qiushi Academy for Advanced Studies Zhejiang University Department of Computer Science Zhejiang University Second Affiliated Hospital of Zhejiang University College of Medicine College of Biomedical Engineering and Instrument Science Zhejiang University

Brain-computer interfaces(BCIs) can provide direct bidirectional communication between the brain and a machine. Recently, the BCI technique has been used in seizure control. Usually, a closed-loop system based on BCI is set up which delivers a therapic electrical stimulus only in response to seizure onsets. In this way, the side effects of neurostimulation can be greatly reduced. In this paper, a new BCI-based responsive stimulation system is proposed. With an efficient morphology-based seizure detector, seizure events can be identified in the early stages which trigger electrical stimulations to be sent to the cortex of the brain. The proposed system was tested on rats with penicillin-induced epileptic seizures. Online experiments show that 83% of the seizures could be detected successfully with a short average time delay of 3.11 s. With the therapy of the BCI-based seizure control system, most seizures were suppressed within 10 s. Compared with the control group, the average seizure duration was reduced by 30.7%. Therefore, the proposed system can control epileptic seizures effectively and has potential in clinical applications.

关键词： Brain-computer interface Epilepsy Seizure detection Responsive neurostimulation

Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan Ren fei Zheng Tingwei Cao qiang Wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation machine learning

Fistulectomy as a surgical option for pulmonary arteriovenous nalformation

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Chinese Medical Journal 2009年第19期122卷 2321-2324页

作者： ZHANG Shao-yan ZHANG Zhi-tai OU Song-lei HU Yan-sheng SONG fei-qiang LI Xin ma Xu-chen ma Xin-xin LIANG Lin LI Dong GUO Lin SUN Zhen Department of Thoracic Surgery Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Background Surgical resection remains the treatment of choice for pulmonary arteriovenous malformation but removes some normal lung parenchyma. This study aimed to evaluate the effect and safety of the lung-saving procedure of fistulectomy as an alternative to lung resection. Methods From July 2003 to July 2008, 6 selected patients with pulmonary arteriovenous malformations underwent fistulectomies. Among them, 1 patient underwent emergency operation and 2 underwent bilateral operations. One patient received postoperative embolotherapy. Results No hospital deaths or postoperative morbidity occurred. PaO2 increased significantly after operation. All patients were free of symptoms and hypoxia during a follow-up for 9 months to 5 years. Conclusions Fistulectomy is a safe and effective procedure for patients with pulmonary arteriovenous malformation and may be an alternative to lung resection.

关键词： fistula benign or congenital lesions, lung pulmonary arteries

Genetic mutations in Chinese glioma patients identified by whole-exome sequencing

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Genetic mutations in Chinese glioma patients identified by w...

magnetron sputtered nickel oxide with suppressed interfacial defect states for efficient inverted perovskite solar cells

第十三届中国医师协会神经外科医师年会

作者： Qun Wu fei-qiang ma Yong-hui Tao Wei Yan Gao Chen Jian-min Zhang Department of Neurosurgery School of MedicineZhejiang University Department of Emergency Second Affiliated HospitalSchool of MedicineZhejiang University Institute of Biochemistry and Cell Biology Chinese Academy of Sciences

Glioma is the most common malignant brain tumor in *** extensive studies attempting to map the genomic landscape of gliomas,most of them were performed in white *** cohort studies are needed in other ethnic *** current study aims to explore genomic abnormalities in Chinese glioma *** performed whole-exome sequencing of tumor tissues collected from 6 Chinese patients diagnosed with World Health Organization（WHO）grades II-IV *** patients exhibited genetic features similar to those observed in white *** IDH1 R132 H mutation was identified in three *** three patients also carry mutations in *** from common mutations,new mutated genes were *** them,mutations in RASSF1,AMOTL2 and PLK3 were validated by Sanger *** together,the current study suggests that gliomas in Chinese population share common molecular characteristics with those of white *** discovery of new mutated genes calls for future studies in larger cohorts to identify specific genetic variations in Chinese glioma patients.

关键词： exome sequencing glioma IDH1 Chinese population

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Journal of Energy Chemistry 2025年第1期100卷 348-355页

作者： Guoqiang ma Qin Tan Zhaoning Li Jingwei Xiu Jiafeng Wang Tianle Cheng Dong He qiang Sun Xuhang ma Francesco Lamberti Zhubing He Department of materials Science and Engineering Institute of Innovative Materials (I2M) Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG)Southern University of Science and Technology (SUSTech) Core Research Facilities Southern University of Science and Technology Department of Chemical Sciences Department of Industrial Engineering University of Padova

Widely used spin-coated nickle oxide （NiOx） based perovskite solar cells often suffer from severe interfacial reactions between the NiOxand adjacent perovskite layers due to surface defect states,which inherently impair device performance in a long-term view,even with surface molecule *** this study,we developed high-quality magnetron-sputtered NiOxthin films through detailed process optimization,and compared systematically sputtered and spin-coated NiOxthin film surfaces from materials to *** sputtered NiOxfilms exhibit improved crystallinity,smoother surfaces,and significantly reduced Ni3+or Ni vacancies compared to their spin-coated ***,the interface between the perovskite and sputtered NiOxfilm shows a substantially reduced density of defect *** solar cells （PSCs） fabricated with our optimally sputtered NiOxfilms achieved a high power conversion efficiency （PCE） of up to 19.93%and demonstrated enhanced stability,maintaining 86.2% efficiency during 500 h of maximum power point tracking under one standard sun ***,with the surface modification using (4-(2,7-dibromo-9,9-dimethylacridin-10（9H）-yl)butyl)p hosphonic acid （DmacPA）,the device PCE was further promoted to 23.07%,which is the highest value reported for sputtered NiOxbased PSCs so far.

关键词： Nickle oxide magnetron sputter Defect Stability Perovskite solar cell

Presurgical serum prolactin level: an early severity and prognostic marker of pituitary apoplexy

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Presurgical serum prolactin level: an early severity and pro...

Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

2015浙江省神经外科学学术年会暨浙闽江赣四省神经外科学术交流会

作者： Wei Yan Dong-Dong Zhao Ming-fei Zhao Feng Cai Yong-jie Wang fei-qiang ma Fang-Jie Shao Qun Wu Gao Chen Jian-min Zhang Department of Neurosurgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang University Department of Infection Sir Run Run Shaw HospitalSchool of MedicineZhejiang University Department of Emergency The Second Affiliated HospitalSchool of MedicineZhejiang University

Objective: To review clinical presentation and surgical outcome of pituitary apoplexy and to explore the clinical significance of presurgical serum prolactin ***: Clinical, diagnostic and therapeutic data were collected from pituitarypatients admitted to our hospital from October, 2010 to October, 2012. Pituitary apoplexy patients were followed up for an average of 440 days. Special attention was paid to the relation between presurgical serum prolactin level and illness severity or ***: 545 pituitary tumor patients were admitted to our hospital during that period, including 38 pituitary apoplexy cases. 9 out of 17 patients in low prolactin level group acquired severe visual impairment, comparing with only 2 out of 21 patients in normal or high prolactin level group(P mal or high prolactin level group suffered from that(P marker of pituitary apoplexy.

关键词： Pituitary apoplexy Prolactin Pituitary function Visual function

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Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun ma Taiwei Dong fei Luan Juanjuan Yang Feng Miao Peifeng Wei College of Pharmacy and First Clinical Medical College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National Drug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MFSD2A) transcytosis

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朝阳营子地区地化异常与铅锌矿的关系

世界有色金属 2018年第2期43卷 147-148页

作者：李飞宇武飞飞米强马瑞琴内蒙古自治区第三地质矿产勘查开发院内蒙古呼和浩特010000

通过地球化学测量可以圈定出元素浓集异常区,在异常区内通过各种手段查证可以确定出矿化体。因此地球化学测量对寻找矿化体有指导性的作用。但是具体表现在哪几个方面那?通过对朝阳营子地区地化异常以及该地区铅锌矿体的研究,基本上可... 详细信息

通过地球化学测量可以圈定出元素浓集异常区,在异常区内通过各种手段查证可以确定出矿化体。因此地球化学测量对寻找矿化体有指导性的作用。但是具体表现在哪几个方面那?通过对朝阳营子地区地化异常以及该地区铅锌矿体的研究,基本上可以推断出地化异常与矿化体的几种关系,即地化异常指引矿化体的空间位置、指示其空间形态、推断其成矿元素、推断其地表规模。

关键词：地化背景异常铅锌矿化体

Co-production of hydrogen, oxygen, and electricity via an integrated solar-driven system with decoupled water electrolyzer and Na-Zn ion battery

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Journal of Energy Chemistry 2025年第1期100卷 621-627页

作者： fei Lv Longjie Liu Jiazhe Wu Pengfei Wang Lixia Pan Dengwei Jing Yubin Chen International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong University

Combining water electrolysis and rechargeable battery technologies into a single system holds great promise for the co-production of hydrogen （H2） and ***,the design and development of such systems is still in its ***,an integrated hydrogen-oxygen （O2）-electricity co-production system featuring a bipolar membrane-assisted decoupled electrolyzer and a Na-Zn ion battery was established with sodium nickelhexacyanoferrate （NaNiHCF） and Zn2+/Zn as dual redox *** decoupled electrolyzer enables to produce H2and O2in different time and space with almost 100%Faradaic efficiency at 100 ma ***,the charged NaNiHCF and Zn electrodes after the electrolysis processes formed a Na-Zn ion battery,which can generate electricity with an average cell voltage of 1.75 V at 10 m A *** connecting Si photovoltaics with the modular electrochemical device,a well-matched solar driven system was built to convert the intermittent solar energy into hydrogen and electric energy with a solar to hydrogen-electricity efficiency of 16.7%,demonstrating the flexible storage and conversion of renewables.

关键词： Hydrogen Electricity Decoupled water electrolyzer Na-Zn ion battery Solar energy