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Perioperative thromboprophylaxis in liver transplant patients

World Journal of Gastroenterology 2018年第27期24卷 2931-2948页

作者： Lesley De Pietri Roberto Montalti Daniele Nicolini Roberto Ivan Troisi federico moccheggiani Marco Vivarelli Division of Anaesthesiology and Intensive Care Unit Department of General SurgeryAUSL Reggio Emilia-IRCCSReggio Emilia 42123Italy Hepatobiliary and Abdominal Transplantation Surgery Department of Experimental and Clinical MedicinePolytechnic University of MarcheAncona 60126Italy Department of General Hepatobiliary and Liver Transplantation SurgeryGhent University Hospital Medical SchoolGhent 185 3K3 9000Belgium

Improvements in surgical and anesthetic procedures have increased patient survival after liver transplantation(LT). However, the perioperative period of LT can still be affected by several complications. Among these, thromboembolic complications(intracardiac thrombosis, pulmonary embolism, hepatic artery and portal vein thrombosis) are relatively common causes of increased morbidity and mortality. The benefit of thromboprophylaxis in general surgical patients has already been established, but it is not the standard of care in LT recipients. LT is associated with a high bleeding risk, as it is performed in a setting of already unstable hemostasis. For this reason, the role of routine perioperative prophylactic anticoagulation is usually restricted. However, recent data have shown that the bleeding tendency of cirrhotic patients is not an expression of an acquired bleeding disorder but rather of coexisting factors(portal hypertension, hypervolemia and infections). Furthermore, in cirrhotic patients, the new paradigm of ‘‘rebalanced hemostasis' ' can easily tip towards hypercoagulability because of the recently described enhanced thrombin generation, procoagulant changes in fibrin structure and platelet hyperreactivity. This new coagulation balance, along with improvements in surgical techniques and critical support, has led to a dramatic reduction in transfusion requirements, and the intraoperative thromboembolic-favoring factors(venous stasis, vessels clamping, surgical injury) have increased the awareness of thrombotic complications and led clinicians to reconsider the limited use of anticoagulants or antiplatelets in the postoperative period of LT.

关键词： Anticoagulation Liver transplantation Antiplatelets Thrombosis Coagulation Heparin Thromboelastography Thromboprophylaxis Hepatic artery thrombosis Portal vein thrombosis

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Algebro-geometrical orientifold and IR dualities

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Communications in Theoretical Physics 2023年第12期75卷 44-56页

作者： federico Manzoni Mathematics and Physics Department Roma TreVia della Vasca Navale 84RomeItaly INFN Roma Tre section Physics DepartmentVia della Vasca Navale 84RomeItaly

Orientifold projections are an important ingredient in the geometrical engineering of Quantum Field ***,an orientifold can break down the superconformal symmetry and no new superconformal fixed points are admitted(scenario Ⅱ);nevertheless,in some cases,dubbed scenarios Ⅰ and Ⅲ orientifold,a new IR fixed point is achieved and,for scenario Ⅲ examples,some still not fully understood IR duality seems to *** we give an algebro-geometrical point of view of orientifold for toric varieties and we propose the existence of relevant operators that deform the starting oriented Conformal Field Theory triggering a *** briefly discuss a possible holographic description of this flow.

关键词： non-perturbative orientifold IR dualities toric geometry RG flow

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γγ interactions with KLOE

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Chinese Physics C 2010年第6期34卷 795-800页

作者： federico Nguyen INFN Sezione 'Roma TRE'

Studies of γγ interactions are performed with the KLOE detector, without tagging of the outgoing e^＋e^-. The data sample is from an integrated luminosity of 240 pb^-1. It was collected at the φ-factory DAONE with e^＋e^- beams colliding at √s ≌1 GeV, below the φ resonance peak. We present preliminary results concerning the observation of the γγ→η process and the evidence for γγ→π^0π^0 production at low π^0π^0 invariant masses.

关键词： e^+e^- collisions pseudoscalar meson width π pair production

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Colored bicycle lanes and intersection treatments:International overview and best practices

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第3期8卷 399-420页

作者： federico Autelitano Felice Giuliani Department of Engineering and Architecture University of ParmaParma 43124Italy

The use of colored pavements for bicycle facilities represents an interesting strategy for supporting the implementation of a high-quality cycling network. The distinctive coloration of dedicated lanes, tracks or shared paths provides a clearly delineated route, making the infrastructure more attractive as well as legible and intuitive, especially through intersections and junctions. The additional emphasis resulting from the coloring enhances a change in the road users' behavior, but its safety effectiveness seems to be particularly related to several site-specific contextual features. Although some of these benefits are well established and multiple applications of colored pavements are widespread around the world, most of cycling design standards and guides, which are usually written only in the language of the country that drafted them and are often difficult to find, completely lack in technical recommendations and concepts regarding the use of color for cycling ***, based on an extensive worldwide literature search from more than 80 official design guidelines, manuals and standards and 50 scientific articles, the authors have structured a guided overview of the state of the art/practice concerning the use of color for bike facilities at the international level, including the latest innovative and experimental schemes. The review is not intended to be a summary of manuals, but is conceived as a decision-makers' and designers' tool for a rational planning, construction, maintenance and management of colored cycling infrastructures, able to favor a cultural and technical interchange. After a first section in which the main locations where to use colored surfaces were highlighted(corridor or spot treatments), the commonly used colors(red, green and blue) have been identified, explaining the hierarchical and/or combined reasons(regulatory and legal limitations, visual-perceptual aspects and application/maintenance requirements) behind this choice. Final

关键词： Road engineering Colored pavement Bike facility Cycling infrastructure Conflict point Safety

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Ion channels in neurodevelopment:lessons from the Integrin-KCNB1 channel complex

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Neural Regeneration Research 2023年第11期18卷 2365-2369页

作者： Alessandro Bortolami federico Sesti Department of Neuroscience and Cell Biology Robert Wood Johnson Medical SchoolRutgers UniversityWest PiscatawayNJUSA

Ion channels modulate cellular excitability by regulating ionic fluxes across biological *** mutations in ion channel genes give rise to epileptic disorders that are among the most frequent neurological diseases affecting millions of individuals *** are trigge red by an imbalance between excitatory and inhibitory ***,pathogenic mutations in the same allele can give rise to loss-of-function and/or gain-of-function va riants,all able to trigger ***,certain alleles are associated with brain malformations even in the absence of a clear electrical *** body of evidence argues that the underlying epileptogenic mechanisms of ion channels are more diverse than originally *** focusing on ion channels in prenatal cortical development have shed light on this apparent *** picture that emerges is that ion channels play crucial roles in landmark neurodevelopmental processes,including neuronal migration,neurite outgrowth,and synapse ***,pathogenic channel mutants can not only cause epileptic disorders by alte ring excitability,but further,by inducing morphological and synaptic abnormalities that are initiated during neocortex formation and may persist into the adult brain.

关键词： developmental and epileptic encephalopathies epilepsy K+channel KCNB1 Kv2.1 neurodevelopment potassium channel

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Temperature-and vacancy-concentration-dependence of heat transport in Li_(3)ClO from multi-method numerical simulations

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npj Computational Materials 2022年第1期8卷 197-205页

作者： Paolo Pegolo Stefano Baroni federico Grasselli SISSA—Scuola Internazionale Superiore di Studi Avanzati 34136TriesteItaly CNR-Istituto Officina dei Materiali SISSA34136TriesteItaly COSMO—Laboratory of Computational Science and Modelling IMXÉcole Polytechnique Fédérale de Lausanne1015LausanneSwitzerland

Despite governing heat management in any realistic device,the microscopic mechanisms of heat transport in all-solid-state electrolytes are poorly known:existing calculations,all based on simplistic semi-empirical models,are unreliable for superionic conductors and largely overestimate their thermal *** this work,we deploy a combination of state-of-the-art methods to calculate the thermal conductivity of a prototypical Li-ion conductor,the Li_(3)ClO *** leveraging ab initio,machine learning,and force-field descriptions of interatomic forces,we are able to reveal the massive role of anharmonic interactions and diffusive defects on the thermal conductivity and its temperature dependence,and to eventually embed their effects into a simple rationale which is likely applicable to a wide class of ionic conductors.

关键词： transport conductivity eventually

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Tuning of frictional properties in torsional contact by means of disk grading

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Friction 2022年第5期10卷 787-802页

作者： Gianluca COSTAGLIOLA federico BOSIA Nicola M PUGNO Civil Engineering Institute Ecole Polytechmique Federale de LausamneLausanne 1015Switzerland Department ofApplied Science and Technology Politecnico di TorinoCorso Duca degli Abruzzi 24Torino 10129Italy Laboratory for BioinspiredBionicNanoMeta Materials&MechanicsDepartment of CivilEnvironmental and Mechanical EngineeringUniversity of TrentoTrento 38123Italy School of Engineering and Materials Science Queen Mary University of LondonLondon EI 4NSUK

The contact of two surfaces in relative rotating motion occurs in many practical applications,from mechanical devices to human joints,displaying an intriguing interplay of effects at the onset of sliding due to the axisymmetric stress *** and numerical models have been developed for some typical configurations,but work remains to be done to understand how to modify the emergent friction properties in this *** this paper,we extend the two-dimensional(2D)spring-block model to investigate friction between surfaces in torsional *** investigate how the model describes the behavior of an elastic surface slowly rotating over a rigid substrate,comparing results with analytical calculations based on energy *** show that an appropriate grading of the tribological properties of the surface can be used to avoid a non-uniform transition to sliding due to the axisymmetric configuration.

关键词： friction torsion numerical simulations grading

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Forecasting Zonda Wind Occurrence with Vertical Sounding Data

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Advances in Atmospheric Sciences 2022年第1期39卷 161-177页

作者： federico OTERO Diego C.ARANEO Instituto Argentino de Nivología Glaciología y Ciencias Ambientales(IANIGLA)CCT Mendoza-CONICET Av.Ruiz Leal s/n.Parque Gral.San MartínMendoza 5500Argentina

Zonda wind is a typical downslope windstorm over the eastern slopes of the Central Andes in Argentina,which produces extremely warm and dry conditions and creates substantial socioeconomic *** aim of this work is to obtain an index for predicting the probability of Zonda wind *** Principal Component Analysis(PCA)is applied to the vertical sounding data on both sides of the *** the use of a binary logistic regression,the PCA is applied to discriminate those soundings associated with Zonda wind events from those that are not,and a probabilistic forecasting tool for Zonda occurrence is *** index is able to discriminate between Zonda and non-Zonda events with an effectiveness close to 91%.The best model consists of four variables from each side of the *** an eventbased statistical perspective,the probability of detection of the mixed model is above 97%with a probability of false detection lower than 7%and a missing ratio below 1%.From an alarm-based perspective,models exhibit false alarm rate below 7%,a missing alarm ratio lower than 1.5%and higher than 93%for the correct alarm *** zonal component of the wind on both sides of the Andes and the windward temperature are the key variables in class *** vertical structure of Zonda wind includes two wind maximums and an unstable lapse rate at midlevels on the lee side and a wind maximum at 700 h Pa accompanied by a relatively stable layer near the mountain top.

关键词： Zonda wind foehn downslope windstorm forecasting

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Current situation and future perspectives of European natural gas sector

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Frontiers in Energy 2015年第1期9卷 1-6页

作者： Vincenzo BIANCO federico SCARPA Luca A. TAGLIAFICO Division of Thermal Energy and Environmental Conditioning DIME/TEC University of Genoa Via All'OperaPia 15/A 16145 Genova Italy

Gas market in Europe is experiencing a radical change for different reasons, partially determined and accelerated by economic downturn of the last period. In the past few years, many European countries adopted energy policies largely based on the utilization of natural gas. In fact, a sharp increase of the demand was observed and, at the same time, a lot of infrastructures were developed to assure the necessary supply. In the last few years, due to the economic downturn, natural gas demand decreased, causing a consistent oversupply on the market, which altered the consolidated dynamics of the sector. Under- standing the changes currently under development in the European gas market is of paramount importance in order to design future strategies for the sector; in particular, it is necessary to understand if the present situation will cause a reshaping of the sector.

关键词： natural gas natural gas market oil-linkedcontracts supply infrastructures gas hubs

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CBE Clima Tool:A free and open-source web application for climate analysis tailored to sustainable building design

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Building Simulation 2024年第3期17卷 493-508页

作者： Giovanni Betti federico Tartarini Christine Nguyen Stefano Schiavon Center for the Built Environment University of California BerkeleyBerkeleyUSA Berkeley Education Alliance for Research in Singapore SingaporeSingapore Heat and Health Research Incubator Faculty of Medicine and HealthThe University of SydneyCamperdownAustralia College of Letters and Sciences University of California BerkeleyBerkeleyUSA

Climate-responsive building design holds immense potential for enhancing comfort,energy efficiency,and environmental ***,many social,cultural,and economic obstacles might prevent the wide adoption of designing climate-adapted *** of these obstacles can be removed by enabling practitioners to easily access,visualize and analyze local climate *** CBE Clima Tool(Clima)is a free and open-source web application that offers easy access to publicly available weather files and has been created for building energy simulation and *** provides a series of interactive visualizations of the variables contained in the EnergyPlus Weather Files and several derived ones like the UTCI or the adaptive comfort *** is aimed at students,educators,and practitioners in the architecture and engineering *** its inception,Clima’s user base has exhibited robust growth,attracting over 25,000 unique users annually from across 70 *** tool is poised to revolutionize climate-adaptive building design,transcending geographical boundaries and fostering innovation in the architecture and engineering fields.

关键词： architectural design climate analysis sustainable building design web application building energy simulation open-source software

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