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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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Knowledge graph construction with structure and parameter learning for indoor scene design

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Computational Visual Media 2018年第2期4卷 123-137页

作者： yuan Liang fei Xu Song-hai Zhang yu-Kun Lai Taijiang Mu TNList Department of Computer ScienceTsinghua UniversityBeijing 100084China School of Computer Science and Informatics Cardiff UniversityCardiffCF24 3AAUK

We consider the problem of learning a representation of both spatial relations and dependencies between objects for indoor scene *** propose a novel knowledge graph framework based on the entity-relation model for representation of facts in indoor scene design, and further develop a weaklysupervised algorithm for extracting the knowledge graph representation from a small dataset using both structure and parameter learning. The proposed framework is flexible, transferable, and readable. We present a variety of computer-aided indoor scene design applications using this representation, to show the usefulness and robustness of the proposed framework.

关键词： knowledge graph scene design structure learning parameter learning

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Pressure Oscillating Flow in Corrugated Parallel Channel

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Communications in Theoretical Physics 2016年第12期65卷 694-700页

作者： yu-fei Wei hai-Jun Wang Yong-Jun Jian Department of Physiology Hetao College Bayannur 015000 China Mathematical Science College Inner Mongolia Normal University Hohhot 010022 China School of Mathematical Sciences Inner Mongolia University Hohhot 010021 China

The approximate analytical solution of velocity is presented for incompressible and viscous fluid driven by the oscillation of the periodic pressure, between two slit parallel plates with corrugated walls by employing perturbation method. The corrugations of the two walls are described as periodic sinusoidal waves with small amplitude either in phase or half-period out of phase. Based on the analysis, we discuss the influence of the dimensionless parameters on velocity u±and mean velocity parameter φ±numerically, such as Reynolds number Re, nondimensional amplitude A of pressure gradient and wave number k.

关键词： corrugated walls perturbation method oscillating pressure

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Preface to the special issue on aluminum alloys for transportation

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Journal of Central South University 2022年第3期29卷 741-743页

作者： yu hai-liang LIU Sheng-dan CAO Ling-fei GUO Ming-xing Light Alloy Research Institute Central South UniversityChangsha 410083China School of Materials and Engineering Central South UniversityChangsha 410083China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

Aluminum alloys have been used widely as structural materials in the field of aerospace,high speed train and car *** to their advantages such as low density,high strength,and good corrosion *** properties of these materials can increase the reliability,durability and life of the structural components,and decrease the cost and CO_(2) *** special issue focuses on the recent development of advanced aluminum alloys applied in the transportation field,particularly aerospace,train and car.

关键词： alloys corrosion strength

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The Evolution of Photospheric Current Density During an X9.3-Class Solar Flare

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Research in Astronomy and Astrophysics 2024年第10期24卷 189-200页

作者： hai-Li Li Hong-fei Liang Xin-Ping Zhou yu Liu Ni Meng yu-Long Feng Department of Physics Yunnan Normal UniversityKunming 650500China State Key Laboratory of Space Weather Chinese Academy of SciencesBeijing 100190China College of Physics and Electronic Engineering Sichuan Normal UniversityChengdu 610068China School of Physical Science and Technology Southwest Jiaotong UniversityChengdu 610068China

This paper deduced the temporal evolution of the magnetic field through a series of high-resolution vector magnetograms and calculated the fine distribution map of current density during an X9.3-class flare eruptions using Ampère's *** results show that a pair of conjugate current ribbons exist on both sides of the magnetic neutral line in this active region,and these conjugate current ribbons persist before,during,and after the *** was observed that the X9.3-class flare brightened in the form of a bright core and evolved into a double-ribbon flare over ***,the position of the double-ribbon flare matches the position of the current ribbons with high accuracy,and their morphologies are very *** investigating the complexity of current density and flare morphology,we discovered a potential connection between the eruption of major flares and the characteristics of current density.

关键词： Sun:activity Sun:magnetic fields Sun:flares methods:data analysis

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Comparison of laboratory parameters,clinical symptoms and clinical outcomes of COVID-19 and influenza in pediatric patients:A systematic review and meta-analysis

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World Journal of Clinical Cases 2022年第29期10卷 10516-10528页

作者： Bang yu hai-Hua Chen Xiao-fei Hu Rui-Zhi Mai hai-Yan He Emergency and Critical Care Center Beijing Jingdu Children’s HospitalBeijing 102200China

BACKGROUND New and more severe clinical manifestations associated with the coronavirus disease 2019(COVID-19) are emerging constantly in the pediatric age *** in this age group are also primary carriers of the influenza virus and are at a higher risk of developing severe ***,studies comparing influenza and COVID-19 to show which condition causes a more severe form of disease amongst the pediatric age group are *** To compare the laboratory results,clinical symptoms and clinical outcomes in pediatric patients with COVID-19 and *** A systematic and comprehensive search was carried out in databases and search engines,including EMBASE,Cochrane,MEDLINE,ScienceDirect and Google Scholar from 1964 until January 2022.A meta-analysis was carried out using a random-effects model and pooled odds ratio(OR) or standardized mean difference(SMD) and 95%*** A total of 16 studies satisfied the inclusion *** COVID-19 patients had a significantly reduced risk of cough(pooled OR = 0.16;95%CI:0.09 to 0.27),fever(pooled OR = 0.23;95%CI:0.12 to 0.43),and dyspnea(pooled OR = 0.54;95%CI:0.33 to 0.88) compared to influenza ***,total hemoglobin levels(pooled SMD = 1.22;95%CI:0.29 to 2.14) in COVID-19 patients were significantly higher as compared to pediatric influenza *** was no significant difference in symptoms such as sore throat,white blood cell count,platelets,neutrophil and lymphocytes levels,and outcomes like mortality,intensive care unit admission,mechanical ventilation or length of hospital *** COVID-19 is associated with a significantly lower rate of clinical symptoms and abnormal laboratory indexes compared to influenza in the pediatric age ***,further longitudinal studies of the outcomes between influenza and COVID-19 pediatric patients are needed.

关键词： COVID-19 Influenza Meta-analysis Pediatrics SARS-CoV-2

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Peripheral nerve fibroblasts secrete neurotrophic factors to promote axon growth of motoneurons

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Neural Regeneration Research 2022年第8期17卷 1833-1840页

作者： Qian-Ru He Meng Cong Fan-Hui yu yu-Hua Ji Shu yu hai-Yan Shi fei Ding Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-Innovation Center of NeuroregenerationJiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairNantong UniversityNantongJiangsu ProvinceChina

Peripheral nerve fibroblasts play a critical role in nerve development and *** previous study found that peripheral nerve fibroblasts have different sensory and motor *** of different phenotypes can guide the migration of Schwann cells to the same sensory or motor *** this study,we analyzed the different effects of peripheral nerve-derived fibroblasts and cardiac fibroblasts on *** with cardiac fibroblasts,peripheral nerve fibroblasts greatly promoted motoneuron neurite *** analysis results identified 491 genes that were differentially expressed in peripheral nerve fibroblasts and cardiac *** these,130 were significantly upregulated in peripheral nerve fibroblasts compared with cardiac *** genes may be involved in axon guidance and neuron *** days after sciatic nerve transection in rats,peripheral nerve fibroblasts accumulated in the proximal and distal nerve stumps,and most expressed brain-derived neurotrophic *** vitro,brain-derived neurotrophic factor secreted from peripheral nerve fibroblasts increased the expression ofβ-actin and F-actin through the extracellular regulated protein kinase and serine/threonine kinase pathways,and enhanced motoneuron neurite *** findings suggest that peripheral nerve fibroblasts and cardiac fibroblasts exhibit different patterns of gene *** nerve fibroblasts can promote motoneuron neurite outgrowth.

关键词： brain-derived neurotrophic factor differential gene expression F-actin fibroblasts motoneurons mRNA sequencing neurite outgrowth peripheral nervous system β-actin

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ON HERMITIAN POSITIVE DEFINITE SOLUTIONS OF MATRIX EQUATION X-A^＊X^-2 A=I

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Journal of Computational Mathematics 2005年第4期23卷 408-418页

作者： yu-hai Zhang School of Mathematics and System Sciences Shandong University Jinan 250100 China

The Hermitian positive definite solutions of the matrix equation X-A^＊X^-2 A=I are studied. A theorem for existence of solutions is given for every complex matrix A. A solution in case A is normal is given. The basic fixed point iterations for the equation are discussed in detail. Some convergence conditions of the basic fixed point iterations to approximate the solutions to the equation are given.

关键词： Matrix equation Positive definite solution Iterative methods

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Assessment of Interannual Sea Surface Salinity Variability and Its Effects on the Barrier Layer in the Equatorial Pacific Using BNU-ESM

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Advances in Atmospheric Sciences 2016年第3期33卷 339-351页

作者： hai ZHI Rong-Hua ZHANG fei ZHENG Pengfei LIN Lanning WANG Peng yu Earth System Modeling Center and College of Atmospheric Sciences Nanjing University of Information Science and Technology Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences International Center for Climate and Environment Science Institute of Atmospheric PhysicsChinese Academy of Sciences State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of Sciences College of Global Change and Earth System Science Beijing Normal University Cooperative Institute for Climate and Satellites University of MarylandCollege Park

As salinity stratification is necessary to form the barrier layer （BL）, the quantification of its role in BL interannual variability is crucial. This study assessed salinity variability and its effect on the BL in the equatorial Pacific using outputs from Beijing Normal University Earth System Model （BNU-ESM） simulations. A comparison between observations and the BNU-ESM simulations demonstrated that BNU-ESM has good capability in reproducing most of the interannual features observed in nature. Despite some discrepancies in both magnitude and location of the interannual variability centers, the displacements of sea surface salinity （SSS）, barrier layer thickness （BLT）, and SST simulated by BNU-ESM in the equatorial Pacific are realistic. During E1 Nifio, for example, the modeled interannual anomalies of BLT, mixed layer depth, and isothermal layer depth, exhibit good correspondence with observations, including the development and decay of E1 Nifio in the central Pacific, whereas the intensity of the interannual variabilities is weaker relative to observations. Due to the bias in salinity simulations, the SSS front extends farther west along the equator, whereas BLT variability is weaker in the central Pacific than in observations. Further, the BNU-ESM simulations were examined to assess the relative effects of salinity and temperature variability on BLT. Consistent with previous observation-based analyses, the interannual salinity variability can make a significant contribution to BLT relative to temperature in the western-central equatorial Pacific.

关键词： feedback interannual variability sea surface salinity barrier layer thickness

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Recent progress in hair follicle stem cell markers and their regulatory roles

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World Journal of Stem Cells 2024年第2期16卷 126-136页

作者： Yi-Zhan Xing hai-Ying Guo fei Xiang yu-Hong Li Department of Cell Biology Army Medical UniversityChongqing 400038China Institute of Burn Research Southwest HospitalArmy Medical UniversityChongqing 400038China

hair follicle stem cells(HFSCs)in the bulge are a multipotent adult stem cell *** can periodically give rise to new HFs and even regenerate the epidermis and sebaceous glands during wound *** increasing number of biomarkers have been used to isolate,label,and trace HFSCs in recent *** more detailed data from single-cell transcriptomics technology,we mainly focus on the important HFSC molecular markers and their regulatory roles in this review.

关键词： hair follicle stem cells Bulge Secondary hair germ Marker Single-cell RNA-sequencing

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