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Proficiency score as a predictor of early trifecta achievement during the learning curve of robot-assisted radical prostatectomy for high-risk prostate cancer:Results of a multicentric series

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Current Urology 2024年第2期18卷 110-114页

作者： Umberto Anceschi Rocco Simone Flammia Antonio Tufano Michele morelli Antonio Galfano Lorenzo Giuseppe Luciani Leonardo Misuraca Paolo Dell’Oglio Gabriele Tuderti Aldo Brassetti Maria Consiglia Ferriero Alfredo Maria Bove Riccardo Mastroianni Francesco Prata Isabella Sperduti Giovanni Petralia SilviaSecco Ettore Di Trapani DanieleMattevi Tommaso Cai Aldo Massimo Bocciardi Giuseppe Simone Department of Urology IRCCS“Regina Elena”National Cancer InstituteRomeItaly Urologic Clinic Department of Maternal-Child and Urologic SciencesSapienza University of RomeItaly Ospedale Niguarda Ca’Granda Department of UrologyMilanItaly Department of Urology APSS Santa Chiara Regional HospitalTrentoItaly Department of Biostatistical Unit IRCCS Regina Elena National Cancer InstituteRomeItaly

Background:Recently,an innovative tool called“proficiency score”was introduced to assess the learning curve for robot-assisted radical prostatectomy(RARP).However,the initial study only focused on patients with low-risk prostate cancer forwhompelvic lymph node dissection(PLND)was not *** address this issue,we aimed to validate proficiency scores of a contemporarymulticenter cohort of patients with high-risk prostate cancer treated with RARP plus extended PLND by trainee *** andmethods:Between 2010 and 2020,4 Italian institutional prostate-cancer datasets weremerged and queried for“RARP”and“high-risk prostate cancer.”High-risk prostate cancer was defined according to the most recent European Association of Urology guidelines as follows:prostate-specific antigen>20 ng/mL,International Society ofUrological Pathology≥4,and/or clinical stage(cT)≥2c on preoperative *** selected cohort(n=144)included clinical cases performed by trainee surgeons(n=4)after completing their RARP learning curve(50 procedures for low-risk prostate cancer).The outcome of interest,the proficiency score,was defined as the coexistence of all the following criteria:a comparable operation time to the interquartile range of the mentor surgeon at each center,absence of any significant perioperative complications Clavien-Dindo Grade 3–5,no perioperative blood transfusions,and negative surgical margins.A logistic binary regression model was built to identify the predictors of 1-year trifecta achievement in the trainee *** all statistical analyses,a 2-sided p<0.05 was considered ***:A proficiency score was achieved in 42.3%*** univariable level,proficiency score was associated with 1-year trifecta achievement(odds ratio,8.77;95%confidence interval,2.42–31.7;p=0.001).After multivariable adjustments for age,nerve-sparing,and surgical technique,the proficiency score independently predicted 1-year trifecta achievement(odds ratio,9.58;95%confidence i

关键词： Trifecta Learning curve Robot-assisted radical prostatectomy High-risk prostate cancer

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Pathophysiological aspects of diverticular disease of colon and role of large bowel motility

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World Journal of Gastroenterology 2003年第10期9卷 2140-2142页

作者： Gabrio Bassotti Fabio Chistolini Antonio morelli Clinica di Gastroenterologia ed Epatologia Dipartimento di Medicina Clinica e SperimentaleUniversità di PerugiaItaly

Colonic diverticular disease (diverticulosis) is one of the most common gastrointestinal disorders in Western countries. This disorder is strictly related to aging and fibre intake, and still bears a discrete amount of morbidity. Numerous etiological co-factors have to date been implicated in the pathogenesis of the disease, yet the supporting evidence is still far from absolute. The present review considers the pathophysiology of colonic diverticular disease, with a special emphasis on factors related to abnormal colonic motility.

关键词： Colon Diverticulosis, Colonic Gastrointestinal Motility Humans

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Toward a definition of colonic inertia

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World Journal of Gastroenterology 2004年第17期10卷 2465-2467页

作者： Gabrio Bassotti Giuseppede Roberto Luca Sediari Antonio morelli Gastroenterology and Hepatology section Department of Clinical and Experimental MedicineUniversity of Perugia Medical SchoolPerugia 06131Italy

Chronic constipation is a relatively frequent symptom; among its subtypes, the so called-colonic inertia represents a disease condition that is often considered for surgery. However, to date, there has been no agreement on definition of colonic inertia, and a literature review showed that this definition was given to numerous entities that differ from each *** this paper these concepts are reviewed and a more stringent definition of colonic inertia is proposed.

关键词： Gastrointestinal Motility Chronic Disease Constipation Humans

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Debris flow hazard assessment by means of numerical simulations:implications for the Rotolon creek valley(Northern Italy)

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Journal of Mountain Science 2017年第4期14卷 636-648页

作者： SALVATICI Teresa morelli Stefano PAZZI Veronica FRODELLA William FANTI Riccardo Department of Earth Sciences University of FlorenceVia La Pira 450121Firenze(Italy)

On 4th November 2OLO, a debris flow detached from a large debris cover accumulated above the lowermost portion of the Rotolon landslide （Vicentine Pre-AIps, NE Italy） and channelized in the valley below within the Rotolon Creek riverbed. Such event evolved into a highly mobile and sudden debris flow, damaging some hydraulic works and putting at high risk four villages located along the creek banks. A monitoring campaign was carried out by means of a ground based radar interferometer （GB-InSAR） to evaluate any residual displacement risk in the affected area and in the undisturbed neighbouring materials. Moreover, starting from the current slope condition, a landslide runout numerical modelling was performed by means of DAN-3D code to assess the impacted areas, flow velocity, and deposit distribution of the simulated events. The rheological parameters necessary for an accurate modelling were obtained through the back analysis of the 2010 debris flow event. Back analysis was calibrated with all of the available terrain data coming from field surveys and ancillary documents, such as topographic, geomorphological and geological maps, with pre- and post-event LiDAR derived DTMs, and with orthophotos. Finally, to identify new possible future debris flow source areas as input data for the new modelling, all the obtained terrain data were reanalysed and integrated with the GB-InSAR displacement maps; consequently, new simulations were made to forecast future events. The results show that the integration of the selected modelling technique with ancillary data and radar displacement maps can be a very useful tool for managing problems related to debris flow events in the examined area.

关键词： Debris flow DAN-3D GB-InSAR Numerical modelling Deep Seated Gravitational Slope Deformation (DSGSD) Rotolon Creek

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Diet and habitat affinities in six raptor species in India

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Avian Research 2018年第4期9卷 354-362页

作者： Satish Pande Reuven Yosef federic. morelli Rajkumar Pawar Ram Mone ELA Foundation C-9 Bhosale ParkSahakarnagrPune 411009India Department of Environmental Sciences Savitribai Phule Pune UniversityGaneshkhindPune 411007India Ben Gurion University of the Negev-Eilat Campus P.O.Box 27288000 EilatIsrael Department of Applied Geoinformatics and Spatial Planning Faculty of Environmental SciencesCzech University of Life Sciences PragueKamycká129165 00 Prague 6Czech Republic

Background: Sympatric species adapt to, and temporally or geographically segregate access to similar limiting ***: We compared nesting habitat and diet affinities of six raptor species in central India between the years ***: A large composition of reptiles in the diet was characteristic for Circaetus gallicus, Spilornis cheela and Elanus caeruleus, while Aquila fasciata, Falco chicquera and Nisaetus cirrhatus show a higher proportion of birds. Species with greatest similarity of diet were C. gallicus and S. cheela. Considering the environmental characterization of areas where raptors built the nest, some species were ecologically closer than others. N. cirrhatus and S. cheela were related to the presence of water bodies, dry deciduous forest and evergreen forests, while E. caeruleus and C. gallicus preferred more open habitats. A. fasciata bred either on cliffs or trees, F. chicquera on trees or mobile towers, and the other four species built their nests exclusively in ***: We conclude that although there was overlap in diet and nesting ecology for a number of species, the geographical separation likely limits competition for resources.

关键词： Raptor species Diet Breeding area Niche overlap Resource partitioning

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Bio-feedback treatment of fecal incontinence: Where are we, and where are we going?

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World Journal of Gastroenterology 2005年第31期11卷 4771-4775页

作者： Giuseppe Chiarioni Barbara Ferri Antonio morelli Guido Iantorno Gabrio Bassotti Gastroenterological Rehabilitation Division of the University of Verona Gastroenterology and Digestive Endoscopy Institute Gastroenterology and Hepatology Section Digestive Motility Unit

Fecal incontinence is a disabling disease, often observed in young subjects, that may have devastating psycho-social consequences. In the last years, numerous evidences have been reported on the efficacy of bio-feedback techniques for the treatment of this disorder. Overall, the literature data claim a success rate in more than 70% of cases in the short term. However, recent controlled trials have not confirmed this optimistic view, thus emphasizing the role of standard care. Nonetheless, many authors believe that this should be the first therapeutic approach for fecal incontinence due to the efficacy, lack of side-effects,and scarce invasiveness. Well-designed randomized,controlled trial are eagerly awaited to solve this therapeutic dilemma.

关键词： Biofeedback Fecal incontinence

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应用中央前回磁化率定性和定量指标对上运动神经元受损为主的肌萎缩侧索硬化症的诊断准确性

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国际医学放射学杂志 2024年第1期 124-125页

作者： F.Lo Russo V.E.Contarino G.Conte C.morelli F.Trogu S.Casale 吴梦琳

摘要目的比较定性和定量评估中央前回磁化率在检测以上运动神经元（UMN）损伤为主的肌萎缩侧索硬化症（ALS）的诊断准确性。方法回顾性收集47例ALS病人的临

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Normal aspects of colorectal motility and abnormalities in slow transit constipation

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World Journal of Gastroenterology 2005年第18期11卷 2691-2696页

作者： Gabrio Bassotti Giuseppe de Roberto Danilo Castellani Luca Sediari Antonio morelli Gastroenterology and Hepatology Section Department of Clinical and Experimental Medicine University of Perugia Medical School Perugia Italy

Human colonic motility is a relatively difficult topic to investigate. However, the refinement of manometric techniques in recent years enabled us to study both the proximal and distal segments of the viscus. The present paper reviews our knowledge about normal aspects of colorectal motility in man and the abnormalities found in slow transit constipation (STC), one of the most frequent and difficult to treat subtypes of constipation. An internetbased search strategy of the Medline and Science Citation Index was performed using the keywords colon, colonic, colorectal, constipation, slow transit, motility, rectal, rectum in various combinations with the Boolean operators AND, OR and NOT. Only articles related to human studies were used, and manual cross-referencing was also performed. Most of colonic motor activity is represented by single nonpropagated contractions, rarely organized in bursts; this activity is maximal during the day, especially after waking and following meals. In addition, a specialized propagated activity with propulsive features is detectable, represented by high-and low-amplitude propagated contractions. In the severe form of constipation represented by the slow transit type, the above motor activity is completely deranged. In fact, both basal segmental activity (especially in response to meals) and propagated activity (especially that of high amplitude) are usually decreased, and this may represent a physiologic marker of this disorder. Human colonic motor activity is quite a complex issue, still only partly understood and investigated, due to anatomic and physiological difficulties. In recent years, however, some more data have been obtained, even in proximal segments. These data have helped in elucidating, although only in part, some pathophysiological mechanisms of chronic constipation, and especially of the STC subtype.

关键词： Colonic motility Constipation Slow transit

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Cell-based therapy in Alzheimer's disease: can human fetal cholinergic neurons “untangle the skein”?

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Neural Regeneration Research 2018年第12期13卷 2105-2107页

作者： Giulia Guarnieri Erica Sarchielli Gabriella B.Vannelli Annamaria morelli Anatomy and Histology Unit Department of Clinical and Experimental Medicine University of Florence

Alzheimer＇s disease（AD）is a devastating neurodegenerative disorder and the most common form of old-age *** disease is characterized by a progressive decline in cognitive functions,gradual loss of memory and ability... 详细信息

关键词： untangle the skein can human fetal cholinergic neurons Cell-based therapy in Alzheimer’s disease

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Manometric assessment of idiopathic megarectum in constipated children

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World Journal of Gastroenterology 2005年第38期11卷 6027-6030页

作者： Giuseppe Chiarioni Giuseppe de Roberto Alessandro Mazzocchi Antonio morelli Gabrio Bassotti Gastroenterological Rehabilitation Division of the University of Verona Gastroenterology and Hepatology Section

AIM: Chronic constipation is a frequent finding in children. In this age range, the concomitant occurrence of megarectum is not uncommon. However, the definition of megarectum is variable, and a few data exist for *** studied anorectal manometric variables and sensation in a group of constipated children with megarectum defined by radiologic criteria. Data from this group were compared with those obtained in a similar group of children with recurrent abdominal ***: Anorectal testing was carried out in both groups by standard manometric technique and rectal balloon expulsion ***: Megarectum patients displayed discrete abnormalities of anorectal variables and sensation with respect to controls. In particular, the pelvic floor function appeared to be impaired in most ***: Constipated children with megarectum have abnormal anorectal function and sensation. These findings may be helpful for a better understanding of the pathophysiological basis of this condition.

关键词： Constipation Manometry Megarectum

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