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Identification of microRNA-mRNA regulatory networks and pathways related to retinoblastoma across human and mouse

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International Journal of Ophthalmology(English edition) 2020年第4期13卷 535-544页

作者： Rui Tian He Zou lu-fei wang Mei-Jiao Song lu Liu Hui Zhang Department of Ophthalmology the Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina

AIM: To explore the m RNA and pathways related to retinoblastoma(RB) genesis and ***: Microarray datasets GSE29683(human) and GSE29685(mouse) were downloaded from NCBI GEO database. Homologous genes between the two species were identified using WGCNA, followed by protein-protein interaction(PPI) network construction and gene enrichment analysis. Disease-related mi RNAs and pathways were retrieved from mi R2 Disease database and Comparative Toxicogenomics Database(CTD), ***: A total of 352 homologous genes were identified. Two pathways including "cell cycle" and "pathway in cancer" in CTD and enrichment analysis were identified and seven mi RNAs(including hsa-mi R-373, hsa-mi R-34 a, hsami R-129, hsa-mi R-494, hsa-mi R-503, hsa-let-7 and hsami R-518 c) were associated with RB. mi RNAs modulate "cell cycle" and "pathway in cancer" pathways via regulating 13 genes(including CCND1, CDC25 C, E2 F2, CDKN2 D and TGFB2).CONCluSION: These results suggest that these mi RNAs play crucial roles in RB genesis through "cell cycle" and "pathway in cancer" pathways by regulating their targets including CCND1, CDC25 C, E2 F2 and CDKN2 D.

关键词： Kyoto Encyclopedia of Genes and Genomes pathway micro RNA retinoblastoma weighted gene co-expression network analysis

A simulation package—SASAL for X-ray and EUV spectroscopy of astrophysical and laboratory plasmas

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Research in Astronomy and Astrophysics 2014年第10期14卷 1351-1366页

作者： Gui-Yun Liang Fang Li fei-lu wang Yong Wu Jia-Yong Zhong Gang Zhao Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of Sciences Data Center for High Energy Density Physics Institute of Applied Physics and Computational Mathematics

For the laboratory astrophysics community, those spectroscopic modeling codes extensively used in astronomy, e.g. Chianti, AtomDB, Cloudy and Xstar, cannot be directly applied to analyzing laboratory measurements due to their discrepancies from astrophysical cases. For example, plasma from an electron beam ion trap has an electron energy distribution that follows a Gaussian profile, instead of a Maxwellian one. The laboratory miniature for a compact object produced by a laser-driven implo- sion shows a departure from equilibrium, that often occurs in celestial objects, so we setup a spectral analysis system for astrophysical and laboratory （SASAL） plasmas to act as a bridge between them, which benefits the laboratory astrophysical community.

关键词： atomic data -- line formation -- plasmas -- X-rays general

Augmenter of liver regeneration promotes hepatocyte proliferation induced by Kupffer cells

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World Journal of Gastroenterology 2006年第30期12卷 4859-4865页

作者： Chun-Ping wang Lin Zhou Shu-Hui Su Yan Chen Yin-Ying lu fei wang Hong-Jun Jia Yong-Yi Feng Yong-Ping Yang Department of Gastroenterology 302 Hospital of Chinese PLA Beijing 100039 China

AIM： To observe the effects of augmenter of liver regeneration （ALR） on Kupffer cells and to determine whether ALR promotes hepatocyte proliferation induced by Kupffer cells. METHODS： Kupffer cells and hepatocytes were cultured in vitro and various concentrations of recombinant rat ALR （rrALR） were added. ^3H-thymidine, BrdU and ^3H-leucine incorporation was determined in cultured Kupffer cells and hepatocytes, in hepatocytes conditioned by Kupffer cells, and in associated medium, rrALR was labeled by iodination and used to determine its binding activity by Scatchard analysis in Kupffer cells and primarily cultured rat hepatocytes. RESULTS： rrALR stimulated DNA replication in Kupffer cells and protein synthesis both in cells and in medium in a non-concentration-dependent manner. The effect was significant at the concentration of 1μg/L ALR. However, rrALR had no effect on primarily cultured hepatocytes, when hepatocytes were cultured with the Kupffer cell medium conditioned by ALR, DNA replication and protein synthesis in hepatocytes increased significantly at the concentration of 1μg/L ALR. When the ALR concentration was increased, its effect on hepatocyte proliferation decreased to the basal level. Scatchard analysis indicated the presence of a single class of high affinity receptors with a dissociation constant （Kd） of 0.883 nmol/L and a maximum binding capacity （Bmax） of 126.1 pmol/g protein in the rat Kupffer cells. CONCluSION： ALR can promote hepatocyte proliferation induced by Kupffer cells, which is associated with the concentration of ALR, suggesting that Kupffer cells play a dual role in liver regeneration.

关键词： Liver regeneration Augmenter of liver regeneration Kupffer cell

Laboratory astrophysics with laser-driven strong magnetic fields in China

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High Power Laser Science and Engineering 2016年第3期4卷 67-70页

作者： fei-lu wang Xiao-Xing Pei Bo Han Hui-Gang Wei Da-Wei Yuan Gui-Yun Liang Gang Zhao Jia-Yong Zhong Zhe Zhang Bao-Jun Zhu Yan-fei Li Fang Li Yu-Tong Li Si-Liang Zeng Shi-Yang Zou Jie Zhang Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences University of Chinese Academy of Sciences Department of Astronomy Beijing Normal University Beijing National Laboratory of Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Institute of Applied Physics and Computational Mathematics Shanghai Jiao Tong University

In this paper, the recent studies of laboratory astrophysics with strong magnetic fields in China have been *** the Shenguang-II laser facility of the National Laboratory on High-Power Lasers and Physics, a laser-driven strong magnetic field up to 200 T has been achieved. The experiment was performed to model the interaction of solar wind with dayside magnetosphere. Also the low beta plasma magnetic reconnection(MR) has been studied. Theoretically, the model has been developed to deal with the atomic structures and processes in strong magnetic field. Also the study of shock wave generation in the magnetized counter-streaming plasmas is introduced.

关键词： Laboratory astrophysics laser strong magnetic fields

A small electron beam ion trap/source facility for electron/neutral-ion collisional spectroscopy in astrophysical plasmas

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Research in Astronomy and Astrophysics 2018年第1期18卷 1-10页

作者： Gui-Yun Liang Hui-Gang Wei Da-Wei Yuan fei-lu wang Ji-Min Peng Jia-Yong Zhong Xiao-Long Zhu Mike Schmidt Günter Zschornack Xin-Wen Ma Gang Zhao Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Department of Astronomy Beijing Normal University Beijing 100875 China Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China DREEBIT GmbH 01109 Dresden Germany

Spectra are fundamental observation data used for astronomical research,but understanding them strongly depends on theoretical models with many fundamental parameters from theoretical *** models give different insights for understanding a specific ***,laboratory benchmarks for these theoretical models become *** electron beam ion trap is an ideal facility for spectroscopic benchmarks due to its similar conditions of electron density and temperature compared to astrophysical plasmas in stellar coronae,supernova remnants and so *** this paper,we will describe the performance of a small electron beam ion trap/source facility installed at National Astronomical Observatories,Chinese Academy of *** present some preliminary experimental results on X-ray emission,ion production,the ionization process of trapped ions as well as the effects of charge exchange on the ionization.

关键词： X-ray:general atomic processes line:formation method:laboratory:atomic

Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan Ren fei Zheng Tingwei Cao Qiang wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning

Controllable synthesis of biomimetic wood stem nanoporous high entropy oxides catalysts for oxygen evolution reaction

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Nano Research 2025年第1期18卷 107-117页

作者： Wei wang Weiqi wang Huihui wang Xing lu Jinwen Zhang Yunzhuo lu School of Materials Science and Engineering Dalian Jiaotong UniversityDalian 116028China School of Intelligence and Electronic Engineering Dalian Neusoft University of InformationDalian 116023China Guangdong Key Laboratory of Materials and Equipment in Harsh Marine Environment Guangzhou Maritime UniversityGuangzhou 510725China

Bubbles generated during the oxygen evolution reaction(OER)in water splitting readily adhere to the electrode surface,thereby impeding contact between the electrolyte and the active sites,thereby increasing the ***,it is imperative to elucidate the bubble release behavior and engineer electrodes that facilitate faster bubble *** this study,inspired by the wood stem of the Norway spruce,we synthesized a gradient nanoporous high-entropy oxide(GNP-HEO)electrode with a controllable pore *** GNP-HEO,featuring a well-controlled gradient in pore size,is achieved through a straightforward strategy combining selective laser melting with selective phase *** unique gradient nanoporous structure not only facilitates bubble release but also diminishes the bubble shielding effect in OER,thereby enhancing electrocatalytic *** affect interaction of Al,Co,Cr,Fe,and Ni,coupled with the gradient nanoporous structure,yields exceptional OER performance,evidenced by an overpotential of 250 mV at a current density of 50 mA/cm^(2) and a Tafel slope of 38.0 mV/dec in 1 M *** functional theory calculations confirm that the GNPHEO adheres to the adsorbate evolution mechanism reaction pathway and exhibits significant *** work highlights a promising approach for the design and synthesis of high-performance OER electrocatalysts.

关键词： oxygen evolution reaction high-entropy oxides selective phase dis-solution selective laser melting gradient nanoporous

Co-production of hydrogen, oxygen, and electricity via an integrated solar-driven system with decoupled water electrolyzer and Na-Zn ion battery

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Journal of Energy Chemistry 2025年第1期100卷 621-627页

作者： fei Lv Longjie Liu Jiazhe Wu Pengfei wang Lixia Pan Dengwei Jing Yubin Chen International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong University

Combining water electrolysis and rechargeable battery technologies into a single system holds great promise for the co-production of hydrogen （H2） and ***,the design and development of such systems is still in its ***,an integrated hydrogen-oxygen （O2）-electricity co-production system featuring a bipolar membrane-assisted decoupled electrolyzer and a Na-Zn ion battery was established with sodium nickelhexacyanoferrate （NaNiHCF） and Zn2+/Zn as dual redox *** decoupled electrolyzer enables to produce H2and O2in different time and space with almost 100%Faradaic efficiency at 100 mA ***,the charged NaNiHCF and Zn electrodes after the electrolysis processes formed a Na-Zn ion battery,which can generate electricity with an average cell voltage of 1.75 V at 10 m A *** connecting Si photovoltaics with the modular electrochemical device,a well-matched solar driven system was built to convert the intermittent solar energy into hydrogen and electric energy with a solar to hydrogen-electricity efficiency of 16.7%,demonstrating the flexible storage and conversion of renewables.

关键词： Hydrogen Electricity Decoupled water electrolyzer Na-Zn ion battery Solar energy

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单体式无人航行器的设计、实验及优化

中国造船 2016年第4期57卷 131-138页

作者：张礼华刘芳华楼飞卢道华王佳江苏科技大学机械工程学院镇江212003 江苏大学镇江流体工程装备技术研究院镇江212009

论文从实用性的角度出发,对单体式无人航行器的结构展开研究,旨在提供一种能够实现水面、水下巡航的载体形式。首先,提出一种能够实现水面、水下巡航的航行器设计方案。在该方案的基础上,基于模块化设计理念,将航行器分为头舱、能源舱... 详细信息

论文从实用性的角度出发,对单体式无人航行器的结构展开研究,旨在提供一种能够实现水面、水下巡航的载体形式。首先,提出一种能够实现水面、水下巡航的航行器设计方案。在该方案的基础上,基于模块化设计理念,将航行器分为头舱、能源舱、动力舱、控制舱四个模块,并进行详细设计。利用Finemarine对航行器的水动力性能进行分析,得到了航行器在水中保持持续稳定状态的条件。分析的结果可作为航行器部分结构优化和控制系统设计与实现的依据。通过制作样机和下水实验,还发现了该航行器尚存在运动性能欠佳的一些缺陷;最后,针对该航行器装配和实验过程中存在的不足,提出了优化设计方案,为结构改进提供了依据。

关键词：无人航行器水动力性能模块化设计优化设计