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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 21-31页

作者： lu Liu Xingyu Wu lufan Zhang Chuan wang School of Artificial Intelligence Beijing Normal University Applied Optics Beijing Area Major Laboratory Beijing Normal University

The multi-class classification of images is a pivotal challenge within the realm of image processing. As the volume of visual data continues to expand, there is a burgeoning interest in harnessing the unique capabilities of quantum computation to augment the efficiency of classification tasks. However, many existing methods for training quantum image multi-classifiers parallel classical machine learning techniques, where the requisite circuit measurements increase linearly with the volume of training data. This work introduces a novel approach for training a quantum image multi-classifier based on the quantum search algorithm. We have meticulously conducted rigorous experiments on a handwritten digit dataset, a classic benchmark in the field. The results have been meticulously compared with previous works, and the comparative analysis not only validates the efficiency of our proposed approach, requiring only O(N/b) measurements during training, but also highlights a significant quadratic speedup of the algorithm.

关键词： quantum computation image recognition quantum search algorithm

Prevalence of hypertension in a hemodialysis population

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Chinese Journal of Biomedical Engineering(English Edition) 2000年第3期9卷 111-116页

作者： LIU Yi,XU Yu lan,ZHEN Chen fei,wang lu ping[WT4”BZ] Blood Detoxification Department ,the First Affiliated Hospital Wenzhou Medical College,Zhejiang province,wenzhou 325000,China

Objective To know the accurate information on prevalence and status of blood pressure (BP) control in hemodialysis patients. Methods The pre/post mid week dialysis BP readings of 114 patients (74 males, 40 females. the average age 49.2±11.6 years) were evaluated. Hypertension was defined as BP>150/90mm Hg. Hypertension was further characterized according to whether the patients had normal or elevated pre dialysis systolic, pre dialysis diastolic, post dialysis systolic or post dialysis diastolic BP reading on 6 sequential dialysis recordings. And the systolic and diastolic pressure was separately graded from 0 to3 and a number designed as hypertension sensitivity index (HSI) was assigned to each patient. Results Of the 114 patients,97(85.1%)were hypertenisve,87(76.3%) had persistent elevation of BP despite being on one or more antihypertensive *** mean HSI for this population was 3.7±*** patients(81.9%) were on calcium channel blockers,29.1% being on Angiotension converting enzyme inhibitors(ACEI) and 29.2% on α *** was correlation between pre dialysis systolic,pre dialysis diastolic BP and the post dialysis body weight change rate with dry *** Hypertension was a frequent finding in our hemodialysis *** of this hypertension was pre dialysis *** was significant correlation between pre dialysis BP and post dialysis body weight change rate with dry weight.

关键词： hypertension hemodialysis

森林经营与管理下的温室气体排放、碳泄漏和净固碳量研究进展

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应用生态学报 2017年第2期28卷 673-688页

作者：刘博杰逯非王效科刘魏魏中国核电工程有限公司北京100840 中国科学院生态环境研究中心城市与区域生态国家重点实验室北京100085 全球变化研究协同创新中心北京100875

森林在减缓全球气候变化和大气CO_2浓度升高上具有重要作用.森林经营与管理下的新造林和森林保护具有显著的固碳功能,其中,新造林和森林保护的固碳速率分别为0.04~7.52、0.33~5.20 t C·hm^(-2)·a^(-1).同时,营造林过程中物资的生产和... 详细信息

森林在减缓全球气候变化和大气CO_2浓度升高上具有重要作用.森林经营与管理下的新造林和森林保护具有显著的固碳功能,其中,新造林和森林保护的固碳速率分别为0.04~7.52、0.33~5.20 t C·hm^(-2)·a^(-1).同时,营造林过程中物资的生产和运输导致边界内产生温室气体排放;营造林导致的活动转移、市场效应和生态环境变化导致边界外产生碳泄漏.本文综述了国内外森林经营与管理活动边界内温室气体排放源的界定、计量方法、温室气体排放量与排放速率;边界外碳泄漏的类型、计量方法与碳泄漏量;净固碳量以及温室气体排放和碳泄漏对固碳的抵消强度.边界内温室气体排放对固碳的抵消强度为0.01%~19.3%,进一步考虑碳泄漏时可增至95%.若仅考虑森林经营与管理在边界内直接产生的温室气体排放与可测量的活动转移碳泄漏,森林经营与管理具有较好的净固碳效益,且相比于农田固碳措施在温室气体净减排方面具有更好的应用前景.随着我国各项重大生态工程新一期的开展和对工程固碳效益的关注,为增加重大生态工程对温室气体的净减排量,有必要在工程开展前进行合理规划、在工程开展过程中加强控制和监测以减少工程实施导致的边界内温室气体排放和边界外碳泄漏.

关键词：森林经营与管理温室气体排放碳泄漏净固碳量

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山楂提取物对高脂损伤果蝇的保护作用

食品研究与开发 2016年第16期37卷 10-15页

作者：赵江陈纯王红王轶菲吕晓玲王浩天津科技大学食品工程与生物技术学院天津300457 天津科技大学生物工程学院天津300457

研究山楂提取物(Hawthorn Fruit Extract,HFE)对高脂致氧化损伤的雄性果蝇寿命的影响并探究其延缓果蝇衰老的分子机制。将2 d龄雄性果蝇随机分组,在高脂培养基中饲喂不同剂量(0.5、1.5、4.5 mg/m L)山楂提取物,研究山楂提取物对果蝇生... 详细信息

研究山楂提取物(Hawthorn Fruit Extract,HFE)对高脂致氧化损伤的雄性果蝇寿命的影响并探究其延缓果蝇衰老的分子机制。将2 d龄雄性果蝇随机分组,在高脂培养基中饲喂不同剂量(0.5、1.5、4.5 mg/m L)山楂提取物,研究山楂提取物对果蝇生存寿命及果蝇体内抗氧化酶活性(铜锌超氧化物歧化酶,Copper-zinc-containing superoxide dismutase,Cu/Zn-SOD;锰超氧化物歧化酶Manganese-containing superoxide dismutase,Mn-SOD;过氧化氢酶,Catalase,CAT)、脂质过氧化产物丙二醛(Malonaldehyde,MDA)含量、蛋白质羰基(Protein Carbonyl,PCO)含量及抗氧化相关基因表达水平的影响。HFE可以显著延长果蝇的平均寿命和最高寿命(4.5 mg/m L,P<0.05);4.5 mg/m L HFE可以显著提高果蝇体内SOD和CAT活性(P<0.05),显著降低MDA(P<0.01)和PCO含量(P<0.05);同时显著上调果蝇体内Cu/Zn-SOD及Nrf2 m RNA表达水平(P<0.05)并且极显著上调Mn-SOD和CAT m RNA表达水平(P<0.01)。HFE对高脂膳食所导致的果蝇氧化损伤具有保护作用,HFE延缓果蝇衰老和抗氧化作用可能与其调控抗氧化基因的表达水平相关。

关键词：山楂提取物果蝇高脂抗氧化

Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia Zhao Taixi Feng Guimin lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

Atomically precise nickel-sulfur clusters for efficient electrochemical 2,5-hydroxymethylfurfural oxidation

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Nano Research 2025年第1期18卷 140-148页

作者： Fen wang lu-Yu Liu Sha-Sha Cui Ting-Ting Li Xiao-Meng Yang Zhijuan Liu Yanyong wang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Chem/Bio-sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Nickel sulfide exhibits excellent catalytic activity in the electrochemical 2,5-hydroxymethylfurfural oxidation reaction(HMFOR).However,due to the polydispersity of nanoparticles,it is difficult to establish a clear structure-activity relationship at the atomic *** this work,we have successfully synthesized atomically precise Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)clusters(PET:2-phenylethanethiol)for ***^(2+)and S_(2)-with atomic ratio of 1:2 was mainly existed in Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)to form Ni-S *** electrochemical test results have suggested both Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)displayed outstanding electrocatalytic ability for *** Ni_(6)(PET)_(12)exhibited better electrocatalytic ability than Ni_(4)(PET)_(8)with higher current density,lower overpotential and faster reaction *** superior electrochemical ability of Ni_(6)(PET)_(12)may be due to the enhanced adsorption towards HMF molecule with strong interaction towards hydroxyl group and furan ***,it found that the Ni^(2+)species in Ni_(6)(PET)_(12)could rapidly oxidized into Ni^(3+)species,which could spontaneously capture electron and proton from HMF for *** theoretical calculation demonstrated that the Ni_(6)(PET)_(12)process lower free energy barrier than Ni_(4)(PET)_(8)to display excellent electrocatalytic *** work is of great significance for designing efficient electrocatalysts for HMFOR.

关键词： atomically precise nickel nanoclusters 2 5-hydroxymethylfurfural electro-oxidation Ni3+species

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

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Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： Lifang Zhao Mingkai Zhang Qimeng Li Xuemin wang Jie lu Ying Han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

Pentacam引导下Toric人工晶状体选择的临床疗效分析

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国际眼科杂志 2021年第1期21卷 156-159页

作者：云睿庄东梅赵梅生王陆飞吉林大学第二医院眼科中心白内障科中国吉林省长春市130041

目的:探讨Pentacam在精确选择Toric人工晶状体型号及轴位中的作用。方法:选择我院2018-01/12拟行白内障超声乳化吸除术的白内障患者46例53眼,术前经AL-Scan和全自动角膜曲率仪检查角膜散光≥1.0D,并应用Pentacam对角膜散光进行评估指导... 详细信息

目的:探讨Pentacam在精确选择Toric人工晶状体型号及轴位中的作用。方法:选择我院2018-01/12拟行白内障超声乳化吸除术的白内障患者46例53眼,术前经AL-Scan和全自动角膜曲率仪检查角膜散光≥1.0D,并应用Pentacam对角膜散光进行评估指导精确选择Toric人工晶状体的型号及植入轴位。手术均由同一手术医师完成。术后跟踪随访3mo。收集术前及术后1d,1wk,1、3mo裸眼视力、最佳矫正视力、全眼散光以及预计残留散光、术后残余散光等,术后主观脱镜率、视觉质量评估等。结果:手术前后患者角膜散光无显著性变化,全眼散光减少,UCVA及BCVA明显提高(P0.05),术后远视脱镜率及视觉质量明显提高。结论:Pentacam评估白内障患者术前的角膜散光更加全面准确,有助于指导准确选择Toric人工晶状体的型号,提高术后预期效果。

关键词： Pentacam Toric人工晶状体白内障散光视力

Nanoparticles for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di lu Jiuping Wu Fuming Liang Huayi wang Junjie Yang Ganggang Zhang Chen wang Yanlian Yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells