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chinese Journal of Polymer Science 2005年第6期23卷 619-626页

作者： Dong-heng Zhang Su-yun Jie Hai-jian Yang fei chang and wen-hua sun key laboratory of engineering plastics,institute of chemistry,chinese academy of sciences,beijing 100080,china key laboratory of engineering plastics Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China

A series of salicylaldimines, synthesized in high yield via microwave-assisted condensation of salicylaldehyde and 2-alkoxyaniline were allowed to react with nickel chloride to form six-coordinated nickel complexes. These nickel complexes were carefully characterized, and the solid structure of la was elucidated by X-Ray diffraction. Activated with MAO, the nickel complexes showed good activity for homopolymerization of norbornene. Reaction parameters, such as the ratio of nickel precursor to MAO, monomer concentration, reaction time and the reaction temperature, as well as the nature of the ligands were found to have significant effects on the catalytic activity and some properties of the resulting polynorbornene.

关键词： Salicylaldirnine Nickel complex Norbornene Vinyl polymerization

POLYMERIZATION OF ETHYLENE WITH UNSYMMETRIC 2,6-BIS(IMINO)PYRIDINE IRON(Ⅱ)COMPLEX

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chinese Journal of Polymer Science 2002年第3期20卷 205-211页

作者： Zhi Ma wen-hua sun Zi-long Li chang-xing Shao You-liang Hu State key laboratory of engineering plastics and the Center for Molecular sciences institute of chemistry chinese academy of sciences, beijing 100080 china State key Lab. of engineering Plast. Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China

An unsymmetric 2,6-bis(imino)pyridine iron(II) complex 1' was synthesized. The relationship between catalyststructure and its activity in ethylene polymerization is discussed. The kinetic behavior of ethylene polymerization and theeffects of polymerization conditions such as temperature, aluminum/iron molar ratio on the activity of catalyst and thecharacteristics of polyethylene were reported. The unsymmetric catalyst 1' has a good catalytic performance of 3.47×10~6 gPE·mol^(-1)·Fe·h^(-1) at 40℃ with aluminum/iron molar ratio = 2500. A dependence of catalyst activity on themethylaluminoxane (MAO) concentration and reaction temperature was found. The molecular weight (MW) of polyethylenewith broad dispersity is about 10~4-10~5 g/mol. The melting temperature and branching of polyethylenes vary with changingreaction temperature and aluminum/iron molar ratio.

关键词： Unsymmetric 2,6-bis(imino)pyridine iron(Ⅱ) complex Ethylene polymerization Catalyst structure Catalytic activity

室温下高探测效率InGaAsP/InP单光子雪崩二极管

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红外与毫米波学报 2024年第1期43卷 1-6页

作者：祁雨菲王文娟孙京华武文梁焰曲会丹周敏陆卫中国科学院大学杭州高等研究院浙江杭州310024 中国科学院上海技术物理研究所红外物理国家重点实验室上海200083 上海理工大学上海200093 上海理工大学光电信息与计算机工程学院上海200093 中国科学院大学北京100049

描述了一种高性能平面InGaAsP/InP单光子雪崩二极管(SPAD),该二极管具有单独的吸收、分级、电荷和倍增(SAGCM)异质结构。通过电场调节和缺陷控制,SPAD在293 K的门控模式下工作,光子探测效率(PDE)为70%,暗计数率(DCR)为14.93 kHz,后脉冲... 详细信息

描述了一种高性能平面InGaAsP/InP单光子雪崩二极管(SPAD),该二极管具有单独的吸收、分级、电荷和倍增(SAGCM)异质结构。通过电场调节和缺陷控制,SPAD在293 K的门控模式下工作,光子探测效率(PDE)为70%,暗计数率(DCR)为14.93 kHz,后脉冲概率(APP)为0.89%。此外,在死区时间为200 ns的主动淬灭模式下工作时,室温下实现了12.49%的PDE和72.29 kHz的DCR。

关键词：单光子雪崩二极管暗计数率光子探测效率后脉冲概率

Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang Li Li‑Jiao Wang Xiang‑Biao Qiu Jing‑wen Li Wei Xu Tao Li Ze‑Bin Lin chang‑Jun Ning Yong‑Hao Chen Rui‑Rui Fan Kang sun Jing‑Yu Tang Rong Zhang Han‑Tao Jing Bo Mei Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping Chen Zhen Chen Zeng‑Qi Cui An‑Chuan Fan chang‑Qing Feng Fan‑Zhen Feng Ke‑Qing Gao Min‑Hao Gu chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑Wei Hu Han‑Xiong huang Wei‑hua Jia Hao‑Yu Jiang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin Ling Kang Bo Li Chao Li Gong Li Jia‑wen Li Xiao Li Yang Li Jie Liu Rong Liu Shu‑Bin Liu Guang‑Yuan Luan Bin‑Bin Qi Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Zhi‑Xin Tan Sheng‑Da Tang Peng‑Cheng Wang Zhao‑Hui Wang Zhong‑Wei wen Xiao‑Guang Wu Xuan Wu Li‑Kun Xie Yi‑Wei Yang Han Yi Yong‑Ji Yu Guo‑Hui Zhang Lin‑Hao Zhang Mo‑Han Zhang Qi‑Wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang Yue Zhang Zhi‑Yong Zhang Mao‑Yuan Zhao Lu‑Ping Zhou Zhi‑Hao Zhou Ke‑Jun Zhu institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State key laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research institute Co.Ltd. Nanjing 211106China Sino‑French institute of Nuclear engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State key laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State key laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China institute of Nuclear Physics and chemistry China Academy of Engineering PhysicsMianyang 621900China key laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest institute of Nuclear Technology Xi’an 710024China University of chinese academy of sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the china Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

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超冷离子源研究进展

物理学报 2024年第17期73卷 46-65页

作者：周文长方锋罗长杰牟宏进卢亮邹丽平程锐杨杰杜广华中国科学院近代物理研究所兰州730000 中山大学中法核工程与技术学院珠海519082 中国科学院大学北京100049 先进能源科学与技术广东省实验室惠州516003 中国科学院近代物理研究所高精度核谱学重点实验室兰州730000

纳米离子束是制备束斑直径在微纳米尺度荷能离子束的先进技术,主要应用于高分辨和高精度的离子束分析、离子束加工和离子束材料改性研究,在材料分析、微纳加工、微电子器件制造和量子计算等方面发挥着重要的作用.高品质离子源作为纳米... 详细信息

纳米离子束是制备束斑直径在微纳米尺度荷能离子束的先进技术,主要应用于高分辨和高精度的离子束分析、离子束加工和离子束材料改性研究,在材料分析、微纳加工、微电子器件制造和量子计算等方面发挥着重要的作用.高品质离子源作为纳米离子束装置的关键部件,其性能指标直接决定着该装置的技术水平.然而,目前常用的传统离子源存在离子种类单一、能散高和结构复杂等问题,已经难以满足新应用场景下的多离子种类和高分辨的要求,突显出研发新型离子源的重要性和迫切性.随着激光冷却技术的日臻成熟,基于光电离冷原子和激光冷却离子技术可以获得温度在mK甚至μK量级的超冷离子,其低温和易于操控等典型特征极大地促进了超冷离子源的发展.超冷离子具有极小的横向速度发散,可以显著提升离子源的亮度和发射度等品质参数,为纳米离子束技术的革新带来了巨大的发展机遇.因此,超冷离子源的研究对于实现更高亮度、更小尺寸、更低能散、更多样化离子种类以及结构更简化的高品质离子源具有重要的意义.本文综述了近年来超冷离子源的研究进展,从制备原理、产生方式以及典型应用等方面介绍了磁光阱离子源、冷原子束离子源和超冷单离子源在基础研究和应用技术研发方面取得的重要成果,并对超冷离子源的未来发展和应用前景进行了展望.

关键词：纳米离子束磁光阱离子源冷原子束离子源超冷单离子源

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Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao Chen Jing-Yu Tang Rui-Rui Fan Qiang Li Gong Li Dong Liu Zheng-Yao Jin Xing-Zhu Cui Tian-Xiang Chen Yi-Wei Yang Rong Liu Han Yi Yang Li Zhen Yang Qi An Hao-Fan Bai Jiang-Bo Bai Jie Bao Ping Cao Qi-Ping Chen Zhen Chen Zeng-Qi Cui An-Chuan Fan chang-Qing Feng Fan-Zhen Feng Ke-Qing Gao Min-Hao Gu chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong huang Wei-hua Jia Hao-yu Jiang Wei Jiang Zhi-jie Jiang Ling Kang Bo Li Chao Li Jia-wen Li Xiao Li Jie Liu Shu-Bin Liu Guang-Yuan Luan chang-Jun Ning Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang sun Zhi-Xin Tan Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang Mo-Han Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Yue Zhang Zhi-Yong Zhang Mao-Yuan Zhao Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French institute of Nuclear engineering and Technology Sun Yat-sen UniversityZhuhai 519082China institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State key laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State key laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry laboratory University of Science and Technology of ChinaHefei 230026China institute of Nuclear Physics and chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State key laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China key laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest institute of Nuclear Technology Xi’an 710024China University of chinese academy of sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the china Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

Ethylene Oligomerization Promoted by Nickel Complexeswith 8-Iminoquinoline Derivatives

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chinese Chemical Letters 2001年第8期12卷 691-692页

作者： Zi Long LI wen hua sun Zhi MA You Liang HU chang Xing SHAO State key laboratory of engineering plastics and The Center for Molecular sciences institute of chemistry The Chinese Academy of SciencesBeijing 100080

A series of 8-iminoquinoline derivatives nickel complexes were synthesized to proceed high activity in ethylene oligomerization.

关键词： Nickel Complex iminoquinoline ethylene oligomerization homogeneous catalysis.

Toll-like receptor 5-mediated signaling enhances liver regeneration in mice

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Military Medical Research 2021年第4期8卷 490-502页

作者： wen Zhang Lei Wang Xue-hua sun Xian Liu Yang Xiao Jie Zhang Ting Wang Hui Chen Yi-Qun Zhan Miao Yu chang-Hui Ge chang-Yan Li Guang-Ming Ren Rong-hua Yin Xiao-Ming Yang Department of Pharmaceutical engineering School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China. State key laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China. School of Basic Medical sciences Anhui Medical UniversityHefei 230032Anhui ProvinceChina. beijing institute of Radiation Medicine Beijing 100850China.

Background:Toll-like receptor 5(TLR5)-mediated pathways play critical roles in regulating the hepatic immune response and show hepatoprotective effects in mouse models of hepatic ***,the role of TLR5 in experimental models of liver regeneration has not been *** study aimed to investigate the role of TLR5 in partial hepatectomy(PHx)-induced liver ***:We performed 2/3 PHx in wild-type(WT)mice,TLR5 knockout mice,or TLR5 agonist CBLB502 treated mice,as a model of liver *** flagellin content was measured with ELISA,and hepatic TLR5 expression was determined with quantitative PCR analyses and flow *** study the effects of TLR5 on hepatocyte proliferation,we analyzed bromodeoxyuridine(BrdU)incorporation and proliferating cell nuclear antigen(PCNA)expression with immunohistochemistry(IHC)*** effects of TLR5 during the priming phase of liver regeneration were examined with quantitative PCR analyses of immediate early gene mRNA levels,and with Western blotting analysis of hepatic NF-κB and STAT3 *** and growth factor production after PHx were detected with real-time PCR and cytometric bead array(CBA)*** Red O staining and hepatic lipid concentrations were analyzed to examine the effect of TLR5 on hepatic lipid accumulation after ***:The bacterial flagellin content in the serum and liver increased,and the hepatic TLR5 expression was significantly up-regulated in WT mice after ***5-deficient mice exhibited diminished numbers of BrdU-and PCNA-positive cells,suppressed immediate early gene expression,and decreased cytokine and growth factor ***,PHx-induced hepatic NF-κB and STAT3 activation was inhibited in Tlr5–/–mice,as compared with WT ***,the administration of CBLB502 significantly promoted PHx-mediated hepatocyte proliferation,which was correlated with enhanced production of proinflammatory cytokines and the recruitment of macrophages

关键词： Liver regeneration Partial hepatectomy Toll-like receptor 5 CBLB502 NF-κB

Predictive Value of Dynamic Peri-Transplantation MRD Assessed By MFC Either Alone or in Combination with Other Variables for Outcomes of Patients with T-Cell Acute Lymphoblastic Leukemia

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Current Medical Science 2021年第3期41卷 443-453页

作者： Zhi-dong WANG Yue-wen WANG Lan-ping XU Xiao-hui ZHANG Yu WANG huan CHEN Yu-hong CHEN Feng-rong WANG Wei HAN Yu-qian sun Chen-hua YAN fei-fei TANG Xiao-dong MO Ya-zhe WANG Yan-rong LIU Kai-yan LIU Xiao-jun huaNG Ying-jun chang Peking University People's Hospital and Peking University institute of Hematology National Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China Research Unit of key Technique for Diagnosis and Treatments of Hematologic Malignancies Chinese Academy of Medical SciencesBeijing 100005China 3Peking-Tsinghua Center for Life SciencesBeijing 100871China Peking-Tsinghua Center for Life sciences Beijing 100871China

We performed a retrospective analysis to investigate dynamic peri-hematopoieticstem cell transplantation(HSCT)minimal/measurable residual disease(MRD)on outcomes inpatients with T-cell acute lymphoblastic leukemia(T-ALL).A total of 271 patients were enrolledand classified into three groups:unchanged ncgative MRD pre-and post-HSCT group(group A),post-MRD non-increase group(group B),and post-MRD increase group(group C).The patientsin group B and group C experienced a higher cumulative incidence of relapse(CIR)(42%vs.71%vs.16%,P<0.001)and lower leukemia-free survival(LFS)(46%vs.21%vs.70%,P<0.001)andoverall survival(OS)(50%vs.28%vs.72%,P<0.001)than in group A,but there was no significantdifference in non-relapse mortality(NRM)among three groups(14%vs.12%vs.8%,P=0.752).Multivariate analysis showed that dynamic peri-HSCT MRD was associated with CIR(HR=2.392,95%CI,1.816-3.151,P<0.001),LFS(HR=1.964,95%CI,1.546-2.496,P<0.001)and os(HR=1.731,95%CI,1.348-2.222,P<0.001).We also established a risk scoring system based ondynamic peri-HSCT MRD combined with remission status pre-HSCT and onsct of chronic graft-versus-host disease(GVHD).This risk scoring system could better distinguish ClR(c=0.730)thanthat for pre-HSCT MRD(c=0.562),post-HSCT MRD(c=0.616)and pre-and post-MRD dynamics(c=0.648).Our results confirm the outcome predictive value of dynamic peri-HSCT MRD eitheralone or in combination with other variables for patients with T-ALL.

关键词： peri-transplantation minimal residual disease risk stratification risk scoring system T-cell acute lymphoblastic leukemia

Exploration of Bioactive Constituents and Immunoregulatory Mechanisms of a Hanshi-Yufei Formulation for Treating COVID-19

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World Journal of Traditional chinese Medicine 2021年第3期7卷 339-346页

作者： wen-Long Wei Shi-fei Wu Zhen-Wei Li Hao-Jv Li hua Qu chang-Liang Yao Jian-Qing Zhang Jia-Yuan Li Gao-Le Zhang Wan-Ying Wu De-An Guo Shanghai Research Center for Modernization of Traditional chinese Medicine National Engineering Laboratory for TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai University of chinese academy of sciences BeijingChina

Objective:The objective of this study was to characterize the chemical compounds of a Hanshi-Yufei formulation(HSYF;a modified formulation of a traditional chinese medicine used for treating COVID-19)to elucidate the mechanism of action and to evaluate potential anti-inflammatory effects of *** and Methods:The chemical constituents of HSYF extract were characterized using UPLC-Q-TOF/***,a set of TCM network pharmacology methods was applied to identify disease-associated genes and to predict target profiles and pharmacological actions associated with the constituents of ***,the antiviral effects of HSYF on H1N1 were assessed in RAW264.7 cells using MTT *** levels of pro-inflammatory cytokines interleukin(IL)-6 and tumor necrosis factor(TNF)-αfollowing infection of RAW264.7 cells with H1N1 were measured using an enzyme-linked immune sorbent assay(ELISA),and expression levels of inflammatory-related factors were detected using western ***:In total,165 chemical constituents(including glycosides,tannins,volatile oils,amino acids,triterpenoids,polyphenols,phenylpropanoids,sesquiterpenes,alkaloids,and flavonoids,among others)were tentatively identified in *** pharmacology demonstrated that HSYF can regulate immunomodulatory-and anti-inflammatory-related targets of multiple pathways through its active ingredients,suggesting potential anti-COVID-19 ***,cell viability assays and ELISA showed that HSYF significantly inhibited H1N1 replication in RAW64.7 cells and markedly reduced expression of pro-inflammatory cytokines TNF-αand IL-6 at the proteins ***:The results of the present study help improve our understanding of the therapeutic effects of HSYF in COVID-19 treatment from multi-level perspectives.

关键词： Anti-inflammatory COVID-19 Hanshi-Yufei prescription immunoregulatory