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KLF17 promotes human naive pluripotency through repressing MAPK3 and ZIC2

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Science China(Life Sciences) 2022年第10期65卷 1985-1997页

作者： Shao-Hua Wang Jing Hao Chao Zhang fei-fei duan Ya-Tzu Chiu Ming Shi Xin Huang Jihong Yang Huiqing Cao Yangming Wang Institute of Molecular Medicine College of Future TechnologyPeking UniversityBeijing 100871China Department of Medicine Columbia Center for Human DevelopmentColumbia Stem Cell InitiativeHerbert Irving Comprehensive Cancer CenterColumbia University Irving Medical CenterNew YorkNY 10032USA

The pluripotent state of embryonic stem cells(ESCs)is regulated by a sophisticated network of transcription *** expression of KLF17 has recently been identified as a hallmark of naive state of human ESCs(h ESCs).However,the functional role of KLF17 in naive state is not ***,by employing various gain and loss-of-function approaches,we demonstrate that KLF17 is essential for the maintenance of naive state and promotes the primed to naive state transition in h ***,we identify MAPK3 and ZIC2 as two direct targets repressed by *** of MAPK3 or ZIC2 partially blocks KLF17 from promoting the naive ***,we find that human and mouse homologs of KLF17 retain conserved functions in promoting naive pluripotency of both ***,we show that Klf17 may be essential for early embryo development in *** findings demonstrate the important and conserved function of KLF17 in promoting naive pluripotency and reveal two essential transcriptional targets of KLF17 that underlie its function.

关键词： KLF17 human embryonic stem cell naive pluripotency primed to naive state transition ZIC2

Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li Peng Hao Hongmei duan fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

A genetically modified attenuated Listeria vaccine expressing HPV16E7 kill tumor cells in direct and antigen-specific manner

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A genetically modified attenuated Listeria vaccine expressin...

2%利多卡因局部注射联合加巴喷丁口服治疗带状疱疹后遗神经痛

中国畜牧兽医学会动物传染病学分会第九次全国会员代表大会暨第十七次全国学术研讨会

作者：贾艳艳 Wei Jun Tan fei fei duan Zhi Ming Pan Xiang Chen Yue Lan Yin Xin An Jiao Jiangsu Key Laboratory of Zoonosis Joint International Research Laboratory of Agriculture & Agri-Product SafetyJiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and ZoonosisYangzhou University

Attenuated Listeria monocytogenes(***,LM)induces specific CD8+and CD4+T cell responses,and has been identified as a promising cancer vaccine *** cancer is the third most common cancer in women worldwide,with human papillomavirus(HPV),particula rly type 16,being the main etiological *** therapeutic HPV vaccines are urgently needed.

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实用皮肤病学杂志 2018年第1期11卷 11-13页

作者：王菲菲王瑞段姣雄郑晓红郑州大学第五附属医院皮肤科 450000

目的采用2%利多卡因注射液局部注射联合加巴喷丁口服治疗带状疱疹后遗神经痛(PHN),观察其有效性和安全性。方法将100例PHN患者随机分为2组,每组50例,分别接受加巴喷丁口服(A组)和2%利多卡因局部注射联合加巴喷丁口服治疗(B组),共治疗10 ... 详细信息

目的采用2%利多卡因注射液局部注射联合加巴喷丁口服治疗带状疱疹后遗神经痛(PHN),观察其有效性和安全性。方法将100例PHN患者随机分为2组,每组50例,分别接受加巴喷丁口服(A组)和2%利多卡因局部注射联合加巴喷丁口服治疗(B组),共治疗10 d。用视觉模拟评分(VAS)和24 h睡眠时间来评价治疗效果,同时观察并发症及药物不良反应。结果在10 d的观察期间,两组患者治疗后各时点与治疗前相比疼痛评分随时间下降,睡眠时间均增加(P<0.05)。B组的VAS评分下降大于A组,24 h睡眠时间增加大于A组(P<0.05)。两组未出现并发症及严重的药物不良反应。结论 2%利多卡因注射液局部注射联合加巴喷丁口服治疗PHN,可迅速缓解疼痛,改善睡眠质量,疗效确切,效果优于单独加巴喷丁口服,且无明显不良反应。

关键词：带状疱疹后遗神经痛 2%利多卡因加巴喷丁

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MRI在肝移植中的应用

实用放射学杂志 2007年第1期23卷 60-62页

作者：黄加胜袁曙光闫东赵新湘郭立杨菲菲段丽芬昆明医学院第二附属医院放射科昆明医学院第二附属医院放射科云南昆明650101

目的评价MRI检查在肝移植术前术后的应用价值。方法将我院2004-01—2005-03收治的22例肝移植患者术前MRI检查结果与手术、病理检查相比较,术后MRI检查与其它影像学检查相比较。结果22例肝移植患者中,肝硬化并门脉高压15例,肝硬化、肝癌6... 详细信息

目的评价MRI检查在肝移植术前术后的应用价值。方法将我院2004-01—2005-03收治的22例肝移植患者术前MRI检查结果与手术、病理检查相比较,术后MRI检查与其它影像学检查相比较。结果22例肝移植患者中,肝硬化并门脉高压15例,肝硬化、肝癌6例,严重肝损伤1例;门静脉栓子5例,其中4例为癌栓,1例是管壁样组织,肝右静脉及下腔静脉瘤栓1例;副肝动脉2例,分别发自腹腔干及肠系膜上动脉;胆管吻合口狭窄或胆漏3例;肝动脉可显示2~3级分支,门静脉可显示2~4级分支,肝静脉可显示1~2级分支,胆管显示2~3级分支。结论MRI对肝移植术前和术后的评估具有很大的价值。

关键词：肝肝移植磁共振成像

Highly active Fe_(7)S_(8) encapsulated in N-doped hollow carbon nanofibers for high-rate sodium-ion batteries

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Journal of Energy Chemistry 2021年第2期30卷 26-35,I0002页

作者： Chengzhi Zhang Donghai Wei fei Wang Guanhua Zhang Junfei duan fei Han Huigao duan Jinshui Liu Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology College of Materials Science and EngineeringHunan UniversityChangsha 410082HunanChina State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082HunanChina School of Materials Science and Engineering Changsha University of Science and TechnologyChangsha 410004HunanChina

Nanostructured iron sulfides are regarded as a potential anode material for sodium-ion batteries in virtue of the rich natural abundance and remarkable theoretical ***,poor rate performance and inferior cycling stability caused by sluggish kinetics and volume swelling represent two main obstacles at present. The previous research mainly focuses on nanostructure design and/or hybridizing with conductive *** boosting the property by adjusting Fe/S atomic ratio in iron sulfides is rarely *** this work,Fe_7 S_8 and FeS_2 encapsulated in N-doped hollow carbon fibers(NHCFs/Fe_7 S_8 and NHCFs/FeS_2) are constructed by a combined chemical bath deposition and subsequent sulfidation *** well-designed NHCFs/Fe_(7) S_(8) electrode displays a remarkable capacity of 517 mAh g^(-1) at 2 A g^(-1)after 1000 cycles and a superb rate capability with a capability of 444 mAh g^(-1) even at 20 A g^(-1) in etherbased ***,the rate capability of NHCFs/Fe_(7) S_(8) is superior to that of the contrast NHCFs/FeS_(2) electrode and also much better than the values of the most previously reported iron sulfide-based *** in-depth mechanism explanation is explained by further experimental analysis and theoretical calculation,revealing Fe_(7) S_(8) displays improved intrinsic electronic conductivity and faster Na^(+) diffusion coefficient as well as higher reaction reversibility.

关键词： Sodium-ion batteries Anode High rate Iron sulfides N-doped hollow carbon fibers

Hydrodynamic Pattern in Drying Saline Droplet with Suspended Nanoparticles

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Journal of Bionic Engineering 2020年第4期17卷 802-808页

作者： Junheng Ren Xin Zhong Lu Shen fei duan School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong UniversityXi'an 710049China

Evaporation of multicomponent droplets has gained much attention nowadays because of their complex flow fields and various deposition *** we observe strong flows in evaporating sodium chloride saline droplets with suspended alumina oxide *** evolution of flow pattern was studied by tracking the trajectories of particles and the velocity field was investigated with Particle Image Velocimetry *** non-uniform evaporation rate along the droplet surface leads to a concentration gradient which induces the convection *** the evaporation process before crystallization happens,evolution of the flow can be divided into two *** Regime I,a centrosymmetric convection recirculation is formed *** RegimeⅡ,the convection recirculation migrates to the droplet edge and evolves into several small *** the late evaporation stage,crystallization could induce strong convection *** is shown that the flow tends to become more chaotic with a lower salt concentration.

关键词： convection flow concentration gradient saline droplet crystallization

Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness

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Frontiers of Medicine 2016年第2期10卷 137-142页

作者： Wenjun Xia fei Liu duan Ma Institute of Biomedical Sciences Fudan University Shanghai 200023 China Key Laboratory of Metabolism and Molecular Medicine Ministry of Education Department of Biochemistry and Molecular Biology Institute of Biomedical Sciences School of Basic MedicalSciences Fudan University Shanghai 200023 China

Hearing impairment is considered as the most prevalent impairment worldwide. Almost 600 million people in the world suffer from mild or moderate hearing impairment, an estimated 10% of the human population. Genetic factors play an important role in the pathogenesis of this disorder. Hereditary hearing loss is divided into syndromic hearing loss （associated with other anomalies） and non-syndromic hearing loss （not associated with other anomalies）. Approximately 80% of genetic deafness is non-syndromic. On the basis of the frequency of hearing loss, hereditary non-syndromic hearing loss can be divided into high-, mid-, low-, and total-frequency hearing loss. An audiometric finding of mid-frequency sensorineural hearing loss, or a ＂bowl-shaped＂ audiogram, is uncommon. Up to now, merely 7 loci have been linked to mid-frequency hearing loss. Only four genetic mid- frequency deafness genes, namely, DFNA10 （EYA4）, DFNA8/12 （TECTA）, DFNA13 （COLIIA2）, DFNA44 （CCDC50）, have been reported to date. This review summarizes the research progress of the four genes to draw attention to mid-frequency deafness genes.

关键词： hereditary non-syndromic hearing loss mid-frequency hearing loss deafiaess genes

On the “spring predictability barrier” for strong El Nio events as derived from an intermediate coupled model ensemble prediction system

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Science China Earth Sciences 2017年第9期60卷 1614-1631页

作者： QI QianQian duan WanSuo ZHENG fei TANG YouMin State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China University of Chinese Academy of Sciences Beijing 100049 China International Center for Climate and Environment Science Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China Second Institute of Oceanology State Oceanic Administration Hangzhou 310012 China

Using predictions for the sea surface temperature anomaly(SSTA) generated by an intermediate coupled model(ICM)ensemble prediction system(EPS), we first explore the "spring predictability barrier"(SPB) problem for the 2015/16 strong El Nio event from the perspective of error growth. By analyzing the growth tendency of the prediction errors for ensemble forecast members, we conclude that the prediction errors for the 2015/16 El Nio event tended to show a distinct season-dependent evolution, with prominent growth in spring and/or the beginning of the summer. This finding indicates that the predictions for the 2015/16 El Nio occurred a significant SPB phenomenon. We show that the SPB occurred in the 2015/16 El Nio predictions did not arise because of the uncertainties in the initial conditions but because of model errors. As such, the mean of ensemble forecast members filtered the effect of model errors and weakened the effect of the SPB, ultimately reducing the prediction errors for the 2015/16 El Nio event. By investigating the model errors represented by the tendency errors for the SSTA component,we demonstrate the prominent features of the tendency errors that often cause an SPB for the 2015/16 El Nio event and explain why the 2015/16 El Nio was under-predicted by the ICM EPS. Moreover, we reveal the typical feature of the tendency errors that cause not only a significant SPB but also an aggressively large prediction error. The feature is that the tendency errors present a zonal dipolar pattern with the west poles of positive anomalies in the equatorial western Pacific and the east poles of negative anomalies in the equatorial eastern Pacific. This tendency error bears great similarities with that of the most sensitive nonlinear forcing singular vector(NFSV)-tendency errors reported by duan et al. and demonstrates the existence of an NFSV tendency error in realistic predictions. For other strong El Nio events, such as those that occurred in 1982/83 and 1997

关键词： 2015/16 strong El Nio event Spring predictability barrier Initial errors Model errors