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The long noncoding RNA ALEX1 confers a functional phase state of ARF3 to enhance rice resistance to bacterial pathogens

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Molecular Plant 2025年第1期18卷 114-129页

作者： Meng-Qi Lei Rui-Rui He Yan-fei zhou Lu Yang Zhen-fei Zhang Chao Yuan Wen-Long Zhao Yu Cheng Jian-Ping Lian Yu-Chan Zhang Wen-Tao Wang Yang Yu Yue-Qin Chen Guangdong Provincial Key Laboratory of Plant Stress Biology State Key Laboratory for BiocontrolSchool of Life SciencesSun Yat-Sen UniversityGuangzhou 510275P.R.China Guangdong Key Laboratory of Crop Germplasm Resources Preservation and Utilization Agro-biological Gene Research CenterGuangdong Academy of Agricultural SciencesGuangzhou 510640P.R.China Plant Protection Research Institute Guangdong Academy of Agricultural SciencesGuangzhou 510640P.R.China

Rice bacterial blight is a devastating disease worldwide,causing significant yield *** how plants defend against microbial infection is critical for sustainable crop *** this study,we show that ALEX1,a previously identified pathogen-induced long noncoding RNA,localizes to the nucleus and directly binds AUXIN RESPONSE FACTOR 3(ARF3).We showed that ARF3 forms the condensates in the nucleus via its intrinsically disordered middle region(MR),and that these ARF3 condensates display solid-like *** further revealed that ALEX1 directly binds the MR of ARF3 to regulate ARF3 condensate dynamics and promote ARF3 *** dispersed,dimeric form of ARF3,referred to as its functional phase state,enhances its ability to transcriptionally repress the expression of downstream target genes such as JAZ13,thereby modulating the jasmonic acid signaling pathway and enhancing pathogen resistance in ***,this study reveals the role of a long noncoding RNA in regulating protein condensation and complex assembly,thus contributing to plant pathogen resistance.

关键词： lncRNA Xoo ARF3 protein condensates

Discovery of primary lung cancer following resection of rectal cancer lung metastasis:A case report

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World Journal of Clinical Oncology 2025年第2期16卷 173-179页

作者： fei-Yan zhou Fang-Hua Song Zhen-Hao Cheng Sen Wu Department of Oncology II Xinhua HospitalDalian UniversityDalian 116000Liaoning ProvinceChina

BACKGROUND Colorectal cancer(CRC)ranks high among the most common types of malignant *** primary cause of cancer-related mortality is metastasis,with lung metastases accounting for 32.9%of all cases of metastatic CRC(MCRC).However,cases of MCRC in the lungs,which present concurrently with primary peripheral lung adenocarcinoma,are exceptionally *** SUMMARY This report describes the case of a 52-year-old female patient who,following a colonoscopy,was diagnosed with moderately differentiated adenocarcinoma based on rectal mucosal biopsy findings.A preoperative chest computed tomography scan revealed a ground-glass nodule in the right lung and a small nodule(approximately 0.6 cm in diameter)in the extramural basal segment of the left lower lobe,which suggested multiple lung metastases from rectal *** treatment and follow-up led to a diagnosis of rectal cancer with left lung metastasis and peripheral adenocarcinoma of the lower lobe of the right *** This case report describes the therapeutic journey of a patient with lung metastasis from rectal cancer in addition to primary peripheral adenocarcinoma,thus underscoring the critical roles of multidisciplinary collaboration,personalized treatment strategies,and comprehensive patient rehabilitation guidance.

关键词： Rectal cancer Metastatic lung cancer Peripheral lung adenocarcinoma Double primary cancer Case report

Concurrently bioprinted scaffolds with autologous bone and allogeneic BMSCs promote bone regeneration through native BMSC recruitment

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Bio-Design and Manufacturing 2025年第1期8卷 85-99,I0042,I0043页

作者： Yu Huan Hongqing Chen Dezhi zhou Xin He Sanzhong Li Xiuquan Wu Bo Jia Yanan Dou Xiaowei fei Shuang Wu zhou fei Tao Xu fei fei Department of Neurosurgery Xijing HospitalAir Force Medical UniversityXi’an 710032China Department of Neurosurgery General Hospital of Northern Theater CommandShenyang 110840China Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationDepartment of Mechanical EngineeringTsinghua UniversityBeijing 100084China Department of Precision Medicine and Healthcare Tsinghua Berkeley Shenzhen InstituteShenzhen 518055China Center for Bio-intelligent Manufacturing and Living Matter Bioprinting Research Institute of Tsinghua University in ShenzhenShenzhen 518057China Department of Ophthalmology Xijing HospitalAir Force Medical UniversityXi’an 710032China

Autologous bone marrow-derived mesenchymal stem cells(BMSCs)have been shown to promote osteogenesis;however,the effects of allogeneic BMSCs(allo-BMSCs)on bone regeneration remain ***,we explored the bone regeneration promotion effect of allo-BMSCs in 3D-printed autologous bone particle(ABP)***,we concurrently printed scaffolds with polycaprolactone,ABPs,and allo-BMSCs for appropriate support,providing bioactive factors and seed cells to promote *** vitro studies showed that ABP scaffolds promoted allo-BMSC osteogenic *** vivo studies revealed that the implantation of scaffolds loaded with ABPs and allo-BMSCs into canine skull defects for nine months promoted *** experiments suggested that only a small portion of implanted allo-BMSCs survived and differentiated into vascular endothelial cells,chondrocytes,and *** implanted allo-BMSCs released stromal cell-derived factor 1 through paracrine signaling to recruit native BMSCs into the defect,promoting bone *** study contributes to our understanding of allo-BMSCs,providing information relevant to their future application.

关键词： Concurrent 3D bioprinting Cranioplasty Autologous bone particles Allogeneic mesenchymal stem cells Recruitment

村干部的情绪劳动与乡村治理逻辑——基于鄂西北S村的田野考察

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安徽乡村振兴研究 2025年第01期4卷 40-50页

作者：周洲周菲吉林大学马克思主义学院成都理工大学马克思主义学院

随着乡村治理体系和治理能力现代化的持续推进，村干部的作用不断凸显，其行动选择对村庄治理成效有着直接而重要的影响。文章通过对鄂西北S村的田野考察，以情绪劳动为切入点，聚焦村干部治理实践中的情绪卷入，阐述情绪劳动下村庄实... 详细信息

随着乡村治理体系和治理能力现代化的持续推进，村干部的作用不断凸显，其行动选择对村庄治理成效有着直接而重要的影响。文章通过对鄂西北S村的田野考察，以情绪劳动为切入点，聚焦村干部治理实践中的情绪卷入，阐述情绪劳动下村庄实现善治的双重逻辑与治理转向。研究发现，情绪劳动的呈现样态为“情绪体验—情绪表达—情绪管理”的链条式结构。村干部在这一过程中实现与各种治理要素的有效互动，使情绪劳动呈现工具理性和价值理性的双重取向，有力推动村庄情感共同体的形成。这一治理转型背景下生动鲜活的村治实践，深刻凸显乡村治理在范式、内容和理念上的新转向。

关键词：情绪劳动乡村治理情感村干部

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基于目标导向理念的《临床技能学》课程思政教学改革

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中国继续医学教育 2025年第2期17卷 11-14页

作者：王畏周飞蚌埠医学院第二附属医院肿瘤外科安徽蚌埠233000 蚌埠医学院第二附属医院宣传科安徽蚌埠233000

探讨目标导向理念深度融合《临床技能学》课程思政教学的应用成效。传统《临床技能学》课程教学存在思政教育欠缺,教学方式创新不足的缺点。目标导向理念强调学生在教育过程中的主体地位,重视学生课程学习的参与度。教师将思想政治教育... 详细信息

探讨目标导向理念深度融合《临床技能学》课程思政教学的应用成效。传统《临床技能学》课程教学存在思政教育欠缺,教学方式创新不足的缺点。目标导向理念强调学生在教育过程中的主体地位,重视学生课程学习的参与度。教师将思想政治教育融入《临床技能学》课程教学,能够优化专业课程教育总体规划,提高学生专业兴趣与能力,实现知识传授与价值引领的有机统一。实践表明,基于目标导向理念的《临床技能学》课程思政教学改革成效显著,不仅优化了教学内容与方法,还有效促进了学生综合素质的提升,对于培养具有创新思维和实践能力的医学人才起到了积极的推动作用。

关键词：课程思政临床技能学目标导向教学改革教学模式医学人才培养

协调故障重构和智能软开关的柔性配电系统故障恢复策略

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电力系统及其自动化学报 2025年第1期37卷 74-83页

作者：叶云周飞张博户政丽杨晓东国网安徽省电力有限公司黄山供电分公司黄山245000 安徽省新能源利用与节能省级实验室(合肥工业大学) 合肥230009

为增强柔性配电系统在极端灾害下的故障恢复能力,提出一种协调故障重构与智能软开关的柔性配电系统故障恢复方法。首先,建立考虑运行特性的智能软开关模型,包括功率输出模型和电压控制模型,并且引入包含智能软开关的虚拟潮流模型用以判... 详细信息

为增强柔性配电系统在极端灾害下的故障恢复能力,提出一种协调故障重构与智能软开关的柔性配电系统故障恢复方法。首先,建立考虑运行特性的智能软开关模型,包括功率输出模型和电压控制模型,并且引入包含智能软开关的虚拟潮流模型用以判别智能软开关的控制模式;其次,提出协调联络开关、分段开关以及智能软开关的重构策略,建立了包含智能软开关的故障重构模型;然后,结合潮流约束、辐射状约束等约束建立柔性配电系统的故障恢复模型,采用二阶锥规划方法进行模型转化和求解;最后,在改进的IEEE 123节点测试系统上进行分析,验证所提模型的正确性和有效性。

关键词：智能软开关故障重构柔性配电系统负荷恢复韧性提升

掺杂改性氮化物基薄膜摩擦、腐蚀与抗菌性能的研究进展

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表面技术 2025年第2期54卷 70-86页

作者：张懋达鞠长滨王珏韩培培赵梁周飞沈阳飞机工业(集团)有限公司沈阳110850 南京航空航天大学直升机传动技术国家级重点实验室南京210016

由于PVD硬质薄膜与金属之间有着较高的黏附强度,且薄膜具有致密结构以及良好的力学、耐磨和耐腐蚀性,同时能够隔绝腐蚀环境中的盐分与材料表面直接接触,因此在其表面沉积具有优异磨损腐蚀和抗菌特性的防护薄膜可以保障金属材料在磨损/... 详细信息

由于PVD硬质薄膜与金属之间有着较高的黏附强度,且薄膜具有致密结构以及良好的力学、耐磨和耐腐蚀性,同时能够隔绝腐蚀环境中的盐分与材料表面直接接触,因此在其表面沉积具有优异磨损腐蚀和抗菌特性的防护薄膜可以保障金属材料在磨损/腐蚀环境中的长期使用。从传统的二元氮化物薄膜入手,针对薄膜耐磨、防腐与抗菌性能日益增长的需求,综述了Si、C、Mo与Ag元素掺杂对PVD氮化物薄膜在空气与水环境中的摩擦学特性、在盐溶液与海水中的电化学腐蚀与磨损腐蚀特性,以及静态抗菌与摩擦诱导抗菌性能的影响。传统二元的氮化物薄膜已经逐渐发展为多元的CrMoSiCN基薄膜,在这个过程中,重点分析了不同三甲基硅烷反应气体流速与Si、Mo、Ag靶材溅射电流下,薄膜的力学性能与摩擦学特性之间的紧密关联;阐述了薄膜在腐蚀性溶液中磨粒磨损、氧化磨损与电化学腐蚀之间的协同耦合关系;阐明了不同Mo、Ag元素含量下,薄膜的抗微生物黏附与抗菌特性的演变机理。指出多元氮化物基薄膜在盐溶液中的摩擦因数与磨损腐蚀材料损失受到薄膜中Si、Mo与Ag元素掺杂量变化的强烈影响,摩擦过程中的氧化与腐蚀产物有效增强了薄膜的自润滑与减磨特性;而含Mo、Ag氮化物基薄膜的杀菌能力主要与磨痕表面氧化物MoO_(x)的形成和Ag^(+)在菌液中的释放、扩散相关。

关键词：磁控溅射薄膜摩擦磨损腐蚀抗菌

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Formation and Characterization of ZrO3 and HfO3 Molecules in Solid Argon

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Chinese Journal of Chemical Physics 2009年第2期22卷 113-118页

作者： Yu Gong Ming-fei zhou Department of Chemistry Shanghai Key Laboratory of Molecular Catalysts and Innovative Materials Advanced Materials Laboratory Fudan University Shanghai 200433 China

ZrO3 and HfO3 molecules were prepared via reactions of metal monoxides with dioxygen in solid argon and were characterized using matrix isolation infrared absorption spectroscopy as well as theoretical calculations. Unlike the titanium monoxide molecule, which reacted spontaneously with dioxygen to form TiO3, the ZrO and HfO molecules reacted with dioxygen to give the ZrO3 and HfO3 molecules only under visible light irradiation. Density functional calculations predicted that both the ZrO3 and HfO3 molecules possess a closed-shell singlet ground state with a non-planar C8 geometry, in which the side-on coordinated O2 falls into the peroxide category.

关键词： Matrix isolation Transition metal oxide Dioxygen complex Infrared spectrum

Neuroprotection mediated by natural products and their chemical derivatives

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Neural Regeneration Research 2020年第11期15卷 2008-2015页

作者： fei fei Ning Su Xia Li zhou fei Department of Ophthalmology Xijing Hospitalthe Fourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Radiation Oncology Xijing Hospitalthe Fourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Neurosurgery Xijing Hospitalthe Fourth Military Medical UniversityXi’anShaanxi ProvinceChina

Neuronal injuries can lead to various diseases such as neurodegenerative diseases,stroke,trauma,ischemia and,more specifically,glaucoma and optic *** cellular mechanisms that regulate neuronal death include calcium influx and calcium overload,excitatory amino acid release,oxidative stress,inflammation and microglial *** attention has been paid to the effective prevention and treatment of neuroprotective drugs by natural *** review summarizes the neuroprotective aspects of natural products,extracted from Panax ginseng,Camellia sinensis,soy and some other plants,and some of their chemical *** antioxidative and anti-inflammatory action and their inhibition of apoptosis and microglial activation are *** will provide new directions for the development of novel drugs and strategies to treat neurodegenerative diseases.

关键词： antioxidant effect brain injuries Camellia sinensis chemical derivatives curcumin genistein natural products neurodegenerative diseases neuroprotection Panax