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Numerical Study of Wave Energy Converter Platform Geometry Layout Design

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Journal of Shanghai Jiaotong university(Science) 2024年第5期29卷 780-790页

作者： pei fei LIN Yan School of Naval Architecture Dalian University of TechnologyDalian116024LiaoningChina State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of TechnologyDalian116024LiaoningChina

The present work is aimed at determining the optimal geometry layout of a wave energy converter platform for plate energy harvesting performance.A linear potential fluid theory method was applied to analyzing the interaction between the platform and *** factors of layout geometry were tested and the performance of the plate was *** methodology of design of experiments was used to confirm factor significance and build response surface *** 1st order model and the 2nd order model were built to describe the relation between factors and plate *** significance of two factors and their interactions were revealed,and an optimal parameter set was *** wave form in front of the plate confirmed the *** is clear that a wide entrance and enclosing channel for waves can maximize the plate performance.

关键词： wave energy converter hydrodynamic response design of experiments response surface methodology factorial design

Experimental Study on Hydrodynamic Response of Semisubmersible Platform-Based Bottom-Hinged Flap Wave Energy Converter

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Journal of Shanghai Jiaotong university(Science) 2022年第3期27卷 307-315页

作者： LIN Yan pei fei State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of TechnologyDalian 116024LiaoningChina School of Naval Architecture Dalian University of TechnologyDalian 116024LiaoningChina

A semisubmersible platform-based(SPB)bottom-hinged flap(BHF)wave energy converter(WEC)concept is presented in this paper,and its platform hydrodynamic response was studied *** at studying the special WEC-mounted platform response problem,both regular and irregular wave experiments were *** frequency domain results of regular wave experiments are described in the form of response amplitude *** time domain results of irregular wave experiments are treated by statistical analysis and fast Fourier *** wave experiments and irregular wave experiments show good *** mooring system strongly affects the whole system,which is a considerable factor for WEC *** influences of BHF mounted on the platform are revealed in both statistic and frequency spectral *** results of experiments give a guide for SPB design aiming to support BHF-WEC.

关键词： wave energy converter(WEC) hydrodynamic response wave tank experiment mooring design

Human paraoxonase gene cluster overexpression alleviates angiotensin II-induced cardiac hypertrophy in mice

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Science China(Life Sciences) 2016年第11期59卷 1115-1122页

作者： Jian-fei pei Yun-fei Yan Xiaoqiang Tang Yang Zhang Shen-Shen Cui Zhu-Qin Zhang Hou-Zao Chen De-pei Liu State Key Laboratory of Medical Molecular Biology Department of Biochemistry and Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences & Peking Union Medical College

Cardiac hypertrophy is the strongest predictor of the development of heart failure, and anti-hypertrophic treatment holds the key to improving the clinical syndrome and increasing the survival rates for heart failure. The paraoxonase(PON) gene cluster(PC) protects against atherosclerosis and coronary artery diseases. However, the role of PC in the heart is largely unknown. To evaluate the roles of PC in cardiac hypertrophy, transgenic mice carrying the intact human PON1, PON2, and PON3 genes and their flanking sequences were studied. We demonstrated that the PC transgene(PC-Tg) protected mice from cardiac hypertrophy induced by Ang II; these mice had reduced heart weight/body weight ratios, decreased left ventricular wall thicknesses and increased fractional shortening compared with wild-type(WT) control. The same protective tendency was also observed with an Apoe^(-/-)background. Mechanically, PC-Tg normalized the disequilibrium of matrix metalloproteinases(MMPs)/tissue inhibitors of MMPs(TIMPs) in hypertrophic hearts, which might contribute to the protective role of PC-Tg in cardiac fibrosis and, thus, protect against cardiac remodeling. Taken together, our results identify a novel anti-hypertrophic role for the PON gene cluster, suggesting a possible strategy for the treatment of cardiac hypertrophy through elevating the levels of the PON gene family.

关键词： cardiac hypertrophy fibrosis paraoxonase gene cluster angiotensin II

Clinical operational tolerance in liver transplantation:state-of-the-art perspective and future prospects

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Hepatobiliary & Pancreatic Diseases International 2013年第1期12卷 12-33页

作者： Xi-Qiang Liu Zhi-Qiu Hu Yao-fei pei Ran Tao Center for Organ Transplantation and Department of Surgery Ruijin HospitalShanghai Jiaotong University School of Medicine Department of Surgery Central Hospital of Minghang District

BACKGROUND:Liver transplantation is the definite treatment for end-stage liver diseases with satisfactory ***,untoward effects of life-long immunosuppression prevent the development of alternative strategies to achieve better longterm *** clinical operational tolerance is the ultimate *** SOURCES:A PubMed and Google Scholar search using terms:"immune tolerance","liver transplantation","clinical trial","operational tolerance" and "immunosuppression withdrawal" was performed,and relevant articles published in English in the past decade were ***-text publications relevant to the field were selected and relevant articles from reference lists were also *** was given to those articles which are relevant to the ***:Because of the inherent tolerogenic property,around 20%-30% of liver transplantation recipients develop spontaneous operational tolerance after immunosuppression withdrawal,and the percentage may be even higher in pediatric living donor liver transplantation *** natural killer and γδT cell related markers have been identified to be associated with the tolerant state in liver transplantation *** the progress,clinical operational tolerance is still rare in liver *** the recipient immune system by creating chimerism and regulatory cell therapies is among newer promising means to achieve clinical liver transplantation tolerance in the ***:Although clinical operational tolerance is still rare in liver transplantation recipients,ongoing basic research and collaborative clinical trials may help to decipher the mystery of transplantation tolerance and extend the potential benefits of drug withdrawal to an increasing number of patients in a more predictable fashion.

关键词： immune tolerance liver transplantation clinical trial

Amino-modified UiO-66-NH_(2) reinforced polyurethane based polymer electrolytes for high-voltage solid-state lithium metal batteries

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Nano Research 2024年第11期17卷 9662-9670页

作者： Danru Huang Lin Wu Qi Kang Zhiyong Shen Qiaosheng Huang Wenjie Lin fei pei Yunhui Huang State Key Laboratory of Low-carbon Smart Coal-fired Power Generation and Ultra-clean Emission China Energy Science and Technology Research Institute Co. Ltd. Nanjing 210023 China State Key Laboratory of Materials Processing and Die and Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China Institute of New Energy for Vehicles School of Materials Science and Engineering Tongji University Shanghai 201804 China

Solid-state polymer electrolytes(SPEs)are candidate schemes for meeting the safety and energy density needs of advanced lithium-based battery because of their improved mechanical and electrochemical stability compared to traditional liquid ***,low ionic conductivity and side reactions occurring in traditional high-voltage lithium metal batteries(LMBs)hinder their practical ***,amino-modified metal-organic frameworks(UiO-66-NH_(2))with abundant defects as multifunctional fillers in the polyurethane based SPEs achieve the collaborative promotion of the mechanical strength and room temperature ionic *** surface modified amino groups serve as anchoring points for oxygen atoms of polymer chains,forming a firmly hydrogen-bond interface with polycarbonate-based polyurethane *** rich interfaces between UiO-66-NH_(2) and polymers dramatically decrease the crystallization of polymer chains and reduce ion transport impedance,which markedly boosted the ionic conductivity to 2.1×10^(−4) S·cm^(−1) with a high Li+transference numbers of *** a result,LiFePO4∣SPEs∣Li cells exhibit prominent cyclability for 700 cycles under 0.5 C with 96.5%capacity *** LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2)(NCM622)∣SPEs∣Li cells deliver excellent long-term lifespan for 260 cycles with a high capacity retention of 91.9%and high average Coulombic efficiency(98.5%)under ambient *** simple and effective hybrid SPE design strategy sheds a milestone significance light for high-voltage Li-metal batteries.

关键词： solid-state polymer electrolyte metal-organic frameworks polyurethane lithium metal batteries high voltage interface

Flexible Si/PEDOT：PSS hybrid solar cells

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Nano Research 2015年第10期8卷 3141-3149页

作者： Shuxin Li Zhibin pei fei Zhou Ying Liu Haibo Hu Shulin Ji Changhui Ye AnhuiKeyLaboratoryofNanomaterials andTechnologyandKeyLaboratoryofMaterialsPhysicsInstituteofSolidStatePhysicsChineseAcademyofSciencesHefei230031China

Si hybrid solar cells have attracted tremendous research attention in recent years because of their low production costs and high performance. However, flexible Si hybrid solar cells have rarely been reported owing to the difficulty of fabricating single-crystalline Si with good flexibility. In this study, we fabricated flexible Si/PEDOT：PSS hybrid solar cells with micro-pyramid-structured Si light absorbers using a facile approach. Compared with planar flexible hybrid solar cells with a power-conversion efficiency of 4%, solar cells with micro-pyramid-structured Si light absorbers have a higher efficiency of 6.3%. External quantum efficiency and electrochemical impedance spectroscopy measurements revealed that the solar cells with micro-pyramid-structured Si light absorbers exhibited a pronounced light-harvesting enhancement in the spectra region of 400-1,000 nm and had a smaller series resistance and larger recombination resistance compared with the planar cells, yielding a higher efficiency. Additionally, in mechanical-bending tests, the flexible solar cells with micro-pyramid-structured Si light absorbers exhibited an excellent performance stability after bending for 600 cycles. Our findings lay the foundation for the real-world applications of flexible Si/PEDOT：PSS hybrid solar cells in next-generation portable electronics.

关键词： flexible devices hybrid solar cells micro-pyramid flexing test

DNA recognition patterns of the multi-zinc-finger protein CTCF: a mutagenesis study

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Acta Pharmaceutica Sinica B 2018年第6期8卷 900-908页

作者： Jingjing Guo Ni Li Jiexiong Han fei pei Tianyu Wang Duo Lu Jiandong Jiang State Key Laboratory of Bioactive Substance and Function of Natural Medicine Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College

CCCTC-binding factor(CTCF) is a zinc-finger protein, serving an important part in the genome architecture as well as some biochemical processes. Over 70,000 CTCF binding DNA sites have been detected genome-wide, and most anchors of chromatin loops are demarcated with the CTCF *** protein or RNA molecules interact with DNA-bound CTCF to conduct different biological functions, and potentially the interfaces between CTCF and its cofactors can be targets for drug development. Here we identify the effective region of CTCF in DNA recognition, which defines the exposed CTCF surface feature for the interaction of cofactors. While the zinc-finger region contributes the most in DNA association, its binding affinity varies based on different DNA sequences. To investigate the effectiveness of individual zinc-fingers, the key residues are mutated to inactivate the DNA binding ability, while the finger configuration and the spacing between fingers are preserved. The strategy is proved to be successful, while clear differences are observed in the DNA binding affinities among the 11 finger mutants and the result is consistent to previous studies in general. With the help of inactivated finger mutants, we identify the ineffective fingers and the dominant effective fingers, which form distinctive patterns on different DNA targets.

关键词： CTCF Zinc-finger Structure integrity Mutagenesis DNA recognition patterns

A critical review on the health promoting effects of mushrooms nutraceuticals

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Food Science and Human Wellness 2018年第2期7卷 125-133页

作者： Gaoxing Ma Wenjian Yang Liyan Zhao fei pei Donglu Fang Qiuhui Hu College of Food Science and Technology Nanjing Agricultural UniversityNanjingJiangsu210095China College of Food Science and Engineering/Collaborative Innovation Center for Modern Grain Circulation and Safety/Key Laboratory of Grains and Oils Quality Control and Processing Nanjing University of Finance&EconomicsNanjingJiangsu 210023China

Extensive elucidations focusing on the efficient health promoting properties and high nutritional values of mushrooms have been expanded dynamically from the past few *** to its high quality of proteins,polysaccharides,unsaturated fatty acids,mineral substances,triterpenes sterols and secondary metabolites,mushrooms have always been appreciated for their vital role in protecting and curing various health problems,such as immunodeficiency,cancer,inflammation,hypertension,hyperlipidemia,hypercholesterolemia and ***,investigations in recent years have revealed the correlations between the health-promoting benefits and gut microbiota regulating effects induced by the mushrooms *** on the immense role in the nutritional and health benefits displayed by mushrooms have become an emergent task to *** present article overviewed and compiled the latest information correlated to the health benefits and underlying functional mechanisms of mushroom nutraceuticals,and concluded that the supplementation of mushrooms as a dietary composition could become a natural adjuvant for the prevention and treatment of several health diseases.

关键词： Mushrooms Bioactive nutraceuticals Health benefits Functional mechanisms Gut microbiota regulation

Effect of cooked rice with added fructo-oligosaccharide on faecal microorganisms investigated by in vitro digestion and fermentation

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Food Science and Human Wellness 2023年第2期12卷 662-668页

作者： fei pei Wen Li Xiaolei Ni Xinyang Sun Yijun Yao Yong Fang Wenjian Yang Qiuhui Hu College of Food Science and Engineering/Collaborative Innovation Center for Modern Grain Circulation and Safety/Key Laboratory of Grains and Oils Quality Control and Processing Nanjing University of Finance and EconomicsNanjing 210023China Department of Food and Human Nutritionl Sciences University of ManitobaWinnipeg MB R3T 2N2Canada

In the present study,the effects of cooked rice(CR)with added fructo-oligosaccharide(FOS)on faecal flora were studied by a simulated in vitro digestion and fermentation *** total carbohydrate content,p H,and s hort-chain fatty acids(SCFAs)were determined during in vitro digestion and *** change in the bacterial phase distribution after the fermentation was also *** results showed that t he total carbohydrate content of the CR with added FOS(FCR)significantly decreased during the simulated ***,the p H of the FCR decreased and the SCFAs concentration increased significantly compared to those of the CR during the simulated *** addition,the FCR showed the advantage of promoting beneficial bacteria,such as Bifidobacterium and Lactobacillus,and inhibiting harmful bacteria,such as Bacteroides and Klebsiella compared to the ***,the FOS as a prebiotic could be recommended to produce the high-quality healthy rice food.

关键词： Fructo-oligosaccharide In vitro Fermentation Rice Short-chain fatty acids Bacterial phase distribution