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Evaluation of an attenuated vaccine candidate based on the genotype C of bovine parainfluenza virus type 3 in albino guinea pigs

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Journal of Integrative Agriculture 2017年第9期16卷 2047-2054页

作者： MA Lei ZHU yuan-mao YANG Ting XUE fei Division of Livestock Infectious Diseases State Key Laboratory of Veterinary BiotechnologyHarbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069P.R.China

Bovine parainfluenza virus type 3（BPIV3） is considered as one of the most important respiratory tract pathogens of both young and adult cattle, and widespread among cattle in the world. BPIV3 was first reported in China in 2008 and four strains of BPIV3 were isolated from Shandong Province, known as genotype C（BPIV3c）. Pathogen investigations had shown that BPIV3 c infection was very common among cattle in China. To date, BPIV3 can be classified into genotypes A, B and C based on genetic and phylogenetic analysis. Serological survey also demonstrates that BPIV3 infection is widespread in China, however, there is still no available vaccine for BPIV3 prevention in China nowadays. In the present study, the BPIV3 c strain SD0835 was continuously passaged on Madin-Darby bovine kidney（MDBK） cells for hundreds of times, and the pathogenicity of passage 209 was reduced in guinea pigs. The passage 209 of BPIV3 c strain SD0835 was used as a live vaccine candidate to immunize the guinea pigs. The vaccination results revealed that two vaccinations could induce excellent serum neutralizing antibody responses as well as proliferation of T lymphocytes. The vaccinated guinea pigs were well protected against challenge with a low passage of BPIV3 c strain SD0835. Additionally, the percentages of CD4~＋ and CD8~＋ T cell subsets of animals in vaccinated group increased after immunization; T cell subsets on day 2 after challenge in both groups decreased, and the decline of CD4~＋ and CD8~＋ T cell subsets levels of four guinea pigs in vaccinated group was relatively moderate, comparing with that of the control group. These data support further testing of the attenuated virus as an effective candidate vaccine.

关键词： bovine parainfluenza virus type 3 attenuated vaccine genotype C guinea pig

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Vector Magnetic Field Measurement of NOAA AR 10197

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Chinese Journal of Astronomy and Astrophysics 2006年第4期6卷 470-476页

作者： Hong-fei Liang Hai-Juan Zhao Fu-yuan Xiang National Astronomical Observatories / Yunnan Observatory Chinese Academy of Sciences Kunming 650011 Graduate School of Chinese Academy of Sciences Beijing 100049 Yunnan Normal University Kunming 650092 National Satellite Meteorological Center China Meteorological Administration Beijing 100081 Xiangtan University Xiangtan 411105

A set of two-dimensional Stokes spectral data of NOAA AR 10197 obtained by the Solar Stokes Spectral Telescope （S^3T） at the Yunnan Observatory are quafitatively analyzed. The three components of the vector magnetic field, the strength H, inclination 7 and azimuth X, are derived. Based on the three components, we contour the distributions of the longitudinal magnetic field and transverse magnetic field. The active region （AR） has two different magnetic polarities apparent in the longitudinal magnetic map due to projection effect. There is a basic agreement on the longitudinal magnetic fields between the S^3T and SOHO/MDI magnetograms, with a correlation coefficient PBl = 0.911. The transverse magnetic field of the AR has a radial distribution from a center located in the southwest of the AR. It is also found that the transverse magnetic fields obtained by Huairou Solar Observing Station （HRSOS） have a similar radial distribution. The distributions of transverse magnetic field obtained by S^3T and HRSOS have correlation coefficients, PAzimu = 0.86 and PBt =0.883, in regard to the azimuthal angle and intensity.

关键词： line: profiles -- sun: sunspots -- sun: vector magnetic field -- polarization

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Development of a database system for operational use in the selection of titanium alloys

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International Journal of Minerals,Metallurgy and Materials 2011年第4期18卷 444-449页

作者： yuan-fei Han Wei-dong Zeng Yu Sun Yong-qing Zhao State Key Laboratory of Solidification Processing Northwestern Polytechnical University Xi＇an 710072 China Northwest Institute for Nonferrous Metal Research Xi＇an 710016 China

The selection of titanium alloys has become a complex decision-making task due to the growing number of creation and utilization for titanium alloys,with each having its own characteristics,advantages,and *** choosing the most appropriate titanium alloys,it is very essential to offer a reasonable and intelligent service for technical *** possible solution of this problem is to develop a database system（DS） to help retrieve rational proposals from different databases and information sources and analyze them to provide useful and explicit *** this purpose,a design strategy of the fuzzy set theory is proposed,and a distributed database system is *** ranking of the candidate titanium alloys,the most suitable material is *** is found that the selection results are in good agreement with the practical situation.

关键词： titanium alloys database system fuzzy set theory evaluation

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New triterpenoid saponins from the leaves of Ilex chinensis and their hepatoprotective activity

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Chinese Journal of Natural Medicines 2021年第5期19卷 376-384页

作者： SHAO Si-yuan LI Ruo-fei SUN Hua LI Shuai State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Seven new triterpenoid saponins,including five ursane-type saponins,ilexchinenosides R–V(1–5),and two oleananetype saponins,ilexchinenosides W–X(6–7),with four known triterpenoid saponins(8–11)were isolated from the leaves of Ilex *** structures were elucidated by comprehensive spectroscopic 1 D and 2 D NMR and HR-ESI-MS *** sugar moieties were determined by HPLC analysis compared with standards after hydrolysis and *** 1,2,4,9 and 10 exhibited potential hepatoprotective activity against N-acetyl-p-aminophenol(APAP)-induced Hep G2 cell injury in vitro.

关键词： Ilex chinensis Ursane and oleanane Triterpenoid saponins Hepatoprotective activity

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AI-Enhanced Constellation Design for NOMA System: A Model Driven Method

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China Communications 2020年第11期17卷 100-110页

作者： Sen Wang Hanxiao Yu Yifei yuan Guangyi Liu Zesong fei Future Mobile Technology Lab China Mobile Research InstituteBeijing 100053China Beijing Institute of Technology Beijing 100081China

Grant-free Non-orthogonal Multiple Access(GF-NOMA)is a promising technology for massive access users and sporadic small-packet transmission for Beyond the 5th Generation mobile communication system(B5G)/the 6th Generation mobile communication system(6G).One of the key aspects in GF-NOMA system is the signature/constellation ***,due to the channel variation and random activation of users,conventional optimization approaches seem unsuitable for such complex *** this paper,as an initial attempt,we propose a human intelligence(HI)-guided artificial intelligence(AI)-enhanced signature/constellation design *** separate design of modulation and power allocation inspired by prior knowledge,the proposed deep neuron network(DNN)for NOMA signature/constellation design not only has smaller size of DNN and less training data,but also has stronger *** the last section,via simulations we demonstrate that in terms of bit error rate,the proposed scheme can achieve significant performance gain over the conventional NOMA schemes.

关键词： NOMA system DNN constellation design power allocation

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Smart and fast reinforcement design for anti-dip bedding rock slopes

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第11期15卷 2943-2953页

作者： Yun Zheng Congxin Chen fei Meng Xiaodong Fu Wei yuan State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China School of Civil Engineering and Architecture Wuhan University of TechnologyWuhan430070China Key Laboratory of Roads and Railway Engineering Safety Control of Ministry of Education Shijiazhuang Tiedao UniversityShijiazhuang050043China

Rock slopes are usually reinforced by a number of rock bolts due to the high efficiency and low ***,where should the rock bolts be installed is still a troublesome *** anti-dip bedding rock slopes(ABRSs),the installation position of rock bolts is a controlling factor that determines the reinforcement *** this work,a theoretical method is firstly proposed for assessing the stability of ABRSs reinforced by rock bolts using a limit equilibrium model.A comparison of theoretical calculations and numerical results was conducted to test the correctness of the theoretical *** on the stability assessment of ABRSs,we introduce adaptive moment estimation method(Adam)to optimize the installation location of rock *** Adam optimizer,the optimal layout of rock bolts with the maximum factor of safety can be determined,and the factor of safety of the slope increases by about 25%using the same amount of rock bolts but with different installation *** proposed method enables the fast stability analysis and supporting design for reinforced ABRSs,which paves the way to smart supporting design of slopes.

关键词： Rock slopes Toppling failure Rock bolts Stability assessment Smart analysis

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A smart post-synthetic route towards[Fe_(2)Co_(2)]molecular capsules with electron transfer and bidirectional switching behaviors

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Science China Chemistry 2021年第8期64卷 1340-1348页

作者： Lingyi Meng Yi-fei Deng Shihao Liu Zhiping Zheng yuan-Zhu Zhang Department of Chemistry Southern University of Science and Technology(SUSTech)Shenzhen518055China

Aldehyde groups were intentionally equipped on the cyanide-bridged[Fe_(2)Co_(2)]square molecules:{[(Tp*)Fe(CN)_(3)Co(bpy^(CHO))_(2)]_(2)-[PF_(6)]_(2)}·4MeOH(1,Tp*=hydrotris(3,5-dimethylpyrazol-1-yl)borate;bpy^(CHO)=4-formyl-4′-methyl-2,2′-bipyridine),thus providing chemical-active windows for post-modification towards desired *** this contribution,by taking advantage of efficient Schiff-base condensation between the aldehyde-substituted bipyridine derivative(bpyCHO)and alkyl diamines(H_(2)N-(CH_(2))_(n)NH_(2)),two discrete[Fe_(2)Co_(2)]compounds{[(Tp∗)Fe(CN)_(3)Co(bpy^(C=N(CH_(2))_(n)N=C)bpy)]2[PF_(6)]_(2)}⋅6DMF(2,n=5;3,n=7)were prepared,where the cyanide-bridged[Fe_(2)Co_(2)]square cores were encapsulated by the flexible alkyl ***-temperature single-crystal X-ray diffraction and magnetic studies revealed complete thermo(T_(1/2)=233 K(2)and 237 K(3))and photo-induced electron transfer event accompanying spin transition between the diamagnetic[Fe^(Ⅱ)_(LS2)Co^(Ⅲ)_(LS2)]state and the paramagnetic[Fe^(Ⅲ)_(LS2)Co^(Ⅱ)_(HS2)]state(LS,low spin;HS,high spin).In addition,the bidirectional switching between the two states was achieved with alternating laser irradiation at 808 and 532 nm at 10 K.

关键词： cyanide capsule supramolecule post-modification electron transfer bidirectional switch

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Effect of rolling deformation on microstructure and texture of spray-deposited magnesium alloy containing Mg-Nd-Zn typed LPSO

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Journal of Materials Science & Technology 2017年第7期33卷 630-636页

作者： Zhenliang Li fei Liu Aiping yuan Baoyu Duan Yiming Li Xiaowei Li School of Materials and Metallurgy Inner Mongolia University of Science & Technology Baotou 014010 China Analysis and Test Center Inner Mongolia University of Science & Technology Baotou 014010 China

Billets of Mg-9Al-3Zn-1Mn-6Ca-2Nd alloy were produced by spray-deposition（the Osprey process）.Effect of rolling deformation（T = 350？C, ε = 5%, 10%, and 15%, respectively） on microstructure and texture evolution of the Mg-9Al-3Zn-1Mn-6Ca-2Nd alloy was investigated by scanning electron microscopy（SEM）, transmission electron microscopy（TEM） and X-ray diffraction（XRD）. Results show that at pass reduction of ε = 5%, 10% and 15% at 350？C respectively, Mg-Nd-Zn typed 24R-LPSO structure was formed in（Ca, Nd）Al2phase（C15 Laves phase）. With the increase in pass reduction（i.e. 5%, 10% and 15%）, the texture pole density level of basal texture（0002） changed little and pyramidal texture（10 1ˉ3） were *** contrast, those of prismatic texture {101ˉ0} 〈11 2ˉ0〉 were increased initially and followed by a reduction, indicating texture randomization in the grain-refined Mg alloy. The combined contribution of LPSO phase and C15 phase was key to randomize the texture of the grain-refined Mg alloy. It was noted that the microcosmic plastic deformation of LPSO phase and nanometer-sized dispersed C15 phase impeded dislocation movement, led to dislocation tangles, and facilitated recrystallization.

关键词： Mg alloy Sub-cells Texture randomization LPSO phase Microcosmic plastic deformation

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Scalable construction of SiO/wrinkled MXene composite by a simple electrostatic self-assembly strategy as anode for high-energy lithium-ion batteries

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Chinese Chemical Letters 2020年第4期31卷 980-983页

作者： Chuanliang Wei Huifang fei yuan Tian Yongling An yuan Tao yuan Li Jinkui Feng Research Center for Carbon Nanomaterials Key Laboratory for Liquid-Solid Structural Evolution&Processing of Materials(Ministry of Education)School of Materials Science and EngineeringShandong UniversityJi'nan 250061 China

Available onlineSilicon monoxide(SiO)is a promising anode material fo r lithium-ion batteries(LIBs)due to its high theoretical specific capacity(~2400 mAh/g),low working potential(<0.5 V ***^+/Li),low cost,easy synthesis,nontoxicity,abundant natural source and smaller volume expansion than ***,low intrinsic electrical conductivity,low initial Coulombic efficiency(ICE)and inevitable volume expansion(~200%)impede its practical *** we fabricate SiO/wrinkled MXene composite(SiO-WM)by an electrostatic self-assembly ***,this method is simple,scalable and taking into account all the issues of *** a result,the SiO-WM exhibits imp roved rate capability,cycling performance and ICE than bare SiO.

关键词： SiO Wrinkled MXene Electrostatic self-assembly Anode Lithium-ion batteries

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Palladium nanoclusters immobilized on defective nanodiamond-graphene core-shell supports for semihydrogenation of phenylacetylene

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Journal of Energy Chemistry 2019年第6期28卷 31-36页

作者： fei Huang Zhimin Jia Jiangyong Diao Hua yuan Dangsheng Su Hongyang Liu Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026AnhuiChina College of Chemistry Chongqing Normal UniversityChongqing 401331China

We report a nanocarbon material with nanodiamond(ND) core and graphene shell(ND@G) as a support for Pd nanocatalysts. The designed catalyst performed good selectivity of styrene(85.2%) at full conversion of phenylacetylene and superior stability under mild conditions. Supported Pd catalysts are characterized by means of high resolution transmission electron microscopy(HRTEM), Raman, X-ray diffraction(XRD), X-ray photoelectron spectroscopy(XPS) and H2 temperature-programmed reduction(H2-TPR).The results clearly show that formation of the strong metal-support interaction(SMSI) between Pd nanoclusters and the defective graphene shell helpfully modifies the selectivity and stability of the Pd-based catalysts.

关键词： Selective hydrogenation Palladium nano clusters Nanocarbon support Liquid-phase hydrogenation

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