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Silymarin in non alcoholic fatty liver disease

World Journal of Hepatology 2013年第3期5卷 109-113页

作者： Fulvio cacciapuoti Anna Scognamiglio Rossella Palumbo Raffaele Forte federico cacciapuoti Department of Internal Medicine and Geriatrics Second University of Naples

AIM: This study was undertaken to evaluate the hepatic effects of silybum marianum on non alcoholic fatty liver disease (NAFLD). METHODS: In 72 patients affected by NAFLD, main metabolic, hepatic and anti-inflammatory parameters were assayed after 3 mo of a restricted diet and before silymarin treatment (twice a day orally). The brightness of liver echography texture (hepatorenal ratio brightness) was also defined at same time. These evaluations were repeated after 6 mo of treatment. RESULTS: Serum levels of some metabolic and anti-inflammatory data nonsignificantly lowered after 6 mo of silymarin. On the contrary, Steato test, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transpeptidase were significantly (P < 0.001) reduced. Instead, the AST/ALT ratio unchanged. Finally, the hepatorenal brightness ratio, as an index of hepatic steatosis, significantly (P < 0.05) dropped. CONCLUSION: The obtained results indicate that silymarin appears to be effective to reduce the biochemical, inflammatory and ultrasonic indices of hepatic steatosis. Some parameters indicative of early stage of atherosclerosis were also lowered.

关键词： Alanine aminotransferase Aspartate aminotransferase Total cholesterol Gamma-glutamyl transpeptidase Non alcoholic fatty liver disease Silymarin Steato test Hepatorenal ultrasonographic index Fasting glucose level High density lipoprotein and low density lipoprotein cholesterol Homeostatic model assessment insulin resistance test

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Space-Time Decomposition of Kalman Filter

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Numerical Mathematics(Theory,Methods and Applications) 2023年第4期16卷 847-882页

作者： Luisa D’Amore Rosalba cacciapuoti University of Naples federico II NaplesItaly

We present an innovative interpretation of Kalman filter(KF)combining the ideas of Schwarz domain decomposition(DD)and parallel in time(PinT)*** we call it *** contrast to standard DD approaches which are already incorporated in KF and other state estimation models,implementing a straightforward data parallelism inside the loop over time,DD-KF ab-initio partitions the whole model,including filter equations and dynamic model along both space and time directions/*** a consequence,we get local KFs reproducing the original filter at smaller dimensions on local ***,sub problems could be solved in *** order to enforce the matching of local solutions on overlapping regions,and then to achieve the same global solution of KF,local KFs are slightly modified by adding a correction term keeping track of contributions of adjacent subdomains to overlapping *** a correction term balances localization errors along overlapping regions,acting as a regularization constraint on local ***,such a localization excludes remote observations from each analyzed location improving the conditioning of the error covariance *** dynamic model we consider shallow water equations which can be regarded a consistent tool to get a proof of concept of the reliability assessment of DD-KF in monitoring and forecasting of weather systems and ocean currents.

关键词： Data assimilation Kalman filter domain decomposition filter localization model reduction numerical algorithm

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Distal femur complex fractures in elderly patients treated with megaprosthesis:Results in a case series of 11 patients

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World Journal of Orthopedics 2022年第5期13卷 454-464页

作者： Fabio Zanchini Antonio Piscopo Valerio Cipolloni federico Fusini Stefano cacciapuoti Davide Piscopo Charlotte Pripp Luigi Aurelio Nasto Enrico Pola Orthopaedics and Traumatology Division Multidisciplinary Department of Medical-Surgical and Dental SpecialtiesUniversity of Campania"Luigi Vanvitelli"School of MedicineNaples 80138Italy Department of Orthopedics and Traumatology Sacro Cuore di GesùFatebenefratelli HospitalBenevento 82100Italy Spine Division Department of Orthopaedics and TraumatologyA.Gemelli IRCCS University HospitalCatholic University of RomeRome 00168Italy Department of Orthopaedic and Traumatology Regina Montis Regalis HospitalMondovì12084Italy Service de Geriatrie et réaaptation HUG H?pital de Bellerive ChemGenève 1205Switzerland

BACKGROUND Surgical treatment of complex fractures of the distal femur in the elderly is *** and pre-existent osteoarthritis are common comorbidities in the elderly which add to the need for early walking and rapid restoration of function and also pose significant obstacles to achievement of satisfactory results with standard fixation ***,several authors have suggested that primary arthroplasty could be a viable alternative option to standard fixation techniques in selected patients with complex distal femur *** To present our experience with 11 cases of distal femur fractures treated with knee arthroplasty and large femoral resection in a population of patients over the age of *** Data from 11 consecutive patients(10 females,1 male)presenting with acute intra-articular supracondylar or intercondylar distal femur fractures and with pre-existent primary osteoarthritis who were treated with primary knee arthroplasty were *** collected standard demographic data,comorbidities and patient reported outcomes including Visual Analogical Scale(VAS),Oxford Knee Score(OKS)and Barthel’s ***-operative joint range of motion(ROM)and standard radiographic data were also *** At a mean follow-up of 23.2 mo,all of the implants were well-positioned and ***,all the patients were alive and walking either independently or with walking *** was a marked improvement in pain(VAS 4.5 postop vs 1.9 at the last follow-up),OKS score(29.5 postop vs 36.81 at the last follow-up),ROM(96.2°postop vs 102°at the last follow-up)and restoration of pre-injury ambulatory status(average Barthel Index 77.3).The radiographic evaluations showed good restoration of the articular *** deaths and no complications were *** In conclusion,we believe that knee megaprosthesis in the case of complex fractures of the distal femur is a valid surgical *** is particularly true in

关键词： Knee Joint replacement Megaprosthesis Elderly Distal femur fracture

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