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The carbon fluxes in different successional stages:modelling the dynamics of tropical montane forests in South Ecuador

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Forest Ecosystems 2017年第2期4卷 143-153页

作者： sebastian paulick claudia dislich jürgen homeier rico fischer andreas huth Department of Ecological Modelling Helmholtz Centre for Environmental Research-UFZPermoserstr1504318 LeipzigGermany Georg-August-University Gottingen Plant EcologyUntere KarspOle 237073 GottingenGermany University of Osnabriick Institute of Environmental Systems ResearchBarbarastr1249076 OsnabruckGermany iDiv German Centre for Integrative Biodiversity Research(iDiv)Halle-Jena-LeipzigDeutscher Platz 5e04103 LeipzigGermany

Background： Tropical forests play an important role in the global carbon（C） ***, tropical montane forests have been studied less than tropical lowland forests, and their role in carbon storage is not well *** forests are highly endangered due to logging, land-use and climate *** objective was to analyse how the carbon balance changes during forest ***： In this study, we used a method to estimate local carbon balances that combined forest inventory data with process-based forest *** utilised such a forest model to study the carbon balance of a tropical montane forest in South Ecuador, comparing two topographical slope positions（ravines and lower slopes vs upper slopes and ridges）.Results： The simulation results showed that the forest acts as a carbon sink with a maximum net ecosystem exchange（NEE） of 9.3 Mg C？（ha？yr）-1during its early successional stage（0–100 years）.In the late successional stage, the simulated NEE fluctuated around zero and had a variation of 0.77 Mg C？（ha？yr）–*** simulated variability of the NEE was within the range of the field *** discovered several forest attributes（e.g., basal area or the relative amount of pioneer trees） that can serve as predictors for NEE for young forest stands（0–100 years） but not for those in the late successional stage（500–1,000 years）.In case of young forest stands these correlations are high, especially between stand basal area and ***： In this study, we used an Ecuadorian study site as an example of how to successfully link a forest model with forest inventory data, for estimating stem-diameter distributions, biomass and aboveground net primary *** conclude, this study shows that process-based forest models can be used to investigate the carbon balance of tropical montane *** this model it is possible to find hidden relationships between forest attributes and forest carbon *** relationships promote a better understandin

关键词： Forest model Tropical montane forest Forest succession Carbon balance Forest productivity FORMIND

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Relationship between MODIS-NDVI data and wheat yield: A case study in Northern Buenos Aires province, Argentina

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Information Processing in Agriculture 2015年第2期2卷 73-84页

作者： Mariano F.Lopresti Carlos M.Di Bella Américo j.Degioanni Instituto Nacional de Tecnología Agropecuaria(INTA) EEA PergaminoRuta 32 km 4.5Pergamino 2700Buenos AiresArgentina INTA-Castelar CNIAInstituto de Clima y AguaLas Cabanas y Los Reseros S/NHurlingham 1686Buenos AiresArgentina UNRC Facultad de Agronomía y VeterinariaDepartamento de Ecología AgrariaRuta Nacional 36 km 601Río Cuarto 5800Co´rdobaArgentina CONICET–Consejo Nacional de Investigaciones Científicas y Técnicas Argentina

In countries like Argentina,whose economy depends heavily on crop production,the estimation of harvests is an elementary *** providing objectivity,the use of remote sensing allows estimating yield in *** the time of maximum leaf area in wheat corresponds with the critical period of the crop,a good relationship is expected between the Normalized Difference Vegetation Index(NDVI)and *** present study was carried out in the North of Buenos Aires province,*** on the type of soil,the study area can be divided into two homogeneous subzones:a subzone with lower clay content in the southwestand a subzone with higher clay content in the *** growing seasons(2003–2011)were *** the first five years,an empirical model was calibrated and validated with field-observed wheat yields and MOD13q1 product-NDVI data,whereas in the other four years,the calibrated model was applied by means of yield maps and by comparing with official *** MOD13q1 image corresponding to julian day 289 showed the best fit between NDVI and yield to estimate wheat yield *** yield maps,better weather conditions showedhigher yields and higher soil productivity presented a greater proportion of the area occupied by higher *** department level,an R2 value of 0.75 was found after relating the estimation of the calibrated empirical model with official *** method used allows predicting wheat yield 30 days before *** yield maps,the NDVI perceived the temporal and spatial variability in the study area.

关键词： Remote sensing Wheat NDVI Yield Empirical models MODIS

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Promoter engineering enables precise metabolic regulation towards efficientβ-elemene production in Ogataea polymorpha

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Synthetic and Systems Biotechnology 2024年第2期9卷 234-241页

作者： Min Ye jiaoqi Gao jingjing Li Wei Yu Fan Bai Yongjin j.Zhou Division of Biotechnology Dalian Institute of Chemical PhysicsChinese Academy of Sciences457 Zhongshan RoadDalian116023PR China CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023PR China Dalian Key Laboratory of Energy Biotechnology Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023PR China University of Chinese Academy of Sciences Beijing100049PR China

Precisely controlling gene expression is beneficial for optimizing biosynthetic pathways for improving the ***,promoters in nonconventional yeasts such as Ogataea polymorpha are always limited,which results in incompatible gene ***,we expanded the promoter library in *** based on transcriptional data,among which 13 constitutive promoters had the strengths ranging from 0–55%of PGAP,the commonly used strong constitutive promoter,and 2 were growth phase-dependent ***,2 hybrid growth phase-dependent promoters were constructed and characterized,which had 2-fold higher ***,promoter engineering was applied to precisely regulate cellular metabolism for efficient production ofβ-*** glyceraldehyde-3-phosphate dehydrogenase gene GAP was downregulated to drive more flux into pentose phosphate pathway(PPP)and then to enhance the supply of acetyl-CoA by using phosphoketolase-phosphotransacetylase(PK-PTA)*** with the phase-dependent expression of synthase module(ERG20∼LsLTC2 fusion),the highest titer of 5.24 g/L with a yield of 0.037 g/(g glucose)was achieved in strain YY150U under fed-batch fermentation in shake *** work characterized and engineered a series of promoters,that can be used to fine-tune genes for constructing efficient yeast cell factories.

关键词： Promoter library Growth phase-dependent promoters Promoter engineering Precise metabolic regulation Ogataea polymorpha

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The global stability and optimal control of the COVID-19 epidemic model

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International journal of Biomathematics 2024年第1期17卷 1-28页

作者： Fengsheng Chien Hassan Saberi Nik Mohammad Shiraziant j.F.Gomez-Aguilar School of Finance and Accounting Fuzhou University of International Studies and Trade Fuzhou 352020 P.R.China Faculty of Business City university of Macao Macao 999078P.R.China Department of Mathematics and Statistics University of Neyshabur NeyshaburIran CONACyT-Tecnologico Nacional de Mécico/CENIDET Interior Internado Palmira S/N Col.Palmira C.P.62490CuernavacaMorelosMérico

This paper considers stability analysis of a Susceptible-Exposed-Infected-Recovered-Virus(SEIRV)model with nonlinear incidence rates and indicates the severity and weakness of control factors for disease *** Lyapunov function using Volterra-Lyapunov matrices makes it possible to study the global stability of the endemic equilibrium *** optimal control strategy is proposed to prevent the spread of coronavirus,in addition to governmental *** objective is to minimize together with the quantity of infected and exposed individuals while minimizing the total costs of treatment.A numerical study of the model is also carried out to investigate the analytical results.

关键词： Global stability SEIRV epidemic model dynamical systems Volterra-Lyapunov stability optimal control

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Brain metastasis in advanced colorectal cancer： results from the South Australian metastatic colorectal cancer (SAmCRC) registry

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Cancer Biology & Medicine 2017年第4期14卷 371-376页

作者： Gonzalo Tapia rico Timothy j. Price Christos Karapetis Cynthia Piantadosi Rob Padbury Amitesh Roy Guy Maddern james Moore Scott Carruthers David Roder Amanda R. Townsend Department of Medical Oncology The Queen Elizabeth Hospital and University of Adelaide Adelaide SA 5011 Australia Department of Medical Oncology Flinders Medical Center and Flinders University Adelaide SA 5042 Australia Department of Surgery Flinders Medical Center Bedford Park SA 5042 Australia Department of Surgery The Queen Elizabeth Hospital Adelaide SA 5011 Australia Department of Surgery University of South Australia Adelaide SA 5005 Australia Department of Surgery Royal Adelaide Hospital Adelaide SA 5000 Australia Department of Radiation Oncology Royal Adelaide Hospital Adelaide SA 5000 Australia Department of Epidemiology University of South Australia Adelaide SA 5005 Australia

Objective:Brain metastasis is considered rare in metastatic colorectal cancer(mCRC);thus,surveillance imaging does not routinely include the *** reported incidence of brain metastases ranges from 0.6% to 3.2%.Methods:The South Australian mCRC Registry(SAmCRC)was analyzed to assess the number of patients presenting with brain metastasis during their *** to small numbers,a descriptive analysis is ***:Only 59 patients of 4,100 on the registry at the time of analysis had developed brain metastasis(1.4%).The clinical characteristics of those with brain metastasis were as follows:the median age was 65.3 years and 51% were *** the V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS)mutation status of the tumor was known,the majority harbored a KRAS mutation(55%);31(53%)underwent craniotomy and 55(93%)underwent whole-brain *** median survival time from diagnosis of brain metastasis was 4.2 months(95% confidence interval 2.9–5.5).Patients who underwent craniotomy and radiotherapy had superior survival compared to those who underwent whole-brain radiotherapy(8.5 months vs.2.2 months,respectively).Data from the SAmCRC(a population-based registry)confirm that brain metastases are rare and the median time to development is approximately 2 ***:Brain metastasis is a rare outcome in advanced *** within the registry tended to be female,young in age,and harbored with higher rates of KRAS *** routine surveillance brain scanning should be considered remains controversial given the relative rarity of developing brain metastases in mCRC and ultimately,most patients with central nervous system involvement die from their extracranial disease.

关键词： Brain metastasis colorectal cancer survival surveillance

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Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype

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journal of Molecular Cell Biology 2020年第7期12卷 499-514页

作者： Eduard Sarró Mónica Durán Ana rico Diana Bou-Teen Vanesa Fernández-Majada Anthony j.Croatt Karl A.Nath Maria Teresa Salcedo justin H.Gundelach Daniel Batlle Richard j.Bram Anna Meseguer Renal Physiopathology Group CIBBIM-NanomedicineVall d’Hebron Research Institute08035 BarcelonaSpain Cardiovascular Diseases Group Vall d’Hebron Research Institute08035 BarcelonaSpain Biomimetic Systems for Cell Engineering Laboratory Institute for Bioengineering of Catalonia(IBEC)The Barcelona Institute of Science and Technology(BIST)08028 BarcelonaSpain Division of Nephrology and Hypertension and Department of Medicine Mayo ClinicRochesterMN 55905USA Department of Pathology Hospital Universitari Vall d’Hebron08035 BarcelonaSpain Department of Pediatric and Adolescent Medicine College of MedicineMayo ClinicRochesterMN 55905USA Department of Biochemistry and Molecular Biology College of MedicineMayo ClinicRochesterMN 55905USA Division of Nephrology and Hypertension Northwestern University Feinberg School of MedicineChicagoIL 60611USA Department of Immunology College of MedicineMayo ClinicRochesterMN 55905USA Departament de Bioquímica i Biologia Molecular Unitat de Bioquímica de MedicinaUniversitat Autònoma de Barcelona08193 BellaterraSpain Red de Investigación Renal(REDINREN) Instituto de Salud Carlos III-FEDER28040 MadridSpain

Restoration of kidney tubular epithelium following sublethal injury sequentially involves partial epithelial–mesenchymal transition(pEMT),proliferation,and further redifferentiation into specialized tubule epithelial cells(TECs).Because the immunosuppressant cyclosporine-A produces pEMT in TECs and inhibits the peptidyl-prolyl isomerase(PPIase)activity of cyclophilin(Cyp)proteins,we hypothesized that cyclophilins could regulate TEC *** we demonstrate that in cultured TECs,CypA silencing triggers loss of epithelial features and enhances transforming growth factorβ(TGFβ)-induced EMT in association with upregulation of epithelial repressors Slug and *** pro-epithelial action of CypA relies on its PPIase *** contrast,CypB emerges as an epithelial repressor,because CypB silencing promotes epithelial differentiation,prevents TGFβ-induced EMT,and induces tubular structures in 3D *** addition,in the kidneys of CypB knockout mice subjected to unilateral ureteral obstruction,inflammatory and pro-fibrotic events were *** silencing/knockout leads to Slug,but not Snail,*** support of Slug expression depends on its endoplasmic reticulum location,where it interacts with calreticulin,a calcium-buffering chaperone related to Slug *** CypB silencing reduces ionomycin-induced calcium release and Slug upregulation,we suggest that Slug expression may rely on CypB modulation of calreticulin-dependent calcium *** conclusion,this work uncovers new roles for CypA and CypB in modulating TEC plasticity and identifies CypB as a druggable target potentially relevant in promoting kidney repair.

关键词： cyclophilins epithelial phenotype Slug TGFβ UUO fibrosis

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Modulation of IL-10/IL-10R expression by mafosfamide, a derivative of 4-hydroxycyclophosphamide, in a rat B-cell lymphoma

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BIOCELL 2012年第2期36卷 91-95页

作者： MARÍA j.rico PABLO MATAR O.GRACIELA SCHAROVSKY Instituto de Genética Experimental Facultad de Ciencias MédicasUniversidad Nacional de RosarioSanta Fe 3100(2000)RosarioArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET). Consejo de Investigaciones UNRRosarioArgentina

We have already shown that IL-10 plays an important role in immunosuppression and metastatic dissemination in the rat B-cell lymphoma L-TACB *** was suggested that the up-regulation of IL10 production and IL-10 receptor(IL-10R)expression would be part of the transition from primary tumor to metastatic phenotype and that IL-10,besides its immunosuppressive activity,may act as a growth factor for metastatic L-TACB *** treatment of L-TACB-bearing rats with a single low-dose cyclophosphamide decreased IL-10 production,reverted immunosuppression and induced the immunologic rejection of tumor metastasis without any effect on primary tumor *** current aim was to investigate the effects of cyclophosphamide on the expression of IL-10 and IL-10R on primary and metastatic L-TACB *** that cyclophosphamide is a prodrug,we used mafosfamide,a compound that yields in vitro the same active metabolites as cyclophosphamide does in *** induced down-regulation of IL-10 production and IL-10R expression on metastatic cells and,concomitantly,inhibited metastatic cell *** suggest that mafosfamide would inhibit the regulatory loop mediated by the IL-10/IL-10R system and,as a consequence,metastatic cell *** results may have a considerable impact on the design of new therapies for metastatic lymphomas.

关键词： metastasis cyclophosphamide cell proliferation

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Complexed amino acid minerals ***-glycinate chelated minerals:Impact on the performance of old laying hens

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Animal Nutrition 2024年第1期16卷 395-408页

作者： Marcos j.B.Santos Maria C.M.M.Ludke Leandro M.Silva Carlos B.V.Rabello Mércia R.Barros Fabiano S.Costa Clariana S.Santos jamille S.S.Wanderley Department of Animal Science Rural Federal University of PernambucoRecifePEBrazil Department of Veterinary Science Rural Federal University of PernambucoRecifePEBrazil

The present study was to evaluate the effect of trace minerals(Zn,Mn,and Cu)from complexed amino acid minerals(ZMCAA)and bis-glycinate chelated minerals(ZMCGly)in laying hen diets on performance,internal and external egg quality,yolk mineral deposition,intestinal morphometry,and bone *** 78 to 98 weeks of age,400 White LSL-Lite strain laying hens were distributed in a randomized design with 4 treatments with 10 replicates per *** were distributed in a 2×2 factorial arrangement using either Zn,Mn,and Cu of ZMCAA or ZMCGly source at 2 levels:low(20,20,and 3.5 mg/kg of Zn,Mn,and Cu,respectively)or high(40,40,and 7 mg/kg of Zn,Mn,and Cu,respectively).The analysis of variance was performed,and in cases where differences were observed,the means were compared using Tukey?s test(Pfed ZMCAA had higher egg production(P=0.01),egg weight(P=0.02),egg mass(P=0.01),and lower feed conversion ratio(P=0.05)compared to those fed *** ZMCAA supplementation showed higher albumen height(P=0.01),albumen weight(P=0.01),and eggshell thickness(Pfed ZMCAA exhibited superior performance,egg quality,deposition of trace minerals in the egg yolk,and bone density compared to hens fed *** this study,older laying hens supplemented with ZMCAA at lower levels demonstrated adequate levels of supplementation.

关键词： Bis-glycinates Metal-amino acids Radiodensity Trace minerals

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Prognostic factors and predictive model for in-hospital mortality following hip fractures in the elderly

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Chinese journal of Traumatology 2018年第3期21卷 163-169页

作者： j. Sanz-Reig j. Salvador Marin j. Ferrandez Martinez D. Orozco Beltran j.F. Martinez Lopez j.A. Quesada rico Department of Orthopedic Surgery Sant Joan d' Alacant University Hospital Alicante Spain Department of Medicine Miguel Hernandez University Elche Spain

Purpose： The incidence of hip fractures is increasing within the aging population. Our objective was to identify and quantify the risk factors and develop a predictive model for the in-hospital mortality among hip fracture patients older than 65 years. Methods： This is a prospective study conducted on 331 hip fracture patients older than 65 years admitted to our hospital from 2011 to 2014. Patients＇ demographics, prehospitalization residential status, pre- fracture comorbidity data, anti-aggregant and anticoagulant medication, preoperative hemoglobin value, type of fractures, type of treatments, time to surgery, and complications were recorded. Results： The average age was 83 years, 73% female, and 57% of them sustained a femoral neck fracture. In 62.8% of patients, the number of pre-fracture baseline comorbidities was 〉2. The in-hospital mortality rate was 11.4%. In multivariate analysis, age over 90 years, congestive heart failure, asthma, rheumatologic disease, lung cancer, and not taking antiaggregant medication were independently associated with in-hospital mortality. A formula and risk stratification scoring for predicting the risk for in-hospital mortality was developed, Risk-adjustment model based on these variables had acceptable accuracy for predicting in-hospital mortality （c-statistic 0.77）. Conclusion： Advanced age, and five prefracture comorbidities have a strong association with in-hospital mortality in a hip fracture patient older than 65 years old. Our predictive model was specifically designed for the old hip fracture population. It has an accuracy similar to other risk models. The specificity, positive predictive value, and negative predictive value are high. In addition, it could discriminate a high risk patient from a low risk patient for in-hospital mortality.

关键词： Hip fractures In-hospital mortality Prognostic factors Elder population

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Biomass gasification,catalytic technologies and energy integration for production of circular methanol:New horizons for industry decarbonisation

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journal of Environmental Sciences 2024年第6期140卷 306-318页

作者： Luis F.Bobadilla Lola Azancot Miriam González-Castañ Estela Ruíz-López Laura Pastor-Pérez Francisco j.Durán-Olivencia Runping Ye Katie Chong Paula HBlanco-Sánchez Zenthao Wu Tomás R.Reina joséA.Odriozola Departamento de Química Inorgánica e Instituto de Ciencia de Materiales de Sevilla Centro Mixto CSIC-Universidad de SevillaAvda.Américo Vespucio 49Sevilla 41092Spain Departamento de Ingeniería Universidad Loyola AndalucíaAvda.de Las Universidades s/nSevilla 41704Spain Key Laboratory of jiangxi Province for Environment and Energy Catalysis School of Chemistry and Chemical EngineeringNanchang UniversityNanchang330031China Energy and Bioproducts Research Institute(EBRI) Aston UniversityBirminghamB47ETUnited Kingdom Department of Chemical and Process Engineering University of SurreyGuildfordGU27XHUnited Kingdom

The Intergovernmental Panel on Climate Change(IPCC)recognises the pivotal role of renewable energies in the future energy system and the achievement of the zero-emission *** implementation of renewables should provide major opportunities and enable a more secure and decentralised energy supply *** fuels provide long-term solutions for the transport sector,particularly for applications where fuels with high energy density are *** addition,it helps reducing the carbon footprint of these sectors in the *** on biomass characteristics feedstock is essential for scaling-up gasification from the laboratory to *** review deals with the transformation biogenic residues into a valuable bioenergy carrier like biomethanol as the liquid sunshine based on the combination of modified mature technologies such as gasification with other innovative solutions such as membranes and microchannel *** abatement is a critical process in product gas upgrading since tars compromise downstream processes and equipment,for this,membrane technology for upgrading syngas quality is discussed in this *** reactor technology with the design of state-of-the-art multifunctional catalysts provides a path to develop decentralised biomethanol synthesis from biogenic ***,the development of a process chain for the production of(i)methanol as an intermediate energy carrier,(ii)electricity and(iii)heat for decentralised applications based on biomass feedstock flexible gasification,gas upgrading and methanol synthesis is analysed.

关键词： Biogenic residues Gasification Biomethanol Circular Economy Microreactors

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