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Variation of Polyphenols, Anthocyanins and Antioxidant Power in the Strawberry Grape (<i>Vitis labrusca</i>) after Simulated Gastro-Intestinal Transit and Evaluation of <i>in Vitro</i>Antimicrobial Activity

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Food and Nutrition Sciences 2014年第1期5卷 60-65页

作者： Tiziana Granese federica cardinale Autilia Cozzolino Selenia Pepe Maria Neve Ombra Filomena Nazzaro Raffaele Coppola Florinda Fratianni Institute of Food Science ISA-CNR Avellino Italy Institute of Food Science ISA-CNR Avellino Italy.

The influence of a simulated digestive process on some biochemical and biological aspects of strawberry grape (Vitis labrusca) was investigated. The amount of total polyphenols and anthocyanins as well as the antioxidant power were evaluated. Results evidenced that the simulated gastrointestinal transit caused a decrease of the polyphenols content and total anthocyanins;these last, however, were more resistant than polyphenols, decreasing only of 50% respect to the initial value (31.50 μg/ml of extract). The extract exhibited an excellent antioxidant power (EC50 3.8 mg/ml), which decreased of about four times after the simulated gastrointestinal transit. The antimicrobial activity of the extract, evaluated against three Escherichia coli, Pseudomonas aeruginosa and Bacillus cereus pathogen strains was enhanced by the simulated digestion, with an increase of the inhibition halo.

关键词： Strawberry Grape Antioxidants Polyphenols Anthocyanins Antimicrobial Activity

Polyphenol Composition and Antioxidant Activity of Two Autochthonous Brassicaceae of the Campania Region, Southern Italy

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Food and Nutrition Sciences 2014年第1期5卷 66-70页

作者： Florinda Fratianni federica cardinale Autilia Cozzolino Tiziana Granese Selenia Pepe Riccardo Riccardi Patrizia Spigno Raffaele Coppola Filomena Nazzaro Cooperative ARCA Acerra Italy Institute of Food Science ISA-CNR Avellino Italy Institute of Food Science ISA-CNR Avellino Italy

Torzella (Brassica oleracea acephala) is one of the most ancient kinds of cauliflower developed in the Mediterranean area. Broccolo (Brassica oleracea botrytis cimosa), var. “San Pasquale” is a leafy vegetable cultivated in Campania too, mainly in the province of Naples. We evaluated the polyphenols content and the antioxidant activity of these two Brassicaceae, provided by the same experimental plant of the Campania region. Both vegetables showed high content of total polyphenols (6.37 mM GAE/g and 2.24 mM GAE/g of Torzella and Broccolo, respectively), and a remarkable antioxidant activity (EC50 1.53 mg and EC50 6.51 mg, in Torzella and Broccolo, respectively). Polyphenol composition, determined by ultra performance liquid chromatography (UPLC), allowed us to detect a certain number of compounds (gallic, ferulic, chlorogenic, p-coumaric and caffeic acids, catechin, luteolin, naringenin) common to both species. Therefore, epicatechin was found only in the extract of san Pasquale broccoli;on the contrary, rutin and apigenin were detected only in the extracts of torzella broccoli. Hence, such products can be considered therapeutic functional foods due to their extraordinary reserve of secondary metabolites and bioactive constituents that are beneficial for managing and preventing several chronic illnesses in humans.

关键词： Brassicaceae Antioxidants Polyphenols

Common features between neoplastic and preneoplastic lesions of the biliary tract and the pancreas

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World Journal of Gastroenterology 2019年第31期25卷 4343-4359页

作者： Piera Zaccari Vincenzo cardinale Carola Severi federica Pedica Guido Carpino Eugenio Gaudio Claudio Doglioni Maria Chiara Petrone Domenico Alvaro Paolo Giorgio Arcidiacono Gabriele Capurso Department of Internal Medicine and Medical Specialties Gastroenterology UnitSapienza University of RomeRome 00161Italy Department of Medico-Surgical Sciences and Biotechnologies Sapienza University of Rome00161 RomeItaly Pathology Department Pancreas Translational and Clinical Research CenterSan Raffaele Scientific Institute IRCCSMilan 20132Italy Department of Movement Human and Health SciencesDivision of Health SciencesUniversity of Rome"Foro Italico"Rome 00161Italy Department of Anatomical HistologicalForensic Medicine and Orthopedics SciencesDivision of Human AnatomySapienza University of RomeRome 00161Italy PancreatoBiliary Endoscopy and EUS Division Pancreas Translational and Clinical Research CenterSan Raffaele Scientific Institute IRCCSMilan 20132Italy Department of Translational and Precision Medicine Sapienza University of RomeRome 00161Italy

the bile duct system and pancreas show many similarities due to their anatomical proximity and common embryological ***,preneoplastic and neoplastic lesions of the bile duct and pancreas share analogies in terms of molecular,histological and pathophysiological *** neoplasms are reported in biliary tract,as biliary intraepithelial neoplasm(BilIN),and in pancreas,as pancreatic intraepithelial neoplasm(PanIN).Both can evolve to invasive carcinomas,respectively cholangiocarcinoma(CCA)and pancreatic ductal adenocarcinoma(PDAC).Intraductal papillary neoplasms arise in biliary tract and *** papillary neoplasm of the biliary tract(IPNB)share common histologic and phenotypic features such as pancreatobiliary,gastric,intestinal and oncocytic types,and biological behavior with the pancreatic counterpart,the intraductal papillary mucinous neoplasm of the pancreas(IPMN).All these neoplastic lesions exhibit similar immunohistochemical phenotypes,suggesting a common carcinogenic ***,CCA and PDAC display similar clinic-pathological features as growth pattern,poor response to conventional chemotherapy and radiotherapy and,as a consequence,an unfavorable *** objective of this review is to discuss similarities and differences between the neoplastic lesions of the pancreas and biliary tract with potential implications on a common origin from similar stem/progenitor cells.

关键词： Biliary Pancreatic Progenitors Preneoplastic Common Tumor

Effectiveness of chest radiography,lung ultrasound and thoracic computed tomography in the diagnosis of congestive heart failure

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World Journal of Radiology 2014年第6期6卷 230-237页

作者： Luciano cardinale Adriano Massimiliano Priola federica Moretti Giovanni Volpicelli Institute of Radiology University of Turin AOU San Luigi Gonzaga 10043 Orbassano Torino Italy Department of Emergency Medicine Uni-versity of Turin AOU San Luigi Gonzaga 10043 Orbassano Torino Italy

Hydrostatic pulmonary edema is as an abnormal in-crease in extravascular water secondary to elevatedpressure in the pulmonary circulation, due to conges-tive heart failure or intravascular volume *** of hydrostatic pulmonary edema is usuallybased on clinical signs associated to conventional ra-diography findings. Interpretation of radiologic signsof cardiogenic pulmonary edema are often question-able and subject. For a bedside prompt evaluation,lung ultrasound(LUS) may assess pulmonary conges-tion through the evaluation of vertical reverberationartifacts, known as B-lines. These artifacts are relatedto multiple minimal acoustic interfaces between smallwater-rich structures and alveolar air, as it happens incase of thickened interlobular septa due to increase of extravascular lung water. The number, diffusion and in-tensity of B lines correlates with both the radiologic andinvasive estimate of extravascular lung water. The inte-gration of conventional chest radiograph with LUS canbe very helpful to obtain the correct diagnosis. Com-puted tomography(CT) is of limited use in the work upof cardiogenic pulmonary edema, due to its high cost,little use in the emergencies and radiation ***, a deep knowledge of CT signs of pulmonaryedema is crucial when other similar pulmonary condi-tions may occasionally be in the differential diagnosis.

关键词： Dyspnea Ultrasonography Emergency department Lung diseases Interstitial/ultrasonography Pulmonary edema/radiography Pulmonary edema/ultrasonography Heart failure/complications Heart Failure/ultrasonography

Pathophysiology, clinical features and radiological findings of differentiation syndrome/all-trans-retinoic acid syndrome

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World Journal of Radiology 2014年第8期6卷 583-588页

作者： Luciano cardinale Francesco Asteggiano federica Moretti Federico Torre Stefano Ulisciani Carmen Fava Giovanna Rege-Cambrin Institute of Radiology Department of Clinical and Biological Sciences University of Turin AOU S.Luigi Gonzaga 10043 Orbassano Torino Italy Division of Hematology and Internal Medicine Department of Clinical and Biological Sciences of University of Turin AOU S.Luigi Gonzaga 10043 Orbassano Torino Italy

In acute promyelocytic leukemia, differentiation thera-py based on all-trans-retinoic acid can be complicated by the development of a differentiation syndrome(DS). DS is a life-threatening complication, characterized by respiratory distress, unexplained fever, weight gain, interstitial lung infiltrates, pleural or pericardial effusions, hypotension and acute renal failure. The diagnosis of DS is made on clinical grounds and has proven to be difficult, because none of the symptoms is pathognomonic for the syndrome without any definitive diagnostic criteria. As DS can have subtle signs and symptoms at presentation but progress rapidly, end-stage DS clinical picture resembles the acute respiratory distress syndrome with extremely poor prognosis; so it is of absolute importance to be conscious of these complications and initiate therapy as soon as it was suspected. The radiologic appearance resembles the typical features of cardiogenic pulmonary edema. Diagnosis of DS remains a great skill for radiologists and haematologist but it is of an utmost importance the cooperation in suspect DS, detect the early signs of DS, examine the patients' behaviour and rapidly detect the complications.

关键词： Differentiation syndrome All-trans-retinoic acid syndrome Chest X-ray and computed tomography Lungleukemic infiltrates Acute promyelocytic leukaemia Promyelocytic leukemia/retinoic acid receptor-α

Clinical and epidemiological features of ulcerative colitis patients in Sardinia,Italy:Results from a multicenter study

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World Journal of Clinical Cases 2022年第30期10卷 10921-10930页

作者： Salvatore Magrì Mauro Demurtas Maria Francesca Onidi Marcello Picchio Walter Elisei Manuela Marzo federica Miculan Roberto Manca Maria Pina Dore Bianca Maria Quarta Colosso Antonio Cicu Luigi Cugia Monica Carta Laura Binaghi Paolo Usai Mariantonia Lai Fabio Chicco Massimo Claudio Fantini Alessandro Armuzzi Giammarco Mocci Department of Medical Sciences and Public Health University of CagliariMonserrato 09042Italy Endoscopy Unit Humanitas Istituto Clinico CataneseCatania 95045Italy Endoscopy Unit San Martino HospitalOristano 09170Italy Gastroenterology Unit Brotzu HospitalCagliari 09121Italy Division of General Surgery Ospedale Civile P ColomboVelletri 00049Italy Gastroenterology Unit San Camillo Forlanini HospitalRome 00152Italy Internal Medicine and Gastroenterology Department Cardinale Panico HospitalTricase 73039Italy Department of Surgery San Martino HospitalOristano 09170Italy Division of Gastroenterology Santissima TrinitàHospitalCagliari 09121Italy Dipartimento di Medicina Clinica e Sperimentale University of SassariSassari 07100Italy Department of Medical Science and Public Health University of SassariSassari 07100Italy Unit of Gastroenterology ASL SassariSassari 07100Italy Gastroenterology Unit Santissima Annunziata HospitalSassari 07100Italy Medical Science and Public Health University of CagliariCagliari 09042Italy Medical Sciences and Public health Presidio Policlinico of MonserratoCagliariMonserrato 09042CagliariItaly Department of Internal Medicine University of Rome Tor VergataRome 00133Italy IBD Unit Policlinico Universitario GemelliRome 00168Italy

BACKGROUND There are little data on the epidemiological and clinical features of adult patients with ulcerative colitis(UC) in the different Italian regions,mainly derived from the absence of a national *** prevents correct interpretation of the disease *** To assess the main clinical and epidemiological features of adult patients diagnosed with UC in Sardinia,*** We performed a multicenter,observational,cross-sectional study that included adult patients with UC enrolled in seven gastroenterology unit centers in *** were obtained from the patients’ medical records and from a questionnaire administered at the inclusion *** Four hundred and forty-two patients with UC were *** median age at diagnosis was 39years(interquartile range 28-48).After a median disease duration of 10 years,53 patients experienced proximal extension of proctitis or left-sided ***-five patients developed extraintestinal *** patients(4.3%) developed cancer:two with colorectal cancer and seventeen with extracolonic ***(5-ASA) remains the mainstay of treatment for ***,95 patients(21.5%) were treated with one or more biologic agents,whereas 15 patients(3.4%) underwent surgery,mostly *** Our results provide important insights into the clinical and epidemiological features of patients with UC,and while waiting for a national Italian registry,present eligible data on the UC population in Sardinia.

关键词： Inflammatory bowel disease-basic Inflammatory bowel disease-clinical Ulcerative colitis Epidemiology Natural history Treatment