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Design of artificial biomimetic channels with Na^(+)permeation rate and selectivity potentially outperforming the natural sodium channel

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Nano Research 2024年第9期17卷 8638-8646页

作者： zhi Zhu Yan zhao Chao Chang Shaojian Yan Tingyu Sun Shiyu Gu Yangmei Li Dengsong Zhang Chunlei Wang Xiao Cheng Zeng School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China Innovation Laboratory of Terahertz Biophysics National Innovation Institute of Defense TechnologyBeijing 100071China School of Physics Peking UniversityBeijing 100871China International Joint Laboratory of Catalytic Chemistry College of SciencesShanghai UniversityShanghai 200444China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China

Artificial ion channels that enable high-efficiency ion transport have important implications in nanofluidics and biomedical applications such as drug ***,we show a simulation-based chemical design of a biomimetic sodium channel that possesses permeation rate and selectivity potentially higher than those of the state-of-the-art natural vertebrate voltage-gated sodium ***,our theoretical findings have undergone empirical testing,aligning well with the Arrhenius law as derived from a diverse range of experimental *** high-efficiency ion transport is achieved by anchoring the carboxylate functional groups within the channel filter.A key chemical guiding principle underlying the ion channel design is that the free-energy barrier for the Na^(+)passage across the channel should be comparable to typical thermal energy at room *** the implementation of the chemical design,we found that the relatively low free-energy barrier can be attributed to the compensation effect of the carboxylate groups to the partially lost oxygen shell of the ion within the ion channel,as well as to the consonant vibration of the ions inside and outside the *** mechanistic understanding brings new insight,at the molecular level,into the high-efficiency ion transport across the designed membrane *** proof of principle achieved from the simulations will stimulate future experimental confirmation and potential applications of the high-performance artificial channels in nanofluidics and in bioinspired iontronics.

关键词： sodium channels anchoring carboxylate functional groups molecular dynamics simulations low free-energy barrier for ion passage thermal kinetic energy

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Performance of the walking trail making test in older adults with white matter hyperintensities

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World Journal of Psychiatry 2024年第1期14卷 102-110页

作者： Hong-Yi zhao zhi-Qiang Zhang Yong-Hua Huang Hong Li Fang-Yuan Wei Department of Neurology No.984 Hospital of PLABeijing 100094China Department of Neurology The Seventh Medical Center of PLA General HospitalBeijing 100700China Mental Health Institute of Inner Mongolia Autonomous Region The Third Hospital of Inner Mongolia Autonomous RegionHohhot 010010Inner Mongolia Autonomous RegionChina Department of Neurosurgery No.984 Hospital of PLABeijing 100094China Department of Hand and Foot Surgery Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China Engineering Research Center of Chinese Orthopaedic and Sports Rehabilitation Artificial Intelligent Ministry of EducationBeijing 100029China

BACKGROUND Several studies have reported that the walking trail making test(WTMT)completion time is significantly higher in patients with developmental coordination disorders and mild cognitive *** hypothesized that WTMT performance would be altered in older adults with white matter hyperintensities(WMH).AIM To explore the performance in the WTMT in older people with *** In this single-center,observational study,25 elderly WMH patients admitted to our hospital from June 2019 to June 2020 served as the WMH group and 20 participants matched for age,gender,and educational level who were undergoing physical examination in our hospital during the same period served as the control *** participants completed the WTMT-A and WTMT-B to obtain their gait parameters,including WTMT-A completion time,WTMT-B completion time,speed,step length,cadence,and stance phase *** matter lesions were scored according to the Fazekas *** neuropsychological assessments were carried out to assess cognitive *** relationships between WTMT performance and cognition and motion in elderly patients with WMH were analyzed by partial Pearson correlation *** Patients with WMH performed significantly worse on the choice reaction test(CRT)(0.51±0.09 s vs 0.44±0.06 s,P=0.007),verbal fluency test(VFT,14.2±2.75 vs 16.65±3.54,P=0.012),and digit symbol substitution test(16.00±2.75 vs 18.40±3.27,P=0.010)than participants in the control *** WMH group also required significantly more time to complete the WTMT-A(93.00±10.76 s vs 70.55±11.28 s,P<0.001)and WTMT-B(109.72±12.26 s vs 82.85±7.90 s,P<0.001).WTMT-A completion time was positively correlated with CRT time(r=0.460,P=0.001),while WTMT-B completion time was negatively correlated with VFT(r=-0.391,P=0.008).On the WTMT-A,only speed was found to statistically differ between the WMH and control groups(0.803±0.096 vs 0.975±0.050 m/s,P<0.001),whereas on the WTMT-B,the WMH group exhibited a sign

关键词： White matter hyperintensities Cognitive dysfunction Motor deficits Gait analysis Trail making test Small vessel disease

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Long-term tadalafil once daily in Chinese men with erectile dysfunction:a 2-year final analysis of a post-marketing,multicenter,randomized,open-label trial

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Asian Journal of Andrology 2024年第3期26卷 282-287页

作者： Hui Jiang Lian-Ming zhao Su Yan Ji-Hong Liu zhao-Hui Zhu Jin-Dan Luo Yu-Tian Dai Fu-Biao Li Hao-Cheng Lin zhi-Chao Zhang Department of Urology Peking University First HospitalBeijing 100000China Department of Urology Peking University Third HospitalBeijing 100191China Department of Urology Peking Union Medical College HospitalBeijing 100730China Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Urology Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Urology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Departmentof Andrology Nanjing Drum Tower HospitalNanjing 210008China Department of Andrology The First Hospital of Jilin UniversityChangchun 130021China Andrology Center Department of UrologyPeking University First HospitalBeijing 100034China

The long-term safety and effectiveness of once-daily tadalafil is crucial,but limited data are available in Chinese patients witherectile dysfunction(ED).In this post-marketing,multicenter,randomized,open-label trial with 2-year follow-up,635 ED caseswere randomized to receive daily oral tadalafil 2.5 mg or 5 mg for 3 months,of whom 580 continued once-daily tadalafil 5 mg for21 ***-emergent adverse events in the 12-month and 24-month period were similar,with the most common beingviral upper respiratory tract infection,upper respiratory tract infection,and *** improvement from baseline inthe International Index of Erectile Function-Erectile Function(IIEF-EF)score was detected at month 12(least squares mean[LSM]change:7.9,95%confidence interval[CI]:7.5–8.4,P<0.001)and was maintained to month 24(LSM change:8.6,95%CI:8.1–9.0,P<0.001).The proportions of patients regaining normal erectile function(IIEF-EF score≥26)were 43.7%and 48.0%at months 12 and 24,*** Assessment Questionnaire results showed improved erection function in 97.5%ofpatients and improved ability to engage in sexual activity in 95.9%of patients at month 12;these values were 96.1%and 95.0%at month 24,*** quality of sexual life score based on the Sexual Life Quality Questionnaire(SLQQ)was increased by52.2%at month 12 and by 55.3%at month 24(both P<0.001).The treatment satisfaction score determined by SLQQ(mean±standard deviation)was 62.4±21.0 at month 12 versus 65.9±20.2 at month ***-year daily application of tadalafil 5mg in Chinese men with ED showed a favorable safety profile and durable improvement in sexual performance and satisfaction.

关键词： clinical trial erectile dysfunction long-term safety once-daily dosing tadalafil

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Successful management of severe hypoglycemia induced by total parenteral nutrition in patients with hepatocellular injury: Three cases reports

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World Journal of Clinical Cases 2024年第1期12卷 157-162页

作者： Ling-zhi Fang Hui-Xin Jin Na zhao Yu-Pei Wu Ying-Qin Shi Department of Pharmacy Hebei Key Laboratory of Clinical PharmacyHebei General HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Glucose imbalance is common in total parenteral nutrition(TPN).Hypoglycemia seems to be less frequent than hyperglycemia,but it influences the clinical outcome to a greater ***,it should be effectively prevented and ***,there is no relevant report on how to treat hypoglycemia caused by TPN in patients with liver cell *** SUMMARY We present three patients with liver cell injury who developed severe hypo-glycemia during or after TPN *** causes of severe hypoglycemia and glucose-raising strategies were *** to the physiological charac-teristics of the hepatocellular injury,the ratio of nutrition components prescribed in TPN was appropriately adjusted for the three *** simultaneously reduced the dose of insulin and fat emulsion,and increased the dose of glucose in *** blood glucose level was restored to normal range and clinical symptoms were *** When hypoglycemia occurs during or after TPN in patients with hepatocellular injury,physicians need to simultaneously reduce insulin and fat emulsion,and increase glucose,and correct severe hypoglycemia in time to reduce its adverse consequences.

关键词： Total parenteral nutrition Hepatocellular injury Severe hypoglycemia Treatment Causes Case report

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Producing circularly polarized luminescence by radiative energy transfer from achiral metal-organic cage to chiral organic molecules

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Chinese Chemical Letters 2024年第8期35卷 498-502页

作者： zhao-Xia Lian Xue-zhi Wang Chuang-Wei Zhou Jiayu Li Ming-De Li Xiao-Ping Zhou Dan Li College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and ApplicationsJinan UniversityGuangzhou 510632China College of Chemistry and Chemical Engineering Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong ProvinceShantou UniversityShantou 515063China

The development of circularly polarized luminescence(CPL)materials with high performance is signifi-cantly ***,we develop a facial strategy for fabricating a CPL-active system by employing an achiral luminescent metal-organic cage(MOC)and chiral boron dipyrromethene(BODIPY)*** is achieved by taking advantage of the radiative energy transfer process,in which BODIPY molecules act as energy acceptors and MOCs act as *** CPL performance(maximum luminescence dissymme-try factor up to±1.5×10^(−3))can be tuned by adjusting the ratio between MOCs and ***-light emission with the CPL feature is obtained by using a ternary system including MOC,chiral BODIPY,and Rhodamine *** present work provides a facile and universal strategy to construct a CPL-active system by integrating achiral luminophores and chiral molecules.

关键词： Circularly polarized luminescence Metal-organic cage Radiative energy transfer Chiral small molecules Bodipy Chirality

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Fully sprayed MXene-based high-performance flexible piezoresistive sensor for image recognition

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Nano Materials Science 2024年第1期6卷 77-85页

作者： zhi-Dong Zhang Xue-Feng zhao Qing-Chao Zhang Jie Liang Hui-Nan Zhang Tian-Sheng Zhang Chen-Yang Xue Key Laboratory of Instrumentation Science&Dynamic Measurement of Ministry of Education North University of ChinaTaiyuan030051People's Republic of China State Key Laboratory of ASIC and System Shanghai Institute of Intelligent Electronics&SystemsSchool of MicroelectronicsFudan UniversityShanghai200433People's Republic of China Shanxi Hosipital of Acupuncture and Moxibustion Taiyuan030006People's Republic of China

High-performance flexible pressure sensors provide comprehensive tactile perception and are applied in human activity monitoring,soft robotics,medical treatment,and human-computer ***,these flexible pressure sensors require extensive nano-architectural design and complicated manufacturing and are ***,a highly sensitive,flexible piezoresistive tactile sensor is designed and fabricated,consisting of three main parts:the randomly distributed microstructure on T-ZnOw/PDMS film as a top substrate,multilayer Ti_(3)C_(2)-MXene film as an intermediate conductive filler,and the few-layer Ti_(3)C_(2)-MXene nanosheetbased interdigital electrodes as the bottom *** MXene-based piezoresistive sensor with randomly distributed microstructure exhibits a high sensitivity over a broad pressure range(less than 10 kPa for 175 kPa^(-1))and possesses an out-standing permanence of up to 5000 ***,a 16-pixel sensor array is designed,and its potential applications in visualizing pressure distribution and an example of tactile feedback are *** fully sprayed MXene-based pressure sensor,with high sensitivity and excellent durability,can be widely used in,electronic skin,intelligent robots,and many other emerging technologies.

关键词： Piezoresistive sensor Ti_(3)C_(2)-MXene T-ZnOw/PDMS film Randomly distributed microstructure

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Climate warming is likely to weaken the performance of two-phase closed thermosyphon on the Qinghai-Tibet Plateau

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Advances in Climate Change Research 2024年第1期15卷 90-100页

作者： Guan-Li JIANG Zi-Teng FU Xin-Yu MEN Hong-Ting zhao Si-Ru GAO Yong-zhi LI Qing-Bai WU State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Beiluhe Observation and Research Station on Frozen Soil Engineering and Environment in the Qinghai-Tibet Plateau Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Muli Field Scientific Observation and Research Station for Gas Hydrate China Geological SurveyBeijing 100083China University of Chinese Academy of Sciences Beijing 100049China School of Civil Engineering and Architecture Jiaxing Nanhu UniversityJiaxing 314001China

Over the years,numerous geotechnical approaches have been implemented to mitigate the adverse effects of climate warming on various infrastructures in the permafrost region of the Qinghai-Tibet Plateau(QTP),such as the Qinghai-Tibet Highway and Railway,and achieved the expected engineering ***,little attention has been given to whether the performance of these geotechnical approaches has changed during the ongoing process of climate *** investigate the performance variation of one of these geotechnical approaches,which is two-phase closed thermosyphon(TPCT),during sustained climate warming,we conducted a statistical analysis of soil temperature monitoring data in 2003-2020 from eight regular embankments and six TPCT embankments in our permafrost monitoring *** results indicate that TPCT undeniably has a cooling effect on the permafrost beneath embankments,even rapidly eliminated previously formed taliks beneath ***,further analysis reveals that the performance of TPCT has been weakening during sustained climate warming,which has confirmed by the re-forming of the taliks beneath embankment where they had been previously *** on the current understanding,we attributed the weakening of thermosyphon performance to a significant reduction in the air temperature freezing index caused by ongoing climate *** this study,we aimed to draw attention to the evolving performance of geotechnical approaches in permafrost regions amid climate warming,prompting necessary engineering innovations to address this situation and ensure the sustainable development of the permafrost region on the QTP.

关键词： Two-phase closed thermosyphon Climate warming Supra-permafrost talik Permafrost degradation Qinghai-Tibet Highway

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Asymmetric side-chain engineering of organic semiconductor for ultrasensitive gas sensing

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Chinese Chemical Letters 2024年第3期35卷 428-433页

作者： Xiaoying Ma Xiaojuan Dai Lanyi Xiang Jiajun Chang Danfeng zhi Haozhen zhao Zhenjie Ni Ye Zou Xike Gao Fengjiao Zhang School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China Laboratory of Organic Solids Institute of ChemistryChinese Academy of SciencesBeijing 100190China Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China Binzhou Institute of Technology Binzhou 256606China

Molecular structure of organic semiconductor plays a critical role in determining the performance and functionality of organic electronic devices,by optimizing the electrical,optical and physicochemical *** alkyl chains are fundamental units in tailering the solubility and assemblability,among which the asymmetric properties have been reported as key element for controlling the packing motifs and intrinsic charge ***,we expanded the scope of molecular asymmetry dependent sensing features based on a new series of naphthalene diimides(NDI)-based derivatives substituted with a same branching alkyl chain but various linear-shaped alkyl chains(Cn-).A clear molecular stacking change,from head-to-head bilayer to head-to-tail monolayer packing model,is observed based on the features of anisotropic molecular interactions with the change in the chain *** importantly,a unique LUMO level shift of 0.17 eV is validated for NDI-PhC4,providing a record sensitivity up to 150%to 0.01 ppb ammonia,due to the desired molecular reactivity and device amplification *** results indicate that asymmetric side-chain engineering opens a route for breath healthcare.

关键词： Organic thin film transistor Asymmetric side chain Gas sensing Molecular stacking Energy level manipulating

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Amorphous Sb/C composite with isotropic expansion property as an ultra-stable and high-rate anode for lithium-ion batteries

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Rare Metals 2024年第5期43卷 2039-2052页

作者： Ze-Zhou Yang Cheng-Yi Zhang Yu-Qing Ou zhi-Kang Su Yan zhao Heng-Jiang Cong Xin-Ping Ai Jiang-Feng Qian Hubei Key Laboratory of Electrochemical Power Sources College of Chemistry and Molecular SciencesWuhan UniversityWuhan430072China Institute of Technological Sciences Wuhan UniversityWuhan 430072China

Antimony(Sb)is an intriguing anode material for Li-ion batteries(LIBs)owing to its high theoretical capacity of 660 m Ah·g^(-1)and appropriate working potential of~0.8 V(***^(+)/Li).However,just like all alloying materials,the Sb anode suffers from huge volume expansion(230%)during repeated insertion/extraction of Li+ions,resulting in structural deterioration and rapid capacity *** this work,a novel amorphous Sb/C composite with atomically dispersed Sb particles in carbon matrix is prepared via a straightforward high-energy ball milling *** intimate intermixing of amorphous Sb with C provides homogeneous element distribution and isotropic volume expansion during cycling,resulting in persistent structural ***,the disordered structure of amorphous material shortens the diffusion distance of lithium ions/electrons,promoting fast reaction kinetics and rate *** from the aforementioned effects,the amorphous Sb/C exhibits a high reversible capacity of537.4 m Ah·g^(-1)at 0.1 A·g^(-1)and retains 201.0 m Ah·g^(-1)at an ultrahigh current rate of 10.0 A·g^(-1).Even after 1500deep cycles at 2.0 A·g^(-1),the amorphous Sb/C electrode still maintains 86.3%of its initial capacity,which outperforms all existing Sb-based anodes reported so *** analysis further reveals a greatly reduced volume variation of merely 34.6%for the amorphous Sb/C electrode,much lower than that of 223.1%for crystalline Sb *** study presents a new approach to stabilizing Sb-based alloy anodes and contributes to the construction of high-performance amorphous anode materials for LIBs,enabling advanced energy storage.

关键词： Amorphous Sb/C anode Homogeneous element distribution Isotropic volume expansion Ultra-long cycle stability High-rate capability Lithium-ion battery

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Tunable Phase Structure of Side-chain Liquid Crystalline Polymers Enabled by Molecular Engineering of Dual Mesogenic Cores

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Chinese Journal of Polymer Science 2024年第10期42卷 1459-1469,I0009页

作者： Wen-Huan Yao Lan-Sheng Liu Jie zhao Yan-Xia Wang An-zhi Ma Zheng-Rui Ma Lan-Ying Zhang Ruo-Chen Lan College of Chemistry and Chemical Engineering Hunan UniversityChangsha410082China Key Laboratory of Eco-Functional Polymer Materials of the Ministry of Education Key Laboratory of Eco-Environmental Polymer Materials of Gansu ProvinceCollege of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou730070China Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing100871China Institute of Advanced Materials&Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education College of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang330022China

A series of novel side-chain liquid crystalline(SCLC)copolymers were synthesized by attaching two distinct mesogenic units,namely a chiral cholesteryl-based monomer(M1)and an achiral biphenyl-based monomer(M2),to a poly(3-mercaptopropylmethylsiloxane)(PMMS)backbone via thiol-ene click *** influence of side chain composition on the self-assembly behavior and phase structures of these SCLC copolymers was systematically investigated using different *** indicate that three distinct liquid crystalline phases and four unique molecular configurations were identified within the polymer series,with the emergence of the liquid crystalline phase being a synergistic outcome of the two distinct side *** study underscores the critical influence of side chain dimensions,rigidity,and spatial volume on the self-assembly structures and phase characteristics of liquid crystalline polymers,providing valuable insights for the rational design and development of advanced functional materials with tailored properties.

关键词： Liquid crystalline copolymers Self-assembly Phase structure Chiral molar ratio

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