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Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis

National Science Review 2019年第5期6卷 993-1003页

作者： Xiaocui Xu Guoqiang li Congru li Jing zhang Qiang Wang David K.Simmons Xuepeng Chen Naveen Wijesena Wei Zhu Zhanyang Wang Zhenhua Wang Bao Ju Weimin Ci Xuemei Lu Daqi Yu Qian-fei Wang Neelakanteswar Aluru Paola Oliveri Yong E.zhang Mark Q.Martindale Jiang liu CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute of Apiculture Research Chinese Academy of Agriculture Sciences Whitney Laboratory for Marine Bioscience University of Florida College of life Sciences Yantai University CAS Key Laboratory of Genomics and Precision Medicine Beijing Institute of Genomics Chinese Academy of Sciences Institute of Zoology Chinese Academy of Sciences Biology Department Woods Hole Oceanographic Institution Departments of Genetics Evolution and Environment and Cell and Developmental Biology University College London CAS Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences

Major evolutionary transitions are enigmas, and the most notable enigma is between invertebrates and vertebrates, with numerous spectacular *** search for the molecular connections involved, we asked whether global epigenetic changes may offer a clue by surveying the inheritance and reprogramming of parental DNA methylation across *** focused on gametes and early embryos, where the methylomes are known to evolve divergently between fish and ***, we find that methylome reprogramming during embryogenesis occurs neither in pre-bilaterians such as cnidarians nor in protostomes such as insects, but clearly presents in deuterostomes such as echinoderms and invertebrate chordates, and then becomes more evident in *** association analysis suggests that DNA methylation reprogramming is associated with development, reproduction and adaptive immunity for vertebrates, but not for ***, the single HOX cluster of invertebrates maintains unmethylated status in all stages *** contrast, the multiple HOX clusters show dramatic dynamics of DNA methylation during vertebrate ***, the methylation dynamics of HOX clusters are associated with their spatiotemporal expression in *** study reveals that DNA methylation reprogramming has evolved dramatically during animal evolution, especially after the evolutionary transitions from invertebrates to vertebrates, and then to mammals.

关键词： DNA methylation evolution development reprogramming

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Spectroelectrochemical Investigation on Neutral Red

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Chemical Research in Chinese Universities 1992年第1期8卷 33-36页

作者： Shen Baoen, zhang ming, Tang Yinxuan and li Benle (Department of Chemistry, Hangzhou University, Hangzhou)

Neutral Red can be used as an indicator, a stain reagent or a mediator compound in the studies of biological redox systems. No reports dealing with the electrode process of Neutral Red, especially, about its kinetics have been published. In this paper we report the determinations of formal reduction potentials, the number of electrons transferred, diffusion coefficient as well as the rate constant of heterogeneous electron transfer

关键词： Neutral Red(NR) Spectroelectrochemistry Tin dioxide electrode

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Is recovery enhancement after gastric cancer surgery really a safe approach for elderly patients?

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1334-1343页

作者： Zi-Wei li Xiao-Juan Luo fei liu Xu-Rui liu Xin-Peng Shu Yue Tong Quan Lv Xiao-Yu liu Wei zhang Dong Peng Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Endoscopy Center The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400012China

BACKGROUND This study aimed to evaluate the safety of enhanced recovery after surgery(ERAS)in elderly patients with gastric cancer(GC).AIM To evaluate the safety of ERAS in elderly patients with *** The PubMed,EMBASE,and Cochrane library databases were used to search for eligible studies from inception to April 1,*** mean difference(MD),odds ratio(OR)and 95%confidence interval(95%CI)were pooled for *** quality of the included studies was evaluated using the Newcastle-Ottawa Scale *** used Stata(V.16.0)software for data *** This study consists of six studies involving 878 elderly *** analyzing the clinical outcomes,we found that the ERAS group had shorter postoperative hospital stays(MD=-0.51,I2=0.00%,95%CI=-0.72 to-0.30,P=0.00);earlier times to first flatus(defecation;MD=-0.30,I²=0.00%,95%CI=-0.55 to-0.06,P=0.02);less intestinal obstruction(OR=3.24,I2=0.00%,95%CI=1.07 to 9.78,P=0.04);less nausea and vomiting(OR=4.07,I2=0.00%,95%CI=1.29 to 12.84,P=0.02);and less gastric retention(OR=5.69,I2=2.46%,95%CI=2.00 to 16.20,P=0.00).Our results showed that the conventional group had a greater mortality rate than the ERAS group(OR=0.24,I2=0.00%,95%CI=0.07 to 0.84,P=0.03).However,there was no statistically significant difference in major complications between the ERAS group and the conventional group(OR=0.67,I2=0.00%,95%CI=0.38 to 1.18,P=0.16).CONCLUSION Compared to those with conventional recovery,elderly GC patients who received the ERAS protocol after surgery had a lower risk of mortality.

关键词： Enhanced recovery after surgery Gastric cancer Elderly Mortality

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Glycine Attenuates Myocardial Fibrosis in Myocardial Infarction in Rats Partly through Modulating Signal Transducer and Activator of Transcription 3/Nuclear Factor-κB/Transforming Growth Factor-β axis

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 263-270页

作者： Ning li Yong Wang Chun li Xu Chen Xue-Feng zhang Nan Nan Tan Yi-Qin Hong ming-Yan Shao Bing-Hua Tang Dong-Qing Guo School of life Science Beijing University of Chinese MedicineBeijingChina College of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Modern Research Center of Traditional Chinese Medicine School of Traditional Chinese Material MedicaBeijing University of Chinese MedicineBeijingChina

Objective: Inflammation and fibrosis are strongly associated with each other. Glycine is present in various traditional Chinese medicines and exhibits anti-inflammatory activity. However, the effects of glycine on myocardial fibrosis(MF) in rats with myocardial infarction(MI) have not been reported. The purpose of this study is to investigate the effects of glycine therapy on MF and comprehend its underlying mechanisms. Materials and Methods: Left anterior descending artery ligation-induced MI in Sprague Dawley rats was leveraged to assess the therapeutic effects of Glycine. Rats received either normal saline or glycine(0.5 mg/g bodyweight) for 7 days. Results: Glycine upregulated cardiac ejection fraction and fractional shortening to improve cardiac function, as evaluated by echocardiography. Histological and immunohistochemical analyses demonstrated that glycine could decrease inflammatory cell infiltration and alleviate collagen deposition. Western blotting revealed that nuclear factor-κB(NF-κB)-mediated inflammatory signaling was also downregulated by glycine treatment. The expression of signal transducer and activator of transcription 3(STAT3), tumor necrosis factor-α, and transforming growth factor-β(TGF-β) was decreased significantly in the glycine-treated group compared to the model group. Thus, glycine plays a protective role against myocardial ischemia and subsequent MF. Conclusion: The protective effects of glycine were achieved partly through STAT3/NF-κB/TGF-β signaling pathway.

关键词： Glycine myocardial fibrosis signal transducer and activator of transcription 3/nuclear factor-κB/transforming growth factor-β

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Pro-inflammatory microenvironment and systemic accumulation of CXCR3+cell exacerbate lung pathology of old rhesus macaques infected with SARS-CoV-2

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3033-3044页

作者： Hong-Yi Zheng Xiao-Yan He Wei li Tian-zhang Song Jian-Bao Han Xiang Yang Feng-liang liu Rong-Hua Luo Ren-Rong Tian Xiao-li Feng Yu-Hua Ma Chao liu ming-Hua li Yong-Tang Zheng Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnanChina Kunming College of life Science University of Chinese Academy of SciencesKunmingYunnanChina Kunming National High-Level Biosafety Research Center for Non-Human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnanChina National Resource Center for Non-Human Primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnanChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouChina

Understanding the pathological features of severe acute respiratory syn drome coronavirus 2(SARS-CoV-2)infect io n in an animal model is crucial for the treatment of coronavirus disease 2019(COVID-19).Here,we compared imnnunopathological changes in young and old rhesus macaques(RMs)before and after SARS-CoV-2 infection at the tissue *** analysis of multiplex immunofluoresce nee staining images of formali n-fixed paraffi n-embedded(FFPE)sections showed that SARS-CoV-2 infectio n specifically induced elevated levels of apoptosis,autophagy,and nuclear factor kappa-B(NF-kB)activation of angiotensirv convert!ng enzyme 2(ACE2)+cells,and increased interferon a(IFN-a)-and interleukin 6(IL-6)-secreting cells and C-X-C motif chemokine receptor 3(CXCR3)+cells in lung tissue of old *** pathological pattern,which may be related to the age-related pro-inflammatory microenvironment in both lungs and spleens,was significantly correlated with the systemic accumulation of CXCR3+cells in lungs,spleens,and peripheral ***,the ratio of CXCR3+to T-box protein expression in T cell(T-bet)+(CXCR3+/T-bet+ratio)in CD8+cells may be used as a predictor of severe *** findings uncovered the impact of aging on the immunopathology of early SARS-CoV-2 infection and demonstrated the potential application of CXCR3+cells in predicting severe COVID-19.

关键词： CXCR3 spleen lung

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基于云模型的网络系统状态评估与预测模型研究

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四川大学学报（工程科学版） 2010年第6期42卷 99-104页

作者：李飞张仕斌成都信息工程学院网络工程学院四川成都610225

目前,国内外众多网络系统可生存性研究都主要集中在理论上的研究,且均使用经典的数学理论来研究复杂多变环境下的网络系统状态,也没有形成完整的理论体系,而实际上网络系统状态具有不确定性、随机性等特性。以可信网络的可生存性为研究... 详细信息

目前,国内外众多网络系统可生存性研究都主要集中在理论上的研究,且均使用经典的数学理论来研究复杂多变环境下的网络系统状态,也没有形成完整的理论体系,而实际上网络系统状态具有不确定性、随机性等特性。以可信网络的可生存性为研究背景,首先分析了网络可生存性等关键问题。考虑到网络系统状态具有不确定性、随机性等特征,引入云模型和有限状态机理论对网络系统状态来进行描述和检测,提出了基于云模型的网络系统状态评估与预测模型,并从理论上进行了具体的分析和求证。最后通过仿真实验与分析,进一步说明了本研究的模型的可行性与合理性,为当前错综复杂的网络系统的可生存性研究提供了一种有价值的新思路。

关键词：云模型网络系统有限状态机状态评估预测模型

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Identification of an H1N1 subtype of swine influenza virus and serological analysis

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Journal of Integrative Agriculture 2019年第7期18卷 1436-1442页

作者： SUN Fa-chao TAN Min zhang Yuan-chao WANG Yu-chao CAO Sheng-liang DING Guo-fei CONG Fang-yuan GUO li-hong liU Si-dang XIAO Yi-hong Department of Basic Veterinary Medicine College of Animal Science and Veterinary Medicine/Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention/Shandong Provincial Engineering Technology Research Center of Animal Disease Control and PreventionShandong Agricultural University

To investigate the epizootic of swine influenza virus(SIV),60 nasal swabs were collected from a clinical cases of pig farm in Tai’an City,Shandong Province of China in April *** was isolated by inoculating into 10-day-old Special Pathogen Free embryonated eggs and the whole genome was *** H1N1 subtype SIV was isolated and designated as A/swine/Shandong/TA04/2017(H1N1).Phylogenetic analysis showed that apart from the polymerase A(PA) fragment belonging to the 2009 pandemic H1N1 branch,seven genome segments belonged to avian-like H1N1 influenza virus *** cleavage site sequence of the hemagglutinin(HA) protein was PSIQSR↓G,which is a typical molecular biological *** potential N-glycosylation sites(N14,N26,N277,N484 and N543) were found in the HA *** further investigate the epidemiology of SIV in this farm,the 995 serum samples were assessed with EAH1N1 2009 pandemic H1N1 and H3 N2 *** results showed that the total positive rate was 65.43%.The positive rates of single virus infection detected by EAH1N1,2009 pdmH1N1 and H3 N2 for serum HI(Hemagglutination inhibition) were 48.35,30.85 and 7.47%,*** results showed that SIV in Shandong Province has been reassorted in some segments and the SIV-positive rate was high on the SIV outbreak *** data provide evidence of an epizootic of SIV.

关键词： SIV H1N1 subtype genetic analysis molecular feature serology

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Clinical and Laboratory Diagnosis of Intestinal Tuberculosis

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Chinese Medical Journal 2016年第11期129卷 1330-1333页

作者： Xiao-Chun Shi li-Fan zhang Yue-Qiu zhang Xiao-Qing liu Gui-Jun fei Department of Infectious Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Gastroenterology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background： Tuberculosis （TB） remains a worldwide problem. Intestinal TB （ITB） constitutes a major public health problem in developing countries and has been associated with significant morbidity and mortality. The aim of this study was to characterize the clinical, radiological, endoscopic, and pathological features of ITB and to define the strategy for establishing the diagnosis. Methods： A retrospective study （from January 2000 to June 2015） was carried out in Peking Union Medical College Hospital and all hospitalized cases were diagnosed as ITB during the study period were included. The relevant clinical information, laboratory results, microbiological, and radiological investigations were recorded. Results： Of the 85 cases, 61 cases （71.8%） were ranged from 20 to 50 years. The ileocecal region was involved in about 83.5% （71/85） of patients. About 41.2% （35/85） of patients had co-existing extra ITB, especially active pulmonary TB. Abdominal pain （82.4%） was the most common presenting symptom followed by weight loss （72.9%） and fever （64.7%）. Both T-cell spot of TB test （***） and purified protein derivatives （PPD） tests were performed in 26 patients： 20 （76.9%） positive *** and 13 （50.0%） positive PPD were detected, with a statistical significant difference （P- 0.046）. Twenty cases （23.5%） were histopathology and/or pathogen confirmed TB; 27 cases （31.8%） were diagnosed by clinical manifestation consistent with ITB and evidence of active extra ITB; 38 cases （44.7%） were diagnosed by good response to diagnostic anti-TB therapy. Conclusions： ITB is difficult to diagnose even with modem medical techniques due to its nonspecific clinical and laboratory features. At present, combination of clinical, endoscopic, radiological, and pathological features continues to be the key to the diagnosis of ITB.

关键词： Diagnosis Intestinal Tuberculosis Extra-intestinal Tuberculosis

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Biodiversity of zooplankton in 0-3000 m waters from the eastern Indian Ocean in spring 2019 based on metabarcoding

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Water Biology and Security 2022年第1期1卷 41-52页

作者： Xia-Wen Cheng Lan-Lan zhang fei Gao Ye-Hui Tan Rong Xiang Zhuo-Ya Qiu li-Jun He State Key Laboratory of Marine Resources Utilization in South China Sea College of Marine ScienceHainan UniversityHaikou570228China Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou511458China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou511458China State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai200241China

To increase knowledge on zooplankton diversity in the deep sea,42 zooplankton samples(depths of 0–3000 m)were taken across five stations throughout the northeastern Indian Ocean using a vertical multi-plankton *** to metabarcoding results of the V4 region of the 18S rRNA gene,Copepoda,Hydrozoa and Malacostraca were present at all stations,while Polychaeta,Scyphozoa,and Thaliacea mainly appeared in the Bay of Bengal.A correlation heatmap showed that the abundance of surface species belonging to Copepoda,Gastropoda,Thaliacea,and Sagittoidea responded most closely to temperature,dissolved oxygen and chlorophyll-a,while the abundance of deep-water species belonging to Thecofilosea,Copepoda,Sagittoidea,and Polychaeta was negatively correlated with temperature,suggesting that temperature differences were driving depth-based variation in zooplankton community distributions in the tropical ***,Copepods are important for differentiating depth assemblages in the Indian *** minutus,Lucicutia ovalis,Heterostylites major and Metridia asymmetrica prefer the mesopelagic *** vertical distribution of zooplankton diversity showed a bimodal ***,communities between 200 and 400 m at stations ZS1,ZS3 and ZS4 differed greatly from those of 0–200 ***,at stations ZS2 and ZS5,communities between 200 and 400 m had high similarity with those of 0–200 m,possibly due to the influence of *** from this study significantly improve our understanding of zooplankton diversity and ecological functions in the deep sea.

关键词： Indian Ocean 18S rRNA Zooplankton diversity Depth profile Spatial variation

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戊唑醇对映体在新型纤维素键合手性固定相上的拆分

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高等学校化学学报 2007年第2期28卷 258-260页

作者：明永飞赵亮张红丽师彦平李永民中国科学院兰州化学物理研究所甘肃省天然药物重点实验室

The chiral stationary pahse of 3,5-dimethylphenylcarbamates of cellulose chemically bonded to 3-aminopropyl silica gel at the 6-position of the glucose units was *** racemates of tebuconazole were resolved on the new immobilized chiral stationary phase,and the influences of modifiers(alcohols,THF and chloroform) in the mobile phase on the resolution were *** chromatographic conditions were *** results show that the new immobilized chiral stationary phase exhibits a good stereoselectivity to *** best resolution of 1.51 of tebuconazole was obtained by using hexane/2-propanol/ THF(volume ratio 90∶5∶5) as the mobile phase on a 150 mm column.

关键词：键合手性固定相手性拆分戊唑醇

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