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Tea domain transcription factor TEAD4 mitigatesTGF-β signaling and hepatocellular carcinomaprogression independently of YAP

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Journal of Molecular Cell Biology 2023年第2期15卷 3-16页

作者： Weicheng Luo Yi Li Yi Zeng Yining Li Minzhang Cheng Cheng zhang fei Li Yiqing Wu Chunhong Huang Xiaolong Yang Joachim Kremerskothen Jianmin zhang Chunbo zhang Shuo Tu zhihua Li zhĳun Luo zhenghong Lin Xiaohua Yan Department of Biochemistry and Molecular Biology School of Basic Medical SciencesNanchang University Jiangxi Medical CollegeNanchang 330031China Department of Rheumatology and Clinical Immunology Jiangxi Provincial People’s HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006China Center for Experimental Medicine The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Pathology and Molecular Medicine Queen’s UniversityKingstonON K7L 3N6Canada Department of Nephrology Hypertension and RheumatologyUniversity Hospital MünsterMünster 48149Germany Department of Cancer Genetics&Genomics Roswell Park Comprehensive Cancer CenterElm and Carlton StreetsBuffaloNY 14203USA School of Pharmacy Nanchang University Jiangxi Medical CollegeNanchang 330008China Key Laboratory of Breast Diseases of Jiangxi Province Nanchang People’s HospitalNanchang 330025China Department of Pathology School of Basic Medical SciencesNanchang University Jiangxi Medical CollegeNanchang 330006China School of Life Sciences Chongqing UniversityChongqing 405200China

Tea domain transcription factor 4 (TEAD4) plays a pivotal role in tissue development and homeostasis by interacting with Yesassociated protein (YAP) in response to Hippo signaling inactivation. TEAD4 and YAP can also cooperate with transforminggrowth factor-β (TGF-β)-activated Smad proteins to regulate gene transcription. Yet, it remains unclear whether TEAD4 playsa YAP-independent role in TGF-β signaling. Here, we unveil a novel tumor suppressive function of TEAD4 in liver cancer viamitigating TGF-β signaling. Ectopic TEAD4 inhibited TGF-β-induced signal transduction, Smad transcriptional activity, and targetgene transcription, consequently suppressing hepatocellular carcinoma cell proliferation and migration in vitro and xenografttumorgrowth in mice. Consistently, depletion of endogenous TEAD4 by siRNAs enhanced TGF-β signaling in cancer cells. Mechanistically,TEAD4 associates with receptor-regulated Smads (Smad2/3) and Smad4 in the nucleus, thereby impairing the binding of Smad2/3to the histone acetyltransferase p300. Intriguingly, these negative effects of TEAD4 on TGF-β/Smad signaling are independent ofYAP, as impairing the TEAD4–YAP interaction through point mutagenesis or depletion of YAP and/or its paralog TAZ has little ***, these results unravel a novel function of TEAD4 in fine tuning TGF-β signaling and liver cancer progression in a YAPindependent manner.

关键词： TGF-β TEAD4 p300 signaling regulation transcriptional activity hepatocellular carcinoma

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STI571 combined with vincristine greatly suppressed the tumor formation of multidrug-resistant K562 cells in a human-nude mice xenograft model

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Chinese Medical Journal 2006年第11期119卷 911-918页

作者： GA0 Lei CHEN Li fei Xin-hong QIU Hui-ying zh0U Hong WANG Jian-min Department of Hematology Changhai Hospital Second Military Medical University Shanghai 200433 China

Background The development of the targeted signal transduction inhibitor STI571 has prompted us to treat chronic myeloid leukemia in different ways. Since STI571 may reverse multidrug-resistance of K562/MDR cells in vitro, we studied the effect of STI571 on multidrug-resistant K562 cells in vivo. Methods Multidrug-resistant human leukemia cell line K562-n/VCR expresses both bcr/abl fusion gene and multi-drug resistance （mdrl） gene. It is a vincristine resistant cell line subcloned from the vincristine （VCR） sensitive cell line K562-n induced by vincristine in vitro. K562-n and K562-n/VCR cells were inoculated subcutaneously into both sides of nude mice breast （5×10^6 cells/each） to establish a human leukemia xenograft model. The incidence and volume of tumor were observed. In the tumor-bearing nude mice, anti-tumor drugs vincristine, daunorubicin （DNR）, STI571, and STI571 plus VCR for the treatment of mdrl and bcr/abl double positive leukemia were studied respectively. Results The tumor incidence was 100% in the nude mice inoculated with either K562-n or K562-n/VCR. The transcription of the mdrl gene and expression of P-gp were negative in K562-n cells but positive in K562-n/VCR cells. The intracellular accumulation of DNR in K562-n cells was higher than that in K562-n/VCR cells （P〈0.05） The tumor incidence of K562-n/VCR cells in nude mice was much higher than that of K562-n cells in chemotherapy groups, and the mean volume of the tumors was also larger （P〈0.05）. STI571 combined with VCR significantly suppressed the proliferation of K562-n/VCR cells. Conclusions The MDR characteristics of K562-n/VCR in vivo were the same as in vitro. STI571 had a significant tumor-suppressing effect on VCR-sensitive leukemia ceils and a moderate effect on MDR leukemia cells. VCR combined with STI571 had an excellent tumor-suppressing effect on both K562-n/VCR and K562-n in the human-nude mice xenograft model.

关键词： K562 cells leukemia multidrug-resistance imatinib mesylate xenograft model antitumor assays

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Exploring fermionic multiplet dark matter through precision measurements at the CEPC

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Chinese Physics C 2022年第9期46卷 159-172页

作者： Lin-Qing Gao Xiao-Jun Bi Jin-Wei Wang Qian-fei Xiang Peng-fei Yin Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Scuola Internazionale Superiore di Studi Avanzati(SISSA) via Bonomea 26534136 TriesteItaly INFN Sezione di Triestevia Valerio 234127 TriesteItaly Institute for Fundamental Physics of the Universe(IFPU) via Beirut 234151 TriesteItaly Center for High Energy Physics Peking UniversityBeijing 100871China

New physics could be explored through loop effects using the precision measurements at the Circular Electron Positron Collider(CEPC)owing to its clean collision environment and high *** this paper,we focus on two dark matter models that involve additional electroweak fermionic *** calculate their one-loop corrections in five processes,i.e.,e^(+)e^(-)→μ^(+)μ^(-),zh,W^(+)W^(-),ZZ,and,Zγ,and investigate the corresponding signatures at the CEPC with the projected *** observe that the detectable parameter regions of these processes are *** combined analysis shows that the mass of dark matter m_(χ^(0)_(1))in these two models can be probed up to-150GeV and-450GeV,respectively,at a 95%confidence level.

关键词： CEPC dark matter loop correction

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Non-isothermal Kinetics of Pyrolysis of Three Kinds of Fresh Biomass

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Journal of China University of Mining and Technology 2007年第1期17卷 105-111页

作者： MIN Fan-fei zhANG Ming-xu CHEN Qing-ru Department of Matertal Sctence and Engmeermg Anhut Umverstty of Sctence and Technology Huaman Anhut 232001 China Key Laboratory of Modern Mining Engineering of Anhui Province Huainan Anhui 232001 China School of Chemical and Engineering Technology China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

The pyrolysis kinetics of three different kinds of fresh biomass (grass: triple A, wheat straw, corn straw) in nitrogen flow were studied by thermogravimetric analysis at five different heating rates. The kinetic parameters of the pyrolysis process were calculated using the method of ozawa-Flynn-Wall and the mechanism of reactions were investi- gated using the method of Popescu. It was found that the values of activation energy varied in different temperature ranges. The pyrolysis processes are well described by the models of zhuravlev (zh) and valid for diffusion-controlled between 200 ℃ and 280 ℃, by Ginstling-Brounshtein (G-B), valid for diffusion-control between 280 ℃ and 310 ℃, for first-order chemical reaction between 310℃ and 350 ℃, by zhuravlev (zh) valid for diffusion-control between 350 ℃ and 430 ℃ and by the one-way transport model when temperatures are over 430 ℃.

关键词： non-isothermal kinetics fresh biomass pyrolysis thermogravimetric analysis

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Influences of fluid physical properties,solid particles,and operating conditions on the hydrodynamics in slurry reactors

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Chinese Journal of Chemical Engineering 2022年第4期35卷 51-71页

作者： He Yang Aqiang Chen Shujun Geng Jingcai Cheng fei Gao Qingshan Huang Chao Yang Key Laboratory of Biofuels Qingdao Institute of Bioenergy and Bioprocess Technology(QIBEBT)Chinese Academy of Sciences(CAS)Qingdao 266101China Dalian National Laboratory for Clean Energy(DNL) Dalian 116023China Synthetic Biology Technology Innovation Center of Shandong Province Qingdao 266101China Key Laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100080China Petrochemical Research Institute China National Petroleum Corporation(CNPC)Beijing 100083China

Slurry reactors are popular in many industrial processes,involved with numerous chemical and biological mixtures,solid particles with different concentrations and properties,and a wide range of operating *** factors can significantly affect the hydrodynamic in the slurry reactors,having remarkable effects on the design,scale-up,and operation of the slurry *** article reviews the influences of fluid physical properties,solid particles,and operating conditions on the hydrodynamics in slurry ***,the influence of fluid properties,including the density and viscosity of the individual liquid and gas phases and the interfacial tension,has been ***,the solid particle properties(i.e.,concentration,density,size,wettability,and shape)on the hydrodynamics have been discussed in detail,and some vital but often ignored features,especially the influences of particle wettability and shape,as well as the variation of surface tension because of solid concentration alteration,are highlighted in this ***,the variations of physical properties of fluids,hydrodynamics,and bubble behavior resulted from the temperature and pressure variations are also summarized,and the indirect influences of pressure on viscosity and surface tension are addressed ***,conclusions and perspectives of these notable influences on the design and scale-up of industrial slurry reactors are presented.

关键词： Multiphase reactors Fluid physical properties Particle operating conditions Bubble column Airlift loop reactor

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Degradable magnesium alloy suture promotes fibrocartilaginous interface regeneration in a rat rotator cuff transosseous repair model

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Journal of Magnesium and Alloys 2024年第1期12卷 384-393页

作者： Baoxiang zhang Wen zhang fei zhang Chao Ning Mingyang An Ke Yang Lili Tan Qiang zhang Department of Sports Medicine Chinese PLA General HospitalBeijing 100853China Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Medical School of PLA Beijing 100853China Institute of orthopedics Chinese PLA General HospitalBeijing Key Lab of Regenerative Medicine in OrthopedicsKey Lab of Musculoskeletal Trauma&War Injuries of Chinese PLABeijing 100853China

Despite transosseous rotator cuff tear repair using sutures is widely accepted for tendon-bone fixation,the fibrocartilaginous enthesis regeneration is still hardly achieved with the traditional *** the present work,degradable magnesium(Mg)alloy wire was applied to suture supraspinatus tendon in a rat acute rotator cuff tear model with Vicryl Plus 4±0 absorbable suture as *** shoulder joint humerus-supraspinatus tendon complex specimens were retrieved at 4,8,and 12 weeks after *** Mg alloy suture groups showed better biomechanical properties in terms of ultimate load to *** observation showed that hyperplastic response of the scar tissue at the tendon-bone interface is progressively alleviated over time in the both Mg alloy suture and Vicryl suture *** the histological analysis,for Mg alloy suture groups,chondrocytes appear to proliferate at 4 weeks postoperatively,and the tendon-bone interface showed an orderly structural transition zone at 8 weeks *** collagenous fiber tended to be aligned and the tendon-bone interlocking structures apparently formed,where transitional structure from unmineralized fibrocartilage to mineralized fibrocartilage was closer to the native fibrocartilaginous *** vivo degradation of the magnesium alloy wire was completed within 12 *** results indicated that Mg alloy wire was promising as degradable suture with the potential to promotes fibrocartilaginous interface regeneration in rotator cuff repair.

关键词： Rotator cuff repair Mg alloy wire Tendon-bone healing Fibrocartilaginous interface

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基于不等高度数据采集的刀具磨损三维检测

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组合机床与自动化加工技术 2017年第5期 103-107页

作者：高飞周兆锋盐城工学院机械工程学院江苏盐城224051

由于刀具磨损对切削过程以及表面加工质量有着重要的影响,因此刀具磨损程度的检测对于提高零件的表面加工质量有重要的意义。文章提供了一种新的刀具磨损检测方法,该方法主要基于在不同高度对磨损区域拍照所得的图像,并对磨损区域进行... 详细信息

由于刀具磨损对切削过程以及表面加工质量有着重要的影响,因此刀具磨损程度的检测对于提高零件的表面加工质量有重要的意义。文章提供了一种新的刀具磨损检测方法,该方法主要基于在不同高度对磨损区域拍照所得的图像,并对磨损区域进行相应的三维重构,最终能得到刀具磨损区域的三维形貌图,其不仅能使得刀具的磨损区域得到重现,而且能对磨损的体积进行较为精确的测量。将该技术对实际加工中不同切削条件下的刀具的磨损进行检测,最终得到了不同切削条件下的刀具的磨损,结果表明该方法对于刀具磨损的检测不仅方便,而且精度较高。

关键词：磨损刀具寿命三维重建切削条件

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(n,k)-星图网络的t/m-诊断度及诊断算法

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高校应用数学学报（A辑） 2018年第3期33卷 331-340页

作者：翟亚飞许力林丽美福建师范大学数学与信息学院福建福州350007 福建师范大学网络安全与密码技术重点实验室福建福州350007 福建农林大学计算机与信息学院福建福州350002

故障诊断度在衡量多处理机系统可靠性上起着极其重要的作用.t/m-诊断分析是一种能极大提高多处理机系统自我诊断性能的诊断策略,该诊断策略能至多识别t个故障处理机,其中最多包含m个被误诊的无故障处理机.在PMC诊断模型下,证明了(n,k)-... 详细信息

故障诊断度在衡量多处理机系统可靠性上起着极其重要的作用.t/m-诊断分析是一种能极大提高多处理机系统自我诊断性能的诊断策略,该诊断策略能至多识别t个故障处理机,其中最多包含m个被误诊的无故障处理机.在PMC诊断模型下,证明了(n,k)-星图是n+(m-1)k-2m+1/m-可诊断的,其中2≤m≤4,且给出了复杂度为o(NlogN)的快速诊断算法来识别所有的故障节点,其中N是(n,k)-星图网络节点总数.

关键词： t/m-诊断度诊断算法 PMC诊断模型 (n,k)-星图

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2010-2017年青岛市居民甲状腺癌发病与死亡分析

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中华肿瘤防治杂志 2019年第17期26卷 1231-1236页

作者：罗亭亭孟迪张华李斐斐宁锋汪韶洁青岛大学医学部公共卫生学院山东青岛266071 青岛市疾病预防控制中心慢性非传染病防治科山东青岛266033

目的我国甲状腺癌的发病率增幅明显,且沿海城市的上升趋势显著,已经引起社会的关注。本研究通过分析青岛市居民2010-2017年甲状腺癌发病与死亡时间变化趋势,旨在为其预防工作提供参考。方法收集青岛市肿瘤登记地区上报的甲状腺癌发病与... 详细信息

目的我国甲状腺癌的发病率增幅明显,且沿海城市的上升趋势显著,已经引起社会的关注。本研究通过分析青岛市居民2010-2017年甲状腺癌发病与死亡时间变化趋势,旨在为其预防工作提供参考。方法收集青岛市肿瘤登记地区上报的甲状腺癌发病与死亡资料。按年龄和性别分层,分别计算发病率、死亡率、标化率、变化百分比(percent change,PC)及年度变化百分比(annual percent change,APC)。以2010年全国第六次人口普查资料为标准计算标化率。结果2010-2017年青岛市居民甲状腺癌累积发病3 551例,死亡185例,标化发病率为5.10/10万,标化死亡率为0.21/10万;女性发病率是男性的2.9倍(χ^2=861.019,P<0.001),死亡率是男性的1.4倍(χ^2=4.280,P=0.039),差异均有统计学意义。女性50~54岁为发病高峰,死亡率随年龄增长呈上升趋势,在80~85岁年龄段,女性死亡率达到高峰,之后快速下降,男性死亡率达到最低值,之后快速上升。甲状腺癌的标化发病率由2010年的1.00/10万上升到2017年的11.68/10万,发病率APC为30.21%(t=4.200,P<0.05),标化死亡率由2010年的0.13/10万上升到2017年的0.20/10万,死亡率APC为8.65%(t=2.377,P=0.055)。结论青岛市甲状腺癌发病率有上升趋势,死亡率呈平稳状态,50~54岁为甲状腺癌发病高峰,女性发病率及死亡率均高于男性,提示中年女性应作为重点防治人群。

关键词：甲状腺癌发病率死亡率年度变化百分比时间趋势分析

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高速摆动条件下PTFE编织复合材料干摩擦热行为研究

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材料工程 2011年第11期39卷 15-17,22页

作者：康克家杜三明张永振赵飞河南科技大学材料科学与工程学院河南洛阳471003

利用自制高速摩擦实验机,以聚四氟乙烯(PTFE)编织复合材料为研究对象,与不锈钢9Cr18Mo配副,进行高速摆动下的干摩擦实验,研究摩擦热的影响因素及变化规律;利用扫描电子显微镜对摩擦表面进行观察,分析其磨损机制。结果表明:摩擦温度随载... 详细信息

利用自制高速摩擦实验机,以聚四氟乙烯(PTFE)编织复合材料为研究对象,与不锈钢9Cr18Mo配副,进行高速摆动下的干摩擦实验,研究摩擦热的影响因素及变化规律;利用扫描电子显微镜对摩擦表面进行观察,分析其磨损机制。结果表明:摩擦温度随载荷增加而升高,在摩擦初期摩擦温度随频率增加而降低,之后又随频率增加而升高,并最终达到动态平衡;摩擦因数随时间的增加先急剧降低后小范围缓慢回升,最终保持相对稳定,且与摩擦温度有一定的对应关系;磨损机制以剥落与黏着磨损为主,温度是影响摩擦过程与磨损机制的重要因素。

关键词： PTFE 编织复合材料干摩擦摩擦热

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