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Three-dimensional models:from cell culture to Patient-Derived Organoid and its application to future liposarcoma research

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Oncology Research 2025年第1期33卷 1-13页

作者： SAYUMI TAHARA SYDNEY RENTSCH FERNANDA COSTAS CASAL DE FARIA PATRICIA SARCHET ROMA KARNA federica CALORE RAPHAEL E.POLLOCK Department of Surgery Division of Surgical OncologyThe James Comprehensive Cancer CenterThe Ohio State University Wexner Medical CenterColumbusOH 43210USA Department of Cancer Biology and Genetics The James Comprehensive Cancer CenterThe Ohio State University Wexner Medical CenterColumbusOH 43210USA

Liposarcoma is one of the most common soft tissue sarcomas,however,its occurrence rate is still rare compared to other *** to its rarity,in vitro experiments are an essential approach to elucidate liposarcoma *** cell culture-based research(2D cell culture)is still playing a pivotal role,while several shortcomings have been recently under *** vivo,mouse models are usually adopted for pre-clinical analyses with expectations to overcome the issues of 2D cell ***,they do not fully recapitulate human dedifferentiated liposarcoma(DDLPS)***,three-dimensional(3D)culture systems have been the recent research focus in the cell biology field with the expectation to overcome at the same time the disadvantages of 2D cell culture and in vivo animal models and fill in the gap between *** the liposarcoma rarity,we believe that 3D cell culture techniques,including 3D cell cultures/co-cultures,and Patient-Derived tumor Organoids(PDOs),represent a promising approach to facilitate liposarcoma investigation and elucidate its molecular mechanisms and effective therapy *** this review,we first provide a general overview of 3D cell cultures compared to 2D cell *** then focus on one of the recent 3D cell culture applications,Patient-Derived Organoids(PDOs),summarizing and discussing several PDO ***,we discuss the current and future applications of PDOs to sarcoma,particularly in the field of liposarcoma.

关键词： Cell culture Liposarcoma Patient-Derived Organoid(PDO) Spheroid Three-dimensional(3D)cell culture

Dorsal and ventral streams across sensory modalities

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Neuroscience Bulletin 2012年第3期28卷 291-300页

作者： Anna Sedda federica Scarpina Department of Humanistic Studies- Psychology Section University of Pavia

In this review, we describe the current models of dorsal and ventral streams in vision, audition and touch. Available theories take their first steps from the model of Milner and Goodale, which was developed to explain how human actions can be efficiently carried out using visual information. Since then, similar concepts have also been applied to other sensory modalities. We propose that advances in the knowledge of brain functioning can be achieved through models explaining action and perception patterns independently from sensory modalities.

关键词： sensorimotor integration action control perception dorsal stream ventral stream cross-modal

Effect of acoustic field on C02 desorption in a fluidized bed of fine activated carbon

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Particuology 2015年第6期13卷 8-15页

作者： federica Raganati Paola Ammendola Riccardo Chirone Department of Chemical Engineering Materials and Industrial Production University of Naples Federico II P. le V. Tecchio 80 80125 Napoli Italy Istituto di Ricerche sulla Combustione CNR P. le K Tecchio 80 80125 Napoli Italy

Adsorption using solid sorbents has the potential to complement or replace current absorption technol- ogy, because of its low energy requirements. Among the commercially available adsorbent materials, attention is focused on activated carbons because they are easily regenerable by reason of their low heat of adsorption. These sorbents are generally available in the form of fine powders. Sound-assisted fluidization can process large amounts of fine powders, promoting and enhancing CO2 capture on fine sorbents, because it maximizes gas-solid contact. Temperature swing adsorption （TSA）, consisting of inducing sor- bent regeneration and CO2 recovery by appropriate temperature increase and gas purge, is one of the most promising techniques. This study investigates the CO2 desorption process by TSA in a sound-assisted flu- idized bed of fine activated carbon. Desorption tests were performed under ordinary and sound-assisted fluidization conditions to assess the capability of sound to promote and enhance the desorption efficiency in terms of CO2 recovery, CO2 purity, and desorption time. The results show that the application of sound results in higher desorption rates, CO2 recovery and purity. Regular and stable desorption profiles can be obtained under sound-assisted fluidization conditions. This stability makes it possible to successfully realize a cyclic adsorption/desorption process.

关键词： Temperature swing adsorption Sound-assisted fluidization CO2 capture Activated carbons Fine powders

Severe chronic diarrhea and maculopapular rash:A case report

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World Journal of Gastroenterology 2011年第34期17卷 3948-3952页

作者： Alessandra Elvevi federica Grifoni federica Branchi Umberto Gianelli Dario Conte Gastrointestinal Unit 2 Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico and University of Milan federica Grifoni Hematology Unit Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico and University of Milan Umberto Gianelli Department of Pathology Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico and University of Milan

Systemic mastocytosis (SM) is a heterogeneous disease of the bone marrow characterized by abnormal growth, accumulation and activation of clonal mast cells (MCs). We report a case of SM with multiorgan involvement. A 30-year-old man presented with diarrhea, flushing, maculopapular rash with itching and weight loss. The upper and lower gastrointestinal endoscopies showed macroscopic involvement of stomach and duodenum; mucosal samples from stomach, duodenum, colon and distal ileum showed mucosal inf iltration by large, spindleshaped MCs with abnormal surface molecule expression (CD2 and CD25), a picture fully consistent with SM, according to the World Health Organization diagnostic criteria. A computed tomography scan showed diffuse lymphadenopathy, hepatosplenomegaly and diffuse small bowel involvement. Bone marrow aspirate and biopsy were diagnostic for SM; serum tryptase levels were increased (209 ng/mL, normal values < 20 ng/mL). The conclusive diagnosis was smouldering SM. There wereno therapeutic indications except for treatment of symptoms. The patient was strictly followed up because of the risk of aggressive evolution.

关键词： Mast cells Systemic mastocytosis Bone marrow Tryptase

Estimation of the effective properties of two-dimensional cellular materials:a review

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Theoretical & Applied Mechanics Letters 2018年第4期8卷 209-230,298页

作者： federica Ongaro School of Engineering and Materials Science Queen Mary University of LondonLondonUK

In a vast number of engineering fields like medicine,aerospace or robotics,materials are required to meet unusual performances that simple homogeneous materials are often not able to ***,many efforts are currently devoted to develop future generations of materials with enhanced properties and unusual *** many instances,biological systems served as a source of inspiration,as in the case of cellular *** observed in nature,cellular materials offer useful combinations of structural properties and low weight,yielding the possibility of coexistence of what used to be antagonistic physical properties within a single *** to their peculiar characteristics,they are very promising for engineering applications in a variety of industries including aerospace,automotive,marine and ***,their use is conditional upon the development of appropriate constitutive models for revealing the complex relations between the microstructure's parameters and the macroscopic *** this point of view,a great variety of analytical and numerical techniques have been proposed and exhaustively discussed in recent *** contributions,suggesting different assumptions and techniques are critically presented in this review paper.

关键词： Cellular materials Effective properties Computational homogenization Analytical modelling

NK2 homeobox gene cluster: Functions and roles in human diseases

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Genes & Diseases 2023年第5期10卷 2038-2048页

作者： Catia Mio federica Baldan Giuseppe Damante Dipartimento di Area Medica Universitàdegli Studi di UdineUdine 33100Italy Istituto di Genetica Medica Azienda Sanitaria Universitaria Friuli CentraleUdine 33100Italy

NK2 genes (NKX2 gene cluster in humans) encode for homeodomain-containing transcription factors that are conserved along the phylogeny. According to the most detailed classifications, vertebrate NKX2 genes are classified into two distinct families, NK2.1 and NK2.2 . The former is constituted by NKX2-1 and NKX2-4 genes, which are homologous to the Drosophila scro gene;the latter includes NKX2-2 and NKX2-8 genes, which are homologous to the Drosophila vnd gene. Conservation of these genes is not only related to molecular structure and expression, but also to biological functions. In Drosophila and vertebrates, NK2 genes share roles in the development of ventral regions of the central nervous system. In vertebrates, NKX2 genes have a relevant role in the development of several other organs such as the thyroid, lung, and pancreas. Loss-of-function mutations in NKX2-1 and NKX2-2 are the monogenic cause of the brain-lung-thyroid syndrome and neonatal diabetes, respectively. Alterations in NKX2-4 and NKX2-8 genes may play a role in multifactorial diseases, autism spectrum disorder, and neural tube defects, respectively. NKX2-1 , NKX2-2 , and NKX2-8 are expressed in various cancer types as either oncogenes or tumor suppressor genes. Several data indicate that evaluation of their expression in tumors has diagnostic and/or prognostic value.

关键词： Drosophila melanogaster Evolutionary conservation Homeobox Homeotic genes NK2 genes

Oligodendrocyte precursor cell maturation: role of adenosine receptors

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Neural Regeneration Research 2021年第9期16卷 1686-1692页

作者： federica Cherchi Anna Maria Pugliese Elisabetta Coppi Department of Neuroscience PsychologyDrug Research and Child Health-Neurofarba-Division of Pharmacology and ToxicologyUniversity of FlorenceFlorenceItaly

Oligodendrocyte-formed myelin sheaths allow fast synaptic transmission in the brain and their degeneration leads to demyelinating diseases such as multiple sclerosis. Remyelination requires the differentiation of oligodendrocyte progenitor cells into mature oligodendrocytes but, in chronic neurodegenerative disorders, remyelination fails due to adverse environment. Therefore, a strategy to prompt oligodendrocyte progenitor cell differentiation towards myelinating oligodendrocytes is required. The neuromodulator adenosine, and its receptors(A1, A(2A), A(2B) and A3 receptors: A1R, A(2A)R, A(2B)R and A3R), are crucial mediators in remyelination processes. It is known that A1Rs facilitate oligodendrocyte progenitor cell maturation and migration whereas the A3Rs initiates apoptosis in oligodendrocyte progenitor cells. Our group of research contributed to the field by demonstrating that A(2A)R and A(2B)R inhibit oligodendrocyte progenitor cell maturation by reducing voltage-dependent K^+ currents necessary for cell differentiation. The present review summarizes the possible role of adenosine receptor ligands as potential therapeutic targets in demyelinating pathologies such as multiple sclerosis.

关键词： adenosine receptors K^+channels oligodendrocyte differentiation oligodendrocyte progenitor cells remyelination

Regenerative capacity of Müller cells and their modulation as a tool to treat retinal degenerations

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Neural Regeneration Research 2023年第1期18卷 139-140页

作者： federica M.Conedera Volker Enzmann Advanced Microscopy Program Center for Systems BiologyMassachusetts General HospitalBostonMAUSA Wellman Center for Photomedicine Massachusetts General HospitalBostonMAUSA(Conedera FM)Department of OphthalmologyUniversity HospitalUniversity of BernBernSwitzerland Department of BioMedical Research University of BernBernSwitzerland

Vision is one of our most precious senses,and its impairment has a high socio-economic *** the industrialized world,degenerative diseases of the retina lead to vision loss,particularly among the *** degenerations include,for instance,retinitis pigmentosa,age-related macular degeneration,and diabetic *** treatments are evolving to manage late-stage symptoms of retinal degenerations,no effective therapies to recover vision loss *** degeneration often involves loss or damage to specialized neural cells,such as photoreceptors,and their death stimulates the activation and proliferation of Müller cells(Salman et al.,2021).

关键词： degeneration diseases impairment

Exploring pre-degenerative alterations in humans using induced pluripotent stem cell-derived dopaminergic neurons

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Neural Regeneration Research 2017年第7期12卷 1068-1070页

作者： federica Bono Chiara Fiorentini Division of Pharmacology Department of Molecular andTranslational Medicine University of Brescia Brescia Italy

Understanding the cellular and molecular mechanisms underlying human neurological disorders is hindered by both the complexity of the disorders and the lack of suitable experimental models recapitulating key pathological features of the *** is a crucial issue since a limited understanding of pathogenic mechanisms precludes the development of drugs counteracting the progression of the *** neurological disorders,

关键词： in Exploring pre-degenerative alterations in humans using induced pluripotent stem cell-derived dopaminergic neurons stem DAT been that of cell PSC