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A Retrospective Analysis of Intoxicated Patients Admitted to the Intensive Care Unit: A Single-Institution Assessment in the Post-Pandemic Period

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Journal of Biosciences and Medicines 2024年第3期12卷 159-167页

作者： Müge Arikan Abdullah Yeşilkaya Büşra Nur taşdelen İbrahim Özyiğit Department of Anesthesia and Intensive Care Faculty of Medicine Karabuk University Karabuk Turkey

Background: The aim of this study was to evaluate the clinical and epidemiological characteristics of patients with acute intoxication admitted to the Intensive Care Unit (ICU). Material and Methods: An observational retrospective study was conducted on intoxicated patients who admitted to ICU between January 2022 and January 2024. Data were collected from the patients medical records. The demographic characteristics, causes of intoxications, clinical parameters, the mean stay in the ICU, treatment modalities and prognosis were recorded. Results: A total of 2875 critically ill patients were admitted during the study period, and 109 (3.79%) of them were acute intoxications. Their mean of ages was 38.09 ± 12.29. The female-to-male ratio was 1.37/1. Drugs were found to be the primary cause (62.39%) of intoxications, and analgesics, antidepressants, and antibiotics were the most frequent agents. Suicidal attempts were present in 66 patients, most of them were female (62.13%) and between 17 - 24 years (40.91%). The other common causes of intoxications were carbon monoxide (CO) (22.02%), methyl/ethyl alcohol (8.26%) and mushroom (5.50%). The mean stay in the ICU was 2.69 ± 0.89 days. Mechanical ventilation was applied to 10 of our patients. Renal replacement therapy was required in 6 patients. Despite all treatments, 6 of our patients died, and we found the mortality rate to be 5.50%. Conclusion: Intoxications were more frequent in young female patients and drugs were the most common cause with suicidal intent. Unfortunately, CO poisoning continues to be a very important problem in our city. These findings provided significant information about the characteristics of intoxications in Karabuk.

关键词： Intoxication Intensive Care Unit Suicidal Mortality

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Protection of steel hooks embedded in glass-fiber-reinforced concrete against macrocell corrosion

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Petroleum Research 2024年第2期9卷 317-326页

作者： Husnu Gerengi Muhammed Maraşlı Marziya Rizvi Beni Kohen Ismail taşkıran Corrosion Research Laboratory Department of Mechanical EngineeringDuzce University81620DuzceTurkey Department of Engineering and Applied Sciences University of BergamoBGItaly Fibrobeton Company R&D Center DuzceTurkey Department of Chemistry Babasaheb Bhimrao Ambedkar UniversityLucknow226003U.PIndia

This study evaluated the corrosion behavior of steel hooks embedded in GFRC,which were protected by a zinc-rich(96%Zn)galvanizing *** coating provided the hooks with active cathodic protection and a passive physical *** corrosion may form when the anode is smaller than the total steel ***,the steel hooks at the embedment juncture were additionally sealed against water ingress and air exchange using a construction *** study was conducted in three phases in a salt-spray ***,the electrogalvanized steel hooks embedded in GFRC were allowed to freely corrode for 7 *** the second phase,the electrogalvanized steel hooks were painted with the zinc-rich coating and observed over 7 *** the third phase,the steel hooks were protected by the zinc-rich coating together with a primer and construction sealant,and observed over 7 *** evaluate the electrogalvanized hooks and the corrosion products formed,the thickness of the material was *** on the metal surface was inferred by studying the surface morphology of the hooks at various points of contact and after different periods of time.

关键词： Steel rebars Concrete corrosion GFRC Galvanization Sealant

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GLOBAL EXISTENCE OF CLASSICAL SOLUTIONS TO THE TYPICAL FREE BOUNDARY PROBLEM FOR GERENAL QUASILINEAR HYPERBOLIC SYSTEMS AND ITS APPLICATIONS

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Chinese Annals of Mathematics,Series B 1990年第1期11卷 15-32页

作者：李大潜赵彦淳 Dedicated to the Tenth Anniversary of camInstitute of Mathematics Fudan UniversityShanghaiChina Dedicated to the Tenth Anniversary of cam Institute of Mathematics Fudan UniversityShanghaiChina

In this paper the authors prove the existence and uniqueness of global classicalsolutions to the typical free boundary problem for general quasilinear hyperbolic *** an application,a unique global discontinuous solution only containing n shocks ont≥0 is obtained for a class of generalized Riemann problem for the quasilinear hyperbolicsystem of n conservation laws.

关键词： hyperbolic Riemann uniqueness discontinuous conservation generalize proof priori 二七 quasi

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Insights into gastric neuroendocrine tumors burden

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Chinese Journal of Cancer Research 2017年第2期29卷 137-143页

作者： taíssa Maíra Thomaz Araújo Williams Fernandes Barra André Salim Khayat Paulo Pimentel de Assumpcao Oncology Research Center Federal University of paráPara 66073-005Brazil

Type 1 gastric neuroendocrine tumors （gNETs） are usually small lesions, restricted to mucosal and sub-mucosal layers of corpus and fundus, with low aggressive behavior, for the majority of cases. Nevertheless, some cases present aggressive behavior. The increasing incidence of gNETs brings together a new relevant problem： how to identify potentially aggressive type I gNETs. The challenging problem seems to be finding out signs or features able to predict potentially aggressive cases, allowing a tailored approach, since the involved societies dedicated to provide guidelines for management of these neoplasms apparently failed in producing staging systems able to accurately predict prognosis of these tumors. Additionally, it is also important to try to find out explanations for increasing incidence, as well as to identify potential targets aiming to reach better control of this neoplasia. Here, we discuss potential pathways implicated in aggressive behavior, as well as new strategies to improve clinical management of these tumors.

关键词： gNETs gastrin receptor epidemiology

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Examination of the Illness Representations among Children with T1DM in Relation to Mental Health Factors

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International Journal of Mental Health Promotion 2023年第8期25卷 961-969页

作者： Brigitta Munkácsi EnikőFelszeghy Flóra Kenyhercz Beáta Erika Nagy Faculty of Medicine Department of Pediatrics Pediatric Psychology and Psychosomatic UnitKálmán Laki Doctoral SchoolUniversity of DebrecenDebrecen4032Hungary Department of Behavioural Sciences University of DebrecenDebrecen4032Hungary

The most common comorbid psychiatric disorders in children with type 1 diabetes mellitus(T1DM)are depression,anxiety and behavioral *** with comorbid psychopathology are less capable of psychically adjusting to the new life situation resulting from T1DM,which may negatively affect glycemic control and adherence related to the *** aimed to investigate the association between mental health and type 1 diabetes including illness representation.115 children and adolescents with T1DM were recruited through the outpatient clinic in Debrecen,***:PRISM-D,Child Depression Inventory(CDI),Cantril Ladder and Self-rated Health,Glycosylaeted haemoglobin(HbA1C)were *** having depressive symptoms drew fewer circles with less *** not drawing any important relationships possessed more depressive *** diagnosed at a younger age displayed smaller distance between the Self-and *** PRISM-D test can be a promising tool to analyse emotional and cognitive representations and the psychological burden of T1DM.

关键词： T1DM illness representation mental health depression children and adolescents

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Resource Allocation Based on SFLA Algorithm for D2D Multicast Communications

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Computer Systems Science & Engineering 2023年第5期45卷 1517-1530页

作者： Wisam Hayder Mahdi Necmi taşpınar University of Diyala Department of Communications EngineeringDiyalaBaquba32001Iraq Erciyes University Department of Electrical and Electronics EngineeringKayseri38039Turkey

Multicast device-to-device(D2D)communication technology is considered as one of the new technologies in the fifth generation(5G)networks that directly addresses the need for content sharing among internet *** fact,when direct communication is available between devices,the spectral efficiency is improved by reusing the licensed cellular *** current studies show that D2D communication increases network capacity and reduces *** order to achieve the alternate capabilities,coordination is required to implement interference *** considered subcarrier allocation for the uplink,in addition to the power control that takes place on the underlay *** completed data rate in single multicast communication is significantly reduced and limited by nodes with lower channel *** this paper,we used Shuffled Frog Leaping Algorithm(SFLA)for resource allocation(ra)in D2D multicast *** compared the results of the SFLA algorithm with the Firefly Algorithm(FA),Ant Colony Optimization(ACO)and Particle Swarm Optimization(PSO);in terms of D2D user throughput,Cellular User(CU)throughput,network average throughput,network interference and signal interference noise ratio(SINR)*** simulation results show that SFLA clearly outperforms other algorithms in terms of data rate under the high pressure of infeasibility.

关键词： Resource Allocation(ra) SFLA D2D 5G

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GLI1改变的间叶性肿瘤2例临床病理学分析

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中华病理学杂志 2024年第10期53卷 1030-1033页

作者：倪响白辰光徐晶晶张丽明雪峰塔娜胡小木海军军医大学长海医院病理科上海复旦大学附属华山医院病理科上海

目的探讨GLI1改变的间叶性肿瘤临床病理学特征。方法收集海军军医大学长海医院病理科2021年1月和2023年8月明确诊断的伴有GLI1改变的间叶性肿瘤2例, 结合文献复习, 总结其临床病理特征。结果例1, 患儿男, 3岁;例2, 患者女, 57岁。2例患...

目的探讨GLI1改变的间叶性肿瘤临床病理学特征。方法收集海军军医大学长海医院病理科2021年1月和2023年8月明确诊断的伴有GLI1改变的间叶性肿瘤2例, 结合文献复习, 总结其临床病理特征。结果例1, 患儿男, 3岁;例2, 患者女, 57岁。2例患者均表现为单发于舌部的结节, 肿瘤最大径均不超过2 cm, 2例均无疼痛、味觉异常等其他症状。镜下肿瘤细胞形态相似, 表现为多角形细胞片状、分叶状分布, 与周围组织边界不清, 可见核分裂象, 2例免疫组织化学肿瘤细胞均不表达cam5.2、广谱细胞角蛋白、p63、p40、CD34、ERG、S-100蛋白、SOX10、结蛋白、CD99, 2例肿瘤细胞均表达波形蛋白、CD56、cyclin D1, 例1局灶弱表达平滑肌肌动蛋白、上皮细胞膜抗原, 例2少量表达p63、p53和CDK4, 2例肿瘤荧光原位杂交检测均显示GLI基因断裂。随访均无复发和转移。结论 GLI1改变的间叶性肿瘤是一种罕见的肿瘤类型, 好发于舌, 组织学表现为浸润性生长的增生活跃的上皮样细胞, 免疫组织化学提示无明确分化方向, 确诊依赖于分子检测, 患者预后较好。

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(E)-2-Benzylidenecycloalkanones XII.*Kinetic Measurement of Bovine and Human Serum Albumine Interaction with Selected Chalcones and Their Cyclic Chalcone Analogues by UV Spectrophotometry

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Spectral Analysis Review 2015年第1期3卷 1-8页

作者： Beáta Veliká Vladimíra Tomecková Krisztina Fodor Ivan Kron Pál Perjési Department of Medical Chemistry Biochemistry and Clinical BiochemistryFaculty of Medicine UPJSTrieda SNP 1KosiceSlovakia Institute of Pharmaceutical Chemistry University of PécsPécsHungary

UV-VIS spectroscopic investigations of interaction of bovine and human serum albumin with selected chalcones (1) and their cyclic chalcone analogues: (E)-2-(4’-X-benzylidene-1-tetralones (3), benzosuberones (4) with dimethylamino and methoxy substituents and (E)-2-(2’,4’-dimethox- ybenzylidene)-1-indanone (2) were performed in polar respiration medium. Absorption maxima of the tested compounds were investigated in the presence of bovine and human serum albumin at the 0, 10, 30 and 60 minute timepoints of the interaction. The absorbance of all studied compounds in the presence of proteins decreased after one hour of the reaction. Molecule 4a showed the strongest and fastest kinet initial interaction with both albumins.

关键词： Chalcones Cyclic Chalcone Analogues UV Spectra Kinetic Measurements Binding Constant Bovine Serum Albumin Human Serum Albumin

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Real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors

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World Journal of Pediatrics 2023年第10期19卷 992-1008页

作者： Barbara Vodicska Júlia Déri Dóra Tihanyi Edit Várkondi EnikőKispéter Róbert Dóczi Dóra Lakatos Anna Dirner Mátyás Vidermann Péter Filotás Réka Szalkai-Dénes István Szegedi Katalin Bartyik Krisztina Míta Gábor Réka Simon Péter Hauser György Péter Csongor Kiss Miklós Garami István Peták Oncompass Medicine Hungary Kft Retek Str.34Budapest 1024Hungary Division of Pediatric Hematology-Oncology Department of PediatricsFaculty of MedicineUniversity of DebrecenDebrecenHungary Department of Pediatrics Albert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Onco-Hematology Department Velkey LászlóPaediatric Health CentreMiskolcHungary Department of Paediatrics Semmelweis UniversityBudapestHungary Onco-Hematology Department Heim Pál Children’s HospitalBudapestHungary Department of Pharmacology and Pharmacotherapy Semmelweis UniversityBudapestHungary Department of Pharmaceutical Sciences University of Illinois at ChicagoChicagoUSA Genomate Health CambridgeMAUSA

Background The utility of routine extensive molecular profiling of pediatric tumors is a matter of debate due to the high number of genetic alterations of unknown significance or low evidence and the lack of standardized and personalized decision support *** drug assignment(DDA)is a novel computational method to prioritize treatment options by aggregating numerous evidence-based associations between multiple drivers,targets,and targeted *** has been validated to improve personalized treatment decisions based on the outcome data of adult patients treated in the SHIVA01 clinical *** aim of this study was to evaluate the utility of DDA in pediatric *** Between 2017 and 2020,103 high-risk pediatric cancer patients(ram,and samples from 100 patients were eligible for further *** or blood samples were analyzed by whole-exome(WES)or targeted panel sequencing and other molecular diagnostic modalities and processed by a software system using the DDA algorithm for therapeutic decision ***,a molecular tumor board(MTB)evaluated the results to provide therapy *** Of the 100 cases with comprehensive molecular diagnostic data,88 yielded WES and 12 panel sequencing *** identified matching off-label targeted treatment options(actionability)in 72/100 cases(72%),while 57/100(57%)showed potential drug *** reached 88%(29/33)by 2020 due to the continuous updates of the evidence *** approved the clinical use of a DDA-top-listed treatment in 56 of 72 actionable cases(78%).The approved therapies had significantly higher aggregated evidence levels(AELs)than dismissed *** of WES results for targeted panels missed important mutations affecting therapy *** DDA is a promising approach to overcome challenges associated with the interpretation of extensive molecular profiling in the routine car

关键词： Computational decision support Pediatric tumors Precision oncology Tumor board

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Distribution and space use of seed-dispersing rodents in central Pyrenees:implications for genetic diversity,conservation and plant recruitment

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Integrative Zoology 2018年第3期13卷 307-318页

作者： Jon URGOITI Alberto MUÑOZ Josep Maria ESPELta raúl BONAL CREAF Cerdanyola del VallésCataloniaSpain Department of Didactics of Experimental Sciences Faculty of EducationUniversity Complutense of MadridMadridSpain Forest Research Group INDEHESAUniversity of ExtremaduraPlasenciaSpain DITEG Research Group University of Castilla-La ManchaToledoSpain Research group of Genetic and Cultural Biodiversity Research centre for Cinegetic Resources(CSIC-UCLM-JCCM)Ciudad RealSpain

The function and conservation of many forest ecosystems depend on the distribution and diversity of the community of rodents that consume and disperse *** habitat preferences and interactions are especially relevant in alpine systems where such granivorous rodents reach the southernmost limit of their distribution and are especially sensitive to global *** analyzed the community of granivorous rodents in the Pyrenees,one of the southernmost mountain ranges of *** species were identified by DNA with particular attention to the Apodemus species,which are prominent seed-dispersing rodents in *** confirmed for the first time the presence of the yellow-necked mouse,Apodemus flavicollis,in central Pyrenees,a typical Eurosiberian species that reaches its southernmost distribution limit in this *** also found the wood mouse,Apodemus sylvaticus,a related species more tolerant to Mediterranean *** rodents were spatially segregated by *** was rare at high altitudes,which might cause the genetic differentiation between populations of the different valleys reported *** also found other seed consumers like dormice,Elyomis quercinus,and voles,Myodes glareolus,with marked habitat *** suggest that population isolation among valleys may increase the genetic diversity of rodents,like *** also highlight the potential threat that global warming may represent for species linked to high-altitude refuges at the southern edge of its distribution,like Apodemus ***,we discuss how this threat may have a dimension in the conservation of alpine forests dispersed by these rodent populations.

关键词： DNA analysis Pyrenees rodents seed dispersal vegetation structure

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