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Reductive demetalation of manganese corroles:The substituent effect

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Chinese Chemical Letters 2008年第8期19卷 1000-1003页

作者： Hai Yang Liu Ling Chen fei yam Hai Ying Zhan Xiao Ying Xiang Li Wang Huan Feng Jiang Chi Kwong Chang Department of Chemistry South China University of Technology Guangzhou 510641 China Department of Chemistry The Hong Kong University of Science and Technology Hong Kong China Department of Applied Physics South China University of Technology Guangzhou 510641 China

The reductive demetalation of manganese corroles was investigated in CH2Cl2/HCl （aqueous） solvent by using SnCl2 as reducing agent. It was found that the demetalation yields depend on the substituents of corrole macrocycle significantly. Electron- rich manganese corrole undergoes reductive demetalation more easily than electron-deficient ones. The isolated reductive demetalation yield of manganese 5,10,15-tris（phenyl）corrole in present system is moderate （46%）. As for electron-deficient Mn（Ⅲ） 5,10,15-tris（pentafluorophenyl）corrole, the acid-induced demetalation in HOAc-HESO4 （V/V = 3：1） is preferable with an isolated yield of 67%.

关键词： Corrole Manganese Demetalation

Antidiabetic and antioxidant activities of Nypa fruticans Wurmb. vinegar sample from Malaysia

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Asian Pacific Journal of Tropical Medicine 2015年第8期8卷 589-597页

作者： Nor Adlin Yusoff Mun fei yam Hooi Kheng Beh Khairul Niza Abdul Razak Tri Widyawati Roziahanim Mahmud Mariam Ahmad Mohd Zaini Asmawi School of Pharmaceutical Sciences Universiti Sains Malaysia Integrative Medicine Cluster Advanced Medical and Dental InstituteUniversiti Sains Malaysia Pharmacology Department Medical FacultyUniversity of Sumatera Utara

Objective: To study the antidiabetic and antioxidant activities of nipa palm vinegar(NPV) used in traditional Malay medicine for treating diabetes. Methods: NPV was extracted using liquid-liquid extraction method and the obtained samples were subjected to antidiabetic studies using normal and streptozotocin-induced diabetic rat models whereas antidoxidant activities were investigated via in vitro antioxidant tests namely 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azinobis-3-ethylbenzothiozoline-6-sulfonic acid free radicals scavenging activities and the reducing power assay. Results: Single administration of NPV and its extracts were not effective in both normal and diabetic rats. In intraperitoneal glucose tolerance test, NPV and its aqueous extract showed significant blood glucose lowering effect. In the sub-acute study, compared with the diabetic control, aqueous extract of NPV showed the most notable blood glucose lowering effect(56.6%) and a significant improvement in serum insulin levels(79.8%, P<0.05). To assess NPV's antioxidant activity, three in vitro antioxidant tests were employed: 2,2-diphenyl-1-picryhydrazyl and 2,2'-azinobis-3-ethylbenzothiozoline-6-sulfonic acid free radical-scavenging assays, and the reducing power assay. Ethyl acetate extract had the greatest antioxidant potential and content of phenolic and flavonoid compounds. A linear positive correlation between the antioxidant parameters was observed. Chemical profiling analysis of aqueous extract of NPV revealed the presence of acetic acid(35.25%), the main active constituent which significantly contributed to the observed antidiabetic activity. Conclusions: Aqueous extract of NPV possesses antihyperglycaemic activities comparable to the metformin, while the ethyl acetate extract precipitated significant antioxidant effects attributable to its high phenolic content. These findings suggest that antioxidant compounds of NPV do not contribute much towards the overall observed antidiabetic effect.

关键词： Nypa fruticans Wurmb. Vinegar Antidiabetic Streptozotocin-induced diabetes Antioxidant Phenolics

Decomposition and Reformulation of Banxia Baizhu Tianma Decoction:A Vasodilatory Approach

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Chinese Herbal Medicines 2017年第2期9卷 134-146页

作者： Chu Shan Tan Yean Chun Loh Yung Sing Ch'ng Mariam Ahmad Mohd.Zaini Asmawi Mun fei yam Department of Pharmacology School of Pharmaceutical SciencesUniversiti Sains Malaysia College of Pharmacy Fujian University of Traditional Chinese Medicine

Objective To decompose and reformulate Banxia Baizhu Tianma Decoction（BBT） in order to optimize its ratio for vasodilatory *** fingerprints of these six component herbs were also studied via Tri-step FTIR *** The herbal components of BBT were extracted separately with different solvents,such as 95%ethanol,50%ethanol,and distilled *** vasodilatory effect of the extracts was studied using the in vitro pre-contracted aortic ring *** these extracts,the water extracts of Pinellia ternata[PT（W）]and Citri reticulatae[CR（W）],50%ethanol extracts of Castrodia elata[GE（50）]and Clycyrrhiza uralensis[GU（50）],and 95%ethanol extracts of Atractylodes macrocephala[AM（E）],and Poria cocos[PC（E）]were selected for the orthogonal stimulus-response compatibility group study due to their high effectiveness in *** The best combination ratio（G2） was GE（50）,GU（50）,AM（E）,PC（E）,CR（W）,and PT（W） at EC0,EC5,EC5,EC5,EC5,and EC5,with EC50 of（0.06 ± 0.01） mg/*** between the vasodilatory effects of extracts derived from G2 and BBT were also *** the results,the 50%ethanol extract following G2 ratio was found to be most potent extract with the highest vasodilatory effect compared with other extracts derived from G2 or BBT,with EC50 of（0.05 ±0.005） mg/*** The optimum ratio and appropriate extraction method for the new BBT formulae are obtained.G2 is determined as the best formulae with the highest potency in producing the vasodilatory effect on isolated rat aortic *** results obtained suggest that 50%ethanol is found to be the best solvent to extract the vasoactive compounds of G2 in order to exhibit the highest efficacy of vasodilatory effect.

关键词： Banxia Baizhu Tianma Decoction compatibility group study reformulation traditional Chinese medicine Tri-step FTIR vasodilation assay

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金属锰Corrole的脱金属研究(英文)

无机化学学报 2009年第8期25卷 1420-1425页

作者：练萍刘海洋陈玲任飞张启光赣南师范学院化学与生命科学系赣州341000 华南理工大学化学系广州510641 香港科技大学化学系

合成了中位带有不同取代基的锰corrole配合物1-Mn,2-Mn,3-Mn,4-Mn,并研究了其酸解和还原脱金属特性。结果表明取代基的性质对脱金属产率有很大的影响。缺电子金属锰corrole的酸解脱金属产率比富电子金属锰corrole高,而还原脱金属产率的... 详细信息

合成了中位带有不同取代基的锰corrole配合物1-Mn,2-Mn,3-Mn,4-Mn,并研究了其酸解和还原脱金属特性。结果表明取代基的性质对脱金属产率有很大的影响。缺电子金属锰corrole的酸解脱金属产率比富电子金属锰corrole高,而还原脱金属产率的顺序则正好相反。

关键词：锰 corrole 脱金属

Enantio-selective Catalytic Epoxidation by a New Chiral Manganese Corrole

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Enantio-selective Catalytic Epoxidation by a New Chiral Mang...

Eradication of malaria through genetic engineering:the current situation

全国第十四届大环化学暨第六届超分子化学学术讨论会

作者： LIU Hai-yang~(1,2*) yam fei~1 YEUNG Lam-lung~1 CHANG Chi-kwong~(1*) 1 Department of Chemistry, The Hong Kong University of Science and technology, Hong Kong 2 Department of Chemistry, South China University of Technology, Guangzhou 510641

＜正＞Corrole is a ring-contracted anologue of *** the history of corrole may be traced over 30 years ago,study on corrole chemistry has not received extensive interests for decades due to the limted synthetic *** 199...

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Asian Pacific Journal of Tropical Medicine 2013年第2期6卷 85-94页

作者： Wing-Chui Chong Rusliza Basir yam Mun fei Department of Human Anatomy Pharmacology UnitFaculty of Medical and Health SciencesUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia School of Pharmaceutical Sciences Universiti Sains Malaysia11800 MindenPulau PinangMalaysia

Malaria is an intra-cellular parasitic protozoon responsible for millions of deaths *** and parasite genetic factors are crucial in affecting susceptibility to malaria and progression of the *** increased deployment of vector controls and new artemisinin combination therapies have dramatically reduced the mortality and morbidity of malaria ***, the gradual emergence of parasite and mosquito resistance has raised alarm regarding the effectiveness of current artemisinin-based *** this review,mechanisms of anti-malarial drug resistance in the Plasmodium parasite and new genetically engineered tools of research priorities are *** complexity of the parasite lifecycle demands novel interventions to achieve global ***,turning laboratory discovered transgenic interventions into functional products entails multiple experimental phases in addition to ethical and safety *** over the regulatory status and public acceptance further discourage the implementation of genetically modified organisms.

关键词： Malaria Vector control Resistance Plasmodium parasite Genetically engineered tools

Rational design of platinum(Ⅱ)complexes with orthogonally oriented triazolyl ligand with emission enhancement characteristics for cancer chemotherapy in vivo

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Science China Chemistry 2023年第10期66卷 2878-2884页

作者： Yeye Ai Zherui Zhang Yuexuan fei Ruirong Ye Angela Sin-Yee Law Zong-Wan Mao Junqiu Liu Yongguang Li Vivian Wing-Wah yam Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education College of Material Chemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China Institute of Molecular Functional Materials State Key Laboratory of Synthetic Chemistry and Department of ChemistryThe University of Hong KongHong KongChina School of Chemistry Sun Yat-Sen UniversityGuangzhou 510275China State Key Laboratory of Supramolecular Structure and Materials Jilin UniversityChangchun 130012China

The mitochondria are essential for tumorigenesis and have been regarded as important targets in cancer ***,the mitochondria-targeted platinum(Ⅱ)complexes have been *** introduction of the triazole group with larger steric hindrance through post-click reaction converts the hybridization of carbon from sp to sp^(2),endowing the complexes with an orthogonally oriented ligand with restricted rotation and emission enhancement *** of the triazolyl ligand has led to platinum(Ⅱ)complexes that can efficiently enter cancer cells and selectively accumulate in mitochondria,leading to significant enhancement in *** vivo anti-cancer investigations have demonstrated their distinct antitumor efficacy in substantial inhibition of tumor growth in breast cancer mice through dissipation of mitochondrial membrane potential,inducing apoptosis of tumor cell with negligibly systemic cytotoxicity.

关键词： platinum(Ⅱ)complexes post-click reaction emission enhancement mitochondria-targeting antitumor

代谢组学结合LASSO回归机器学习方法识别太谷山药和铁棍山药中的差异标志物

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食品工业科技 2024年第18期45卷 1-8页

作者：安莉周娟马婧玮陈贺王飞梁慧珍郝晨宇吴绪金河南省农业科学院农产品质量安全研究所河南郑州450002 河南省农业科学院植物保护研究所河南郑州450002 河南省农业科学院中药材研究所河南郑州450002 天津中医药大学公共卫生与健康科学学院天津301617

本研究旨在利用代谢组学筛选出太古山药和铁棍山药之间的差异代谢物,并通过LASSO回归机器学习方法确定作为预测不同山药品种的差异标志物。研究采用超高效液相色谱-四级杆飞行时间串联质谱(ultraperformance liquid chromatography-quad... 详细信息

本研究旨在利用代谢组学筛选出太古山药和铁棍山药之间的差异代谢物,并通过LASSO回归机器学习方法确定作为预测不同山药品种的差异标志物。研究采用超高效液相色谱-四级杆飞行时间串联质谱(ultraperformance liquid chromatography-quadrupole time of flight tandem mass spectrometry,UPLC-Q-TOF-MS/MS)分析两种山药中的代谢物,通过主成分分析(principal component analysis,PCA)和正交偏最小二乘判别分析(orthogonal partial least squares-discriminant analysis,OPLS-DA)识别出两种山药中的差异代谢物,利用最小绝对收缩和选择算子(least absolute shrinkage and selection operator,LASSO)回归方法筛选出差异性标志物,建立用于品种鉴别的预测模型。结果显示,在两种山药中共鉴别出206种代谢物,PCA分析发现太谷山药和铁棍山药之间区分明显,OPLS-DA进一步筛选出56种存在显著性差异的代谢物。基于这些差异代谢物进行LASSO回归分析,得到ophiogenin 3-O-beta-L-rhamnopyranosyl-beta-D-glucopyranoside、天冬氨酸、表儿茶素没食子酸酯、夏佛塔苷以及没食子儿茶素5种关键差异标志物,建立了用于太谷山药和铁棍山药品种鉴别的LASSO回归预测模型。本研究基于代谢组学和LASSO回归机器学习方法,识别出太谷山药和铁棍山药的差异标志物,构建了不同品种山药的预测模型,为山药的鉴别提供了新的思路。

关键词：代谢组学机器学习太谷山药铁棍山药差异标志物

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V区温度及螺杆转速对挤压膨化牛肉制品理化性质的影响

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中国调味品 2024年第3期49卷 68-73,91页

作者：张根生田阳李思锦韩冰费英敏哈尔滨商业大学食品工程学院哈尔滨150028 黑龙江民族职业学院哈尔滨150066

利用挤压膨化技术加工高粱-山药-牛肉混合物料,以水溶性、吸水性、色差值、粒度、质构、膨化度、糊化度及红外光谱各基团峰值为指标,分析V区温度和螺杆转速对挤压膨化产品理化性质的影响。结果表明,提高V区温度能够提高产品的红度值、... 详细信息

利用挤压膨化技术加工高粱-山药-牛肉混合物料,以水溶性、吸水性、色差值、粒度、质构、膨化度、糊化度及红外光谱各基团峰值为指标,分析V区温度和螺杆转速对挤压膨化产品理化性质的影响。结果表明,提高V区温度能够提高产品的红度值、黄度值、硬度、脆度和咀嚼度,吸水性、水溶性、粒度、膨化度、糊化度及红外光谱各基团峰值呈先上升后下降的趋势,亮度值显著下降(P<0.05);同时,随着螺杆转速的提升,产品的红度值、黄度值和糊化度显著下降(P<0.05),吸水性、水溶性、粒度和膨化度呈先上升后下降的趋势,硬度、脆度、咀嚼度及红外光谱各基团峰值先下降后上升,亮度值显著下降(P<0.05)。综合理化指标确定V区温度最佳值为150℃,螺杆转速最佳值为160 r/min。

关键词：挤压膨化理化性质 V区温度螺杆转速

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