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Inhibition of histone deacetylase 2 mitigates profibrotic TGF-β1 responses in fibroblasts derived from Peyronie＇s plaque

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Asian Journal of Andrology 2013年第5期15卷 640-645页

作者： Ji-Kan Ryu Woo-Jean Kim Min-Ji Choi Jin-Mi Park Kang-Moon Song Mi-Hye Kwon nando-Dulal Das Ki-Dong Kwon Dulguun Batbold Guo-Nan Yin Jun-Kyu Suh National Research Center for Sexual Medicine and Department of Urology Inha University School of Medicine Incheon 400-711 Korea

Epigenetic modifications, such as histone acetylation/deacetylation, have been shown to play a role in the pathogenesis of fibrotic disease. Peyronie＇s disease （PD） is a localized fibrotic process of the tunica albuginea, which leads to penile deformity. This study was undertaken to determine the anti-fibrotic effect of small interfering RNA （siRNA）-mediated silencing of histone deacetylase 2 （HDAC2） in primary fibroblasts derived from human PD plaque. PD fibroblasts were pre-treated with HDAC2 siRNA and then stimulated with transforming growth factor-p1 （TGF-β1）. Protein was extracted from treated fibroblasts for Western blotting and the membranes were probed with antibody to phospho-Smad2/Smad2, phospho-Smad3/Smad3, smooth muscle α-actin and extracellular matrix proteins, including plasminogen activator inhibitor-β 1, fibronectin, collagen I and collagen IV. We also performed immunocytochemistry to detect the expression of extracellular matrix proteins and to examine the effect of HDAC2 siRNA on the TGF-β1-induced nuclear translocation of Smad2/3 in fibroblasts. Knockdown of HDAC2 in PD fibroblasts abrogated TGF-β1-induced extracellular matrix production by blocking TGF-β1-induced phosphorylation and nuclear translocation of Smad2 and Smad3, and by inhibiting TGF-β1-induced transdifferentiation of fibroblasts into myofibroblasts. Decoding the individual function of the HDAC isoforms by use of siRNA technology, preferably siRNA for HDAC2, may lead to the development of specific and safe epigenetic therapies for PD.

关键词： cell culture fibrosis histone deacetylase Peyronie's disease transforming growth factor-beta

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Prediction of Air Permeability in Hybrid Nanocomposite Based on Bromobutyl/Epichlorohydrin Rubber Blends as Tire Inner Liner Using Finite Element Method

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材料科学与工程（中英文B版） 2016年第4期6卷 169-178页

作者： Kumar Sankaran Kaushik Mukherjee Partheban Manoharan Golok B. nando Santanu Chattopadhyay Rubber Technology Centre Indian Institute of Technology Kharagpur 721302 India Department of Mechanical Engineering lndian Institute of Technology Kharagpur 721302 India

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Analytic Invariant Curves for an Iterative Equation Related to Ricker-type Second-order Equation

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Acta Mathematica Sinica,English Series 2021年第7期37卷 1041-1052页

作者： Hou Yu ZHAO Michal feCKAN School of Mathematics Chongqing Normal UniversityChongqing 401331P.R.China Department of Mathematical Analysis and Numerical Mathematics Comenius University in BratislavaMlynska dolina84248 BratislavaSlovakia Mathematical Institute of Slovak Academy of Sciences Stefanikova 4981473 BratislavaSlovakia

In this paper,we consider the existence of analytic invariant curves of an iterative equation f(f(x))=xea-x-f(x)which arises from Ricker-type second-order *** reducing the equation with the Schr?der transformation to an auxiliary equation,the author discusses not only that the parameter at resonance,i.e.,at a root of the unity,but also the parameter near resonance under the Brjuno condition.

关键词： Difference equation invariant curves analytic solution small divisor

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芪冬颐心口服液联合氢溴酸西酞普兰用于PCI术后并发焦虑状态患者的效果

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临床和实验医学杂志 2024年第11期23卷 1149-1153页

作者：张景鑫王霏常晓烨苏海燕曹文娟常生荣张家口市第一医院心内科河北张家口075000 衡水市第四人民医院检验科河北衡水053000 衡水市第四人民医院药剂科河北衡水053000

目的观察芪冬颐心口服液联合氢溴酸西酞普兰用于经皮冠状动脉介入治疗(PCI)术后并发焦虑状态患者的效果。方法回顾性选取2020年9月至2023年3月张家口市第一医院收治的首次发作急性心肌梗死后接受PCI术3个月后并发焦虑状态的40例患者... 详细信息

目的观察芪冬颐心口服液联合氢溴酸西酞普兰用于经皮冠状动脉介入治疗(PCI)术后并发焦虑状态患者的效果。方法回顾性选取2020年9月至2023年3月张家口市第一医院收治的首次发作急性心肌梗死后接受PCI术3个月后并发焦虑状态的40例患者作为研究对象。按照简单随机法将其分为对照组(n=20)和联合组(n=20)。两组均给予对症治疗,对照组给予氢溴酸西酞普兰治疗,联合组在对照组基础上联合芪冬颐心口服液治疗。评估并比较两组治疗前和治疗3个月后的汉密尔顿焦虑量表(HAMA)评分、匹兹堡睡眠质量指数量表(PSQI)评分、中医症状评分的差异,比较两组治疗前和治疗3个月后的心功能[左心室舒张末内径(LVEDD)、左心室收缩末内径(LVESD)、二尖瓣口舒张早期与晚期峰值血流速度比值(E/A)、左室射血分数(LVEF)]、B型脑钠肽(BNP)、炎症因子[高敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)]水平,统计两组主要心血管不良事件(MACE)发生率。结果治疗3个月后,联合组的总有效率为95.00%,高于对照组(70.00%),差异有统计学意义(P0.05)。结论芪冬颐心口服液联合氢溴酸西酞普兰用于PCI术后并发焦虑状态患者治疗,可减轻患者焦虑状态,提高睡眠质量,改善心功能,抑制炎症反应。

关键词：焦虑心肌梗死芪冬颐心口服液氢溴酸西酞普兰焦虑状态心功能睡眠质量炎症反应

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Assessment of Heavy Metals Contamination in Sediments of the Vridi Canal (Côte d’Ivoire)

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Journal of Geoscience and Environment Protection 2016年第10期4卷 65-73页

作者： Kouakou Adjoumani rodrigue.Benjamin Yao Albert Trokourey Adouby Kopoin Laboratoire de Chimie Physique Université Félix Houphou&#235t Boigny Abidjan C&#244te d’Ivoire Laboratoire des Procédés industriels de Synthèse de l’Environnement et des Energies Nouvelles Institut National Polytechniques Felix Houphou&#235t Boigny (INPHB) Yamoussoukro CLaboratoire de Chimie Physique Université Félix Houphou&#235t Boigny Abidjan C&#244te d’Ivoirete d’Ivoire

The concentrations of cadmium, copper, lead and zinc in sediment samples from the Vridi Canal (Harbour area of economic capital of Cote d’Ivoire) were determined to evaluate the level of contamination. All metal concentrations in sediment samples, except Cu, were greater than the concentration of Upper Continental Crust (UCC). Sediment pollution assessment was undertaken by using Enrichment Factor (EF), geoaccumulation index (Igeo) and Pollution Load Index (PLI). The enrichment factor (Cd: EF = 20.04;Pb: EF = 3.43;Zn: EF = 1.56) and géoaccumulation index (Cd: Igeo = 4.29;Pb: Igeo = 1.81) showed that the sediments were polluted. The Pollution Load Index (PLI > 1) indicated that the sediments of the studied area were heavily contaminated. Based on the comparison with sediment quality guidelines, the concentrations of cadmium, lead and zinc would be toxic to one or more species of aquatic organisms living in the sediments.

关键词： Heavy Metals Vridi Canal Contamination

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PARALLEL DYNAMIC ITERATION METHODS FOR SOLVING NONLINEAR TIME-PERIODIC DIFfeRENTIAL-ALGEBRAIC EQUATIONS

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Journal of Computational Mathematics 2003年第3期21卷 367-374页

作者： Yao-lin Jiang(Institute of Information fe System Sciences, School of Science, Xi’an Jiaotong University,Xi’an 710049, China) Institute of Information & System Sciences School of Science Xi'an Jiaotong University Xi'an 710049

In this paper we presented a convergence condition of parallel dynamic iteration methods for a nonlinear system of differential-algebraic equations with a periodic constraint. The convergence criterion is decided by the spectral expression of a linear operator derived from system partitions. Numerical experiments given here confirm the theoretical work of the paper.

关键词： Nonlinear dynamic equations Periodic solutions Dynamic iterations Engi- neering applications.

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Planning and Profit Sharing in Overlay WiFi and LTE Systems toward 5G Networks

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Journal of Software Engineering and Applications 2019年第11期12卷 491-508页

作者： Danielle Saliba rodrigue.Imad Sebastien Houcke Bachar El Hassan Signal and Communication Mines Telecom Atlantique Brest France Mechatronics University of Balamand Al Kurah Lebanon Telecommunication and Networking Lebanese University Tripoli Lebanon

With the increasing demand for data traffic and with the massive foreseen deployment of the Internet of Things (IoT), higher data rates and capacity are required in mobile networks. While Heterogeneous Networks (HetNets) are under study toward 5G technology, Wireless Fidelity (WiFi) Access Points (APs) are considered a potential layer within those multiple Radio Access Technologies (RATs). For this purpose, we have proposed in this paper a novel WiFi dimensioning method, to offload data traffic from Long Term Evolution (LTE) to WiFi, by transferring the LTE energy consuming heavy users, to the WiFi network. First, we have calculated the remaining available capacity of the WiFi network based on the estimated load of each WiFi physical channel using the overlapping characteristic of the channels. Then, we were able through this dimensioning method, to calculate the minimum needed number of WiFi APs that ensure the same or better throughput for the LTE transferred users. By this method, we have ensured additional capacity in the LTE network with minimum investment cost in the WiFi network. Finally, we have estimated the profit sharing between LTE and WiFi by considering data bundles subscription revenues and the infrastructure capital and operational costs. We have calculated for each network the profit share using a coalition game theory Shapley value that pinpoints the benefit of the cooperation using the proposed dimensioning method.

关键词： LTE WiFi Offload and Coexistence 5G Heterogeneous Networks Shapley Value Profit Sharing

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Drought Forecasting: A Bibliometric Analysis and Future Research Directions

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Journal of Environmental Protection 2022年第12期13卷 972-990页

作者： rodrigue.B. W. Vodounon Henoc Soude Ossénatou Mamadou Department of Computer Science Institute of Mathematics and Physics (IMSP) Porto-Novo Benin

Droughts represent one of the most dangerous natural disasters in the world, due to their ability to progressively spread over large areas up to continental scale, as well as their adverse environmental, human and socio-economic effects. Unfortunately, these effects are increasingly accentuated under the influence of climate change. One of the main challenges today is to mitigate the damage associated with droughts by developing tools capable of predicting the occurrence of such events in advance. Many solutions have been implemented for this purpose. But with the great progress in artificial intelligence, many scientists propose the use of Machine Learning to provide more optimal solutions to the problem related to droughts. In the present study, a bibliometric analysis was conducted to assess the current level of research on forecasting and monitoring of droughts in the world in general, particularly in West Africa through different methods based on the artificial intelligence. A search for articles on the topic was performed in the Web of Science (WoS) database, which is a global, publisher-independent citation database. The search identified a total of 3284 documents and the collected data was analyzed using a bibliometric tool called Bibliometrix. The main results are presented and discussed, followed by some potential avenues for research.

关键词： Droughts Forecasting Climate Change Bibliometric Web of Science (WoS)

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微创全髋关节置换术SuperPath入路与直接前方入路的疗效比较

微创全髋关节置换术SuperPath入路与直接前方入路的疗效比较

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作者： GLELE AHO LETONHAN rodrigue.GRACE 江苏大学

学位级别：硕士

目的:比较Super Path微创全髋关节置换术与直接前方入路(DAA)全髋关节置换术的临床效果。方法:2018年2月到2019年9月对江苏大学附属人民医院收住骨科的患者中,连续97例患者接受了单侧微创全髋关节置换术,采用了前瞻随机对照设计的方法,... 详细信息

目的:比较Super Path微创全髋关节置换术与直接前方入路(DAA)全髋关节置换术的临床效果。方法:2018年2月到2019年9月对江苏大学附属人民医院收住骨科的患者中,连续97例患者接受了单侧微创全髋关节置换术,采用了前瞻随机对照设计的方法,将患者分为两组,分别采用Super Path入路,或者采用DAA入路对以上患者进行手术。通过Harris髋关节功能评分(Harris hip score,HHS)、以及疼痛视觉模拟评分(VAS)来对比两组的临床疗效,并且将两组间的手术相关数据以及围手术期并发症进行对比。结果:Super Path组手术切口长度、手术时间以及首次下床时间都明显优于DAA组,对比两组失血量、输血率以及术后肢体长度差均无统计学差异;两组中Super Path组出现手术并发症较少。在Super Path组统计术后1个月、3个月、和6个月时HHS评分明显高于DAA组的评分(P0.05),在Super Path组术后6h、12h、和1周的VAS评分显示明显优于DAA组(P0.05)。结论:Super Path入路相比DAA入路切口更小,功能恢复更快,术后短期HHS评分功能更好,可以提供患者满意的临床结果。

关键词：全髋关节置换术微创手术 SuperPath Harris髋关节评分 VAS视觉模拟评分

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反复人工流产的发生率—前瞻性定群研究

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实用妇产科杂志 1995年第3期11卷 176-177页

作者： Skjeldestad fe

反复人工流产发生率尚无详细报道,本文目的是观察反复人工流产发生率,确定在首次人工流产时可能发生再次人工流产的危险因素。资料来自具有25万居民区中的挪威 Trandheim 大学附属医院妇产科进行人工流产的妇女,从1987年1月1日至1991年1... 详细信息

反复人工流产发生率尚无详细报道,本文目的是观察反复人工流产发生率,确定在首次人工流产时可能发生再次人工流产的危险因素。资料来自具有25万居民区中的挪威 Trandheim 大学附属医院妇产科进行人工流产的妇女,从1987年1月1日至1991年12月31日共人工流产3810人,以往有流产史的885人除外,故实际分析对象为2925名妇女(共人工流产3189次),其中7%(206人)作第2次人工流产,1%(29人)作第3次人工流产。采

关键词：代帐名化

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