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miR-99a-5p modulates doxorubicin resistance via the COX-2/ABCG2 axis in triple-negative breast cancer: from the discovery to in vivo studies

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Cancer Communications 2022年第12期42卷 1412-1416页

作者： Iris Garrido-Cano Anna Adam-Artigues Ana Lameirinhas Juan F.Blandez Vicente Candela-Noguera federico rojo Sandra Zazo Juan Madoz-Gúrpide Ana Lluch Begoña Bermejo Felix Sancenón Juan Miguel Cejalvo Ramón Martínez-Mañez Pilar Eroles Biomedical Research Institute INCLIVA Valencia 46010Spain Bioengineering Biomaterials and Nanomedicine Networking Biomedical Research Centre(CIBER-BBN)Madrid 28029Spain Interuniversity Research Institute for Molecular Recognition and Technological Development(IDM) Polytechnic University of ValenciaUniversity of ValenciaValencia 46010Spain Joint Unit CIPF-UPV of Mechanisms of Diseases and Nanomedicine ValenciaPolytechnic University of ValenciaPrince Felipe Research CenterValencia 46012Spain Joint Research Unit in Nanomedicine and Sensors Polytechnic University of ValenciaMedical Research Institute Hospital La FeValencia 46026Spain Biomedical Research Networking Center in Oncology(CIBERONC) Madrid 28029Spain Department of Pathology Fundación Jiménez Díaz University Hospital Health Research InstituteMadrid 28040Spain Department of Clinical Oncology University Clinical Hospital of ValenciaValencia 46010Spain Department of Medicine University of ValenciaValencia 46010Spain Department of Physiology University of ValenciaValencia 46010Spain

Dear Editor,Breast cancer(BC)is the most commonly diagnosed cancer and the fifth cause of cancer-related death worldwide[1].Despite the advances in BC targeted therapies,cytotoxic chemotherapy is still widely used[2].However,around 20%-30%of BC patients develop metastasis after treatment as a consequence of drug resistance[3].In this context,microRNAs have emerged as potential therapeutic targets to overcome therapy resistance[4].Therefore,we aimed to elucidate the molecular mechanisms underlying resistance to doxorubicin,one of the most effective chemotherapeutic agents used in *** are detailed in Supplementary Materials.

关键词： doxorubicin ABCG2 chemotherapy

Distinct vibrational signatures and complex phase behavior in metallic oxygen

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Matter and Radiation at Extremes 2024年第2期9卷 4-11页

作者： Philip Dalladay-Simpson Bartomeu Monserrat Li Zhang federico Gorelli Center for High Pressure Science Technology Advanced Research 1690 Cailun RoadShanghai 201203China Department of Materials Science and Metallurgy University of Cambridge27 Charles Babbage RoadCambridge CB3 OFSUnited Kingdom Cavendish Laboratory University of CambridgeJ.J.Thomson AvenueCambridge CB3 OHEUnited Kingdom Istituto Nazionale di Ottica Consiglio Nazionale delle Ricerche(CNR-INO)50125 FlorenceItaly Shanghai Advanced Research in Physical Sciences(SHARPS) ShanghaiChina

Evidence for metallization in dense oxygen has been reported for over 30 years[Desgreniers et al.,***.94,1117(1990)]at a now routinely accessible 95 GPa[Shimizu et al.,Nature 393,767(1998)].However,despite the longevity of this result and the technological advances since,the nature of the metallic phase remains poorly constrained[Akahama et al.,***.74,4690(1995);Goncharov et al.,***.B 68,224108(2003);Ma,***.B 76,064101(2007);and Weck et al.,***.102,255503(2009)].In this work,through Raman spectroscopy,we report the distinct vibrational characteristics of metallicζ-O_(2) from 85 to 225 *** comparison with numerical simulations,weﬁnd reasonable agreement with the candidate structure up to about 150 *** higher pressures,the C2/mstructure is found to be unstable and incompatible with experimental *** candidate structures,and Ci,with C2/m C2/conly two molecules in the primitive unit cell,are found to be stable and more compatible with measurements above 175 GPa,indicative of the dissociation of(O_(2))4 ***,we report and discuss a strong hysteresis and metastability with the precursory phaseϵ-O_(2).Theseﬁndings will reinvigorate experimental and theoretical work into the dense oxygen system,which will have importance for oxygen-bearing chemistry,prevalent in the deep Earth,as well as fundamental physics.

关键词： metallic phase vibrational

Navigating the autophagic landscape:Epigenetic modulation in gastrointestinal cancer

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World Journal of Gastroenterology 2024年第31期30卷 3628-3634页

作者： Davide Ramoni federico Carbone Fabrizio Montecucco Department of Internal Medicine University of GenoaGenoa 16132Italy Department of Internal Medicine University of Genoa and IRCSS Policlinico San MartinoGenoa 16132Italy

This editorial comments on the manuscript by Chang et al,focusing on the still elusive interplay between epigenetic regulation and autophagy in gastrointestinal diseases,particularly ***,essential for cellular homeostasis,exhibits diverse functions ranging from cell survival to death,and is particularly implicated in physiological gastrointestinal cell ***,its role in pathological backgrounds remains intricate and *** underscore the dual nature of autophagy in cancer,where its early suppressive effects in early stages are juxtaposed with its later promotion,contributing to *** discrepancy is attributed to the dysregulation of autophagy-related genes and their intricate involvement in cellular *** modifications and regulations of gene expression,including non-coding RNAs(ncRNAs),emerge as critical players in exerting regulatory control over autophagy flux,influencing treatment responses and tumor *** epigenetic mechanisms and improving strategies involving the inhibition or induction of autophagy through pharmacological or genetic means present potential avenues to sensitize tumor cells to ***,nanocarrier-based delivery of ncRNAs offers innovative therapeutic *** the intricate interaction between autophagy and ncRNA regula-tion opens avenues for the development of targeted therapies,thereby improving the prognosis of gastrointestinal malignancies with poor outcomes.

关键词： Epigenetic regulation Autophagy Gastrointestinal cancer Non-coding RNAs Target therapies

Deep diving in the PACIFIC:Practical issues in stage III non-small cell lung cancer to avoid shipwreck

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World Journal of Clinical Oncology 2020年第11期11卷 898-917,I0003页

作者： Xabier Mielgo-Rubio federico rojo Laura Mezquita-Pérez Francesc Casas Amadeo Wals Manel Juan Carlos Aguado Javier Garde-Noguera David Vicente Felipe Couñago Department of Medical Oncology Hospital Universitario Fundación AlcorcónMadrid 28922Spain Department of Pathology IIS-Jiménez Díaz-CIBERONC FoundationMadrid 28040Spain Department of Medical Oncology Hospital ClinicLaboratory of Translational Genomics and Targeted Therapeutics in Solid TumorsIDIBAPSBarcelona 08036Spain Department of Radiation Oncology Hospital ClinicBarcelona 08036Spain Department of Radiation Oncology Hospital Universitario Virgen MacarenaSevilla 41009Spain Department of Immunology Service Hospital ClínicUniversitat de BarcelonaBarcelona 08036Spain Department of Medical Oncology Hospital Universitario Clínico San CarlosMadrid 28040Spain Department of Medical Oncology Hospital Universitario Virgen MacarenaSevilla 49001Spain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridHospital La LuzUniversidad Europea de MadridMadrid 28028Spain

After publication of the PACIFIC trial results,immune checkpoint inhibitor-based immunotherapy was included in the treatment algorithm of locally advanced non-small cell lung cancer(NSCLC).The PACIFIC trial demonstrated that 12 mo of durvalumab consolidation therapy after radical-intent platinum doublet chemotherapy with concomitant radiotherapy improved both progression-free survival and overall survival in patients with unresectable stage III *** is the first treatment in decades to successfully improve survival in this clinical setting,with manageable toxicity and without deterioration in quality of *** integration of durvalumab in the management of locally advanced NSCLC accentuates the need for multidisciplinary,coordinated decision-making among lung cancer specialists,bringing new challenges and controversies as well as important changes in clinical work *** aim of the present article is to review—from a practical,multidisciplinary perspective—the findings and implications of the PACIFIC *** evaluate the immunobiological basis of durvalumab as well as practical aspects related to programmed cell death ligand 1 *** addition,we comprehensively assess the efficacy and toxicity data from the PACIFIC trial and discuss the controversies and practical aspects of incorporating durvalumab into routine clinical ***,we discuss unresolved questions and future *** short,the present document aims to provide clinicians with a practical guide for the application of the PACIFIC regimen in routine clinical practice.

关键词： Durvalumab Non-small cell lung cancer PACIFIC Immunotherapy Immune checkpoint inhibitors Anti-programmed cell death ligand 1 Consolidation therapy Unresectable stage III lung cancer

Stable diffusion gradients in microfluidic conduits bounded by fluid walls

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Microsystems & Nanoengineering 2024年第3期10卷 357-367页

作者： federico Nebuloni Cyril Deroy Peter R.Cook Edmond J.Walsh Department of Engineering Science Osney Thermo-Fluids InstituteUniversity of OxfordOxford OX20ESUK Sir William Dunn School of Pathology University of OxfordOxford OX13REUK

Assays mimicking in vitro the concentration gradients triggering biological responses like those involved in fighting infections and blood clotting are essential for biomedical *** assays prove especially attractive as they allow precise control of gradient shape allied to a reduction in *** microfluidic devices are fabricated using solid plastics that prevent direct access to responding ***-walled microfluidics allows the manufacture of circuits on standard Petri dishes in seconds,coupled to simple operating methods;cell-culture medium sitting in a standard dish is confined to circuits by fluid walls made of an immiscible *** develop and experimentally validate an analytical model of diffusion between two or more aqueous streams flowing at different rates into a fluid-walled conduit with the cross-section of a circular *** solid walls,fluid walls morph during flows as pressures fall,with wall shape changing down the *** model is validated experimentally for Fourier numbers<0.1 using fluorescein diffusing between laminar *** enables a priori prediction of concentration gradients throughout a conduit,so allowing rapid circuit design as well as providing bioscientists with an accurate way of predicting local concentrations of bioactive molecules around responsive and nonresponsive cells.

关键词： walls diffusion attractive

Facing ethical concerns in the age of precise gene therapy:Outlook on inherited arrhythmias

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World Journal of Cardiology 2024年第2期16卷 64-66页

作者： federico Carbone Fabrizio Montecucco Department of Internal Medicine University of GenoaGenoa 16132Italy IRCCS Ospedale Policlinico San Martino Genoa Italian Cardiovascular NetworkGenoa 16132Italy

This editorial,comments on the article by Spartalis et al published in the recent issue of the World Journal of *** here provide an outlook on potential ethical concerns related to the future application of gene therapy in the field of inherited *** monogenic diseases with no or few therapeutic options available through standard care,inherited arrhythmias are ideal candidates to gene therapy in their *** with inherited arrhythmias typically have a poor quality of life,especially young people engaged in agonistic *** genome editing for treatment of inherited arrhythmias still has theoretical application,advances in CRISPR/Cas9 technology now allows the generation of knock-in animal models of the ***,clinical translation is somehow expected soon and this make consistent discussing about ethical concerns related to gene editing in inherited *** off-target activity is a known technical issue,but its relationship with ethnical and individual genetical diversity raises concerns about an equitable ***,the costeffectiveness may further limit an equal distribution of gene *** economic burden of gene therapies on healthcare systems is is increasingly recognized as a pressing concern.A growing body of studies are reporting uncertainty in payback periods with intuitive short-term effects for insurance-based healthcare systems,but potential concerns for universal healthcare systems in the long term as ***,those aspects strongly indicate a need of regulatory entities to manage those issues.

关键词： Ethics Inherited arrhythmias CRISPR/Cas9 Gene therapy Equitable accessibility

Coated boron layers by boronization and a real-time boron coating using an impurity powder dropper in the LHD

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Plasma Science and Technology 2024年第8期26卷 25-31页

作者： Naoko ASHIKAWA Robert LUNSFORD federico NESPOLI Erik GILSON Yaowei YU Jiansheng HU Shinichiro KADO National Institute for Fusion Science Toki 509-5292Japan Princeton Plasma Physics Laboratory Princeton NJ 08540United States of America Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People’s Republic of China Institute of Advanced Energy Kyoto UniversityKyoto 611-0011Japan

In the Large Helical Device(LHD),diborane(B2H6)is used as a standard boron source for boronization,which is assisted by helium glow *** 2019,a new Impurity Powder Dropper(IPD)system was installed and is under evaluation as a real-time wall conditioning *** the LHD,which is a large-sized heliotron device,an additional helium(He)glow discharge cleaning(GDC)after boronization was operated for a reduction in hydrogen recycling from the coated boron *** operational time of 3 h was determined by spectroscopic data during glow discharges.A flat hydrogen profile is obtained on the top surface of the coated boron on the specimen exposed to *** results suggest a reduction in hydrogen at the top surface by *** oxygen in coated boron was obtained by boronization,and the coated boron,which has boron-oxide,on the first wall by B-IPD was also *** the difference in coating areas between B2H6 boronization and B-IPD operation,it would be most effective to use the IPD and B2H6 boronization coating together for optimized wall conditioning.

关键词： boron layer oxygen impurity hydrogen recycling impurity powder dropper LHD EAST

Ultrasound unveiling:Decoding venous congestion in heart failure for precision management of fluid status

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World Journal of Cardiology 2024年第6期16卷 306-309页

作者： Davide Ramoni federico Carbone Fabrizio Montecucco Department of Internal Medicine University of GenoaGenoa 16132Italy Department of Internal Medicine IRCCS Ospedale Policlinico San MartinoGenoa 16132Italy

This editorial discusses the manuscript by Di Maria et al,published in the recent issue of the World Journal of *** here focus on the still elusive pathophysiological mechanisms underlying cardio-renal syndrome(CRS),despite its high prevalence and the substantial worsening of both kidney function and heart *** the measure of right atrial pressure through right cardiac catheterization remains the most accurate albeit invasive and costly procedure,integrating bedside ultrasound into diagnostic protocols may substantially enhance the staging of venous congestion and guide therapeutic *** particular,with the assessment of Doppler patterns across multiple venous districts,the Venous Excess Ultrasound(VExUS)score improves the management of fluid overload and provides insight into the underlying factors contributing to cardio-renal *** specific echocardiographic parameters,particularly those concerning the right heart,may thus improve the VExUS score sensitivity,offering perspective into the nuanced comprehension of cardio-renal dynamics.A multidisciplinary approach that consistently incorporates the use of ultrasound is emerging as a promising advance in the understanding and management of CRS.

关键词： Cardio-renal syndrome Fluid overload Heart failure Ultrasound assessment Venous congestion Venous excess ultrasound score

Thermoelectrocatalysis: an emerging strategy for converting waste heat into chemical energy

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National Science Review 2024年第4期11卷 19-21页

作者： Yuqiao Zhang Shun Li Jianming Zhang Li-Dong Zhao Yuanhua Lin Weishu Liu federico Rosei Institute of Quantum and Sustainable Technology(IQST) School of Chemistry and Chemical Engineering Jiangsu University School of Materials Science and Engineering Beihang University State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University Department of Materials Science and Engineering Southern University of Science and Technology Centre for Energy Materials and Telecommunications Institut national de la recherche scientifique

Waste heat emissions are universally present in the environment and industrial production. Innovations aimed at efficiently utilizing low-grade thermal energy have long been desired. Among these, thermoelectric materi...

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