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Multiplexing metal grating coupler based on MIM structure

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Optoelectronics Letters 2025年

作者： liu yang liu fei MA Yunxia zhang Ailing Engineering Research Center of Communication Devices and Technology， Ministry of Education， Tianjin Key Laboratory of Film Electronic and Communication Devices， School of Integrated Circuit Science and Engineering， Tianjin University of Technology

We propose and numerically investigate a multiplexing metal grating coupler based on metal/insulator/metal （MIM） structure. The coupler consists of gold grating/silicon/gold layers， which combines with MIM waveguide， concurrently achieving path multiplexing and wavelength multiplexing through TMnmodes coupling. In visible light band， TM waves are coupled to the upper surface of gold plate， and the coupling efficiency reaches maximum of 31.67% at wavelength of 736 nm. In near infrared and mid infrared bands， TM waves are coupled into MIM waveguide， and the coupling efficiency reaches maximum of 53.57% at wavelength of 2550 nm. There can be four modes of TM0， TM1， TM2and TM3simultaneously in MIM waveguide， which are excited at different wavelengths. The preparation process of the structure designed in this article is simple， with dimensions at the micrometer level， easy to be integrated， and can be applied to be integrated optical circuits.

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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying liu Bei Peng Xiaoyan Zhou Lixia qin Lingyan Liang Yichen Wei qingping zhang Xiaocheng Li Haixia qin Yinqi Lai Yian Lu yan zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun liu Jianrong yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu fei Niu Xinlong Dong Bin zhang Baiyun liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis

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Science China Life Sciences 2025年

作者： Rongmei Gao Kanchao Chen Yimin Wang Rongxia Guo Xiaoyu zhang Peng Wu Weili Wang qingxiang Huang Xuemei Xie Shangda yang yanling Lü Qian Ren fei liu Song Chen Fengxia Ma Tao Cheng Hui Cheng State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College CAMS Center for Stem Cell Medicine PUMC Department of Stem Cell and Regenerative Medicine

Hematopoiesis is a finely tuned process that generates all blood cell types through self-renewal and differentiation, which is crucial for maintaining homeostasis. Acute infections can prompt a hematopoietic response known as emergency myelopoiesis. In this study, using a Candida albicans (C. albicans) infection model, we demonstrated for the first time that disruption of Fhl2 led to increased fungal burden,heightened inflammatory response and reduced survival rates. Impaired myeloid hematopoiesis and immune cell production were evident, as proved by the decreased numbers of hematopoietic stem and progenitor cells (HSPCs) and granulocytes in the bone marrow of Fhl2-deficient mice. In conclusion, FHL2 regulated emergency myelopoiesis in response to C. albicans, affecting the host’s defense against pathogens.

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Enhanced rate capability and cycle stability of Ti2C MXene for sodium storage through an aniline molecules welding strategy

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Tungsten 2025年第1期 161-171页

作者： Hao Chen ya-qin Wang Dong-Ting zhang Bei Zhao Min-Peng Li Chen-yang Li Tian-Peng Xu Mao-Cheng liu State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals Lanzhou University of Technology School of Materials Science and Engineering Lanzhou University of Technology School of Computer and Communication Technology Lanzhou University of Technology

MXenes obtained significant attention in the field of energy storage devices due to their characteristic layered structure,modifiable surface functional groups,large electrochemically active surface,and regulable interlayer ***,the self-restacking and sluggish ions diffusion kinetics performance of MXenes during the alkali metal ions insertion/extraction process severely impedes their cycle stability and rate *** paper proposes an aniline molecule welding strategy for welding p-phenylenediamine（PPDA） into the interlayers of Ti2C through a dehydration condensation *** welded PPDA molecules can contribute pillar effect to the layered structure of *** pillar effect effectively maintains the structural stability during the sodium ions insertion/extraction process and effectively expands the interlayer spacing of Ti2C from 1.16 to 1.38 nm,thereby enhancing ions diffusion kinetics performance and improving the long-term cycle *** Ti2C-PPDA demonstrates outstanding Na+storage capability,exhibiting a specific capacity of 100.2 mAh·g-1at a current density of 0.1 A·g-1over 960 cycles and delivering a remarkable rate capability 81.2 mAh·g-1at a current density of 5 A·*** study demonstrates that expanding interlayer spacing is a promising strategy to enhance the Na+storage capacity and improve long-term cycling stability,which provides significant guidance for the design of two-dimensional Na+storage materials with high-rate capability and cycle stability.

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City-Bus-Route Demand-based Efficient Coupling Driving Control for Parallel Plug-in Hybrid Electric Bus

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Chinese Journal of Mechanical Engineering 2018年第3期31卷 168-178页

作者： qin-Pu Wang Chao yang ya-Hui liu Yuan-Bo zhang Zhongtong Bus Hold Co. Ltd. State Key Laboratory of Automotive Safety and Energy Tsinghua University

Recently,plug?in hybrid electric bus has been one of the energy?e cient solutions for urban transportation. However,the current vehicle e ciency is far from optimum,because the unpredicted external driving conditions are di cult to be obtained in advance. How to further explore its fuel?saving potential under the complicated city bus driving cycles through an e cient control strategy is still a hot research issue in both academic and engineering area. To realize an e cient coupling driving operation of the hybrid powertrain,a novel coupling driving control strategy for plug?in hybrid electric bus is presented. Combined with the typical feature of a city?bus?route,the fuzzy logic inference is employed to quantify the driving intention,and then to determine the coupling driving mode and the gear?shifting strategy. Considering the response deviation problem in the execution layer,an adaptive robust controller for electric machine is designed to respond to the transient torque demand,and instantaneously compensate the response delay and the engine torque fluctuation. The simulations and hard?in?loop tests with the actual data of two typical driving conditions from the real?world city?bus?route are carried out,and the results demonstrate that the pro?posed method could guarantee the hybrid powertrain to track the actual torque demand with 10.4% fuel economy improvement. The optimal fuel economy can be obtained through the optimal combination of working modes. The fuel economy of plug?in hybrid electric bus can be significantly improved by the proposed control scheme without loss of drivability.

关键词： Hybrid electric vehicle Single?shaft parallel electromechanical powertrain Coupling driving mode Adaptive robust control

Relationship between Thermal Metamorphism of Coal and the Periodic Variation Law of Geochemical Behavior of Elements:A Study on the C2 Coal Seam in the Fengfeng Mining Area of the Handan Coalfield in Hebei,China

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Acta Geologica Sinica(English Edition) 2021年第5期95卷 1684-1694页

作者： yang Jianye qin Shenjun zhang Weiguo liu Shande XU fei College of Material Science and Engineering Xi’an University of Science and TechnologyXi’an 710054China Key Laboratory for Resource Exploration Research of Hebei Province Hebei University of EngineeringHandanHebei 056038China College of Geology and Environment Xi’an University of Science and TechnologyXi’an 710054China Xi’an Research Institute Co. Ltd.China Coal Science and Industry GroupXi’an University of Science and TechnologyXi’an 710077China

This study highlights the response of the periodic variation of the geochemical behavior of elements to the thermal metamorphism of coal by considering the differentiation mode and differentiation degree of elements of the C2 coal seam in the Fengfeng mining area of the Handan Coalfield in Hebei,*** periodic variation of the geochemical behavior of elements was observed to change towards a certain direction as the degree of metamorphism of a geological body *** on the coincidence degree(or similarity degree)between the geochemical behavior of elements and periodic variation of elements,the 57 elements in this study were divided into two *** periodic variation of the geochemical behavior of first-level elements was largely synchronous with that of their first ionization energy,suggesting that only one differentiation mode exists and the elements are mainly inorganically *** differentiation mode of the second-level elements deviated to a certain extent from their first ionization energy;the larger the deviation,the more complicated and diverse was the differentiation *** the second-level elements,the grade of coal metamorphism has evident and intuitive effects on the proportion of elements with particular structural features,such as the 4q+3 type of elements and the odd-odd *** addition,the distribution of elements in organic and inorganic matter within coal are subject to the structural features of the *** differentiation mode and differentiation intensity of elements could be characterized by the hierarchical parameter and differentiation *** hierarchical parameter and differentiation intensity of certain elements showed a good positive or negative correlation with R_(max) in *** 57 elements in this study were quantitatively ordered according to the degree of magmatic hydrothermal fluid influence and thermal metamorphism of coal through graphs depicting the goodness of fit,correlation coeffic

关键词： elements in coal geochemical behavior periodic variation thermal metamorphism magmatic hydrothermal fluids

Li掺杂对4H-SiC光电性质影响的理论研究

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原子与分子物理学报 2025年第2期42卷 151-158页

作者：李萍尹伟潘学聪庞国旺马亚斌杨亚宏杨菲宇张盼秦彦军新疆理工学院理学院阿克苏843100 新疆理工学院机电工程学院阿克苏843100

采用基于密度泛函理论的第一性原理方法,计算了Li掺杂4H-SiC体系的电子结构及光学性质.结果表明,掺杂前后的4H-SiC均为间接带隙半导体,Li原子间隙掺杂后形成n型半导体,Li原子替位式掺杂体系的禁带中出现了杂质能级,降低了电子跃迁时所... 详细信息

采用基于密度泛函理论的第一性原理方法,计算了Li掺杂4H-SiC体系的电子结构及光学性质.结果表明,掺杂前后的4H-SiC均为间接带隙半导体,Li原子间隙掺杂后形成n型半导体,Li原子替位式掺杂体系的禁带中出现了杂质能级,降低了电子跃迁时所需的能量;对电荷差分密度图的分析表明,Li原子失去电子,导致Li-C键和Li-Si键的共价性降低,以离子性为主;在可见光区域,相比于4H-SiC体系,掺杂体系的吸收率峰值均有所提高,其中Li间隙掺杂体系吸收带边最小,吸收率峰值最大,掺杂后的4H-SiC体系对红外、可见光、紫外均能够有所吸收,说明Li掺杂能够有效拓宽4H-SiC对光的响应范围.

关键词： Li掺杂 4H-SiC 电子结构光学性质第一性原理

Preparation of a functional fracturing fluid with temperature-and salt-resistance,and low damage using a double crosslinking network

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Petroleum Science 2023年第5期20卷 3223-3230页

作者： yang zhang An Chen Jin-Cheng Mao Song-Hai qin Jin Li Xiao-Jiang yang Chong Lin Zhi-Yu Huang ya-fei liu State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengduSichuan610500China Development Division PetroChina Southwest Oil and Gas Field CompanyChengduSichuan610066China Downhole Services Company CNPC Bohai Drilling Engineering Company LtdRenqiuHebei062550China Sinopec Zhongyuan Oilfield Company PuyangHenan457001China

Fracturing fluids(FFs)have been widely used to stimulate the tight ***,current FFs will not only lose their rheological property at high temperatures and high salt but also show an incomplete gel-breaking ***,a double crosslinking network FF with pretty superiorities in rheology and low damage to the core was constructed by introducing both physical crosslinking and chemical crosslinking into the *** construction of double crosslinking networks enhanced the rheology of this functional *** particle sizes of gel-breaking fluids are mainly distributed in 1.0e10,000 nm;furthermore,for every 10,000 mg/L increase in salinity,the particle size of the gel-breaking fluid is decreased by almost *** adsorption capacity(<1.0 mg/g)gradually decreased with the increase of salinity at 20℃.Moreover,the adsorption of gel-breaking fluids on the rock decreased first and then kept stable with temperature increasing at a salinity of ≤30,000 mg/L,however,showed the opposite trend at 40,000 mg/*** results of rheology,particle size,static adsorption,and core damage showed that this functional FF could be an alternative for the stimulation of a tight reservoir with high temperature and recycling of produced water with high salinity.

关键词： Fracturing fluid Temperature-and salt-resistance Particle size Static adsorption Low damage