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Resource requirements of an edge-based digital twin service:an experimental study

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Virtual Reality & Intelligent Hardware 2022年第6期4卷 506-520页

作者： federico MUNGARI Milan GROSHEV Carla Fabiana CHIASSERINI Department of Electronics and Telecommunications Politecnico di TorinoTurin 10129Italy Departamento de Ingenieria Telematica Universidad Carlos III de MadridMadrid 28911Spain

Digital Twin(DT)is a pivotal application under the industrial digital transformation envisaged by the fourth industrial revolution(Industry 4.0).DT defines intelligent and real-time faithful reflections of physical entities such as industrial robots,thus allowing their remote *** on the latest advances in Information and Communication Technologies(ICT),namely Network Function Virtualization(NFV)and Edge-computing,DT can be deployed as an on-demand service in the factories close proximity and offered leveraging radio access ***,with the purpose of achieving the well-known scalability,flexibility,availability and performance guarantees benefits foreseen by the latest ICT,it is steadily required to experimentally profile and assess DT as a Service(DTaaS)***,the dependencies between the resources claimed by the service and the relative demand and work loads require to be *** this work,an Edge-based Digital Twin solution for remote control of robotic arms is deployed in an experimental testbed where,in compliance with the NFV paradigm,the service has been segmented in virtual network *** research has primarily the objective to evaluate the entanglement among overall service performance and VNFs resource requirements,and the number of robots consuming the service *** profiles show the most critical DT features to be the inverse kinematics and trajectory ***,the same analysis has been carried out as a function of the industrial processes,namely based on the commands imposed on the robots,and particularly of their ion-level,resulting in a novel trade-off between computing and time resources requirements and trajectory *** derived results provide crucial insights for the design of network service scaling and resource orchestration fra-meworks dealing with DTaaS ***,we empirically prove LTE shortage to accommodate the minimum DT latency requirements.

关键词： Digital twin Edge NFV Testbed Performance evaluation

HLA class Ⅰ loss in colorectal cancer:implications for immune escape and immunotherapy

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Cellular & Molecular Immunology 2021年第3期18卷 556-565页

作者： Per Anderson Natalia Aptsiauri Francisco Ruiz-Cabello federico Garrido Instituto de Investigaci6n Biosanitaria(ibs.GRANADA) GranadaSpain Servicio de Analisis Clinicos e Inmunologia Hospital Universitario Virgen de las Nieves18014 GranadaSpain Departamento de Bioqufmica Bioiogta Molecular 3 e InmunologiaUniversidad de GranadaGranadaSpain

T cell-mediated immune therapies have emerged as a promising treatment modality in different malignancies including colorectal cancer(CRC).However,only a fraction of patients currently respond to *** the lack of responses and finding biomarkers with predictive value is of great *** is evidence that CRC is a heterogeneous disease and several classification systems have been proposed that are based on genomic instability,immune cell infiltration,stromal content and molecular subtypes of gene *** leukocyte antigen class Ⅰ(HLA-Ⅰ)plays a pivotal role in presenting processed antigens to T lymphocytes,including tumour *** molecules are frequently lost in different types of cancers,including CRC resulting in tumour immune escape from cytotoxic T lymphocytes during the natural history of cancer *** aim of this review is to(i)summarize the prevalence and molecular mechanisms behind HLA-Ⅰ loss in CRC,(ii)discuss HLA-Ⅰ expression/loss in the context of the newly identified CRC molecular subtypes,(iii)analyze the HLA-Ⅰ phenotypes of CRC metastases disseminated via blood or the lymphatic system,(iv)discuss strategies to recover/circumvent HLA-I expression/loss and finally(v)review the role of HLA class Ⅱ(HLA-Ⅱ)in CRC prognosis.

关键词： Colorectal cancer Immune escape HLA ClassⅠ

Trial eligibility in advanced hepatocellular carcinoma: Does it support clinical practice in underrepresented subgroups?

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World Journal of Gastroenterology 2021年第24期27卷 3429-3439页

作者： federico Piñero Leonardo Gomes da Fonseca Hepatology and Liver Unit Hospital Universitario AustralSchool of MedicineAustral UniversityBuenos Aires B1629HJArgentina Clinical Oncology Insituto do Cancer do Estado de São PauloUniversity of São PauloSão Paulo 05403-000Brazil

Although hepatocellular carcinoma is considered a highly lethal malignancy,recent therapeutic advances have been achieved during the last 10 *** scenario resulted in an unprecedented improvement in survival for patients with advanced hepatocellular carcinoma,almost reaching 20-26 mo of overall survival after first-second line sequential *** advent of the combination of atezolizumab with bevacizumab showed,for the first time,superiority over sorafenib with improvement in overall ***,first and second-line trials were correctly based on the premise that a strict selection of patients enhances the power to capture the positive effect of treatment by excluding competing risks for mortality such as liver failure,decompensated cirrhosis or other underlying medical *** a result,the inclusion criteria used in clinical trials do not support the use of novel therapies in several real-world scenarios involving underrepresented subgroups,such as patients with unpreserved liver function,other comorbid conditions,a history of solid-organ transplantation,autoimmune disorders and those with a high risk of *** present text aims at discussing treatment strategies in these subgroups.

关键词： Eligibility Systemic therapies End-stage Hepatocellular carcinoma

Antimicrobial management of intra-abdominal infections:Literature's guidelines

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World Journal of Gastroenterology 2012年第9期18卷 865-871页

作者： Massimo Sartelli Fausto Catena federico Coccolini Antonio Daniele Pinna Department of General Surgery Macerata Hospital Department of General Emergency and Transplant SurgerySant'Orsola-Malpighi University Hospital

Antimicrobial management of severe intra-abdominal infections (IAIs) involves a delicate balance of optimizing empirical therapy,which has been shown to improve clinical outcomes,while simultaneously reducing unnecessary antimicrobial *** sets of guidelines for the management of intra-abdominal infections were recently *** 2010,the Surgical Infection Society and the Infectious Diseases Society of America (SIS-IDSA) created guidelines for the diagnosis and management of complicated *** new SIS-IDSA guidelines replace those previously published in 2002 and *** World Society of Emergency Surgery (WSES) guidelines represent additional contributions,made by specialists worldwide,to the debate regarding proper antimicrobial drug *** guidelines represent the conclusions of the consensus conference held in Bologna,Italy,in July 2010 during the first congress of the WSES.

关键词： Intra-abdominal infections Antimicrobial the-rapy Literature's guidelines

Prevalence of overweightedness in patients with gastro-esophageal reflux

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World Journal of Gastroenterology 2007年第34期13卷 4602-4605页

作者： Luca Piretta federico Alghisi Fiorella Anzini Enrico Corazziari Dipartimento di Scienze Cliniche Gastroenterologia A Università di Roma "La Sapienza" Viale del Policlinico 155-00161 Roma Italy

AIM: To evaluate whether the prevalence of overweight and obese conditions is increased in gastro-esophageal reflux disease (GERD) patients (with 24-h pathological pH recordings) in comparison to general population. METHODS: A total of 196 consecutive patients (103 females, age range 18-83 years) with symptoms of gastro-esophageal reflux (GER) and 24-h pathological esophageal pH-metry. Body mass index (BMI) of the patients was calculated and its distribution (%) was compared with that of the Italian general population as assessed by National Bureau of Census (ISTAT). To evaluate the association of GERD with weight categories, the binomial test was employed. P < 0.05 was considered statistically significant. RESULTS: In males, overweightedness (BMI 25-25.9) was present in 43% of GERD patients vs 41.8% of Italian population (IP) (ns), obesity (BMI ≥ 30) in 10.9% vs 9.1% (ns). In females overweight was present in 34.9% of GERD patients vs 25.7% of IP (P < 0.01), obesity in 13.6% of GERD patients vs 9.1% of IP (P < 0.01). No statistically significant differences were noted in different age classes. CONCLUSION: In comparison to the Italian general population, the prevalence of overweightedness and obesity is increased in female but not in male patients with ascertained gastro-esophageal reflux disease.

关键词： Gastro-esophageal reflux Obesity Overweight 24-h pH-metry Body mass index

Consumer attitudes towards the mountain product label: Implications for mountain development

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Journal of Mountain Science 2021年第9期18卷 2255-2272页

作者： BASSI Ivana CARZEDDA Matteo GRASSETTI Luca ISEPPI Luca NASSIVERA federico Department of Agricultural FoodEnvironmental and Animal SciencesUniversity of Udinevia delle Scienze 206UdineItaly Department of Economics BusinessMathematics and StatisticsUniversity of Triestevia Tigor 22TriesteItaly Department of Economics and Statistics University of Udinevia Tomadini 30/AUdineItaly

To protect and promote the originality and authenticity of mountain foodstuffs, the European Union set Regulation No 1151/2012 to create the optional quality term "mountain product". Our research aimed at exploring the attractiveness of the mountain product label for consumers, considering both attitude towards the label itself and purchase intentions. We propose a model to investigate relationships between four latent constructs-mountain attractiveness, mountain food attractiveness, attitude towards the mountain product label, and purchase intention-which have been tested, thus confirming the statistical relevance of the relationships. All 47 items selected for describing the latent constructs are suitable for this purpose. Ridge and LASSO results also show that 17 items of the first three constructs are relevant in explaining purchase intentions. Some contextual variables, such as age, income, geographical origin of consumers, and knowledge of mountain products and mountains for tourism purposes, can positively influence consumers’ behavior. These findings could support the design of mountain development strategies, in particular marketing actions for both the product and the territory.

关键词： Mountain product label Consumer attitudes Purchase intentions Structural Equation Model(SEM) LASSO regression

Comparing practice-ready forecast models for weekly and monthly fluctuations of average daily traffic and enhancing accuracy by weighting methods

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Journal of Traffic and Transportation Engineering(English Edition) 2018年第4期5卷 239-253页

作者： Andrea Pompigna federico Rupi Department of Civil Chemical Environmental and Materials Engineering University of Bologna Bologna 40136 Italy R&M Associati Bologna 40134 Italy

Knowing daily traffic for the current year is recognized as being essential in many fields of transport analysis and practice, and short-term forecasting models offer a set of tools to meet these needs. This paper examines and compares the accuracy of three representative parametric and non-parametric prediction models, selected by the analysis of the numerous methods proposed in the literature for their good combi- nation of forecast accuracy and ease of calibration, using real-life data on Italian motorway stretches. Non-parametric K-NN regression model, Gaussian maximum likelihood model and double seasonality Holt-Winters exponential smoothing model confirm their goodness to predict the weekly and monthly fluctuations of average daily traffic with varying degrees of performance, while maintaining an easy use in professional practice, i.e. requiring ordinary professional skills and conventional analysis tools. Since combining several prediction models can give, on average, more accuracy than that of the individual models, the paper compares two weighting methods of easy implementation and susceptible to a direct use, namely the widely used information entropy method and the less widespread Shapley value method. Despite being less common than the information entropy method, the Shapley value method proves to be more capable in better combining single forecasts and produces improvements in the predictions for test data. With these remarks, the paper might be of interest to traffic technicians or analysts, in various and not uncommon tasks they might find in their work.

关键词： Short-term traffic forecasting Non-parametric regression Gaussian maximum likelihood Double seasonal Holt-Winters exponential smoothing Entropy weighting method Shapley value weighting method

Collagen-based biological glue after Appleby operation for advanced gastric cancer

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World Journal of Gastroenterology 2011年第35期17卷 4044-4047页

作者： Gianluca Baiocchi Nazario Portolani federico Gheza Stefano M Giulini Department of Medical and Surgical Sciences Surgical Clinic Brescia University25127 Brescia Italy

Pancreatic fistula is a common complication of distal pancreatectomy; although various surgical procedures have been proposed, no clear advantage is evident for a single technique. We herein report the case of a 38-year-old patient affected by an advanced gastric carcinoma infiltrating the pancreas body, with exten- sive nodal metastases involving the celiac trunk, who underwent total gastrectomy with lymphadenectomy, distal pancreatectomy and resection en bloc of the celiac trunk (Appleby operation). At the end of the demolitive phase, the pancreatic stump and the aorta at the level of the celiac ligature were covered with a layer of Tachosil, a horse collagen sponge made with human coagulation factors (fibrinogen and thrombin). Presenting this case, we wish to highlight the possible sealing effect of this product and hypothesize a role in preventing pancreatic fistula and postoperative lymphorrhagia from extensive nodal dissection.

关键词： Gastric cancer Pancreatic fistula Vascular infiltration Biologic sealant

Significance of ipsilateral breast tumor recurrence after breast conserving treatment: role of surgical removal

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Chinese Journal of Cancer Research 2013年第1期25卷 22-31页

作者： Romano Demicheli Ilaria Ardoino federico Ambrogi Roberto Agresti Elia Biganzoli Scientific Directorate IRCCS National Cancer Institute Medical Statistics and Biometry University of Milan Breast Surgery IRCCS National Cancer Institute Medical Statistics and Biometry IRCCS National Cancer Institute

Objective： To analyze the pattern over time （dynamics） of further recurrence and death after ipsilateral breast tumor recurrence （IBTR） in breast cancer patients undergoing breast conserving treatment （BCT）. Methods： A total of 338 evaluable patients experiencing IBTR were extracted from a database of 3,293 patients undergoing BCT. The hazard rates for recurrence and mortality throughout 10 years of follow-up after IBTR were assessed and were compared to the analogous estimates associated to the primary treatment. Results： In a time frame with the time origin at the surgical treatment for IBTR, the hazard rate for further recurrence displays a bimodal pattern （peaks at the second and at the sixth year）. Patients receiving mastectomy for IBTR reveal recurrence and mortality dynamics similar to that of node positive （N＋） patients receiving mastectomy as primary surgery, apart from the first two-three years, when IBTR patients do worse. If the patients with time to IBTR longer than 2.5 years are considered, differences disappear. Conclusions： The recurrence and mortality dynamics following IBTR surgical removal is similar to the corresponding dynamics following primary tumor removal. In particular, patients with time to IBTR in excess of 2.5 years behave like N＋ patients following primary tumor removal. Findings may be suitably explained by assuming that the surgical manoeuvre required by IBTR treatment is able to activate a sudden growing phase for tumor foci most of which, as suggested by the systemic model of breast cancer, would have reached the clinical level according to their own dynamics.

关键词： Breast cancer IBTR recurrence dynamics effects of surgery conservative surgery tumor homeostasis