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Epigenetics and transgenerational inheritance in domesticated farm animals

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Journal of Animal Science and Biotechnology 2015年第2期6卷 123-129页

作者： Amanda feeney Eric Nilsson Michael K Skinner Center for Reproductive Biology School of Biological Sciences Washington State University

Epigenetics provides a molecular mechanism of inheritance that is not solely dependent on DNA sequence and that can account for non-Mendelian inheritance patterns. Epigenetic changes underlie many normal developmental processes, and can lead to disease development as well. While epigenetic effects have been studied in well-characterized rodent models, less research has been done using agriculturally important domestic animal species. This review will present the results of current epigenetic research using farm animal models （cattle, pigs, sheep and chickens）. Much of the work has focused on the epigenetic effects that environmental exposures to toxicants, nutrients and infectious agents has on either the exposed animals themselves or on their direct offspring. Only one porcine study examined epigenetic transgenerational effects; namely the effect diet micronutrients fed to male pigs has on liver DNA methylation and muscle mass in grand-offspring （F2 generation）. Healthy viable offspring are very important in the farm and husbandry industry and epigenetic differences can be associated with production traits. Therefore further epigenetic research into domestic animal health and how exposure to toxicants or nutritional changes affects future generations is imperative.

关键词： Environment EDiclenetics Pig. Review Transgenerational

Experimental evidence that cuckoos preferentially parasitize host nests early in their laying cycle

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Avian Research 2022年第3期13卷 328-331页

作者： Longwu Wang Gangbin He Yuhan Zhang Wei Liang William E.feeney School of Life Sciences Guizhou Normal UniversityGuiyang550001China Ministry of Education Key Laboratory for Ecology of Tropical Islands Key Laboratory of Tropical Animal and Plant Ecology of Hainan ProvinceCollege of Life SciencesHainan Normal UniversityHaikou571158China Department of Behavioural Ecology and Evolutionary Genetics Max Planck Institute for OrnithologySeewiesen82319Germany Department of Biosciences Durham UniversityDurhamDH13LEUnited Kingdom

Brood parasites,such as the Common Cuckoo(Cuculus canorus),rely on manipulating hosts from other species to raise their *** should favor individuals that are able to identify and choose host nests that closely match the incubation stage of their own *** intuitive,and supported by the findings of numerous longterm monitoring studies,experimental evidence of this remains *** using video monitoring,we used three experimental groups to explore whether Common Cuckoos preferentially choose host Oriental Reed Warbler(Acrocephalus orientalis)nests that are early in their laying *** found that Common Cuckoos preferentially parasitize nests of the host Oriental Reed Warbler that are earlier in their laying(less *** eggs)or nesting cycle(eggs ***),and videos of our experiments provide direct insights into their decision making *** results provide strong experimental evidence that Common Cuckoos are able to assess nesting stage and strategically choose nests that increase the likelihood of successful parasitism.

关键词： Brood parasitism Common Cuckoo Clutch size Egg laying Oriental Reed Warbler

Neoadjuvant radiotherapy for rectal cancer management

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World Journal of Gastroenterology 2019年第33期25卷 4850-4869页

作者： Gerard feeney Rishabh Sehgal Margaret Sheehan Aisling Hogan Mark Regan Myles Joyce Michael Kerin Department of General/Colorectal Surgery Galway University HospitalGalway H91 YR71Ireland Department of Histopathology Galway University HospitalGalway H91 YR71Ireland

Thirty per cent of all colorectal tumours develop in the *** location of the rectum within the bony pelvis and its proximity to vital structures presents significant therapeutic challenges when considering neoadjuvant options and surgical *** patients with early rectal cancer can be adequately managed by surgery ***,a significant proportion of patients with rectal cancer present with locally advanced disease and will potentially benefit from down staging prior to *** therapy involves a variety of options including radiotherapy,chemotherapy used alone or in *** radiotherapy in rectal cancer has been shown to be effective in reducing tumour burden in advance of curative *** gold standard surgical rectal cancer management aims to achieve surgical removal of the tumour and all draining lymph nodes,within an intact mesorectal package,in order to minimise local *** is critically important that all rectal cancer cases are discussed at a multidisciplinary meeting represented by all relevant ***-operative staging including CT thorax,abdomen,pelvis to assess for distal disease and magnetic resonance imaging to assess local involvement is *** radiology and MDT discussion are integral in identifying patients who require neoadjuvant *** Neoadjuvant radiotherapy is potentially beneficial it may also result in morbidity and thus should be reserved for those patients who are at a high risk of local failure,which includes patients with nodal involvement,extramural venous invasion and threatened circumferential *** aim of this review is to discuss the role of neoadjuvant radiotherapy in the management of rectal cancer.

关键词： Rectal cancer Neoadjuvant therapy Low anterior resection syndrome Stoma Transanal endoscopic microsurgery Trans-anal total mesorectal excision Robotic surgery Watch and wait

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奥尔罕·帕慕克：跨越东西方的桥梁

疯狂英语（初中天地） 2007年第9期 22-24页

作者： Mark feeney Darren

在2006年诺贝尔文学奖公布以前,帕慕克这个名字对于中国读者来说也许还十分陌生。其实此时的他已经是享誉国际的作家,被认为是欧洲当代最杰出的小说家之一。从去年起,这位土耳其文坛巨擘的作品被陆续介绍到中国,并在国内掀起了一股读书... 详细信息

在2006年诺贝尔文学奖公布以前,帕慕克这个名字对于中国读者来说也许还十分陌生。其实此时的他已经是享誉国际的作家,被认为是欧洲当代最杰出的小说家之一。从去年起,这位土耳其文坛巨擘的作品被陆续介绍到中国,并在国内掀起了一股读书热潮,延续至今。以下是帕慕克获诺贝尔奖前的一篇采访记。通过这篇文章,我们不难发现东西方文明给这位作家的人生及其作品留下的不可磨灭的印记。

关键词：帕慕克诺贝尔文学奖

Technology Integration On Cargo Handling Systems

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Technology Integration On Cargo Handling Systems

Liquid biopsy in ovarian cancer:Catching the silent killer before it strikes

作者： Mark DiTroia Daniel feeney Suzanne Kralle Naval Surface Warfare Center Carderock DivisionShip SystemsEngineering Station(Code 9732)Philadelphia.PAUSA

Naval cargo handling systems have traditionally been designed as two independent systems:the hardware itself and theinformation systems that control *** lack of integration often posed *** operator might not discover that alimit switch needed repair until performing the tedious process of routine maintenance,or when the system failed to operate and anextensive troubleshooting procedure *** today’s technology,however,that has all *** switches and *** maintenance devices,and programmable logic controllers are integrated via networks such as DeviceNet and Ethernet toform the new generation of cargo handling *** systems not only reduce workload and manning through more powerfultroubleshooting tools and semi-automation,but they also decrease system downtime and maintenance costs by being able to identifymaintenance concerns before they cause a *** of the integrated networks installed on vertical package conveyors aspart of the Smart Carrier Program will illustrate how new technology and integrated networks are currently being applied to Navalcargo handling systems and how they might be used to further reduce shipboard workload,manning,and maintenance costs in theyears to come.

关键词： integrated networks cargo handling systems programmable logic controller

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World Journal of Clinical Oncology 2020年第11期11卷 868-889,I0002页

作者： Laura feeney Ian JG Harley W Glenn McCluggage Paul B Mullan James P Beirne Patrick G Johnston Centre for Cancer Research Queens UniversityBelfast BT97AEUnited Kingdom Northern Ireland Gynaecological Cancer Centre Belfast Health and Social Care TrustBelfast BT97ABUnited Kingdom Department of Pathology Belfast Health and Social Care TrustBelfast BT126BLUnited Kingdom Trinity St James Cancer Institute St.James’HospitalDublin 8Ireland

Epithelial ovarian cancer(EOC)is the most lethal gynaecological malignancy in the western *** majority of women presenting with the disease are asymptomatic and it has been dubbed the“silent killer”.To date there is no effective minimally invasive method of stratifying those with the disease or screening for the disease in the general *** molecular and pathological discoveries,along with the advancement of scientific technology,means there is a real possibility of having disease-specific liquid biopsies available within the clinical environment in the near *** this review we discuss these discoveries,particularly in relation to the most common and aggressive form of EOC,and their role in making this possibility a reality.

关键词： Epithelial ovarian cancer Molecular profile Liquid biopsy Circulating tumor DNA Biomarker discovery Precision medicine

Avoiding the Will O’ the Wisp: Challenges in Measuring High Levels of Immunization Coverage with Precision

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World Journal of Vaccines 2014年第3期4卷 97-99页

作者： David W. Brown Anthony H. Burton Griffith feeney Marta Gacic-Dobo Scarsdale Solutions New York USA United Nations Children’s Fund New York USA World Health Organization Geneva Switzerland

There have been tremendous improvements in immunization coverage since the Expanded Programme on Immunization was launched. We highlight inherent challenges in measuring immunization coverage with precision as coverage levels increase due to the sensitivity of coverage to the accuracy of target population estimates. In fact, when comparing across groups at high levels of coverage, error in target population estimates can obscure differences in immunization coverage.

关键词： Immunization Vaccination Coverage Population Precision

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真空绝热油管：项目实例及应用

新疆石油科技信息 2000年第3期21卷 67-68页

作者： feeney,S 潘富清天津市华北石油学校机电科

Baseball Sans Borders

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Beijing Review 2006年第7期49卷 46-页

作者： ADAM feeney is an American living in Dalian

If anyone needs a reminder that the word "fan" is merely the short form of "fanatic," they need only observe me watching baseball on the Internet. No, I'm not talking about a webcast with images of the game actually b... 详细信息

关键词： Baseball Sans Borders