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The breast cancer tumor microenvironment and precision medicine:immunogenicity and conditions favoring response to immunotherapy

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Journal of the National Cancer Center 2024年第1期4卷 14-24页

作者： Andrea Nicolini Paola Ferrari Roberto Silvestri federica gemignani Department of Oncology Transplantations and New Technologies in MedicineUniversity of PisaPisaItaly Department of Biology Genetic UnitUniversity of PisaPisaItaly

Some main recent researches that have dissected tumor microenvironment(TME)by imaging mass cytometry(IMC)in different subtypes of primary breast cancer samples were *** many phenotypic variants,clusters of epithelial tumor and immune cells,their structural features as well as the main genetic aberrations,sub-clonal heterogeneity and their systematic classification also have been *** evolution has been assessed in primary and metastatic breast cancer ***,based on these findings the current concept of precision medicine is questioned and challenged by alternative therapeutic *** the last two decades,immunotherapy as a powerful and harmless tool to fight cancer has received huge ***,the tumor immune microenvironment(TIME)composition,its prognostic role for clinical course as well as a novel definition of immunogenicity in breast cancer are *** clinical trials carried out by us and other findings suggest that G0-G1 state induced in endocrine-dependent metastatic breast cancer is more suitable for successful immune *** micro-metastatic disease seems to be another specific condition that can significantly favor the immune response in breast and other solid tumors.

关键词： Breast cancer Tumor microenvironment Immunotherapy

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Narrow-band imaging with magnifying endoscopy is accurate for detecting gastric intestinal metaplasia

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World Journal of Gastroenterology 2013年第17期19卷 2668-2675页

作者： Edoardo Savarino Marina Corbo Pietro Dulbecco Lorenzo gemignani Elisa Giambruno Luca Mastracci federica Grillo Vincenzo Savarino Gastroenterology Unit Department of Surgical Oncological and Gastroenterological Sciences University of Padua Gastroenterology Unit Department of Internal Medicine University of Genoa Department of Anatomic Pathology University of Genoa

AIM:To investigate the predictive value of narrowband imaging with magnifying endoscopy (NBI-ME) for identifying gastric intestinal metaplasia (GIM) in unselected patients. METHODS:We prospectively evaluated consecutive patients undergoing upper endoscopy for various indications, such as epigastric discomfort/pain, anaemia, gastro-oesophageal reflux disease, suspicion of peptic ulcer disease, or chronic liver diseases. Patients underwent NBI-ME, which was performed by three blinded, experienced endoscopists. In addition, five biopsies (2 antrum, 1 angulus, and 2 corpus) were taken and examined by two pathologists unaware of the endoscopic findings to determine the presence or absence of GIM. The correlation between light blue crest (LBC) appearance and histology was measured. Moreover, we quantified the degree of LBC appearance as less than 20% (+), 20%-80% (++) and more than 80% (+++) of an image field, and the semiquantitative evaluation of LBC appearance was correlated with IM percentage from the histological findings. RESULTS:We enrolled 100 (58 F/42 M) patients who were mainly referred for gastro-esophageal reflux disease/dyspepsia (46%), cancer screening/anaemia (34%), chronic liver disease (9%), and suspected celiac disease (6%); the remaining patients were referred for other indications. The prevalence of Helicobacter pylori (H. pylori ) infection detected from the biopsies was 31%, while 67% of the patients used proton pump inhibitors. LBCs were found in the antrum of 33 patients (33%); 20 of the cases were classified as LBC+, 9 as LBC++, and 4 as LBC+++. LBCs were found in the gastric body of 6 patients (6%), with 5 of them also having LBCs in the antrum. The correlation between the appearance of LBCs and histological GIM was good, with a sensitivity of 80% (95%CI:67-92), a specificity of 96% (95%CI:93-99), a positive predictive value of 84% (95%CI:73-96), a negative predictive value of 95% (95%CI:92-98), and an accuracy of 93% (95%CI:90-97). The NBI-ME ex

关键词： Narrow-band imaging Magnification Gastric intestinal metaplasia Light blue crest Gastric cancer Endoscopy Precancerous conditions Gastric biopsy

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