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Thyroid hormone analogues and derivatives:Actions in fatty liver

World Journal of Hepatology 2014年第3期6卷 114-129页

作者： Maria Coppola Daniela Glinni Maria Moreno federica cioffi Elena Silvestri Fernando Goglia Department of Science and Technologies University of Sannio

Fatty liver or nonalcoholic fatty liver disease(NAFLD),a problem of increasing clinical significance and prevalence worldwide,is associated with increased risk for the development of cirrhosis and hepatocellular *** several therapeutic approaches can be used in the context of NAFLD,dietary and physical activities are still the most frequently used *** pharmacological agents show promising results although no conclusions can be drawn from recent clinical *** hormones[THs;thyroxine(T4)and3,3′,5-triiodo-L-thyronine(T3)]coordinate a diverse array of physiological events during development and lipid/energy homeostasis and have some potentially therapeutic actions which include inducing weight loss,and lowering plasma cholesterol levels and tissue *** thyroid hormones exert their physiological effects by binding to specific nuclear receptors[thyroid hormone receptors(TR)]of which the TRβisoform is liver specific and has been considered a putative target for the treatment of dyslipidemia and fatty *** view of this,the aim of the review is(1)to provide an overview of the action of T3 on lipid metabolism with implications for liver steatosis and(2)to provide an update on the current knowledge concerning the administration of TRβselective thyromimetics(GC-1 and MB07811),as well as of 3,5-diiodo-L-thyronine and its novel functional analogue TRC150094 in animal models of overweight and related disorders including primarily fatty liver.

关键词： Fatty liver Thyroid hormones Thyromimetics 3,5-diiodo-L-thyronine Lipid metabolism

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