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Pulmonary rehabilitation protocols in urgent lung transplantation patients

World Journal of Emergency Medicine 2024年第1期15卷 47-51页

作者： fei zeng Lingyun Cai Luyao Guo Meijuan Lan Jiangshuyuan Liang Peipei Gu Nursing Department the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China

BACKGROUND:Prolonged invasive respiratory support and extracorporeal membrane oxygenation(ECMO)in patients requiring urgent lung transplantation(ULTx)present signifi cant challenges to clinical practice due to severe underlying diseases and complex *** aim of the study was to report the clinical outcomes of patients who received ULTx and followed the perioperative rehabilitation protocol implemented in a lung transplant ***:A retrospective analysis was conducted in ULTx patients who required preoperative invasive mechanical ventilation(IMV)and ECMO between January 2018 and January *** were retrieved from electronic medical records at our lung transplant ***:Fourteen patients(mean age 57.43±10.97 years;12 males,2 females)underwent ULTx with bridging ECMO and *** mean body mass index was 23.94±3.33 kg/m²,and the mean Acute Physiology and Chronic Health Evaluation(APACHE)II score was 21.50±*** Nutritional Risk Screening 2002(NRS 2002)scores were≥*** was performed after an 8.5-day waiting period(interquartile interval[IQR]5.0-26.5 d).Following the surgeries,the average lengths of ECMO and IMV were 1.0(IQR 1.0-2.0)d and 5.0(IQR 3.0-7.3)d,*** total length of hospital stay was 60.1±30.8 d,with an average intensive care unit stay of 38.3±22.9 d and post-operative hospitalization stay of 45.8±26.1 *** patients died within 30 d after ULTx,with a 30-day survival rate of 85.71%.CONCLUSION:Patients receiving ULTx showed an acceptable short-term survival rate,validating the practicality and safety of the treatment protocols implemented in our center.

关键词： Urgent lung transplantation End-stage lung disease Extracorporeal membrane oxygenation Invasive respiratory support Pulmonary rehabilitation.

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Pharmacotherapy of urethral stricture

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Asian Journal of Andrology 2024年第1期26卷 1-9页

作者： Hui Luo Ke-Cheng Lou Ling-Yu Xie fei zeng Jun-Rong Zou The First Clinical College Gannan Medical UniversityGanzhou 341000China Department of Urology The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000China Institute of Urology The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000China Jiangxi Engineering Technology Research Center of Calculi Prevention Ganzhou 341000China

Urethral stricture is characterized by the chronic formation of fibrous tissue,leading to the narrowing of the urethral *** the availability of various endoscopic treatments,the recurrence of urethral strictures remains a common *** pharmacotherapy targeting tissue fibrosis is a promising option for reducing recurrence *** drugs cannot replace surgery,they can be used as adjuvant therapies to improve *** this regard,many drugs have been proposed based on the mechanisms underlying the pathophysiology of urethral *** studies have obtained substantial progress in treating urethral strictures,highlighting the potential for improved drug effectiveness through appropriate clinical delivery ***,this review summarizes the latest researches on the mechanisms related to the pathophysiology of urethral stricture and the drugs to provide a theoretical basis and new insights for the effective use and future advancements in drug therapy for urethral stricture.

关键词： adjuvant therapy pathophysiology pharmacotherapy urethra urethral stricture

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Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy

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Acta Pharmaceutica Sinica B 2024年第2期14卷 795-807页

作者： Yongchun Pan Xiaowei Luan fei zeng Xuyuan Wang Shurong Qin Qianglan Lu Guanzhong He Yanfeng Gao Xiaolian Sun Xin Han Bangshun He Yujun Song Department of Laboratory Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006China College of Engineering and Applied Sciences State Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210023China State Key Laboratory of Natural Medicines Key Laboratory of Drug Quality Control and PharmacovigilanceDepartment of Pharmaceutical AnalysisChina Pharmaceutical UniversityNanjing 211198China School of Medicine&Holistic Integrative Medicine Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing University of Chinese MedicineNanjing 210023China

Recent innovations in nanomaterials inspire abundant novel tumor-targeting CRISPR-based gene ***,the therapeutic efficiency of traditional targeted nanotherapeutic strategies is limited by that the biomarkers vary in a spatiotemporal-dependent manner with tumor ***,we propose a self-amplifying logic-gated gene editing strategy for gene/H_(2)O_(2)-mediated/starvation multimodal cancer *** this approach,a hypoxia-degradable covalent-organic framework(COF) is synthesized to coat a-ZIF-8 in which glucose oxidase(GOx) and CRISPR system are *** intensify intracellular redox dyshomeostasis,DNAzymes which can cleave catalase mRNA are loaded as *** the nano system gets into the tumor,the weakly acidic and hypoxic microenvironment degrades the ZIF-8@COF to activate GOx,which amplifies intracellular H^(+)and hypoxia,accelerating the nanocarrier degradation to guarantee available CRISPR plasmid and GOx release in target *** tandem reactions deplete glucose and oxygen,leading to logic-gated-triggered gene editing as well as synergistic gene/H_(2)O_(2)-mediated/starvation ***,this approach highlights the biocomputing-based CRISPR delivery and underscores the great potential of precise cancer therapy.

关键词： CRISPRdelivery Enzymeencapsulation Logic gate Hybridmaterial Hypoxia Gene editing Precise nanomedicine Multimodal therapy

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Clinical effect of acupuncture at ghost points combined with fluoxetine hydrochloride on mild-to-moderate depression

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World Journal of Psychiatry 2024年第6期14卷 848-856页

作者： Yi Wang Qun Lu Ittipalanukul Penpat Juan Wu Dilinuer Abulikemu fei-Cui zeng Jia-Ying Huang Zhi-Hai Hu Department of Acupuncture and Moxibustion Shanghai Hospital of Integrated Traditional Chinese and Western MedicineThe Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200082China Department of Laboratory Medicine Shanghai Hospital of Integrated Traditional Chinese and Western MedicineThe Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200082China Department of Postgraduate Student Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Radiology Shanghai Hospital of Integrated Traditional Chinese and Western MedicineThe Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200082China Department of General Practice Shanghai University of Traditional Chinese Medicine Affiliated Shuguang HospitalShanghai 200120China General Practice of Traditional Chinese Medicine North Bund Street Community Health Service CenterShanghai 200080China General Practice of Traditional Chinese Medicine Shanghai Hongkou District Jiaxing Road Community Health Service CenterShanghai 200082China

BACKGROUND Depression is a common,chronic,and recurrent mood disorder that has become a worldwide health *** hydrochloride,a common treatment method,can inhibit 5-hydroxytryptamine(5-HT)recycling in the presynaptic membrane;however,the efficacy of a single drug is *** present,mildto-moderate depression can be treated with acupuncture of ghost caves,but the clinical curative effect of combined therapy with fluoxetine hydrochloride has not been sufficiently *** To evaluate the clinical effect of acupuncture at ghost points combined with fluoxetine hydrochloride in the treatment of mild-to-moderate *** This retrospective study included 160 patients with mild-to-moderate depression who were admitted to Shanghai Hospital of Integrated Traditional Chinese and Western Medicine,Affiliated to Shanghai University of Traditional Chinese Medicine,between January 2022 and June *** were separated into a single-agent group(fluoxetine hydrochloride treatment,n=80)and a coalition group(fluoxetine hydrochloride treatment combined with acupuncture at ghost points,n=80).Pre-treatment symptoms were recorded,and the clinical curative effect and adverse reactions[Asberg Antidepressant Side Effects Scale(SERS)]were *** before and after treatment[Hamilton Depression Scale(HAMD)-24],neurotransmitter levels[5-HT,norepinephrine(NE),dopamine(DA)],oxidative stress indicators[superoxide dismutase(SOD),malondialdehyde(MDA)],and sleep quality[Pittsburgh Sleep Quality Index(PSQI)]were *** The total efficacy rate was 97.50%in the coalition group and 86.25%in the single-agent group(P<0.05).After 2,4,6,and 8 wk of treatment,the HAMD,self-rating depression scale,and SERS scores of the coalition and single-agent groups decreased compared with pre-treatment,and the decrease was more significant in the coalition group(P<0.05).After 8 wk of treatment,the levels of NE,DA,5-HT,and SOD in the coalition and single-agent group

关键词： Depression Prick Fluoxetine hydrochloride Curative effect Depressive symptoms Oxidative stress index

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Achieving a remarkable low-temperature tensile ductility in a high-strength tungsten alloy

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Tungsten 2024年第1期6卷 150-161页

作者： Xiang Cheng Zhuo-Ming Xie Xue-Feng Xie Long-fei zeng Rui Liu Jun-Feng Yang Xue-Bang Wu Xian-Ping Wang Chang-Song Liu Qiang-Feng Fang Key Laboratory of Materials Physics Institute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China Faculty of Materials Metallurgy and Chemistry Jiangxi University of Science and TechnologyGanzhou 341000China

Hot-swaging yields a high ultimate tensile strength of 712 MPa but a limited tensile ductility with the total elongation of3.6%at a testing temperature of 200℃in a representative W-0.5wt.%ZrC *** this work,the evolution of Vickers microhardness with annealing temperatures is investigated in detail,which contributes to a rough index chart to guide the search for an optimized post-annealing *** the post-annealing around 1300℃,an outstanding tensile ductility at200℃,including a uniform elongation of 14%and a total elongation of~25%,has been achieved without the sacrifice of its *** evolution of dislocations and grain structures with the annealing temperatures accessed through backscattered scanning electron microscope and transmission electron microscope analysis reveals that the improved low-temperature tensile ductility has resulted from the reduction of residual dislocations and dislocation tanglement via the static recovery,which provides more room to accommodate dislocations,and hence stronger strain hardening ability and tensile ductility.

关键词： Tungsten Low-temperature ductility Annealing Dislocations

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Assessment of perianal fistulizing Crohn’s disease activity with endoanal ultrasound: A retrospective cohort study

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2494-2502页

作者： Na Hong Wei-Yong Liu Jin-Long Zhang Kai Qian Jie Liu Xian-Jun Ye fei-Yan zeng Yue Yu Kai-Guang Zhang Cheeloo College of Medicine Shandong UniversityJinan 250012ShandongChina Department of Gastroenterology The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Ultrasound Medicine The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Rehabilitation Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Radiology The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001Anhui ProvinceChina

BACKGROUND Perianal fistulas pose dual challenges to Crohn's disease(CD)*** patient compliance due to the complexity of existing examination methods plagues the treatment and follow-up management of perianal *** To determine the accuracy of endoanal ultrasound(EUS)and shear wave elastography(SWE)for evaluating perianal fistulizing CD(PFCD)*** This was a retrospective cohort study.A total of 67 patients from August 2022 to December 2023 diagnosed with CD were divided into three groups:Non-anal fistula group(n=23),low-activity perianal fistulas[n=19,perianal disease activity index(PDAI)≤4],high-activity perianal fistulas(n=25,PDAI>4)based on the *** patients underwent assessments including EUS+SWE,pelvic magnetic resonance[pelvic magnetic resonance imaging(MRI)],C-reactive protein,fecal calprotectin,CD activity index,*** The percentage of fistulas indicated by pelvic MRI and EUS was consistent at 82%,and there was good consistency in the classification of perianal fistulas(Kappa=0.752,P<0.001).Significant differences were observed in the blood flow Limberg score(χ^(2)=8.903,P<0.05)and shear wave velocity(t=2.467,P<0.05)between group 2 and *** wave velocity showed a strong negative correlation with magnetic resonance novel index for fistula imaging in CD(Magnifi-CD)score(r=-0.676,P<0.001),a weak negative correlation with the PDAI score(r=-0.386,P<0.05),and a weak correlation between the Limberg score and the PDAI score(r=0.368,P<0.05).CONCLUSION EUS combined with SWE offers a superior method for detecting and quantitating the activity of perianal fistulas in CD *** may be the ideal tool to assess PFCD activity objectively for management strategies.

关键词： Endoanal ultrasound Shear wave elastography Perianal fistulizing Crohn’s disease Perianal disease activity index

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猫咬伤致新型布尼亚病毒感染患者的护理

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中华急危重症护理杂志 2024年第2期5卷 147-149页

作者：王灯曾妃浙江中医药大学附属第一医院/浙江省中医院急诊科杭州市310006 浙江大学医学院附属第二医院ICU

总结1例猫咬伤导致新型布尼亚病毒感染的护理体会。护理要点:通过不典型伤口追溯感染源;建立白细胞危象预警机制;中医手法治疗顽固性呕吐;实施闭环感控管理;预防创伤后综合征。患者住院7 d出院,恢复良好。

关键词：布尼亚病毒科感染白细胞减少蜱咬伤中医护理感染控制

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先天性心脏病产妇体外膜肺氧合期间继发纤溶亢进的护理

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中华急危重症护理杂志 2024年第10期5卷 937-940页

作者：鲁玉萍曾妃杭州市浙江大学医学院附属第二医院护理部 310051

总结1例先天性心脏病产妇体外膜肺氧合(extracorporeal membrane oxygenation,ECMO)治疗期间纤溶亢进的护理体会。针对患者疾病进展迅速,无法即刻行手术治疗,采用静脉-动脉ECMO(VA-ECMO)辅助支持治疗,其间患者凝血系统异常活化,继发纤... 详细信息

总结1例先天性心脏病产妇体外膜肺氧合(extracorporeal membrane oxygenation,ECMO)治疗期间纤溶亢进的护理体会。针对患者疾病进展迅速,无法即刻行手术治疗,采用静脉-动脉ECMO(VA-ECMO)辅助支持治疗,其间患者凝血系统异常活化,继发纤溶亢进。护理要点:VA-ECMO纤溶亢进的早期预警;ECMO膜肺快速衔接无缝更换;以目标出入量为导向的容量管理;以产妇为主体的个体化护理,其中ECMO膜肺更换是该案例的难点及重点。经过精心治疗及护理,患者病情趋于稳定,VA-ECMO支持第38天顺利撤除ECMO,入科第41天成功拔除气管插管,入院72 d后病情稳定出院。

关键词：心脏缺损,先天性肺动脉高压体外膜肺氧合作用继发纤溶亢进危重病护理

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基于级联式模糊控制的电氢耦合直流微网能量管理策略研究

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电力系统保护与控制 2024年第18期52卷 87-100页

作者：李建林梁策曾飞袁晓冬国家能源用户侧储能创新研发中心(北方工业大学) 北京100144 国网江苏省电力有限公司电力科学研究院江苏南京211103

针对电氢混合储能系统在平抑直流微网中功率波动时面临的功率分配问题,提出了一种基于级联式模糊控制的电氢耦合直流微网能量管理策略。该策略中一次模糊控制器依据储氢罐储氢状态(stateofhydrogenstorage,SOH)与锂电池荷电状态(state o... 详细信息

针对电氢混合储能系统在平抑直流微网中功率波动时面临的功率分配问题,提出了一种基于级联式模糊控制的电氢耦合直流微网能量管理策略。该策略中一次模糊控制器依据储氢罐储氢状态(stateofhydrogenstorage,SOH)与锂电池荷电状态(state of charge, SOC)求解出一次功率分配因子,对直流微网净功率进行一次分配;二次模糊控制器结合一次功率分配参考值与SOH对一次功率分配因子作出校正。此外,为使氢储能系统中具有非线性工作特性的电流控制型装置(电解槽、燃料电池)能够对能量管理系统作出高效响应,采用插值法将功率分配参考值转换为电流参考值。通过Matlab/Simulink仿真结果证明,所提能量管理策略有效缩小了氢储能系统在非合理区间的功率波动范围并提高了氢储能系统中装置的响应精度与速度。

关键词：直流微网电氢耦合混合储能系统能量管理级联式模糊控制插值法

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1例肝肺联合移植术后患者的延续护理

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中华护理杂志 2024年第12期59卷 1497-1500页

作者：梁江淑渊曾妃顾培培浙江大学医学院附属第二医院护理部杭州市310000

总结1例肝肺联合移植术后患者的延续护理。护理要点:定期复查联合远程指导;动态优化肺康复方案;严格监测他克莫司血药浓度;严格预防并控制感染;规范管理移植后糖尿病;积极干预骨质疏松症;帮助患者自我赋能,实现全方位康复。术后随访2年... 详细信息

总结1例肝肺联合移植术后患者的延续护理。护理要点:定期复查联合远程指导;动态优化肺康复方案;严格监测他克莫司血药浓度;严格预防并控制感染;规范管理移植后糖尿病;积极干预骨质疏松症;帮助患者自我赋能,实现全方位康复。术后随访2年8个月,患者移植肺功能和移植肝功能均正常,生存质量良好。

关键词：肝肺联合移植康复生存质量护理

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