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培养角膜缘上皮移植后穿透性角膜移植术的早期结果

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美国医学会眼科杂志（中文版） 2005年第4期17卷 202-207,234页

作者： Virender S. Sangwan Himanshu P. Matalia Geeta K. Vemuganti Ghazala Ifihekar Anees fatima Shashi Singh, Gullapalli N. Rao 董白霞（译）马景学（校） Sudhakar and Sreekanth Ravi Stem Cell Biology Laboratory Hyderabad India. Cornea and Anterior Segment Service Hyderabad India. Ophthalmic Pathology Laaoratory Hyderabad India. LV Prasad Eye Institute and Center for Cellular and Molecular Biology Hyderabad India 不详

目的：描述曾行培养角膜缘上皮移植的患者再行穿透性角膜移植（PKP）的早期结果。方法：对因化学烧伤造成角膜缘干细胞缺乏而行培养的角膜缘上皮移植后又进行穿透性角膜移植术的患者有关人口统计学、原发病因、角膜缘移植类型、眼表稳... 详细信息

目的：描述曾行培养角膜缘上皮移植的患者再行穿透性角膜移植（PKP）的早期结果。方法：对因化学烧伤造成角膜缘干细胞缺乏而行培养的角膜缘上皮移植后又进行穿透性角膜移植术的患者有关人口统计学、原发病因、角膜缘移植类型、眼表稳定性、视力、移植片透明度和并发症方面的资料进行回顾和复习。对受体角膜片组织病理学特征进行研究，重点观察上皮状态。结果：在患有角膜缘干细胞缺乏而进行培养的角膜缘上皮移植术的125例患者中，15例接受了穿透性角膜移植术（PKP）。角膜缘上皮移植术后（自体移植组n=11，同种异体移植组n=4）平均间隔时间为7个月（范围2—12个月）。同种异体移植组的4例患者均接受了免疫抑制疗法。15只眼中14只眼（93％）获得了含有稳定的角膜上皮的健全的角膜植片。15只眼中14只眼术前最佳矫正视力低于20／200。PKP后平均随访8．3±5．0个月，8只眼最佳矫正视力高于20／60，5只眼最佳矫正视力20／200至20／60。2只眼低于20／200。15只眼中3只眼发生异体角膜植片的排斥反应但被成功治疗。1只眼发生植片排斥的同时发生了青光眼。同种异体角膜缘上皮移植无一例显示排斥表现。结论：培养的角膜缘上皮移植后，在形成稳定的眼表后行PKP的早期结果是良好的。为了避免排斥反应，培养的同种异体角膜缘上皮移植者行充分的免疫抑制治疗是必需的。角膜同种异体移植能够单独排斥同种异体角膜缘移植物。

关键词：角膜缘上皮移植术穿透性角膜移植术移植后培养早期角膜缘干细胞缺乏同种异体移植免疫抑制治疗组织病理学特征排斥反应

AtDREB2A-CA Influences Root Architecture and Increases Drought Tolerance in Transgenic Cotton

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Agricultural Sciences 2017年第10期8卷 1195-1225页

作者： Maria Eugenia Lisei-de-Sa Fabricio B.M.Arraes Giovani G.Brito Magda A.Beneventi Isabela T.Lourenco-Tessutti Angelina M.M.Basso Regina M.S.Amorim Maria C.M.Silva Muhammad Faheem Nelson G.Oliveira Junya Mizoi Kazuko Yamaguchi-Shinozaki Maria fatima Grossi-de-Sa Embrapa Recursos Genéticos e Biotecnologia BrasíliaBrazil Empresa de Pesquisa Agropecuária de Minas Gerais UberabaBrazil Universidade Federal do Rio Grande do Sul Porto AlegreBrazil Embrapa Clima Temperado PelotasBrazil Universidade de Brasília BrasíliaBrazil Embrapa Agroenergia BrasíliaBrazil Japan International Research Center for Agricultural Sciences(JIRCAS) TsukubaJapan Universidade Catolica de Brasilia BrasiliaBrazil

Drought is a major environmental factor limiting cotton (Gossypium hirsutum L.) productivity worldwide and projected climate changes could increase their negative effects in the future. Thus, targeting the molecular mechanisms correlated with drought tolerance without reducing productivity is a challenge for plant breeding. In this way, we evaluated the effects of water deficit progress on AtDREB2A-CA transgenic cotton plant responses, driven by the stress-inducible rd29 promoter. Besides shoot and root morphometric traits, gas exchange and osmotic adjustment analyses were also included. Here, we present how altered root traits shown by transgenic plants impacted on physiological acclimation responses when submitted to severe water stress. The integration of AtDREB2A-CA into the cotton genome increased total root volume, surface area and total root length, without negatively affecting shoot morphometric growth parameters and nor phenotypic evaluated traits. Additionally, when compared to wild-type plants, transgenic plants (17-T0 plants and its progeny) highlighted a gradual pattern of phenotypic plasticity tosome photosynthetic parameters such as photosynthetic rate and stomatal conductance with water deficit progress. Transgene also promoted greater shoot development and root robustness (greater and deeper root mass) allowing roots to grow into deeper soil layers. The same morpho-physiological trend was observed in the subsequent generation (17.6-T2). Our results suggest that the altered root traits shown by transgenic plants are the major contributors to higher tolerance response, allowing the AtDRE2A-CA-cotton plants to maintain elevated stomatal conductance and assimilate rates and, consequently, reducing their metabolic costs involved in the antioxidant responses activation. These results also suggest that these morpho-physiological changes increased the number of reproductive structures retained per plant (26% higher) when compared with its non-transgenic cou

关键词： Dehydration Responsive Element Binding Factors Water Deficit Tolerance Gossypium hirsutum Physiological Phenotyping Transcription Factor Stress-Inducible Promoter

Closing the gap of children’s surgery in Pakistan

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World Journal of Pediatric Surgery 2019年第1期2卷 20-20页

作者： Simra Siddiqui Dominique Vervoort Alexander W Peters Haitham Shoman Nabeel M Ashraf Irum fatima Lubna Samad Center for Essential Surgical and Acute Care Indus Health NetworkKarachiPakistan Program in Global Surgery and Social Change Department of Global Health and Social MedicineHarvard Medical SchoolBostonMassachusettsUSA Department of Surgery Weill Cornell Medical CollegeNew York CityNew YorkUSA

Two billion children worldwide lack access to safe surgical and anesthesia care when needed.1 The global pediatric surgical work-force is limited,and children and adolescents with surgical conditions often get absorbed into adult surgical services as pediatric surgeons are absent or *** an estimated population of 68.5 million chil-dren younger than 15 years(35%of the total population),Pakistan also faces similar chal-lenges in delivering adequate surgical care to *** investments in maternal and child health in recent years,Pakistan was unable to attain the Millennium Development Goals in *** death rate from congenital anomalies before the age of 5 years is still 77.2 children per 100000 live births,and a quarter of all deaths among children ages 5 and 14 years are a result of injuries.2 Despite this high burden,pediatric surgical care remains limited throughout Pakistan,with 0.4 pedi-atric surgeons per million population in the entire country,in contrast to upper-middle and high-income countries which have more than two pediatric surgeons per million popu-lation.

关键词： anesthesia injuries spite

Finding a Practical IT Solution-Open Source Accounting Software

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通讯和计算机（中英文版） 2012年第4期9卷 406-413页

作者： Manar Abu Talib Adel Khelifi Osama El-Temtamy fatima Ismaeel Mahra Rashed Najah Hasan Summaya Khaled College of Information Technology Zayed University Abu Dhabi P.O. BOX4783 UAE Department of Software Engineering AI Hosn University Abu Dhabi P.O. BOX38772 UAE College of Business Zayed University Abu Dhabi P.O. BOX4783 UAE

Companies, both large and small, are currently emerging in the UAE, and an important step for these firms, and a challenging one, is choosing the right accounting software. Open-source software is gaining acceptance and has become a prominent software paradigm today, which, unlike proprietary off-the-shelf software with its restrictive copyright licenses, is available free of charge. A better understanding of the role of open-source accounting software will result in higher performance accounting and finance departments. With this kind of software, companies can access the source code, change it, and customize it to suit their needs, as well as redistribute it in either modified or unmodified form. There are some companies in the UAE using proprietary accounting software who are not aware of the availability of such an alternative. This research paper studies the state of art of accounting software used in the UAE, and then demonstrates how open-source accounting software could provide a valuable solution for the business sector.

关键词：会计软件开放源码 IT 小型企业开源软件阿联酋研究论文挑战性

转录因子禽类红细胞增多症病毒E26癌基因同系物1是一种新型的盐敏感性高血压肾损害介质

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中华高血压杂志 2015年第2期23卷 199-199页

作者： Feng W Chumley P Prieto MC Miyada K Seth DM fatima H Hua P Rezonzew G Sanders PW Jaimes EA 戴伦练桂丽

转录因子E26特异转录序列（E26transforma—tion—specificsequence，ETS）1是一种调节多种基因表达的转录因子，包括生长因子、趋化因子以及黏附分子。最近的研究显示血管紧张素（angiotensin，Ang）Ⅱ可增强ETS-1在肾小球内的表达，... 详细信息

转录因子E26特异转录序列（E26transforma—tion—specificsequence，ETS）1是一种调节多种基因表达的转录因子，包括生长因子、趋化因子以及黏附分子。最近的研究显示血管紧张素（angiotensin，Ang）Ⅱ可增强ETS-1在肾小球内的表达，并且抑制ETS-1可改善AngⅡ引起的纤维化和促炎症效应。

关键词：转录因子高血压肾损害红细胞增多症盐敏感性同系物癌基因 ETS-1 介质

Mean platelet volume as a novel predictor of systematic inflammatory response in cirrhotic patients with culturenegative neutrocytic ascites

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World Journal of Hepatology 2015年第7期7卷 1001-1006页

作者： Marisol Galvez-Martinez Alfredo I Servin-Caamano Eduardo Perez-Torres Francisco Salas-Gordillo Xaira Rivera-Gutierrez fatima Higuera-de la Tijera Gastroenterology Department Hospital General de México "Dr. Eduardo Liceaga" Internal Medicine Department Hospital General de México "Dr. Eduardo Liceaga" Faculty of Medicine "Universidad Veracruzana"

AIM: To identify a mean platelet volume(MPV) cutoff value which should be able to predict the presence of bacterial ***: An observational, analytic, retrospective study. We evaluated medical records of cirrhotic patients who were hospitalized from January 2012 to January 2014 at the Gastroenterology Department of "Hospital General de México Dr. Eduardo Liceaga", we included 51 cirrhotic patients with ascites fluid infection(AFI), and 50 non-infected cirrhotic patients as control group. Receiver operator characteristic curves were used to identify the best cutoff value of several parameters from hematic cytometry, including MPV, to predict the presence of ascites fluid ***: Of the 51 cases with AFI, 48 patients(94.1%) had culture-negative neutrocytic ascites(CNNA), 2(3.9%) had bacterial ascites, and one(2%)had spontaneous bacterial peritonitis. Infected patients had greater count of leucocytes and polymorphonuclear cells, greater levels of MPV and cardiac frequency(P 0.80). A cutoff MPV value of 8.3 fl was the best to discriminate between cirrhotic patients with AFI and those without infection. CONCLUSION: Our results support that MPV can be an useful predictor of systemic inflammatory response syndrome in cirrhotic patients with AFI, particularly CNNA.

关键词： Mean platelet volume Cirrhosis Ascites fluid infection Culture negative neutrocytic ascites Systemic inflammatory response

镫骨假体植入的平板CT检查:实验及临床研究

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国际医学放射学杂志 2012年第3期 302-302页

作者： K.zaoui J.Kromeier M.Neudert C.C.Boedeker T.Zahnert R.Laszig 乔辉 Department of Otorhinolaryngology Head and Neck SurgeryUniversity-Hospital HeidelbergLudwig-Karls-University HeidelbergIm Neuenheimer Feld 400D-69120 HeidelbergGermany

目的中耳及内耳的解剖信息对于术后评价变得越来越重要,特别是镫骨成形术后气骨导间距(ABG)改善不成功时。截至目前,CT已是检测复发性听力丧失原因的首选方法。CT的缺点包括中耳植入物的金属伪影及相对高的放射剂量。方法平板CT(fpCT)... 详细信息

目的中耳及内耳的解剖信息对于术后评价变得越来越重要,特别是镫骨成形术后气骨导间距(ABG)改善不成功时。截至目前,CT已是检测复发性听力丧失原因的首选方法。CT的缺点包括中耳植入物的金属伪影及相对高的放射剂量。方法平板CT(fpCT)用于实验性植入不同镫骨假体后的3个颞骨标本,以验证中耳及内耳fpCT的准确性。另

关键词：镫骨假体平板CT 影像中耳质量控制

中耳重建平板CT的临床研究:107例病人的研究

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国际医学放射学杂志 2014年第3期 293-293页

作者： K.zaoui J.Kromeier M.Neudert T.Beleites T.Zahner R.Laszig 李晓琼 Department of Otorhinolaryngology Head and Neck SurgeryUniversity Hospital HeidelbergRuprecht Karls UniversityIm Neuenheimer Feld 40069120 HeidelbergGermany

摘要目的部分或完全听小骨置换假体(PORP/TORP)中耳重建术后,可能会因置换假体脱位或位置不当而持续存在气-骨间隙(ABG)。迄今为止,颞骨扫描CT是为术后ABG

关键词：中耳重建术临床研究病人 CT

Concurrent use of aromatase inhibitors and hypofractionated radiation therapy

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World Journal of Radiology 2012年第7期4卷 318-323页

作者： Cyrus Chargari Pablo Castro-Pena Ivan Toledano Marc A Bollet Alexia Savignoni Paul Cottu fatima Laki Franois Campana Patricia De Cremoux Alain Fourquet Youlia M Kirova Department of Radiation Oncology Institut Curie 75005 Paris France Department of Biostatistics Institut Curie 75005 Paris France Department of Medical Oncology Institut Curie 75005 Paris France Department of Surgery Institut Curie 75005 Paris France

AIM: To retrospectively assess the acute and long-term toxicity using aromatase inhibitors (AI) therapy concurrently with hypofractionated radiotherapy (HFRT) in breast cancer patients. METHODS: From November 1999 to October 2007, 66 patients were treated with breast HFRT and concurrent AI. In 63 patients (95.5%), HFRT delivered a total dose of 32.5 Gy to the whole breast within 5 wk (five fractions, one fraction per week). Other fractionations were chosen in three patients for the patients' personal convenience. A subsequent boost to the tumor bed was delivered in 35 patients (53.0%). Acute toxicities were scored according to the Common Toxicity Criteria for Adverse Events v3. Late toxicity was defined as any toxicity occurring more than 6 mo after completion of HFRT and was scored according to the Late Effects Normal Tissue Task Force-Subjective, Objective, Management and Analytic scale. RESULTS: At the end of the HFRT course, 19 patients (28.8%) had no irradiation-related toxicity. Acute grade 1-2 epithelitis was observed in 46 patients (69.7%). One grade 3 toxicity (1.5%) was observed. With a median follow-up of 34 mo (range: 12-94 mo), 31 patients (47%) had no toxicity, and 35 patients (53%) presented with grade 1-2 fibrosis. No grade 3 or greater delayed toxicity was observed. CONCLUSION: We found that AI was well tolerated when given concurrently with HFRT. All toxicities were mild to moderate, and no treatment disruption was necessary. Further prospective assessment is warranted.

关键词： Breast cancer Hypofractionated radiotherapy Skin toxicity Aromatase inhibitors