检索结果-南通市图书馆

chinese Journal of Polymer Science 2005年第6期23卷 619-626页

作者： Dong-heng Zhang Su-yun Jie Hai-jian Yang fei chang and wen-hua sun key laboratory of engineering plastics,institute of chemistry,chinese academy of sciences,beijing 100080,china key laboratory of engineering plastics Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China

A series of salicylaldimines, synthesized in high yield via microwave-assisted condensation of salicylaldehyde and 2-alkoxyaniline were allowed to react with nickel chloride to form six-coordinated nickel complexes. These nickel complexes were carefully characterized, and the solid structure of la was elucidated by X-Ray diffraction. Activated with MAO, the nickel complexes showed good activity for homopolymerization of norbornene. Reaction parameters, such as the ratio of nickel precursor to MAO, monomer concentration, reaction time and the reaction temperature, as well as the nature of the ligands were found to have significant effects on the catalytic activity and some properties of the resulting polynorbornene.

关键词： Salicylaldirnine Nickel complex Norbornene Vinyl polymerization

POLYMERIZATION OF ETHYLENE WITH UNSYMMETRIC 2,6-BIS(IMINO)PYRIDINE IRON(Ⅱ)COMPLEX

在线全文

学校读者我要写书评

暂无评论

chinese Journal of Polymer Science 2002年第3期20卷 205-211页

作者： Zhi Ma wen-hua sun Zi-long Li chang-xing Shao You-liang Hu State key laboratory of engineering plastics and the Center for Molecular sciences institute of chemistry chinese academy of sciences, beijing 100080 china the Center for Molecular sciences institute of chemistry Chinese Academy of Science State Key Laboratory of Engineering Plastics 北京 100080

An unsymmetric 2,6-bis(imino)pyridine iron(II) complex 1' was synthesized. The relationship between catalyststructure and its activity in ethylene polymerization is discussed. The kinetic behavior of ethylene polymerization and theeffects of polymerization conditions such as temperature, aluminum/iron molar ratio on the activity of catalyst and thecharacteristics of polyethylene were reported. The unsymmetric catalyst 1' has a good catalytic performance of 3.47×10~6 gPE·mol^(-1)·Fe·h^(-1) at 40℃ with aluminum/iron molar ratio = 2500. A dependence of catalyst activity on themethylaluminoxane (MAO) concentration and reaction temperature was found. The molecular weight (MW) of polyethylenewith broad dispersity is about 10~4-10~5 g/mol. The melting temperature and branching of polyethylenes vary with changingreaction temperature and aluminum/iron molar ratio.

关键词： Unsymmetric 2,6-bis(imino)pyridine iron(Ⅱ) complex Ethylene polymerization Catalyst structure Catalytic activity

Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao Chen Jing-Yu Tang Rui-Rui Fan Qiang Li Gong Li Dong Liu Zheng-Yao Jin Xing-Zhu Cui Tian-Xiang Chen Yi-Wei Yang Rong Liu Han Yi Yang Li Zhen Yang Qi An Hao-Fan Bai Jiang-Bo Bai Jie Bao Ping Cao Qi-Ping Chen Zhen Chen Zeng-Qi Cui An-Chuan Fan chang-Qing Feng Fan-Zhen Feng Ke-Qing Gao Min-Hao Gu chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong huang Wei-hua Jia Hao-yu Jiang Wei Jiang Zhi-jie Jiang Ling Kang Bo Li Chao Li Jia-wen Li Xiao Li Jie Liu Shu-Bin Liu Guang-Yuan Luan chang-Jun Ning Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang sun Zhi-Xin Tan Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang Mo-Han Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Yue Zhang Zhi-Yong Zhang Mao-Yuan Zhao Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French institute of Nuclear engineering and Technology Sun Yat-sen UniversityZhuhai 519082China institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State key laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State key laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry laboratory University of Science and Technology of ChinaHefei 230026China institute of Nuclear Physics and chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State key laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China key laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest institute of Nuclear Technology Xi’an 710024China University of chinese academy of sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron techniques.Neutron resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an object.The back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the china Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test experiments.The results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at Back-n.This study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

室温下高探测效率InGaAsP/InP单光子雪崩二极管

在线全文

学校读者我要写书评

暂无评论

红外与毫米波学报 2024年第1期43卷 1-6页

作者：祁雨菲王文娟孙京华武文梁焰曲会丹周敏陆卫中国科学院大学杭州高等研究院浙江杭州310024 中国科学院上海技术物理研究所红外物理国家重点实验室上海200083 上海理工大学上海200093 上海理工大学光电信息与计算机工程学院上海200093 中国科学院大学北京100049

描述了一种高性能平面InGaAsP/InP单光子雪崩二极管(SPAD),该二极管具有单独的吸收、分级、电荷和倍增(SAGCM)异质结构。通过电场调节和缺陷控制,SPAD在293 K的门控模式下工作,光子探测效率(PDE)为70%,暗计数率(DCR)为14.93 kHz,后脉冲... 详细信息

描述了一种高性能平面InGaAsP/InP单光子雪崩二极管(SPAD),该二极管具有单独的吸收、分级、电荷和倍增(SAGCM)异质结构。通过电场调节和缺陷控制,SPAD在293 K的门控模式下工作,光子探测效率(PDE)为70%,暗计数率(DCR)为14.93 kHz,后脉冲概率(APP)为0.89%。此外,在死区时间为200 ns的主动淬灭模式下工作时,室温下实现了12.49%的PDE和72.29 kHz的DCR。

关键词：单光子雪崩二极管暗计数率光子探测效率后脉冲概率

Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression

在线全文

学校读者我要写书评

暂无评论

Military Medical Research 2023年第3期10卷 281-298页

作者： fei Pei Ren‑Qi Yao Chao Ren Soheyl Bahrami Timothy RBilliar Irshad HChaudry De‑chang Chen Xu‑Lin Chen Na Cui Xiang‑Ming Fang Yan Kang Wei‑Qin Li wen‑Xiong Li hua‑Ping Liang Hong‑Yuan Lin Ke‑Xuan Liu Ben Lu Zhong‑Qiu Lu Marc Maegele Tian‑Qing Peng You Shang Lei Su Bing‑Wei sun chang‑Song Wang Jian Wang Jiang‑huai Wang Ping Wang Jian‑Feng Xie Li‑Xin Xie Li‑Na Zhang Basilia Zingarelli Xiang‑Dong Guan Jian‑Feng Wu Yong‑Ming Yao Department of Critical Care Medicine the First Affiliated Hospital of Sun Yat-Sen University58 Zhongshan Er RoadYuexiu DistrictGuangzhou 510080GuangdongChina Translational Medicine Research Center Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General Hospital28 Fuxing RoadHaidian DistrictBeijing 100853China Department of Burn Surgery the First Affiliated Hospital of Naval Medical UniversityShanghai 200433China Ludwig-Boltzmann institute for Experimental and Clinical Traumatology 1200 ViennaAustria Department of Surgery University of Pittsburgh Medical CenterPittsburghPA 15213USA Center for Surgical Research and Department of Surgery University of Alabama at BirminghamBirminghamAL 35294USA Department of Critical Care Medicine Ruijin HospitalShanghai Jiaotong UniversityShanghai 200025China Department of Burns the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Critical Care Medicine Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Department of Anesthesiology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 31003China Department of Critical Care Medicine West China Hospital of Sichuan UniversityChengdu 610041China Department of Critical Care Medicine General Hospital of Eastern Theater Command of Chinese PLANanjing 210002China Department of Surgical Intensive Critical Unit Beijing Chao‑Yang HospitalCapital Medical UniversityBeijing 100020China State key laboratory of Trauma Burns and Combined InjuryResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqing 400042China Department of Critical Care Medicine Fourth Medical Center of the Chinese PLA General HospitalBeijing 100048China Department of Anesthesiology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Critical Care Medicine and Hematology the Third Xiangya HospitalCentral South UniversityChangs

Emerged evidence has indicated that immunosuppression is involved in the occurrence and development of sepsis.To provide clinical practice recommendations on the immune function in sepsis,an expert consensus focusing on the monitoring and treatment of sepsis-induced immunosuppression was developed.Literature related to the immune monitoring and treatment of sepsis were retrieved from PubMed,Web of Science,and chinese National Knowledge Infrastructure to design items and expert opinions were collected through an online questionnaire.Then,the Delphi method was used to form consensus opinions,and RAND appropriateness method was developed to provide consistency evaluation and recommendation levels for consensus opinions.This consensus achieved satisfactory results through two rounds of questionnaire survey,with 2 statements rated as perfect consistency,13 as very good consistency,and 9 as good consistency.After summarizing the results,a total of 14 strong recommended opinions,8 weak recommended opinions and 2 non-recommended opinions were produced.Finally,a face-to-face discussion of the consensus opinions was performed through an online meeting,and all judges unanimously agreed on the content of this consensus.In summary,this expert consensus provides a preliminary guidance for the monitoring and treatment of immunosuppression in patients with sepsis.

关键词： Sepsis Immune function monitoring Immunomodulatory therapy Immunosuppression

Ethylene Oligomerization Promoted by Nickel Complexeswith 8-Iminoquinoline Derivatives

在线全文

学校读者我要写书评

暂无评论

chinese Chemical Letters 2001年第8期12卷 691-692页

作者： Zi Long LI wen hua sun Zhi MA You Liang HU chang Xing SHAO State key laboratory of engineering plastics and The Center for Molecular sciences institute of chemistry The Chinese Academy of SciencesBeijing 100080

A series of 8-iminoquinoline derivatives nickel complexes were synthesized to proceed high activity in ethylene oligomerization.

关键词： Nickel Complex iminoquinoline ethylene oligomerization homogeneous catalysis.

Toll-like receptor 5-mediated signaling enhances liver regeneration in mice

在线全文

学校读者我要写书评

暂无评论

Military Medical Research 2021年第4期8卷 490-502页

作者： wen Zhang Lei Wang Xue-hua sun Xian Liu Yang Xiao Jie Zhang Ting Wang Hui Chen Yi-Qun Zhan Miao Yu chang-Hui Ge chang-Yan Li Guang-Ming Ren Rong-hua Yin Xiao-Ming Yang Department of Pharmaceutical engineering School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China. State key laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China. School of Basic Medical sciences Anhui Medical UniversityHefei 230032Anhui ProvinceChina. beijing institute of Radiation Medicine Beijing 100850China.

Background:Toll-like receptor 5(TLR5)-mediated pathways play critical roles in regulating the hepatic immune response and show hepatoprotective effects in mouse models of hepatic diseases.However,the role of TLR5 in experimental models of liver regeneration has not been reported.This study aimed to investigate the role of TLR5 in partial hepatectomy(PHx)-induced liver regeneration.Methods:We performed 2/3 PHx in wild-type(WT)mice,TLR5 knockout mice,or TLR5 agonist CBLB502 treated mice,as a model of liver regeneration.Bacterial flagellin content was measured with ELISA,and hepatic TLR5 expression was determined with quantitative PCR analyses and flow cytometry.To study the effects of TLR5 on hepatocyte proliferation,we analyzed bromodeoxyuridine(BrdU)incorporation and proliferating cell nuclear antigen(PCNA)expression with immunohistochemistry(IHC)staining.The effects of TLR5 during the priming phase of liver regeneration were examined with quantitative PCR analyses of immediate early gene mRNA levels,and with Western blotting analysis of hepatic NF-κB and STAT3 activation.Cytokine and growth factor production after PHx were detected with real-time PCR and cytometric bead array(CBA)assays.Oil Red O staining and hepatic lipid concentrations were analyzed to examine the effect of TLR5 on hepatic lipid accumulation after PHx.Results:The bacterial flagellin content in the serum and liver increased,and the hepatic TLR5 expression was significantly up-regulated in WT mice after PHx.TLR5-deficient mice exhibited diminished numbers of BrdU-and PCNA-positive cells,suppressed immediate early gene expression,and decreased cytokine and growth factor production.Moreover,PHx-induced hepatic NF-κB and STAT3 activation was inhibited in Tlr5–/–mice,as compared with WT mice.Consistently,the administration of CBLB502 significantly promoted PHx-mediated hepatocyte proliferation,which was correlated with enhanced production of proinflammatory cytokines and the recruitment of macrophages and neutrophils in the liver.Furthermore,Tlr5–/–

关键词： Liver regeneration Partial hepatectomy Toll-like receptor 5 CBLB502 NF-κB

Predictive Value of Dynamic Peri-Transplantation MRD Assessed By MFC Either Alone or in Combination with Other Variables for Outcomes of Patients with T-Cell Acute Lymphoblastic Leukemia

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2021年第3期41卷 443-453页

作者： Zhi-dong WANG Yue-wen WANG Lan-ping XU Xiao-hui ZHANG Yu WANG huan CHEN Yu-hong CHEN Feng-rong WANG Wei HAN Yu-qian sun Chen-hua YAN fei-fei TANG Xiao-dong MO Ya-zhe WANG Yan-rong LIU Kai-yan LIU Xiao-jun huaNG Ying-jun chang Peking University People's Hospital and Peking University institute of Hematology National Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China Research Unit of key Technique for Diagnosis and Treatments of Hematologic Malignancies Chinese Academy of Medical SciencesBeijing 100005China 3Peking-Tsinghua Center for Life SciencesBeijing 100871China Peking-Tsinghua Center for Life sciences Beijing 100871China

We performed a retrospective analysis to investigate dynamic peri-hematopoieticstem cell transplantation(HSCT)minimal/measurable residual disease(MRD)on outcomes inpatients with T-cell acute lymphoblastic leukemia(T-ALL).A total of 271 patients were enrolledand classified into three groups:unchanged ncgative MRD pre-and post-HSCT group(group A),post-MRD non-increase group(group B),and post-MRD increase group(group C).The patientsin group B and group C experienced a higher cumulative incidence of relapse(CIR)(42%vs.71%vs.16%,P<0.001)and lower leukemia-free survival(LFS)(46%vs.21%vs.70%,P<0.001)andoverall survival(OS)(50%vs.28%vs.72%,P<0.001)than in group A,but there was no significantdifference in non-relapse mortality(NRM)among three groups(14%vs.12%vs.8%,P=0.752).Multivariate analysis showed that dynamic peri-HSCT MRD was associated with CIR(HR=2.392,95%CI,1.816-3.151,P<0.001),LFS(HR=1.964,95%CI,1.546-2.496,P<0.001)and os(HR=1.731,95%CI,1.348-2.222,P<0.001).We also established a risk scoring system based ondynamic peri-HSCT MRD combined with remission status pre-HSCT and onsct of chronic graft-versus-host disease(GVHD).This risk scoring system could better distinguish ClR(c=0.730)thanthat for pre-HSCT MRD(c=0.562),post-HSCT MRD(c=0.616)and pre-and post-MRD dynamics(c=0.648).Our results confirm the outcome predictive value of dynamic peri-HSCT MRD eitheralone or in combination with other variables for patients with T-ALL.

关键词： peri-transplantation minimal residual disease risk stratification risk scoring system T-cell acute lymphoblastic leukemia

基于白光中子源的^(197)Au中子辐射俘获截面测量及共振参数分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

物理学报 2024年第7期73卷 104-113页

作者：罗淏天张奇玮栾广源王晓宇邹翀任杰阮锡超贺国珠鲍杰孙琪黄翰雄王朝辉吴鸿毅顾旻皓余滔解立坤陈永浩安琪白怀勇鲍煜曹平陈昊磊陈琪萍陈裕凯陈朕崔增琪樊瑞睿封常青高可庆韩长材韩子杰何泳成洪杨黄蔚玲黄锡汝季筱璐吉旭阳蒋伟江浩雨姜智杰敬罕涛康玲康明涛李波李超李嘉雯李论李强李晓李样刘荣刘树彬刘星言穆奇丽宁常军齐斌斌任智洲宋英鹏宋朝晖孙虹孙康孙晓阳孙志嘉谭志新唐洪庆唐靖宇唐新懿田斌斌王丽娇王鹏程王琦王涛峰文杰温中伟吴青彪吴晓光吴煊羊奕伟易晗于莉于永积张国辉张林浩张显鹏张玉亮张志永赵豫斌周路平周祖英朱丹阳朱科军朱鹏朱兴华中国原子能科学研究院核数据重点实验室北京102413 中国科学院高能物理研究所北京100049 散裂中子源科学中心东莞523803 核探测与核电子学国家重点实验室北京100049 中国科学技术大学近代物理系核探测与核电子学国家重点实验室合肥230026 北京大学物理学院核物理与核技术国家重点实验室北京100871 中国工程物理研究院核物理与化学研究所绵阳621900 西北核技术研究院西安710024 中国科学院大学北京100049 中国科学技术大学工程与应用物理系合肥230026 北京航空航天大学物理学院北京100083 华能山东石岛湾核电有限公司荣成264312

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室... 详细信息

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室建立了伽马全吸收装置(Gamma total absorption facility,GTAF),该装置用28块六棱BaF_(2)晶体和12块五棱BaF_(2)晶体构成了外径25 cm,内径10 cm的球壳,覆盖了95.2%的立体角.利用GTAF在中国散裂中子源Back-n束线上,测量了197Au(n,γ)的反应截面数据.测量数据通过能量筛选、PSD方法、晶体多重性筛选进行了初步本底扣除,随后结合对^(nat)C及空样品的测量数据对本底进行了分析及扣除,获得了197Au俘获反应的产额,利用SAMMY程序拟合得到了^(197)Au在1—100 e V的共振能量、中子共振宽度和伽马共振宽度参数.实验测量结果与ENDF/B-VIII.0数据库符合良好,其共振参数存在一定差异,分析原因可能与GTAF能量分辨率、Back-n的中子能谱测量精度、以及实验本底扣除方法相关,这也是下一步工作的重点.

关键词：中子辐射俘获截面共振参数白光中子源伽马全吸收装置

枸杞子多糖提取物LBP1C通过激活TFEB延缓衰老

在线全文

学校读者我要写书评

暂无评论

生物化学与生物物理进展 2023年第8期50卷 1926-1936页

作者：伍东立乔新华韩文生谢婷时畅黄雨云飞孙传鑫丁侃陈畅西南医科大学基础医学院泸州646000 中国科学院生物物理研究所生物大分子国家重点实验室北京100101 中国科学院大学生命科学学院北京100049 中国科学院上海药物研究所受体研究重点实验室药物研究国家重点实验室上海201203

目的探究枸杞子提取物LBP1C延缓人成纤维细胞及线虫自然衰老的效应及机制,以期解读《本草纲目》记载的枸杞子轻身不老、易颜色、变白的科学内涵。方法以人成纤维细胞及线虫自然衰老为模型,用LBP1C处理人成纤维细胞(复制性衰老模式细胞)... 详细信息

目的探究枸杞子提取物LBP1C延缓人成纤维细胞及线虫自然衰老的效应及机制,以期解读《本草纲目》记载的枸杞子轻身不老、易颜色、变白的科学内涵。方法以人成纤维细胞及线虫自然衰老为模型,用LBP1C处理人成纤维细胞(复制性衰老模式细胞),检测P16、P21表达水平及β-gal染色指征衰老水平;用qPCR的方法检测转录因子GATA4及衰老相关分泌表型(senescence associated secretory phenotype,SASP)指标的mRNA水平;通过免疫荧光检测溶酶体生物发生和自噬的关键转录因子EB(transcription factor EB,TFEB)入核水平,通过Western blot检测LC3II/I的水平以指征LBP1C对自噬水平的影响;在细胞及线虫体系检测LBP1C对脂褐质水平进行检测。通过线虫身体在相同时间内的摆动次数和咽部吞咽次数评估LBP1C对线虫运动能力的影响。结果LBP1C处理的人成纤维细胞组中衰老相关指标(P16、P21表达水平及β-gal染色)相比于对照组显著下降,表明LBP1C可延缓细胞衰老;LBP1C还降低了细胞及线虫的脂褐质积累,并提高线虫运动及吞咽能力,促进线虫的健康从而抑制衰老。机制上,LBP1C处理组中TFEB入核比例显著升高,激活了自噬。自噬水平的提高降低了SASP的转录因子GATA4水平,从而降低了SASP相关的IL-1β及诱导型一氧化氮合酶(inducible nitric oxide synthase,iNOS)水平。同时,自噬水平的提高使脂褐质降解加速,降低了细胞及线虫中脂褐质的积累。结论LBP1C通过激活TFEB提高了自噬水平,从而降低了SASP及脂褐质的积累,具有延缓衰老的效应,并促进了健康衰老。本研究初步揭示了枸杞子在抗衰老及抑制脂褐质从而潜在美白作用的效应及机制,为其进一步抗衰老和美白产品的研发提供了科学依据和理论基础。

关键词：枸杞子衰老转录因子EB 自噬衰老相关分泌表型脂褐质