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Vascular units as advanced living materials for bottom-up engineering of perfusable 3D microvascular networks

Bioactive Materials 2024年第8期38卷 499-511页

作者： I.D.Orge H.Nogueira pinto M.A.Silva S.j.Bidarra S.A.Ferreira I.Calejo R.Masereeuw S.M.Mihail C.C.Barrias i3S-Instituto de Investigaçao e Inovaçao em Saúde Universidade do PortoPortoPortugal INEB-Instituto de Engenharia Biomedica Universidade do PortoPortoPortugal ICBAS-Instituto de Ciencias Biomedicas Abel Salazar Universidade do PortoPortoPortugal Division of Pharmacology Utrecht Institute for Pharmaceutical SciencesUtrecht UniversityUtrechtthe Netherlands

The timely establishment of functional neo-vasculature is pivotal for successful tissue development and regen-eration,remaining a central challenge in tissue *** this study,we present a novel(micro)vascular-ization strategy that explores the use of specialized“vascular units”(VUs)as building blocks to initiate blood vessel formation and create perfusable,stroma-embedded 3D microvascular networks from the *** demonstrate that VUs composed of endothelial progenitor cells and organ-specific fibroblasts exhibit high angiogenic potential when embedded in fibrin *** leads to the formation of VUs-derived capillaries,which fuse with adjacent capillaries to form stable microvascular beds within a supportive,extracellular matrix-rich fibroblastic *** a custom-designed biomimetic fibrin-based vessel-on-chip(VoC),we show that VUs-derived capillaries can inosculate with endothelialized microfluidic channels in the VoC and become ***,VUs can establish capillary bridges between channels,extending the microvascular network throughout the entire *** VUs and intestinal organoids(IOs)are combined within the VoC,the VUs-derived capillaries and the intestinal fibroblasts progressively reach and envelop the *** promotes the formation of a supportive vascularized stroma around multiple IOs in a single *** findings un-derscore the remarkable potential of VUs as building blocks for engineering microvascular networks,with ver-satile applications spanning from regenerative medicine to advanced in vitro models.

关键词： Engineered tissue Organ-on-chip Microtissue Spheroid endothelial colony-forming cells

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Synthesis and structure of a praseodymium (Ⅲ) complex with carboxylate ligand：A thermal and spectroscopic study

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journal of Rare Earths 2018年第10期36卷 1090-1097页

作者： Kátia Veronica Tenório josé Augusto Teixeira Leandro Moreira de Campos pinto Flávio júnior Caires Oswaldo Treu-Filho Fáhio Alencar dos Santos Tiago André Denck Colman Alexandre Cuin Cláudio Teodoro de Carvalho Federal University of Grande Dourados CP 364 79804-970 Dourados MS Brazil Institute of Chemistry State University of Sao Paulo 14.801-970 Araraquara SP Brazil Chemistry Institute Federal University of Mato Grosso do Sul 79074-460 Campo Grande MS Brazil Chemistry Department State University of Sao Paulo 17033-360 Bauru SR Brazil Federal University of juiz de Fore 36036-330 Juiz de Fora MG Brazil

One Pr（Ⅲ） lanthanide ion complex was initially synthesized and characterized by TGA-DSC in air atmosphere, as well as characterized by CHN elemental analysis, defining the stoichiometric ratio as Pr（DMBz）3. The gaseous products evolved during the thermal decomposition were also monitored in N2 atmosphere employing TGA/FT-IR system. A crystal structure is obtained by state-of-the-art powder X-rays diffraction methods measured in conventional laboratory equipment and refined by the Rietveld method, which defined it as a monoclinic system of the space group P21/C with a polymeric crystal structure, [Pr（DMBZ）3]n. FT-IR theoretical spectrum and time-dependent density functional theory（TD-DFT） were calculated from TGA-DSC and crystalline system data. The experimental and theoretical FT-IR spectra present a high correlation degree when the main stretching bands are compared, while the energy transfer（HOMO - LUMO） in their neighborhoods suggests the main contributions of the light-emitting states.

关键词： Complex Thermal analysis Powder diffraction state-of-art Polymeric structure Theoretical calculation Rare earths

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Comparative mitogenome phylogeography of two anteater genera (Tamandua and Myrmecophaga;Myrmecophagidae, Xenarthra): Evidence of discrepant evolutionary traits

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Zoological Research 2021年第5期42卷 525-547页

作者： Manuel Ruiz-García Daniel Pinilla-Beltrán Oscar E.Murillo-García Christian Miguel pinto jorge Brito joseph Mark Shostell Laboratorio de Genética de Poblaciones Molecular-Biología Evolutiva Departamento de BiologíaFacultad de CienciasPontificia Universidad JaverianaBogotáDC 110231Colombia Grupo de Investigación en Ecología Animal Departamento de BiologíaFacultad de Ciencias Naturales y ExactasUniversidad del ValleApartado AéreoCali 25360Colombia Instituto de Ciencias Biológicas Escuela Politécnica NacionalQuito 17012759Ecuador Instituto Nacional de Biodiversidad(INABIO) Quito 170135Ecuador Math Science and Technology DepartmentUniversity of Minnesota CrookstonCrookstonMN 56716USA

The species within Xenarthra(sloths,anteaters,and armadillos)are quintessential South American *** the three groups,Vermilingua(anteaters)contains the fewest extant and paleontological ***,we sampled and sequenced the entire mitochondrial genomes(mitogenomes)of two Tamandua species(Tamandua tetradactyla and ***)(n=74)from Central and South America,as well as Myrmecophaga tridactyla(n=41)from South *** Tamandua,we detected three different *** oldest(THI)contained many specimens with the *** morphotype(but also several with the *** morphotype)and originated in southeastern South America(currently Uruguay)before moving towards northern South America,where the THII haplogroup *** primarily contained specimens with the *** morphotype(but also several with the *** morphotype)and was distributed in Central America,Colombia,and *** and THII yielded a genetic distance of 4%.THII originated in either northern South America or“in situ”in Central America with haplogroup THIII,which consisted of~50%*** and 50%*** *** was mostly located in the same areas as THII,i.e.,Central America,Ecuador,and Colombia,though mainly in the *** three haplogroups overlapped in Colombia and ***,*** and *** were not reciprocally *** this reason,we considered that a unique species of Tamandua likely exists,i.e.,*** contrast to Tamandua,*** did not show different morphotypes throughout its geographical range in the ***,two very divergent genetic haplogroups(MHI and MHII),with a genetic distance of~10%,were *** basal haplogroup,MHI,originated in northwestern South America,whereas the more geographically derived haplogroup,MHII,overlapped with MHI,but also expanded into central and southern South ***,Tamandua migrated from south to north whereas Myrmecophaga migrated from

关键词： Anteaters Genetic diversity Mitogenomes Myrmecophaga Neotropics Phylogeography Spatial structure Tamandua

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Endoscopic balloon dilation of crohn's disease stricturessafety,efficacy and clinical impact

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World journal of Gastroenterology 2017年第41期23卷 7397-7406页

作者： Susana Lopes Eduardo Rodrigues-pinto Patrícia Andrade joana Afonso Todd H Baron Fernando Magro Guilherme Macedo Gastroenterology Department Faculty of MedicineHospital de Sao Joao Department of Pharmacology and Therapeutics University of Porto Division of Gastroenterology and Hepatology University of North Carolina

AIM To evaluate the incidence of anastomotic strictures after intestinal resection in Crohn's disease(CD), demonstrate long-term efficacy and safety of endoscopic balloon dilation(EBD) in CD strictures and its impact on the diagnosis of subclinical postoperative endoscopic recurrence. METHODS Retrospective single tertiary center study based on prospectively collected data between 2010 and 2015including anastomotic and non-anastomotic strictures. RESULTS29% of 162 CD patients included developed an anastomotic stricture. 43 patients with anastomotic strictures and 37 with non-anastomotic strictures underwent EBD; technical success was 97.7% and 100%, respectively, however, 63% and 41% needed repeat dilation during the 4.4-year follow-up. Longer periods between surgery and index colonoscopy and higher lactoferrin levels were associated with the presence of stricture after surgery. Calprotectin levels > 83.35 μg/g and current or past history of smoking were associated with a shorter time until need for dilation(HR = 3.877, 95%CI: 1.480-10.152 and HR = 3.041, 95%CI: 1.213-7.627). Anastomotic strictures had a greater need for repeat dilation(63% vs 41%, P = 0.047). No differences were found between asymptomatic and symptomatic cohorts. Disease recurrence diagnosis was only possible after EBD in a third of patients. CONCLUSION EBD is an effective and safe alternative to surgery, with a good short and long-term outcome, postponing or even avoiding further surgery. EBD may allow to diagnose disease recurrence in patients with no clinical signs/biomarkers of disease activity.

关键词： Crohn’s disease Endoscopic recurrence Anastomotic strictures Non-anastomotic strictures Endoscopic balloon dilation

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Values and Valuing Across Cultures and Time Zones

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ECNU Review of Education 2021年第2期4卷 376-387页

作者： Marcia Maria Fusaro pinto Universidade Federal do Rio de janeiro

Highlights:Values and valuing are seen as enhancing pedagogical actions.•Throughout the papers,the review of the literature is complemented and each research includes specific theoretical constructs.•Regarding research methods,quantitative comparative research projects,which explore students'values related to mathematics,have been influencing other research about values.•A broad and shared theme by the group is the observation of the educational phenomena from a perspective that acknowledges culture and the humanness of the mathematical *** their research,the collective of authors truly incorporates humaneness in the production and in the teaching and learning of mathematics.

关键词： Culture mathematics education values values-alignment valuing

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Diet as an epigenetic factor in inflammatory bowel disease

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World journal of Gastroenterology 2023年第41期29卷 5618-5629页

作者： Karina Marangoni Gilson Dorneles Daniella Miranda da Silva Letícia Pereira pinto Carina Rossoni Sabrina Alves Fernandes Egas Moniz School of Health and Science Caparica-AlmadaPortugalCaparica 2820-062Portugal National Institute of Sciences and Technology-Theranostics and Nanobiotechnology Federal University of Uberlandia-MGBrazilUberlândia 38400-902Brazil Corporate Social Responsibility Hospital Moinhos de VentoPorto Alegre 90035-004Brazil Postgraduate Program in Gastroenterology Universidade Federal do Rio Grande do SulPorto Alegre 91540-000Brazil Department of Nutrition Uniasselvi-Group VitruSanta Catarina 89082-262Brazil Postgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil Master in Physical Activity and Health Polytechnic Institute of BejaBeja 7800-000Portugal Degree in Nutrition Sciences Lusófona UniversityLisboa 1749-024Portugal

Inflammatory bowel disease(IBD)has as a main characteristic the exacerbation of the immune system against enterocytes,compromising the individual’s intestinal *** inflammatory cascade causes several nutritional deficiencies,which further compromise immunological functioning and,as a result,worsen the *** vicious cycle can be interrupted as the patient’s dietary pattern meets their needs according to their clinical condition,acting directly on the inflammatory process of IBD through the interaction of food,intestinal microbiota,and *** nutritional intervention for IBD has a crucial role in preventing and managing disease *** review addresses epigenetic modifications through dietary compounds as a mechanism for modulating the intestinal microbiota of patients with IBD.

关键词： Inflammatory bowel disease Epigenetics Nutrition Nutrigenetics

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The Ideational Elements of Brazil’s Arab Strategy:An Assessment(2002-2010)

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Asian journal of Middle Eastern and Islamic Studies 2015年第4期9卷 100-120,I0006页

作者： Vânia Carvalho pinto Institute of International Relations University of Brasilia

Relations between the countries of Latin America and the Middle East have been an under researched topic within their respective fields.②This can be attributed,at least partly,to the fact that both regions have a comparatively low level of diplomatic and economic interactions,when contrasted,for example,with relations between Latin America and the European Union,or between the Gulf Cooperation Council and *** the specific case of Brazil,even though the latter has decades old relations with selected Arab countries,such as Iraq,very little has been written about its interactions with the Arab world in *** of the reasons for this may be attributed to the dearth of issues of high politics underscoring this relationship,issues that if present could assist in capturing media and academic *** article seeks to contribute to the study of both regions by focusing on a particular moment of Brazilian foreign policy when relations with the Arab world were at their peak in terms of visibility.

关键词： Brazil and the Middle East Latin America International Relations Brazil and the Gulf

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具有无界非线性项的广义逐段常变量微分方程拓扑等价函数的正则性

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中国科学：数学 2020年第6期50卷 847-872页

作者：邹长武夏永辉 Manuel pinto 福州大学数学与计算机科学学院福州350116 浙江师范大学数学与计算机科学学院金华321004 Departamento de Matematica Universidad de ChileCasilla 653Chile

关于微分方程的拓扑等价以及拓扑等价函数的正则性一直是微分方程研究的焦点之一.当非线性项有界时,已经有很多学者证明了微分方程的拓扑等价函数是H?lder正则的.然而,当非线性项无界时,拓扑等价的正则性尚无突破性结果.在无界情形下, ... 详细信息

关于微分方程的拓扑等价以及拓扑等价函数的正则性一直是微分方程研究的焦点之一.当非线性项有界时,已经有很多学者证明了微分方程的拓扑等价函数是H?lder正则的.然而,当非线性项无界时,拓扑等价的正则性尚无突破性结果.在无界情形下, Zou和Shi(2017)得到了拓扑线性化的条件.除Zou和Shi(2017)给出的条件外,在附加的一个前提下,本文证明拓扑等价函数的H?lder正则性.事实上,当系统是有界时,系统线性化的条件足以保证其H?lder正则性.但是,当系统是无界时,这个附加条件是必不可少的.本文举例说明这个事实.这是首篇考虑无界系统拓扑等价H?lder正则的文章.

关键词：微分方程逐段常变量微分方程正则性

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Lightning Changes in Response to Global Warming in Rio de janeiro, Brazil

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American journal of Climate Change 2020年第3期9卷 266-273页

作者： Osmar pinto jr. Iara R. C. A. pinto Brazilian Institute of Space Research (INPE) S. J. dos Campos Brazil

Physical concepts based on the Clausius-Clapeyron relation and on the thermodynamics and aerosol characteristics associated with updrafts, global climate models assuming different parametrizations and lightning-relat... 详细信息

justify"> Physical concepts based on the Clausius-Clapeyron relation and on the thermodynamics and aerosol characteristics associated with updrafts, global climate models assuming different parametrizations and lightning-related output variables, and lightning-related data (thunderstorm days) are being used to infer the lightning incidence in a warmer planet, motivated by the global warming observed. In all cases, there are many gaps to be overcome making the lightning response to the global temperature increase still unpredicted. Values from almost 0% (no increase) to 100% have been estimated, being 10% the most common value. While the physical concepts address only part of the problem and the global climate models need to make many simple assumptions, lightning-relate data have strong time and space limitations. In this context, any new evidence should be considered as an important contribution to better understand how will be the lightning incidence in the future. In this article, we described new results about the occurrence of thunderstorms from 1850 to 2010 (a period of 160 years) in the city of Rio de Janeiro, in the Southeast of Brazil. During this period thunderstorm days were recorded in the same location, making this time series one of the longest series of this type available worldwide. The data support an increase of 21% in the mean annual thunderstorm days during the period, while surface temperature increased by 0.6

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Spectrum of diagnostic errors in radiology

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World journal of Radiology 2010年第10期2卷 377-383页

作者： Antonio pinto Luca Brunese Department of Radiology Cardarelli Hospital Department of Health Science Faculty of Medicine and SurgeryUniversity of Molise

Diagnostic errors are important in all branches of medicine because they are an indication of poor patient care. Since the early 1970s,physicians have been subjected to an increasing number of medical malpractice claims. Radiology is one of the specialties most liable to claims of medical *** often,a plaintiff's complaint against a radiologist will focus on a failure to diagnose. The etiology of radiological error is *** fall into recurrent *** arise from poor technique,failures of perception,lack of knowledge and *** work of diagnostic radiology consists of the complete detection of all abnormalities in an imaging examination and their accurate diagnosis. Every radiologist should understand the sources of error in diagnostic radiology as well as the elements of negligence that form the basis of malpractice *** traps need to be uncovered and highlighted,in order to prevent repetition of the same *** article focuses on the spectrum of diagnostic errors in radiology, including a classification of the errors,and stresses the malpractice issues in mammography,chest radiology and obstetric *** fractures in emergency and communication issues between radiologists and physicians are also discussed.

关键词： Diagnostic radiology Medical negligence Medico-legal problems Observer performance Radiological error

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