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Engineering Platelets for Combined Anticancer Therapy

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Bulletin of the Chinese Academy of Sciences 2021年第1期35卷 56-57页

作者： ipe ipe

Tumor targeting and intratumoral penetration are long-standing issues for cancer *** a recent study published inScience Advanceson March 26,researchers from the CAS Institute of Process Engineering(ipe)and the University of Chinese Academy of Sciences(UCAS)have developed a new platelet-based formulation which demonstrated potent therapeutic effects against cancer in murine models.

关键词： cancer Therapy Platelet

Addition of Urban Waste to Semiarid Degraded Soil:Long-term Effect

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Pedosphere 2007年第5期17卷 557-567页

作者： F.bastida J.L.MORENO C.GARC■A T.HERNNDEZ Department of Soil and Water Conservation Centro de Edafologia y Biologia Aplicada del Segura (CEBAS-CSIC) Campus Universitario de Espinardo30100 EspinardoMurcia (Spain).

The addition of municipal solid wastes (MSW) is considered as a possible strategy for soil rehabilitation in southeast *** objective of this study was to evaluate the long-term (17 years) effect of five doses of MSW addition on the microbiological,biochemical,and physical properties of semiarid *** values of several parameters that serve as indicators of general microbiological activity,such as,basal respiration,adenosine triphosphate (ATP) or dehydrogenase activity;microbial population size (microbial biomass C),and extracellular hydrolase activity related to macronutrient cycles,such as,urease,β-glucosidase,and N-α-benzoyl-L-argininamide protease,were observed in the amended *** highest MSW doses showed the highest values in these hydrolase *** incorporation of municipal waste resulted in a more dense development of the plant cover,50% greater in higher doses than in the control treatment,which generated a substantial increase in several C *** organic carbon reached 12 g kg^(-1) soil with the highest MSW doses, compared to 4.30 g kg^(-1) soil in the control *** physical properties of the soil were also improved,showing greater percentage of stable aggregates and water holding *** correlation coefficients between C fractions and parameters related to microbial activity and aggregate stability were *** these improvements were greater in the soils receiving the highest doses of organic amendment,the increases were not proportional to the amount added,demonstrating the existence of a threshold,above which an increase in the amount of organic matter added is not reflected in an increase in the soil's physical,biochemical,and microbiological ***,the addition of municipal solid wastes proved its suitability for improving soil quality,thereby indicating the potential of such an amendment,to prevent desertification in Mediterranean areas such as those studied.

关键词：半干旱退化土酶活力长期效应微生物量城市固体废物

Plant performance and morphofunctional differentiation in response to edaphic variation in Iberian columbines: cues for range distribution?

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Journal of Plant Ecology 2014年第4期7卷 403-412页

作者： Jesús M.bastida Pedro J.Rey Julio M.Alcántara Departamento de Biología Animal Biología Vegetal y EcologíaUniversidad de JaénParaje Las Lagunillas s/n.E-23071 JaénSpain

Aims Experimental studies of the response to environmental variation of closely related taxa are needed to understand the mechanisms underly-ing phenotypic divergence,habitat segregation and range span within a radiating *** explored the magnitude of phenotypic differenti-ation and adaptive plasticity in relation to edaphic variation and its sig-nificance for habitat segregation and range span in Iberian *** We performed a common garden experiment varying soil type(cal-careous ***)and depth(rocky-shallow ***)with two pairs of widespread and narrowly distributed subspecies of Iberian columbines:Aquilegia vulgaris(*** and nevadensis)and Aquilegia pyrenaica(*** and cazorlensis).We com-pared tolerance to edaphic variation,trait differentiation and adaptive plasticity of 10 morpho-functional traits between species and distri-bution ***,we obtained estimates of the competitive environment faced by each taxon in two to four populations per *** Findingsresults partially support hypotheses of higher competitive ability and tolerance to edaphic variation in widespread than in narrow endemic *** the species level,the widely distributed taxon was the most tolerant to edaphic *** species,no consistent pattern emerged since the population from the most widespread subspecies was the most tolerant in *** but not in *** were differentiated in many traits at species and range ***,the pattern of differentiation does not fully support the hypothesis of higher specialization and stress toler-ance in narrow *** plasticity was generally low,the results support the hypothesis of adaptive plasticity in widespread but not in restricted taxa at least at species *** differences(adaptive plasticity and competitive ability among others)may have contributed to phenotypic divergence and edaphic niche segregation,as well as to differen

关键词： Aquilegia habitat differentiation phenotypic divergence phenotypic plasticity endemism

Tracing Changes in the Microbial Community of a Hydrocarbon-Polluted Soil by Culture-Dependent Proteomics

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Pedosphere 2010年第4期20卷 479-485页

作者： F.bastida C.NICOLS J.L.MORENO T.HERNNDEZ C.GARCIA Department of Soil and Water Conservation Centro de Edafologia y Biologia Aplicada del Segura(CEBAS-CSIC)Campus Universitario de Espinardo

Hydrocarbon contamination may affect the soil microbial community, in terms of both diversity and function. A laboratory experiment was set-up, with a semi-arid control soil and the same soil but artificially contaminated with diesel oil, to follow changes in the dominant species of the microbial community in the hydrocarbon-polluted soil via proteomics. Analysis of the proteins extracted from enriched cultures growing in Luria-Bertani (LB) media showed a change in the microbial community. The majority of the proteins were related to glycolysis pathways, structural or protein synthesis. The results showed a relative increase in the complexity of the soil microbial community with hydrocarbon contamination, especially after 15 days of incubation. Species such as Ralstonia solanacearum, Synechococcus elongatus and different Clostridium sp. were adapted to contamination, not appearing in the control soil, although Bacillus sp. dominated the growing in LB in any of the treatments. We conclude that the identification of microbial species in soil extracts by culture-dependent proteomics is able to partially explain the changes in the diversity of the soil microbial community in hydrocarbon polluted semi-arid soils, but this information is much more limited than that provided by molecular methods.

关键词：微生物群落蛋白质组学污染土壤文化生物群落多样性分子生物学方法碳氢化合物跟踪

Complex patterns of environmental niche evolution in Iberian columbines (genus Aquilegia, ranunculaceae)

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Journal of Plant Ecology 2015年第5期8卷 457-467页

作者： Rafael Jaime Julio M.Alcántara Jesús M.bastida Pedro J.Rey Departamento de Biología Animal Biología Vegetal y EcologíaUniversidad de JaénCampus Las Lagunillass/n.Jaén E-23071Spain

Aims This study explores the patterns of niche differentiation in a group of seven closely related columbines(genus Aquilegia,ranunculaceae)from the Iberian *** of these columbines are subject to complex patterns of divergent selection across environ-ments,which partly explain the taxonomic structure of the *** suggests the hypothesis that niche divergence must have occurred along the process of diversification of the *** We used maxEnt to build environmental niche models of seven subspecies belonging to the three species of Aquilegia present in the Iberian *** these models,we compared the envi-ronmental niches through two different approaches:ENmtools and multivariate *** FindingsmaxEnt distributions conformed closely to the actual distribution of the study *** methods failed to uncover any clear patterns of niche differentiation or conservatism in Iberian *** analyses indicate the existence of dif-ferentiation along altitudinal gradients and along a gradient of climatic conditions determined by the summer precipitation and ***,climatic conditions related to winter tem-perature and precipitation,as well as soil properties,were equally likely to show conservatism or *** complex patterns of niche evolution we found suggest that Iberian Columbines have not been significantly constrained by forces of niche conservatism,so they could respond adaptively to the fast and profound climate changes in the Iberian Peninsula through the glacial cycles of the Pleistocene.

关键词： Aquilegia ecological niche modelling niche divergence niche conservatism evolution maxEnt ENmTools

Response of Soil Microbial Community to a High Dose of Fresh Olive Mill Wastewater

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Pedosphere 2013年第3期23卷 281-289页

作者： J.L.MORENO F.bastida M.A.S NCHEZ-MONEDERO T.HERNNDEZ C.GARCíA Department of Soil and Water Conservation Centro de Edafología y Biología Aplicada del Segura-Consejo Superior de Investigaciones Científicas (CEBAS-CSIC) Campus Universitario de Espinardo

An incubation experiment was designed in order to determine the further microbiological response to an addition (500m^3 ha^(-1) ) of fresh olive mill wastewater (FOMWW) in a soil that has been frequently amended with uncontrolled doses of OMWW since the 1990s in an active disposal site (ADS soil). To achieve this aim, the phospholipid fatty acid (PLFA) profiles, microbial biomass C (C_(mic)), and dehydrogenase (DHA) and urease activities (URA) were monitored at the beginning (T_0), 3 h (T_1) and 97 d (T_f, i.e., the end) of incubation after FOMWW addition. After the FOMWW addition, an increase in the ratio of fungal to bacterial PLFAs was observed in ADS soil. Moreover, a relative increase of monounsaturated fatty acids (MUFAs) with respect to saturated fatty acids (SATFA) was found in the ADS soil. An increase of the Gram-positive to Gram-negative ratio was observed in this soil at the end of the incubation. While DHA and C_(mic) increased in the ADS soil after FOMWW addition, URA showed a decrease. Fungi and Gram-positive bacterial biomass experienced an increase after addition of a high dose of FOMWW in laboratory conditions.

关键词：土壤微生物群落中段废水高剂量橄榄油新鲜微生物生物量碳磷脂脂肪酸细菌生物量

Iodine Concentration of Iodized Salts Consumed in Harper

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Open Journal of Applied Sciences 2022年第9期12卷 1495-1504页

作者： Richard Tamba Simbo Fayia Francis Nyuma Maria fe Rebecca D. Gueta Department of Science and Mathematics College of Arts and Sciences William V.S Tubman University Maryland County Libe-ria

This study determined concentrations of iodine, consistent with WHO iodine fortification standards, in commercial edible salts mostly consumed in Harper. The following hypothesis was put forward in the research study;H1: the iodine content of the two brands of iodized salts is different from the WHO iodine fortification levels;H0: the iodine content of the two brands of iodized salts is not different from the WHO iodine fortification levels. The hypothesis was tested in MS Excel 2010 and 2016 via the T-Test function giving p-value = 0.1476 and p-value = 0.0395 indicative of no significant difference in the iodine concentration of the salts compared with the lower limit of WHO standard 20 mg·Kg-1 and huge contrast in the iodine concentration of the salts compared with the upper limit of WHO standard 40 mg·Kg-1 respectively. The UV spectrophotometric method was used to analyze and measure the iodine concentration in the twelve (12) samples of two different brands bought from grocery stores in Harper city. Results indicated that all samples of the two (2) brands of iodized salts contained iodine of no significant difference relative to the lower limit of WHO standard but far below the upper limit of the WHO standard. The study therefore recommends monitoring of commercial iodized salts by appropriate authorities in Harper to ascertain the WHO iodization fortification standards before reaching consumers.

关键词： Harper Iodized Salt Potassium Iodate Potassium Iodide Spectrophotomet-ric Thyroid Function

Super d-antimagic Labelings of Disconnected Plane Graphs

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Acta Mathematica Sinica,English Series 2010年第12期26卷 2283-2294页

作者： Martin BAA Mirka MILLER Oudone PHANALASY Andrea SEMANIOV-feOVKOV Department of Applied Mathematics Technical University School of Electrical Engineering and Computer Science The University of Newcastle Department of Mathematics University of West Bohemia Department of Computer Science King's College London Department of Mathematics National University of Laos

This paper deals with the problem of labeling the vertices, edges and faces of a plane graph in such a way that the label of a face and the labels of the vertices and edges surrounding that face add up to a weight of that face, and the weights of all s-sided faces constitute an arithmetic progression of difference d, for each s that appears in the graph. The paper examines the existence of such labelings for disjoint union of plane graphs.

关键词： Plane graph d-antimagic labeling super d-antimagic labeling disjoint union of graphs

Erratum to:Aqueous extracts from Tenebrio molitor larval and pupal stages inhibit early hepatocarcinogenesis in vivo

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第4期24卷 371-372页

作者： Dulce María Moreno-García Armando Zepeda-bastida Juan Ocampo-López Brisa Rodope Alarcón-Sánchez Osiris Germán Idelfonso-García Sandra Rosas-Madrigal Diana Ivette Aparicio-Bautista Julio Isael Pérez-Carreón Saúl Villa-Treviño Jaime Arellanes-Robledo Laboratory of Liver Diseases National Institute of Genomic Medicine-INMEGENCDMX14610Mexico Institute of Agricultural Sciences Autonomous University of Hidalgo State-ICAP-UAEHHidalgo43600Mexico Department of Cell Biology Center for Research and Advanced Studies of the National Polytechnic Institute-CINVESTAV-IPNCDMX07360Mexico Laboratory of Cardiovascular Diseases National Institute of Genomic Medicine-INMEGENCDMX14610Mexico Proteomics Unit National Institute of Genomic Medicine-INMEGENCDMX14610Mexico Directorate of Cátedras National Council of Science and Technology-CONACYTCDMX03940Mexico

Following an Assessment by the Autonomous University of Hidalgo State and the National Institute of Genomic Medicine,this erratum corrects the authorship of this article by adding Dulce Maria MORENO-GARCiA as the first *** published article(Zepeda-bastida et al.,2021)has now been updated with the corrected authorship,author contributions,and acknowledgments,which may be seen in this erratum.

关键词： larval adding corrected