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极简LED台灯

设计 2013年第4期26卷 20-20页

作者： Jacob federico Floriani

这是一款造型简洁又功能齐备的灯具，设计师将两条金属腿和一根圆柱形橡木“灯罩”相结合，构成一款极简LED台灯。发光管装在木制灯罩里，既可以拿在手上当手电筒一样使用，也可以由金属腿支撑在桌面上做台灯，并能自由调节光的朝向。... 详细信息

这是一款造型简洁又功能齐备的灯具，设计师将两条金属腿和一根圆柱形橡木“灯罩”相结合，构成一款极简LED台灯。发光管装在木制灯罩里，既可以拿在手上当手电筒一样使用，也可以由金属腿支撑在桌面上做台灯，并能自由调节光的朝向。由于它的部件只有三样，拆分组合也很便利，也便于在台灯不使用时的收藏。设计师之所以将其命名为“123灯”，也因为只需要三个步骤，就可以轻松完成组装。根据用户的发挥，或许还能探索出其他用法。

关键词： LED Light 设计师圆柱形台灯发光管手电筒灯具

Interferon-free treatments in patients with hepatitis C genotype 1-4 infections in a real-world setting

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2017年第2期8卷 137-146页

作者： Huascar Ramos Pedro Linares Ester Badia Isabel Martín Judith Gómez Carolina Almohalla Francisco Jorquera Sara Calvo Isidro García Pilar Conde Begona álvarez Guillermo Karpman Sara Lorenzo Visitación Gozalo Mónica Vásquez Diana Joao Marina de Benito Lourdes Ruiz Felipe Jiménez federico Sáez-Royuela 无 Department of Gastroenterology and Hepatology Hospital Universitario de Burgos Department of Gastroenterology and Hepatology Complejo Asistencial Universitario de León Department of Gastroenterology and Hepatology Hospital Universitario de Salamanca Department of Hepatology Hospital Universitario Rio Hortega CIBERehd IBIOMED Fundación Burgos por la Investigación de la Salud Hospital Universitario de Burgos Department of Gastroenterology and Hepatology Complejo Asistencial de Palencia Department of Gastroenterology and Hepatology Complejo Asistencial de Zamora Department of Gastroenterology and Hepatology Hospital El Bierzo Department of Gastroenterology and Hepatology Hospital Clínico Universitario de Valladolid Department of Gastroenterology and Hepatology Hospital Santos Reyes Asociación Castellano y Leonesa de Hepatología(ACyLHE)

AIM To investigated the real-world effectiveness and safety of various regimens of interferon-free treatments in patients infected with hepatitis C virus(HCV).METHODS We performed an observational study to analyze different antiviral treatments administered to 462 HCV-infected patients, of which 56.7% had liver cirrhosis. HCV RNA after 4 wk of treatment and at 12 wk after treatment sustained virologic response(SVR) as well as serious adverse events(SAEs) was analyzed first for the whole cohort and then separately in patients who met or did not meet the inclusion criteria of a clinical trial(CT-met and CT-unmet, respectively).RESULTS The most frequently prescribed treatment was simeprevir/sofosbuvir(36.4%), followed by sofosbuvir/ledipasvir(24.9%) and ombitasvir/paritaprevir/ritonavir(r)/dasabuvir(19.9%). Ribavirin(RBV) was administered in 198 patients(42.9%). SVRs occurred in 437/462 patients(94.6%). The SVRs ranged between 93.3% and 100% for genotypes 1-4. SVRs were achieved in 96.2% patients in the CTmet group vs 91.9% patients in the CT-unmet group(P = 0.049). Undetectable HCV RNA at week 4 occurred in 72.9% of the patients. In the univariate analysis, the factors associated with SVRs were lower liver stiffness, absence of cirrhosis, higher platelet count, higher albumin levels, no RBV dose reduction, undetectable HCV RNA at week 4 and CT-met group. In the multivariate analysis, only albumin was an independent predictor of treatment failure(P = 0.04). Eleven patients(2.4%) developed SAEs; 5.2% and 0.7% of the patients in the CT-unmet and CT-met groups, respectively(P = 0.003).CONCLUSION A high proportion of patients with HCV infection achieved SVRs. For patients who did not meet the CT criteria, treatment regimens must be optimized.

关键词： Hepatitis C virus infection Genotype 1-4 Real world treatment Direct-acting antiviral agents

Myocarditis in athlete and myocardial bridge:An innocent bystander?

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World Journal of Cardiology 2015年第5期7卷 293-298页

作者： federico Quaranta Emanuele Guerra Fabio Sperandii Francesco De Santis Fabio Pigozzi Leonardo Calò Paolo Borrione Department of Movement Human and Health ScienceUniversity of Rome "Foro Italico" Department of Cardiology Policlinico CasilinoASL Rome B00169 RomeItaly

Myocarditis is a bacterial or viral inflammatory disease,often unnoticed or *** with myocarditis must stop practicing their activity since International medical Literature described some cases of sudden *** the present report,we describe a case of an asymptomatic,apparently healthy,competitive athletes,who was diagnosed a myocarditis and as incidental finding a myocardial *** focused the attention on the importance of anamnesis,electrocardiogram and athletes' entourage for the diagnosis of such insidious pathologies and we evaluated the follow up,focusing the attention on electrocardiogram changes as well as on restitution ad integrum and prognosis,especially for the athletes.

关键词： Myocarditis Sudden cardiac death Preparticipation screening

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看SOHO一族——如何“居家办公二合一”

现代装饰（家居） 2015年第4期 122-129页

作者： Coedition Arco Mimalism Woodieful federico Peri Davide Anzalone Patricia Urquiola A+A COOERN Marco Zanuso Jr Patrick Jouin Victoria Wilmotte Alain Moatti 陈志芳范嘉苑

如果向往自由、开放、弹性的生活方式,同时又拥有充足的资源、本金和能力,那么面对＂A.在家办公、加入SOHO一族,B.打卡上班、成为工薪阶层＂的人生选项时,你会弃A而取B吗？除了谨小慎微的＂保守派＂,大概无人会拒绝＂不受束缚、自主发... 详细信息

如果向往自由、开放、弹性的生活方式,同时又拥有充足的资源、本金和能力,那么面对＂A.在家办公、加入SOHO一族,B.打卡上班、成为工薪阶层＂的人生选项时,你会弃A而取B吗？除了谨小慎微的＂保守派＂,大概无人会拒绝＂不受束缚、自主发展＂的巨大诱惑。尽管不乏前辈谆谆告诫：SOHO＂看上去很美＂、实际上＂如鱼饮水,冷暖自知＂,需＂三思而后行＂,但仍挡不住后辈们＂长江后浪推前浪＂的＂赤诚之心＂。在北上广深等一线城市,越来越多的年轻人都跳入了＂苏豪＂的族群,并细细品尝其中的五味杂陈。

关键词： SOHO 居家办公二合一生活方式工薪阶层自主发展年轻人冷暖

Continuous and comprehensive atmospheric observations in Beijing:a station to understand the complex urban atmospheric environment

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Big Earth Data 2020年第3期4卷 295-321页

作者： Yongchun Liu Chao Yan Zemin Feng Feixue Zheng Xiaolong Fan Yusheng Zhang Chang Li Ying Zhou Zhuohui Lin Yishou Guo Ying Zhang Li Ma Wenshuo Zhou Zhikun Liu Lubna Dada Kaspar Dallenbach Jenni Kontkanen Runlong Cai Tommy Chan Biwu Chu Wei Du Lei Yao Yonghong Wang Jing Cai Juha Kangasluoma Tom Kokkonen Joni Kujansuu Anton Rusanen Chenjuan Deng Yueyun Fu Rujing Yin Xiaoxiao Li Yiqun Lu Yiliang Liu Chaofan Lian Dongsen Yang Weigang Wang Maofa Ge Yuesi Wang Douglas R.Worsnop Heikki Junninen Hong He Veli-Matti Kerminen Jun Zheng Lin Wang Jingkun Jiang Tuukka Petaja federico Bianchi Markku Kulmala Aerosol and Haze Laboratory Beijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijingChina Institute for Atmospheric and Earth System Research/Physics Faculty of ScienceUniversity of HelsinkiHelsinkiFinland State Key Joint Laboratory of Environment Simulation and Pollution Control State Environmental Protection Key Laboratory of Sources and Control of Air Pollution ComplexSchool of EnvironmentTsinghua UniversityBeijingChina State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijingChina Department of Environmental Science&Engineering Fudan UniversityShanghaiChina State Key Laboratory for Structural Chemistry of Unstable and Stable Species Beijing National Laboratory for Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijingChina Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Nanjing University of Information Science&TechnologyNanjingChina State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina Aerodyne Research Inc. BillericaMassachusettsUSA Institute of Physics University of TartuTartuEstonia Joint International Research Laboratory of Atmospheric and Earth System Sciences School of Atmospheric SciencesNanjing UniversityNanjingChina

Due to profound impact on climate and human health,air quality has attracted attention from all levels of the civil *** key step in the provision of required tools for the society to tackle the complex air quality problem is to characterize it in a comprehensive manner with a long-term ***,we describe a continuous and comprehensive observation station and its accompanying state-ofthe-art instrumentation that was established to investigate the complex urban atmospheric environment in a rapidly developing Chinese *** station,located in downtown Beijing,aims to study air quality by identifying the major atmospheric pollutants and key processes determining their formation and loss mechanisms.A few hundreds of parameters are continuously measured with the state-of-the-art instruments,including trace gas concentrations,aerosol particle size distributions,and mass concentrations,covering aerosol particle chemical composition from molecules to micrometer-sized aerosol *** produced long-term,comprehensive big data with around 1�10^(11)bytes per *** this paper,we provide an overview on the facilities of the station,the instrumentation used,the workflow of continuous observations and examples of results from 2018 to 2019 and a basis for establishing a modern long-term,comprehensive atmospheric urban observation station in other megacities.

关键词： Continuous and comprehensive atmospheric observation air pollution complex photochemical smog haze new particle formation

Pedigree analysis of 220 almond genotypes reveals two world mainstream breeding lines based on only three different cultivars

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Horticulture Research 2021年第1期8卷 72-82页

作者： Felipe Perez de los Cobos Pedro J.Martinez-Garcia Agusti Romero Xavier Miarnau Iban Eduardo Werner Howad Mourad Mnejja federico Dicenta Rafel Socias i Company Maria J.Rubio-Cabetas Thomas M.Gradziel Michelle Wirthensohn Henri Duval Doron Holland Pere Arus Francisco J.Vargas Ignasi Batlle Institut de Recerca i Tecnologia Agroalimentaries(IRTA) Mas BoveCtra.Reus-El Morell Km 3843120 ConstantiTarragonaSpain Institut de Recerca i Tecnologia Agroalimentaries(IRTA) Centre de Recerca en Agrigenomica(CRAG)CSIC-IRTA-UAB-UB.Cerdanyola del Valles(Bellaterra)08193 BarcelonaSpain Centro de Edafologia y Biologia Aplicada del Segura Consejo Superior de Investigaciones Cientificas(CEBAS-CSIC)P.O.Box 16430100 EspinardoMurciaSpain Institut de Recerca i Tecnologia Agroalimentaries(IRTA) FruitcentrePCiTALGardeny ParkFruitcentre Building25003 LleidaSpain Centro de Investigacion y Tecnologia Agroalimentaria de Aragon(CITA) Avda.Montanana 93050059ZaragozaInstituto Agroalimentario de Aragon IA2(CITA-Universidad de Zaragoza)ZaragozaSpain University of California 1 Shields AvenueDavisCA 95616USA University of Adelaide Waite ResearchSchool of AgricultureFood and WinePMB 1Glen OsmondAdelaideSA 5064Australia Institut National de la Recherche Agronomique(INRA) Domain St.Maurice CS 6009484143 Montfavet CedexFrance Agricultural Research Organization Newe-Ya’ar Research CenterP.O.Box 1021Ramat Yishad 30095Israel

Loss of genetic variability is an increasing challenge in tree breeding programs due to the repeated use of a reduced number of founder ***,in almond,little is known about the genetic variability in current breeding stocks,although several cases of inbreeding depression have been *** gain insights into the genetic structure in modern breeding programs worldwide,marker-verified pedigree data of 220 almond cultivars and breeding selections were *** coefficients,pairwise relatedness,and genetic contribution were calculated for these *** results reveal two mainstream breeding lines based on three cultivars:“Tuono”,“Cristomorto”,and“Nonpareil”.Descendants from“Tuono”or“Cristomorto”number 76(sharing 34 descendants),while“Nonpareil”has 71 *** mean inbreeding coefficient of the analyzed genotypes was 0.041,with 14 genotypes presenting a high inbreeding coefficient,over *** programs from France,the USA,and Spain showed inbreeding coefficients of 0.075,0.070,and 0.037,*** to their genetic contribution,modern cultivars from Israel,France,the USA,Spain,and Australia trace back to a maximum of six main founding *** the group of 65 genotypes carrying the S f allele for self-compatibility,the mean relatedness coefficient was 0.125,with“Tuono”as the main founding genotype(24.7%of total genetic contribution).The results broaden our understanding about the tendencies followed in almond breeding over the last 50 years and will have a large impact into breeding decision-making process *** current genetic variability is required in almond breeding programs to assure genetic gain and continuing breeding progress.

关键词： breeding cultivar founding

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M89酒店意大利米兰

世界建筑导报 2018年第5期33卷 80-83页

作者： luca lazzerotti mauro mandelli silvia calzetti alessandro leanti andrea sforzin carlos noriega daniel gonzalez santiago trujillo erica mensi federico simonetti gianluca iannotta niccolò genesio andrea martiradonna(摄) piuarch

M89酒店对面，是Caproni工厂规则排布的厂房，有着别样的棚屋顶，散发着工业考古学般的魅力。新建的M89四星级酒店，位于via Mecenate大街89号。酒店正对着百年前一大型飞机制造厂厂房，经过Piuarch精心改造和扩建，厂房现在已成为古驰... 详细信息

M89酒店对面，是Caproni工厂规则排布的厂房，有着别样的棚屋顶，散发着工业考古学般的魅力。新建的M89四星级酒店，位于via Mecenate大街89号。酒店正对着百年前一大型飞机制造厂厂房，经过Piuarch精心改造和扩建，厂房现在已成为古驰新总部大楼。

关键词：四星级酒店意大利米兰飞机制造厂厂房考古学 via 屋顶

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淡妆浓抹的惬意

现代装饰（家居） 2015年第11期 68-73页

作者： Eszter Imre Daria Pavlova MOAK Team & Emma Van Eijkeren Nicola Bonriposi Silvia Cenal Lesha Galkin Niki Koncz Kairi Eguchi & Enya Hou Daniel Debiasi & federico Sandri 李薇范嘉苑 D2 Studio Diario Studio

一直喜欢四季的变换与交替,因为特点分明的四季带会来各不相同的风景,为生活增添几分乐趣,不论是银装素裹、分外妖娆的冬天,还是五彩缤纷、千娇百态的春天,或淡妆或浓抹,或素净雅致或香浓艳丽,都是相宜美妙的,让人倍感欢喜。＂淡妆＂与... 详细信息

一直喜欢四季的变换与交替,因为特点分明的四季带会来各不相同的风景,为生活增添几分乐趣,不论是银装素裹、分外妖娆的冬天,还是五彩缤纷、千娇百态的春天,或淡妆或浓抹,或素净雅致或香浓艳丽,都是相宜美妙的,让人倍感欢喜。＂淡妆＂与＂浓抹＂都是一种美,只是美的格调不同。

关键词：千娇百态身体感清透天然木材设计原型设计灵感玻璃管整体外形简约设计木偶奇遇记

Role of molecular imaging in the management of patients affected by inflammatory bowel disease:State-of-the-art

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World Journal of Radiology 2016年第10期8卷 829-845页

作者： federico Caobelli Laura Evangelista Natale Quartuccio Demetrio Familiari Corinna Altini Angelo Castello Mariapaola Cucinotta Rossella Di Dato Cristina Ferrari Aurora Kokomani Iashar Laghai Riccardo Laudicella Silvia Migliari Federica Orsini Salvatore Antonio Pignata Cristina Popescu Erinda Puta Martina Ricci Silvia Seghezzi Alessandro Sindoni Martina Sollini Letterio Sturiale Anna Svyridenka Vittoria Vergura Pierpaolo Alongi Department of Nuclear Medicine Universitatsspital Basel Department of Nuclear Medicine Istituto Oncologico Veneto Wolfson Molecular Imaging Centre Univer-sity of Manchester Department of Nuclear Medicine A.R.N.A.S. Nuclear Medicine Unit Univer-sity"Aldo Moro"of Bari Department of Nuclear Medicine University of Florence Department of medical-surgical science and translational medicine "La Sapienza"University Nuclear Medicine Unit Department of Biomedical Sciences and Morphological and Functional ImagesUniversity of Messina Department of Nuclear Medicine University of Parma Department of Nuclear Medicine University Hospital"Maggiore della Carita di Novara" Department of Nuclear Medicine Niguarda Ca'Grande Hospital Department of Nuclear Medicine Hospital of Treviglio Humanitas University Department of Nuclear Medicine University of Bologna Nuclear Medicine Unit Department of Radio-logical SciencesG.Giglio Institute

AIM To present the current state-of-the art of molecular imaging in the management of patients affected by inflammatory bowel disease(IBD).METHODS A systematic review of the literature was performed in order to find important original articles on the role of molecular imaging in the management of patients affected by IBD. The search was updated until February 2016 and limited to articles in *** Fifty-five original articles were included in this review, highlighting the role of single photon emission tomography and positron emission tomography. CONCLUSION To date, molecular imaging represents a useful tool to detect active disease in IBD. However, the available data need to be validated in prospective multicenter studies on larger patient samples.

关键词： White blood cell scintigraphy Inflammatory bowel disease Inflammation ^(18)F-Fluorodehoxiglucose positron emission tomography/computed tomography Molecular imaging