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Insights into induction of the immune response by the hepatitis B vaccine

World Journal of Gastroenterology 2022年第31期28卷 4249-4262页

作者： federico alej.ndro di lello Alfredo Pedro Martínez diego Martín Flichman Microbiology Universidad de Buenos Aires.Facultad de Farmacia y Bioquímica.Instituto de Investigaciones en Bacteriología y Virología MolecularBuenos Aires C1113AADArgentina Consejo Nacional de Investigaciones Científicas y Técnicas Buenos Aires C1425FQBArgentina Virology Section Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno“CEMIC”Buenos Aires C1431FWOArgentina Microbiology Universidad de Buenos AiresInstituto de Investigaciones Biomédicas en Retrovirus y Síndrome de Inmunodeficiencia AdquiridaBuenos Aires C1121ABGArgentina

After more than four decades of hepatitis B virus(HBV)vaccine implementation,its safety and efficacy in preventing HBV infection have been proven and several milestones have been *** countries have included HBV immunization schedules in their health policies and progress has been made regarding universalization of the first HBV vaccine dose at *** of these actions have significantly contributed to reducing both the incidence of HBV infection and its related ***,there are still many drawbacks to *** main concerns are the deficient coverage rate of the dose at birth and the large adult population that has not been reached timely by universal ***,the current most widely used second-generation vaccines do not induce protective immunity in 5%to 10%of the population,particularly in people over 40-years-old,obese(body mass index>25 kg/m2),heavy smokers,and patients undergoing dialysis or infection with human immunodeficiency *** developed and approved novel vaccine formulations using more potent adjuvants or multiple antigens have shown better performance,particularly in difficult *** advances re-launch the expectations of achieving the World Health Organization’s objective of completing hepatitis control by 2030.

关键词： Hepatitis B virus Vaccine Immune response Antibodies Neutralizing

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Hepatitis C virus treatment failure:Clinical utility for testing resistance-associated substitutions

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World Journal of Hepatology 2021年第9期13卷 1069-1078页

作者： Ezequiel Ridruejo Matias Javier Pereson diego M Flichman federico alej.ndro di lello Hepatology Section Department of MedicineCentro de Educacion Medica e Investigaciones Clinicas Norberto Quirno“CEMIC”Ciudad Autonoma de Buenos Aires C1425ASUnspecifiedArgentina Facultad de Farmacia y Bioquimica Instituto de Investigaciones en Bacteriologea y Virologea Molecular(IBaViM)Universidad de Buenos AiresCiudad Autonoma de Buenos Aires 1113Argentina Instituto de Investigaciones Biomedicas en Retrovirus y Sindrome de Inmunodeficiencia Adquirida(INBIRS) Universidad de Buenos AiresCiudad Autonoma de Buenos Aires 1113Argentina

The hepatitis C virus has a high mutation capacity that leads to the emergence of resistance-associated substitutions(RAS).However,the consequence of resistance selection during new direct-acting antiviral drug(DAA)treatment is not necessarily the therapeutic *** fact,DAA treatment has shown a high rate(>95%)of sustained virological response even when high baseline RAS prevalence has been *** the context of RAS emergence and high rates of sustained viral response,the clinical relevance of variants harboring RAS is still ***,in order to summarize the data available in international guidelines,we have reviewed the clinical utility of testing RAS in the era of new pangenotypic DAA drugs.

关键词： Hepatitis C virus Treatment failure Resistance direct-acting antiviral

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