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A Comprehensive Study of the Association between LEPR Gene rs1137101 Variant and Risk of Digestive System Cancers

Biomedical and Environmental Sciences 2024年第5期37卷 445-456页

作者： HU Wei Qiong ZHOU Wei Guang ZHOU Guang Wei LIAO Jia Xi SHI Jia Xing XIE fengYang LI Shou Heng WANG Yong feng xian hong GU Xiu Li CHEN Bi feng Department of Biological Science and Technology School of ChemistryChemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070HubeiChina Institute of WUT-AMU Wuhan University of TechnologyWuhan 430070HubeiChina Department of Clinical Laboratory Wuhan Xinzhou District People’s HospitalWuhan 430499HubeiChina Department of Reproductive Genetics Wuhan Huake Reproductive HospitalWuhan 430013HubeiChina

Objective The leptin receptor,encoded by the LEPR gene,is involved in tumorigenesis.A potential functional variant of LEPR,rs1137101(Gln223Arg),has been extensively investigated for its contribution to the risk of digestive system(DS)cancers,but results remain conflicting rather than ***,we performed a case–control study and subsequent meta-analysis to examine the association between rs1137101 and DS cancer *** A total of 1,727 patients with cancer(gastric/liver/colorectal:460/480/787)and 800 healthy controls were *** of rs1137101 was conducted using a polymerase chain reactionrestriction fragment length polymorphism(PCR-RFLP)assay and confirmed using Sanger ***-four eligible studies were included in the *** After Bonferroni correction,the case–control study revealed that rs1137101 was significantly associated with the risk of liver cancer in the Hubei Chinese *** meta-analysis suggested that rs1137101 is significantly associated with the risk of overall DS,gastric,and liver cancer in the Chinese *** The LEPR rs1137101 variant may be a genetic biomarker for susceptibility to DS cancers(especially liver and gastric cancer)in the Chinese population.

关键词： LEPR gene rs1137101 Digestive system cancers Genetic susceptibility Meta-analysis

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An Investigation of the Effects of B7-H4 Gene rs10754339 and miR-125a Gene rs12976445 on Cancer Susceptibility

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生物医学与环境科学:英文版 2023年第9期36卷 814-825页

作者： JIN Yu Chen DONG Li Juan YANG Qin Yue XIONG Wei Ning WANG Wei Yi feng xian hong YU Wei HUANG Wei CHEN Bi feng Department of Biological Science and Technology School of ChemistryChemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430081HubeiChina Department of Biotechnology Institute of WUTAMUWuhan University of TechnologyWuhan 430081HubeiChina Department of Clinical Laboratory Wuhan Xinzhou District People's HospitalWuhan 430400HubeiChina Department of Air Crew Service School of Civil AviationWuhan Business and Trade Vocational CollegeWuhan 430062HubeiChina

Objective To investigate the effects of the B7-H4 gene rs10754339 and miR-125a gene rs12976445 on cancer susceptibility through a case-control study and *** A total of 1,490 cancer patients(lung/gastric/liver/:550/460/480)and 800 controls were recruited in this case-control *** meta-analysis was performed by pooling the data from previous related studies and the present *** The results of this study showed that in the Hubei Han Chinese population,the rs10754339gene was significantly associated with the risk of lung and gastric cancer but not liver cancer,and the rs12976445 gene was significantly associated with the risk of lung cancer but not liver or gastric *** meta-analysis results indicated that rs10754339 and rs12976445 contributed to cancer susceptibility in the Chinese population and also revealed a significant association between rs10754339and breast cancer risk,as well as between rs12976445 and lung cancer *** The B7-H4 gene rs10754339 and miR-125a gene rs12976445 may be the potential genetic markers for cancer susceptibility in the Chinese population,which should be validated in future studies with larger sample sizes in other ethnic populations.

关键词： B7-H4 gene miR-125a gene rs10754339 rs12976445 Cancer susceptibility

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The rs2227481 C>T Polymorphism in the IL22 Gene Promoter Significantly Reduces the Risk of Liver,Lung,and Gastric Cancer in a Han Chinese Population

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Biomedical and Environmental Sciences 2021年第7期34卷 572-576页

作者： CHAI Long Long XIAO Ying Xuan MENG Ling Han WANG Huan feng xian hong GU Xiu Li LI Qi Chang XIONG Qian Tao CHEN Bi feng Department of Biological Science and Technology School of ChemistryChemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070HubeiChina Department of Biotechnology Institute of WUT-AMUWuhan University of TechnologyWuhan 430070HubeiChina Clinical Laboratory Wuhan Xinzhou District People's HospitalWuhan 430400HubeiChina Center of Reproductive Medicine Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074HubeiChina Department of Reproductive Genetics Wuhan Tongji Reproductive Medicine HospitalWuhan 430010HubeiChina Department of Laboratory Maternal and Child Health Hospital of Hubei ProvinceWuhan 430070HubeiChina

Cancer is a serious threat to public health and the economy *** data from the World Health Organization(WHO)in 2018 have demonstrated that lung cancer is the most commonly diagnosed cancer(11.6%of the total cases)and the leading cause of cancer death(18.4%of the total cancer deaths),closely followed bygastric cancer(5.7%and 8.2%),and liver cancer(4.7%and 8.2%).

关键词： IL22 Cancer Gastric

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Evaluation of transmission risk of respiratory particles under different ventilation strategies in an elevator

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Building Simulation 2024年第5期17卷 771-784页

作者： Liangyu Zhu xian Li Bujin feng Fan Liu School of Civil Engineering and Architecture Linyi UniversityLinyi276000China College of Agriculture Shandong Agricultural UniversityTaian271018China School of Environment and Architecture University of Shanghai for Science and TechnologyShanghai200093China

People in elevators are at risk of respiratory infection because the elevator cabin is crowded and has poor *** exhaled particles may be inhaled by the susceptible person,deposited on the surface and suspended in the elevator,which can result in direct and indirect ***,whether the air vent designs adopted in the elevator can effectively reduce the transmission risk of respiratory particles remains *** this study,the dispersion of particles under four common ventilation strategies used in the commercial elevator was investigated by proven computational fluid dynamics(CFD)*** flow field was simulated with the RNG κ-ξ turbulence model and the Lagrangian method was adopted to track particle *** effects of air vent layout and airflow rate on particle transmission were *** found that more than 50% of exhaled particles(average value)were suspended in the cabin and difficult to discharge under the investigated ventilation *** deposited fraction of particles on the susceptible person reached up to 39.14% for infiltration ventilation,which led to a high risk of contact *** the ventilation rate could not significantly reduce the inhalation proportion of particles due to the poor airflow distribution inside the elevator.A more proper ventilation strategy should be explored for the elevator to control transmission risk.

关键词： particle dispersion transmission risk elevator ventilation strategy computational fluid dynamics(CFD)

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3个高香茶树品种(系)制作沙县红边茶香气特征研究

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茶叶学报 2024年第3期65卷 1-10页

作者：李鑫磊陈泉宾孔祥瑞杨卫琼冯鸿弦林忠平陈常颂福建省农业科学院茶叶研究所福建福州350013 三明市沙县区良种繁育场福建三明365504 三明市沙县区经济作物技术推广中心福建三明365500 福建省沙县宏苑茶业有限公司福建三明365501 国家茶树改良中心福建分中心福建福州350013

【目的】明确高香茶树品种(系)制成的沙县红边茶(下称红边茶)香气品质及香气特征,加快茶树良种应用,促进红边茶产业发展。【方法】以沙县当地推广种植的高香乌龙茶品种(系)‘0318E’‘黄玫瑰’和‘茗科1号’为原料,‘福建水仙’为对照,... 详细信息

【目的】明确高香茶树品种(系)制成的沙县红边茶(下称红边茶)香气品质及香气特征,加快茶树良种应用,促进红边茶产业发展。【方法】以沙县当地推广种植的高香乌龙茶品种(系)‘0318E’‘黄玫瑰’和‘茗科1号’为原料,‘福建水仙’为对照,制成红边茶。采用感官审评与顶空固相微萃取结合气相色谱-质谱联用技术分别对不同品种红边茶感官品质及香气组分进行综合比较。【结果】感官审评结果表明,0318E红边茶香气花香浓郁,黄玫瑰和茗科1号红边茶为花香显;0318E与黄玫瑰红边茶滋味表现为鲜醇,茗科1号为浓醇鲜爽;在花香与滋味鲜度上新品种均明显提升。香气成分测定结果表明,0318E红边茶香气组成最为独特,其吲哚、脱氢芳樟醇、1-乙基-1H-吡咯、己酸己酯、橙花叔醇、2-戊基呋喃、β-紫罗兰酮、乙酸苯酯、3-呋喃甲醛、(Z)-3-己酸己烯酯、(E)-4,8-二甲基壬基-1,3,7-三烯、芳樟醇氧化物C等多种花果香气组分相对丰度最高;茗科1号制作的红边茶α-法呢烯、β-罗勒烯、芳樟醇和芳樟醇氧化产物等部分重要萜类物质含量较高,吲哚、脱氢芳樟醇、橙花叔醇等花果香气成分仅次于0318E。【结论】高香茶树品种(系)0318E和茗科1号制作红边茶香气品质特征鲜明,适宜进一步推广应用。

关键词：沙县红边茶高香茶树品种感官品质香气组分

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Lysosome-targeted carbon dots with a light-controlled nitric oxide releasing property for enhanced photodynamic therapy

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Chinese Chemical Letters 2024年第4期35卷 420-425页

作者： Hao Cai Xiaoyan Wu Lei Jiang feng Yu Yuxiang Yang Yan Li xian Zhang Jian Liu Zijian Li hong Bi School of Materials Science and Engineering Anhui UniversityHefei 230601China School of Chemistry and Chemical Engineering Anhui UniversityHefei 230601China School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China

The reactive oxygen species(ROS) generation efficiency is always limited by the extreme tumor microenvironment(TME), leading to unsatisfactory antitumor effects in photodynamic therapy(PDT). As a promising gas therapy molecule, nitric oxide(NO) is independent of oxygen and could even synergize ROS to enhance the therapeutic effect. However, the short half-life, instability, and uncontrollable release of exogenous NO limited the application of tumor synergistic therapy. Herein, we reported a novel kind of red-emissive carbon dots(CDs) that was capable of lysosome-targeted and light-controlled NO delivery. The CDs were synthesized by using metformin and methylene blue(MB) via a hydrothermal *** obtained metformin-MB CDs(MMCDs) exhibited a higher1O2quantum yield and NO generation efficiency under light emitting diode(LED) light irradiation. Noteworthily, the1O2could further in situ oxidize NO into peroxynitrite anions(ONOO-), which own the higher cytotoxicity against cancer *** experiments indicate that MMCDs could destruct lysosome membrane integrity and kill almost 80%of Hep G2 cells under light irradiation while very low cytotoxicity in the dark. Moreover, MMCDs significantly decreased tumor volume and weight after phototherapy in hepatoma Hep G2-bearing mice. Our study provides a new strategy for light-controlled NO generation as well as precise lysosome-targeting for enhancement of PDT efficiency.

关键词： Carbon dots Nitric oxide Lysosome-targeting Photodynamic therapy Cancer

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Addressing chemoresistance with a lipid gemcitabine nanotherapeutic strategy for effective treatment of pancreatic cancer

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Nano Research 2024年第9期17卷 8377-8388页

作者： Jiawei hong Shiyun xian Shusen Zheng Hangxiang Wang Donghai Jiang The First Affiliated Hospital NHC Key Laboratory of Combined Multi-Organ TransplantationCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesState Key Laboratory for Diagnosis and Treatment of Infectious DiseasesSchool of MedicineZhejiang UniversityHangzhou 310003China Jinan Microecological Biomedicine Shandong Laboratory Jinan 250117China

Resistance to gemcitabine in pancreatic cancer poses a significant clinical *** investigation is warranted to assess whether nano-formulation strategy can be employed to enhance the sensitivity of resistant strains to gemcitabine *** this study,using gemcitabine-resistant pancreatic cancer cell lines,we examined the therapeutic potential of a gemcitabine nanodelivery platform and assessed the ability to overcome drug resistance against resistant *** of human equilibrative nucleoside transporter 1(hENT1)led to reduced cellular uptake of gemcitabine,resulting in chemoresistance in pancreatic *** nanoparticles circumvented the entry blockade caused by hENT1 silencing through *** entry via clathrin-mediated endocytosis increased intracellular gemcitabine accumulation in gemcitabine-resistant pancreatic cancer ***,gemcitabine nanoparticles are preferential in vivo delivery to tumor tissues,likely due to the enhanced permeability and retention *** comparison to free gemcitabine,gemcitabine nanoparticles demonstrate a more pronounced cytotoxic effect on gemcitabine-resistant pancreatic cancer cells,with favorable *** study improved the efficacy of gemcitabine through nanotechnology,providing a novel strategy to address gemcitabine-resistant pancreatic cancer.

关键词： pancreatic cancer gemcitabine resistance gemcitabine nanoparticle human equilibrative nucleoside transporter 1

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Nanomedicine Disrupts Stromal Barriers to Augment Drug Penetration for Improved Cancer Therapy

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Chinese Journal of Chemistry 2024年第10期42卷 1175-1189页

作者： Guo-feng Luo Wei-Hai Chen xian-Zheng Zhang state Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei KeyLaboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanHubei 430079China Key Laboratoryof Biomedical Polymers of Ministry of Education&Departmentof Chemistry Wuhan UniversityWuhanHubei 430072China

Tumor stroma composing diverse extracellular matrixes(ECM)and stromal cells shapes a condensed physical barrier,which severely hampers the efficient accessibility of nanomedicine to tumor cells,especially these deep-seated in the core of *** barrier significantly compromises the antitumor effects of drug-loaded nanomedicine,revealing the remarkable importance of disrupting stromal barrier for improved tumor therapy with deep penetration *** achieve this goal,various nanoparticle-based strategies have been developed,including direct depleting ECM components via delivering anti-fibrotic agents or targeting stromal cells to suppress ECM expression,dynamic regulation of nanoparticles’physicochemical properties(i.e.,size,surface charge,and morphology),mechanical force-driven deep penetration,natural/biomimetic self-driven nanomedicine,and transcytosis-inducing *** these nanostrategies were systemically summarized in this review,and the design principles for obtaining admirable nanomedicine were *** the rapid development of nanotechnology,elaborate design of multifunctional nanomedicine provides new opportunities for overcoming the critical stromal barriers to maximize the therapeutic index of various therapies,such as chemotherapy,photodynamic therapy,and immunotherapy.

关键词： Nanomedicine Tumor stroma Deep penetration Enhanced drug perfusion Cancer therapy Drug carriers Biomaterials Nanotechnology

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Multi-Objective Optimization of VBHF in Deep Drawing Based on the Improved QO-Jaya Algorithm

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 189-202页

作者： xiangyu Jiang Zhaoxi hong Yixiong feng Jianrong Tan State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province Zhejiang UniversityHangzhou 310027China Ningbo Innovation Center Zhejiang UniversityNingbo 315100China

Blank holder force(BHF)is a crucial parameter in deep drawing,having close relation with the forming quality of sheet ***,there are different BHFs maintaining the best forming effect in different stages of deep *** variable blank holder force(VBHF)varying with the drawing stage can overcome this problem at an *** optimization of VBHF is to determine the optimal BHF in every deep drawing *** this paper,a new heuristic optimization algorithm named Jaya is introduced to solve the optimization *** improved“Quasi-oppositional”strategy is added to Jaya algorithm for improving population ***,an innovated stop criterion is added for better ***,the quality evaluation criteria for wrinkling and tearing are ***,the Kriging models are developed to approximate and quantify the relation between VBHF and forming defects under random ***,the optimization models are established and solved by the improved QO-Jaya algorithm.A VBHF optimization example of component with complicated shape and thin wall is studied to prove the effectiveness of the improved Jaya *** optimization results are compared with that obtained by other algorithms based on the TOPSIS method.

关键词： Variable blank holder force Multi-objective optimization QO-Jaya algorithm Algorithm stop criterion

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Effect of oxide inclusions on MnS precipitates and tensile mechanical property of high-strength low-alloy steel

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Journal of Iron and Steel Research International 2024年第5期31卷 1210-1220页

作者： Xiao-yong Gao hong Wei Li-feng Zhang School of Mechanical Engineering Yanshan UniversityQinhuangdao066004HebeiChina School of Materials Science and Engineering Yanshan UniversityQinhuangdao066004HebeiChina School of Mechanical and Materials Engineering North China University of TechnologyBeijing100144China

The key role of oxide inclusions on the microstructure and mechanical property of a high-strength low-alloy steel was *** field emission scanning electron microscope equipped with energy-dispersive spectrometry was used to characterize MnS *** inclusions play an important role in the shape control of MnS *** oxides fovored to decrease the size and the aspect ratio of MnS *** less oxide inclusions in the steel,approximately over 16.7%MnS precipitates were with aspect ratio a>5 and pure MnS precipitates accounted for 75.9%in ***,with more oxide inclusions in the steel,only 7.4%MnS precipitates were with a>5 and pure MnS precipitates accounted for 60.1%in *** of MnS by oxide inclusions improved the strength and inhibited the *** oxide inclusions in the steel increased the yield strength and tensile strength of the steel in both longitudinal and transverse directions,and lowered the anisotropy of the mechanical property.

关键词： High-strength low-alloy steel MnS Oxide inclusion Mechanical property Anisotropy

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