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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-fei song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Flotation of niobite,fersmite,and ilmenorutile

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International Journal of Minerals,Metallurgy and Materials 2009年第3期16卷 249-254页

作者： Hao Ren Gui-lan song fei-fei Ji School of Chemistry and Chemical Engineering University of Jinan Jinan 250022 China

The flotation ofniobite, fersmite, and ilmenorutile was studied using 3 collectors with various concentration and pulp pH. The collecting property of different representative collectors was investigated. Experimental results show that diphosphonic acid is an effective collector for valuable niobium-containing minerals. A flotation recovery of 90.87%-91.7% is obtained with 75 mg/L diphosphonic acid at pH 2-4. The chemical adsorption of diphosphonic acid on these 3 minerals＇ surface might lead to the high recovery efficiency of the minerals, which is proved by IR and X-ray photoelectron spectroscopy spectra.

关键词： flotation collector diphosphonic acid niobite fersmite ilmenorutile

On a Spanning K-tree Containing Specified Vertices in a Graph

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Acta Mathematicae Applicatae Sinica 2019年第4期35卷 919-923页

作者： fei-fei song Zhi-quan HU Department of Information & Computational Science He’nan Agricultural University Zhengzhou 450002 China Faculty ofMath & Statistics Central China Normal UniversityWuhan 430079 China

A k-tree is a tree with maximum degree at most k. In this paper, we give a sharp degree sum condition for a graph to have a spanning k-tree in which specified vertices have degree less than t, where 1≤t≤*** denote by σ_k(G) the minimum value of the degree sum of k independent vertices in a graph G. Let k≥2,s≥0 and 1≤t≤k be integers, and suppose G is an(s + 1)-connected graph with σ_k(G)≥|G|+(k-t)*** for any s specified vertices, G contains a spanning k-tree in which every specified vertex has degree at most t. This improves a result obtained by Matsuda and Matsumura.

关键词： spanning tree k-tree (s + 1)-connected graphs degree sum condition specified vertices

Heteropolyacids-Immobilized Graphitic Carbon Nitride:Highly Efficient Photo-Oxidation of Benzyl Alcohol in the Aqueous Phase

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Engineering 2021年第1期7卷 94-102页

作者： Lifu Wu Sai An Yu-fei song State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China

Benzaldehyde is a highly desirable chemical due to its extensive application in medicine,chemical synthesis and food sector among ***,its production generally involves hazardous solvents such as trifluorotoluene or acetonitrile,and its conversion,especially selectivity in the aqueous phase,is still not up to ***,developing an environmentally benign,synthetic process for benzaldehyde production is of paramount ***,we report the preparation of a photocatalyst(PW_(12)-P-UCNS,where PW_(12)is H3PW_(12)O_(40)xH_(2)O and P-UCNS is phosphoric acid-modified unstack graphitic carbon nitride)by incorporating phosphotungstic acid on phosphoric acid-functionalised graphitic carbon nitride(g-C_(3)N_(4))*** performance of PW_(12)-P-UCNS was tested using the benzyl alcohol photo-oxidation reaction to produce benzaldehyde in H_(2)O,at room temperature(20℃).The asprepared PW12-P-UCNS photocatalyst showed excellent photocatalytic performance with 58.3%conversion and 99.5%selectivity within 2 ***,the catalyst could be reused for at least five times without significant activity *** importantly,a proposed Z-scheme mechanism of the PW_(12)-P-UCNScatalysed model reaction was *** carefully investigated its transient photocurrent and electrochemical impedance,and identified superoxide radicals and photogenerated holes as the main active species through electron spin-resonance spectroscopy and scavenger *** show that the designed PW_(12)-P-UCNS photocatalyst is a highly promising candidate for benzaldehyde production through the photo-oxidation reaction in aqueous phase,under mild conditions.

关键词： Photocatalysis Heteropolyacids Graphitic carbon nitride Benzaldehyde

Synthesis and DNA Cleavage Studies of 2,6-Dimethoxyhydroquinone-3-Mercaptoacetic Acid Conjugates

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Chinese Chemical Letters 2001年第8期12卷 697-700页

作者： Yu fei song Pin YANG Institute of Molecular Science Shanxi UniversityTaiyuan 030006

In an effort to investigate the use of short peptide chains as carriers of new anti-tumor agents, we synthesized four tripeptide-cytotoxic agent conjugates: DMQ-MA-Lys(DMQ-MA)-Phe -Arg-Ome, DMQ-MA-Lys(DMQ-MA)-Ile-Arg-Ome, DMQ-MA-Lys(DMQ-MA)-Val-Arg-Ome, DMQ-MA-Lys(DMQ-MA)-Lys(Cbz)-Arg-Ome. The cytotoxic agent conjugated to the N-terminal and the xi -amino group of Lysine of the tripeptide is 2,6-dimethoxyhydroquinone-3-mercaptoacetic acid (DMQ-MA). The tripeptides were synthesized by coupling protected amino acid residues according to Pfp/DCC methods (Pfp: pentafluorophenol, DCC:N,N'-dicyclohexyl-carbodiimide) in solution. Agarose gel electrophoresis showed that these compounds can cleave supercoiled DNA into open-circular form in drug concentration as low as 4-50 mu M without H2O2 and UV irradiation. Further studies on their cytotoxicity for these conjugates are ongoing.

关键词： 2 6-Dimethoxyhydroquinone-3-mercaptoacetic acid tripeptide cleavage pBR322 DNA.

A Well-Conditioned, Nonconforming Nitsche’s Extended Finite Element Method for Elliptic Interface Problems

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Numerical Mathematics(Theory,Methods and Applications) 2020年第1期13卷 99-130页

作者： Xiaoxiao He fei song Weibing Deng Department of Mathematics Nanjing UniversityNanjing 210093JiangsuChina Department of Applied Mathematics Nanjing Forestry UniversityNanjing 210037JiangsuChina

In this paper,we introduce a nonconforming Nitsche’s extended finite element method(NXFEM)for elliptic interface problems on unfitted triangulation *** solution on each side of the interface is separately expanded in the standard nonconforming piecewise linear polynomials with the edge averages as degrees of *** jump conditions on the interface and the discontinuities on the cut edges(the segment of edges cut by the interface)are weakly enforced by the Nitsche’s *** the method,the harmonic weighted fluxes are used and the extra stabilization terms on the interface edges and cut edges are added to guarantee the stability and the well *** prove that the convergence order of the errors in energy and L 2 norms are ***,the errors are independent of the position of the interface relative to the mesh and the ratio of the discontinuous ***,we prove that the condition number of the system matrix is independent of the interface *** examples are given to confirm the theoretical results.

关键词： Elliptic interface problems NXFEM nonconforming finite element condition number

Joint DOA and channel estimation with data detection based on 2D unitary ESPRIT in massive MIMO systems

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Frontiers of Information Technology & Electronic Engineering 2017年第6期18卷 841-849页

作者： Jing-ming KUANG Yuan ZHOU Ze-song fei School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China

We propose a novel method for joint two-dimensional (2D) direction-of-arrival (DOA) and channel estimation with data detection for uniform rectangular arrays (URAs) for the massive multiple-input multiple-output (MIMO) systems. The conventional DOA estimation algorithms usually assume that the channel impulse responses are known exactly. However, the large number of antennas in a massive MIMO system can lead to a challenge in estimating accurate corresponding channel impulse responses. In contrast, a joint DOA and channel estimation scheme is proposed, which first estimates the channel impulse responses for the links between the transmitters and antenna elements using training sequences. After that, the DOAs of the waves are estimated based on a unitary ESPRIT algorithm using previous channel impulse response estimates instead of accurate channel impulse responses and then, the enhanced channel impulse response estimates can be obtained. The proposed estimator enjoys closedform expressions, and thus it bypasses the search and pairing processes. In addition, a low-complexity approach toward data detection is presented by reducing the dimension of the inversion matrix in massive MIMO *** cases for the proposed method are analyzed by changing the number of antennas. Experimental results demonstrate the validity of the proposed method.

关键词： Two-dimensional (2D) direction-of-arrival (DOA) estimation Channel impulse response estimation Data detection Uniform rectangular array (URA) Massive multiple-input multiple-output (MIMO)

Verification of neutron-induced fission product yields evaluated by a tensor decompsition model in transport-burnup simulations

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Nuclear Science and Techniques 2023年第2期34卷 190-201页

作者： Qu‑fei song Long Zhu Hui Guo Jun Su School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China

Neutron-induced fission is an important research object in basic ***,its product yield data are an indispensable nuclear data basis in nuclear engineering and *** fission yield tensor decomposition(FYTD)model has been developed and used to evaluate the independent fission product *** general,fission yield data are verified by the direct comparison of experimental and evaluated ***,such direct comparison cannot reflect the impact of the evaluated data on application scenarios,such as reactor transport-burnup ***,this study applies the evaluated fission yield data in transport-burnup simulation to verify their accuracy and possibility of ***,the evaluated yield data of235U and239Pu are applied in the transport-burnup simulation of a pressurized water reactor(PWR)and sodium-cooled fast reactor(SFR)for *** the reactor operation stage,the errors in pin-cell reactivity caused by the evaluated fission yield do not exceed 500 and 200 pcm for the PWR and SFR,*** errors in decay heat and135Xe and149Sm concentrations during the short-term shutdown of the PWR are all less than 1%;the errors in decay heat and activity of the spent fuel of the PWR and SFR during the temporary storage stage are all less than 2%.For the PWR,the errors in important nuclide concentrations in spent fuel,such as90Sr,137Cs,85Kr,and99Tc,are all less than 6%,and a larger error of 37%is observed *** the SFR,the concentration errors of ten important nuclides in spent fuel are all less than 16%.A comparison of various aspects reveals that the transport-burnup simulation results using the FYTD model evaluation have little difference compared with the reference results using ENDF/B-Ⅷ.0 *** proves that the evaluation of the FYTD model may have application value in reactor physical analysis.

关键词： Fission product yield Tensor decomposition Transport-burnup simulation Machine learning

Synthesis, and Investigation of the Reactive Oxygen Species of a Novel Cyclicpeptide-2,6-dimethoxyhydroquinone-3- mercaptoacetic Acid Conjugate

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Chinese Chemical Letters 2001年第12期12卷 1075-1078页

作者： Yu fei song Hui Min ZHEN Institute of Molecular Science Shanxi University Taiyuan Teacher's College

In this paper, we report the synthesis of a potential anti-cancer agent: Cyclo[Val-Lys(DMQ-MA)-Gaba]. The cytotoxic agent conjugated to the N-terminal and the xi -amino group of lysine of the tripeptide is 2,6-dimethoxyhydroquinone-3-mercaptoacetic acid (DMQ-MA). By employing the rhodamine B degradation method and ESR spectra, we testify the reactive oxygen species - hydroxyl radicals produced by the drug.

关键词： 2,6-dimethoxyhydroquinone-3-mercaptoacetic acid cyclicpeptide