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Colorectal cancer: Parametric evaluation of morphological,functional and molecular tomographic imaging

World Journal of Gastroenterology 2019年第35期25卷 5233-5256页

作者： Pier Paolo Mainenti Arnaldo Stanzione Salvatore Guarino Valeria Romeo Lorenzo Ugga federica romano Giovanni Storto Simone Maurea Arturo Brunetti Institute of Biostructures and Bioimaging of the National Council of Research (CNR) Naples 80145 Italy University of Naples "Federico II" Department of Advanced Biomedical Sciences Naples 80131 Italy IRCCS-CROB Referral Cancer Center of Basilicata Rionero in Vulture 85028 Italy

Colorectal cancer (CRC) represents one of the leading causes of tumor-related deaths worldwide. Among the various tools at physicians’ disposal for the diagnostic management of the disease, tomographic imaging (e.g., CT, MRI, and hybrid PET imaging) is considered essential. The qualitative and subjective evaluation of tomographic images is the main approach used to obtain valuable clinical information, although this strategy suffers from both intrinsic and operator-dependent limitations. More recently, advanced imaging techniques have been developed with the aim of overcoming these issues. Such techniques, such as diffusion-weighted MRI and perfusion imaging, were designed for the “in vivo” evaluation of specific biological tissue features in order to describe them in terms of quantitative parameters, which could answer questions difficult to address with conventional imaging alone (e.g., questions related to tissue characterization and prognosis). Furthermore, it has been observed that a large amount of numerical and statistical information is buried inside tomographic images, resulting in their invisibility during conventional assessment. This information can be extracted and represented in terms of quantitative parameters through different processes (e.g., texture analysis). Numerous researchers have focused their work on the significance of these quantitative imaging parameters for the management of CRC patients. In this review, we aimed to focus on evidence reported in the academic literature regarding the application of parametric imaging to the diagnosis, staging and prognosis of CRC while discussing future perspectives and present limitations. While the transition from purely anatomical to quantitative tomographic imaging appears achievable for CRC diagnostics, some essential milestones, such as scanning and analysis standardization and the definition of robust cut-off values, must be achieved before quantitative tomographic imaging can be incorporated into

关键词： Colorectal cancer Computed tomography Magnetic resonance imaging Positron emission tomography Parametric imaging Perfusion imaging Diffusion imaging Texture analysis

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自体牙髓干细胞在牙周再生中的应用：病例报告

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中国口腔医学继续教育杂志 2018年第4期21卷 193-198页

作者： Mario Aimetti Francesco Ferrarotti Luca Cricenti Giulia Maria Mariani federica romano 成宵(译) 滕伟(审) 不详中山大学光华口腔医学院·附属口腔医院广州市越秀区中山二路74号中山大学北校区510080

目的：动物模型的组织学研究表明牙髓干细胞（dental pulp stem ***）可能促进骨下袋的牙周再生。材料与方法：这篇病例报告通过临床和影像学的结果描述了自体DPSCs在治疗人类未经治疗的骨内袋中的再生潜能。手术拔除一名慢性牙周炎患... 详细信息

目的：动物模型的组织学研究表明牙髓干细胞（dental pulp stem ***）可能促进骨下袋的牙周再生。材料与方法：这篇病例报告通过临床和影像学的结果描述了自体DPSCs在治疗人类未经治疗的骨内袋中的再生潜能。手术拔除一名慢性牙周炎患者一颗有牙髓活力的第三磨牙．拔除的第三磨牙作为自体DPSCs的来源以再生右侧下颌第二前磨牙的骨下袋。结果：1年后检查发现缺损处充满骨样组织．再次手术翻开观察也证实了这一点。

关键词：牙髓干细胞牙周再生病例报告自体应用第三磨牙再次手术 cells

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Non-invasive diagnostic imaging of colorectal liver metastases

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World Journal of Radiology 2015年第7期7卷 157-169页

作者： Pier Paolo Mainenti federica romano Laura Pizzuti Sabrina Segreto Giovanni Storto Lorenzo Mannelli Massimo Imbriaco Luigi Camera Simone Maurea IBB CNR Advanced Biomedical Science Department Radiology Section University of Naples "Federico II" IRCCS CROB Radiology Department Memorial Sloan-Kettering Cancer Center

Colorectal cancer is one of the few malignant tumors in which synchronous or metachronous liver metastases [colorectal liver metastases(CRLMs)] may be treated with surgery. It has been demonstrated that resection of CRLMs improves the long-term prognosis. On the other hand, patients with un-resectable CRLMs may benefit from chemotherapy alone or in addition to liverdirected therapies. The choice of the most appropriate therapeutic management of CRLMs depends mostly on the diagnostic imaging. Nowadays, multiple non-invasive imaging modalities are available and those have a pivotal role in the workup of patients with CRLMs. Although extensive research has been performed with regards to the diagnostic performance of ultrasonography, computed tomography, positron emission tomography and magnetic resonance for the detection of CRLMs, the optimal imaging strategies for staging and follow up are still to be established. This largely due to the progressive technological and pharmacological advances which are constantly improving the accuracy of each imaging modality. This review describes the non-invasive imaging approaches of CRLMs reporting the technical features, the clinical indications, the advantages and the potential limitations of each modality, as well as including some information on the development of new imaging modalities, the role of new contrast media and the feasibility of using parametric image analysis as diagnostic marker of presence of CRLMs.

关键词： Advances in imaging Colorectal cancer Liver metastases

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Pediatric gastrointestinal bleeding: Perspectives from the Italian Society of Pediatric Gastroenterology

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World Journal of Gastroenterology 2017年第8期23卷 1328-1337页

作者： Claudio romano Salvatore Oliva Stefano Martellossi Erasmo Miele Serena Arrigo Maria Giovanna Graziani Sabrina Cardile federica Gaiani Gian Luigi de'Angelis Filippo Torroni Unit of Pediatrics Department of Human Pathology in Adulthood and Childhood“G.Barresi”University of Messina Department of Pediatrics and Infantile Neuropsychiatry Pediatric Gastroenterology and Liver UnitSapienza University of Rome Institute for Maternal and Child Health IRCCS‘Burlo Garofalo’ Department of Translational Medical Science Section of PediatricsUniversity of Naples“Federico II” Gastroenterology and Endoscopy Unit G.Gaslini Children’s Hospital-IRCCS Gastroenterology and Endoscopy Unit “San Giovanni Addolorata”Hospital Hepatology Gastroenterology and Nutrition UnitBambino GesùChildren’s Hospital Gastroenterology and Endoscopy Unit University of Parma Department of Surgery and Transplantation Digestive Surgery and Endoscopy UnitBambino GesùChildren’s Hospital

There are many causes of gastrointestinal bleeding(GIB) in children, and this condition is not rare, having a reported incidence of 6.4%. Causes vary with age, but show considerable overlap; moreover, while many of the causes in the pediatric population are similar to those in adults, some lesions are unique to children. The diagnostic approach for pediatric GIB includes definition of the etiology, localization of the bleeding site and determination of the severity of bleeding; timely and accurate diagnosis is necessary to reduce morbidity and mortality. To assist medical care providers in the evaluation and management of children with GIB, the "Gastro-Ped Bleed Team" of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition(SIGENP) carried out a systematic search on MEDLINE via Pub Med(http://***/pubmed/) to identify all articles published in English from January 1990 to 2016; the following key words were used to conduct the electronic search: "upper GIB" and "pediatric" [all fields]; "lower GIB" and "pediatric" [all fields]; "obscure GIB" and "pediatric" [all fields]; "GIB" and "endoscopy" [all fields]; "GIB" and "therapy" [all fields]. The identified publications included articles describing randomized controlled trials, reviews, case reports, cohort studies, casecontrol studies and observational studies. References from the pertinent articles were also reviewed. This paper expresses a position statement of SIGENP that can have an immediate impact on clinical practice and for which sufficient evidence is not available in literature. The experts participating in this effort were selected according to their expertise and professional qualifications.

关键词： Gastrointestinal bleeding Endoscopy Lower gastrointestinal bleeding Upper gastrointestinal bleeding Pediatric

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Self Consistent Calibration of Detectors and Sources for Hard and Soft X-Ray Diagnostics

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Modern Instrumentation 2014年第3期3卷 13-23页

作者： Danilo Pacella Afra romano Seung Hun Lee federica Causa Lori Gabellieri Wonho Choe ENEA Unità Tecnica Fusione Rome Italy Korea Advanced Institute of Science and Technology Daejeon Korea

X-Ray sources, detectors and optical components are now used in a wide range of applications. What is crucial is the absolute calibration of such devices to permit a quantitative assessment of the system under study. A new X-ray laboratory has been built in Frascati (ENEA) to develop diagnostics for nuclear fusion experiments and study applications of these X-ray techniques in other domains, like new material science, non destructive tests and so on. An in-house developed selfconsistent calibration procedure is described that permits the absolute calibration of sources (X-ray emitted fluxes) and detectors (detection efficiencies) as function of the X-ray photon energy, in the range 2 - 120 keV. The calibration procedure involves the use of an in-house developed code that also predicts the spectral response of any detector in any experimental condition that can be setup in the laboratory. The procedure has been then applied for the calibration and characterisation of gas and solid state imaging detectors, such as Medipix-2, GEM gas detector, CCD camera, Cd-Te C-MOS imager, demonstrating the versatility of the method developed here.

关键词： X-Ray Detector X-Ray Source Absolute Calibration Plasma Physics Diagnostics

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