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药物洗脱支架与细杆裸金属支架降低再狭窄的比较:一项前瞻性随机研究

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世界核心医学期刊文摘(心脏病学分册) 2006年第3期 46-47页

作者： pache J. Dibra A. mehilli J. A. Kastrati 刘宇 Deutsches Herzzentrum Lazarettstrasse 36 80636 Munich Germany

Aim: Drug-eluting stents have considerably reduced restenosis. Their relative merits have been assessed on the basis of comparisons made with control bare stents with thick struts. However, increased strut thickness negatively affects restenosis. no direct comparisons between drug-eluting stents and bare stents with thin struts have been performed. The aim of this study was to evaluate the relative efficacy of sirolimus-eluting stents(CypherTm) as compared with that of bare stents with thin struts(BestentTm 2). methods and results: A total of 500 patients with coronary artery disease were randomly assigned to receive a Cypher stent or Bestent. The primary endpoint was angiographic restenosis defined as a stenosis diameter ≥ 50% at 6-month angiographic follow-up. The secondary endpoint was the need for target vessel revascularization(TVR) during the year following the procedure. Follow-up angiography was performed in 81.8% of the patients. patients treated with Cypher stents had a lower angiographic restenosis rate 8.3 vs. 25.5% , relative risk, 0.33(95% confidence interval, 0.19-0.56), pnd a lower incidence of TVR 7.2 vs. 18.8% , relative risk, 0.38(0.22-0.66), por smaller vessels(mm), the angiographic restenosis rates were 7.0% with the Cypher stent and 34.2% with the Bestent(por larger vessels(≥ 2.8 mm), angiographic restenosis rates were 10.0% with the Cypher stent and 13.1% with the Bestent(p=0.52). Conclusion: The drug-eluting stent, Cypher, is associated with a significantly lower risk of restenosis compared with the bare thin-strut Bestent. The advantage of the Cypher stent is vastly reduced in large vessels.

关键词：药物洗脱支架再狭窄金属支架矿山支架

动静脉切开术(鞘膜切开术)使视网膜分支静脉阻塞处减压的血管造影表现

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 37-37页

作者： Kube T. feltgen n. pache m. 王海燕 sektion Retinologie Augenklinik Universittsklinikum Freiburg Killianstr. 5 79106 Freiburg Germany

Background: Arteriovenous dissection (sheathotomy) is a new therapeutic option in patients with branch retinal vein occlusion (BRVo) and macular involvement. We present an angiographic follow-up of 22 patients who underwent arteriovenous dissection (AVD). methods: Twenty-two patients (15 women; mean age 68.7±8.0 y ears) were examined preoperatively and 6 weeks, 3 months, 6 months, and 1 year a fter AVD. For assessment of retinal hemodynamics, arteriovenous passage time (AV p) of the affected and unaffected branches at first (AVpe) and at maximal (AVpma x) venous filling were measured. Changes in the foveal avascular zone (FAZ)were calculated to determine foveal structural changes. Visual acuity was assessed as functional parameter. Results: The early AVp (AVpe) of the affected branch incr eased from 4.4±0.8 s preoperatively to 4.9±0.6 s 6 weeks after surgery and dec reased to 2.7±0.4 s 1 year after surgery (p=0.05). When compared to the unaffec ted control branch, AVpe was significantly increased in the affected branch preo peratively (4.5±0.8 s versus 1.5±0.2 s, ps (4.9±0.6 s versus 2 .1±0.3 s, pmonths (2.7±0.4 s versus 1.5±0.2 s, p nd 6 mo nths (3.1±0.4 s versus 2.2±0.3 s, p=0.02) after AVD. After 1 year, AVpe no lon ger differed between the affected and the control branch (2.7±0.4 s versus 2.6 ±0.3 s). AVpmax was significantly increased in the affected branch preoperative ly (11.8±0.8 s versus 7.7±1.0 s, p pmax in the affected branch with the exception of 3 months after surgery (10.2±1.1 s, p s no long er elevated when compared to preoperative values. The area of the FAZ did not ch ange significantly but showed a trend for enlargement. Conclusion: AVD for decom pression of BRVo leads to a significant decrease of AVp and may ameliorate retin al perfusion in the affected branch.

关键词：动静脉切开术鞘膜血管造影无血管区受累静脉静脉充盈充盈时间视网膜功能新型治疗方法于术

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使用双源CT预先低剂量心电触发行肺静脉解剖成像

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国际医学放射学杂志 2010年第5期 503-503页

作者： p.Blanke T.Baumann m.Langer G.pache 陈柱 Department of Diagnostic Radiology University Hospital Freiburg

外力线型眼压计与Goldmann压平眼压计的比较:一项对照研究

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世界核心医学期刊文摘(眼科学分册) 2006年第1期 36-36页

作者： pache m. Wilmsmeyer s. Lautebach s. Funk J. 王永强 University Eye Clinic University of Freiburg Killianstrasse 5 79106 Freiburg Germany

Background: Various sources of error, including central corneal thickness (CCT) and structural corneal rigidity, have been proposed for Goldmann applanation tonometry (GAT). The pascal dynamic contour tonometer (DCT) is a novel device designed for intraocular pressure (Iop) measurements assumed to be largely independent of CCT and corneal curvature. We compared DCT with GAT in eyes with normal corneas of various thickness. methods: We prospectively measured Iop using DCT and GAT in random order in 100 eyes of 100 subjects (m:F=46:54; mean age 42± 19, range 23-88 years). Results: mean DCT values were about 1mmHg higher than GAT readings (16± 3 vs 15± 3 mmHg, p=0.001). Bland-Altman analysis of individual pairs of DCT and GAT measurements revealed a bias of-1.0 mmHg 95% confidence interval(CI):± 1.2. neither GAT nor DCT showed a significant correlation with CCT (533± 48, range 399-641 μ m). Conclusions: In eyes with normal corneas, DCT allows suitable and reliable Iop measurements which are in good concordance with GAT. Comparison of DCT with intracameral manometry is desirable in the future.

关键词：眼压计眼张力计 Goldmann 外力

双能量CT虚拟去钙技术:检测创伤后骨髓病变——可行性研究

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国际医学放射学杂志 2010年第5期 490-490页

作者： G.pache B.Krauss p.strohm U.saueressig p.Blanke s.Bulla 梅习龙 Department of Diagnostic Radiology University Hospital Freiburg

关键词： CT 双能量胫骨股骨下肢骨造血系统骨髓骨挫伤

sIRs评分与ApacheⅡ评分对急诊科AECopD患者预后评估的研究

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实用临床医药杂志 2009年第9期13卷 18-19,23页

作者：何平蒙玉玲海南省人民医院急救中心海南海口570102

目的探讨sIRs和ApacheⅡ两个评分系统对急诊科AECopD患者预后的评估。方法随机观察入住本院急诊ICU的80例AECopD患者,记录患者的一般情况、预后,并对全部患者入院24 h内测量各项指标,取最差值进行sIRs和A-pacheⅡ评分。根据预后将患者... 详细信息

目的探讨sIRs和ApacheⅡ两个评分系统对急诊科AECopD患者预后的评估。方法随机观察入住本院急诊ICU的80例AECopD患者,记录患者的一般情况、预后,并对全部患者入院24 h内测量各项指标,取最差值进行sIRs和A-pacheⅡ评分。根据预后将患者分为死亡组和存活组,并对两组患者的和评分的均值进行比较。结果死亡组和存活组比较,sIRs评分和ApacheⅡ评分的均值比较差异有统计学意义(pp>0.05)。结论sIRs和ApacheⅡ两个评分系统均可对急诊老年下呼吸道感染患者的预后进行评估,且sIRs数据简便易得,是一个简单、独立的评分标准。

关键词： sIRs评分 ApacheⅡ评分 AECopD 预后

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mEWs评分与ApacheⅡ评分在脑外伤患者预后预测中的对比研究

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四川医学 2009年第8期30卷 1261-1263页

作者：李银先汤道雄马国中黄可罗维绵阳市第三人民医院四川绵阳621000

目的探讨改良早期预警评分(mEWs)应用于急诊入院的脑外伤患者预后预测的可行性。方法依据事先设定的入组及排除标准,选取2007年1月～2008年3月经我院急诊收入院的连续脑外伤患者共计94例。入院即刻作为观察起点,采集相关数据或化验标本... 详细信息

目的探讨改良早期预警评分(mEWs)应用于急诊入院的脑外伤患者预后预测的可行性。方法依据事先设定的入组及排除标准,选取2007年1月～2008年3月经我院急诊收入院的连续脑外伤患者共计94例。入院即刻作为观察起点,采集相关数据或化验标本。其后对每一位患者分别进行ApacheⅡ评分及mEWs评分;3个月后为观察终点;预后作为观察指标。资料收集完后进行统计分析。结果以死亡作为预测指标时,ApacheⅡ评分界值是21分,敏感度100%,特异度94.81%;RoC曲线下面积Az=0.9809;U=39.0337;p=0.0000。mEWs评分界值是5分,特异度100%,敏感度88.31%,RoC曲线下面积Az=0.9756;U=35.2844;p=0.0000。均有较强的预测价值。在存活组中,以致残为预测目标时,ApacheⅡ评分界值是16分,Az=0.8653,U=4.2115,p=0.0000,敏感度85.10%,特异度76.00%。mEWs评分界值是3分,Az=0.8255,U=3.8424,p=0.0001。敏感度85.71%,特异度75.71%;均有中等强度预测价值。结论ApacheⅡ评分及mEWs评分对脑外伤患者愈后均具有同等预测价值,但mEWs评分结构简单,获取数据方便,省时、节省费用,故可在急诊入院脑外伤患者预后预测中推广应用。

关键词：改良早期预警评分脑外伤预测预后死亡

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