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Particularities of Tuberculosis in Children and Adolescents with Sickle Cell Disease in Senegal

Open Journal of Pediatrics 2022年第1期12卷 59-66页

作者： Idrissa Demba Ba Indou Deme/Ly Yaye Joor Dieng Abou Ba Babacar Niang Aliou Abdoulaye Ndongo Papa Moctar Faye Guillaye Diagne Amadou Sow fatima tall/fall Amadou Lamine fall Ousmane Ndiaye Hô pital d’enfants Albert-Royer de Fann-Dakar Université Cheikh Anta Diop de Dakar Fann Dakar Senegal

Introduction: Tuberculosis and sickle cell disease are one of the main global health priorities particularly in Africa. We aimed to determine the epidemiological, diagnostic and therapeutic aspects of tuberculosis in children and adolescents with sickle cell disease. Patients and methods: Patients aged 0 - 20 years with sickle cell anemia presented with tuberculosis at the Centre Hospitalier National d’Enfants Albert Royer (CHNEAR), Dakar, Senegal were included in the study. Medical history, risk factors, clinical, bacteriological, and outcome data was collected. Data was analyzed using the SPSS software, version 16. Results: A total of 25 cases of tuberculosis were documented from January 1st, 1991 to December 31st, 2019 (hospital prevalence: 0.97%). Mean age was 12.5 years. The sex ratio was 1.5 (15 girls and 10 boys). Pulmonary tuberculosis in 14 cases was the most frequent followed by lymph nodes in 7 cases involvement and Pott’s disease in 4 cases. In 5 patients Tb was multifocal. Mean duration of treatment was 8.27 months (6 to 12 months). Outcome was good on antituberculosis treatment. None patient died. Conclusion: Children and adolescents with sickle cell disease can be infected with Mycobacterium tuberculosis. Pulmonary tuberculosis, lymph nodes and bone involvement are the most frequent localizations. Outcome is good on antituberculosis treatment.

关键词： Tuberculosis Sickle Cell Disease Children Adolescent Senegal

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Jacob’s Syndrome and Deficiency of 11-Beta-Hydroxylase Enzyme Association Revealed by a Statural Advance: A Case Report

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Case Reports in Clinical Medicine 2023年第6期12卷 207-211页

作者： Wafa Aitifali fatima Zahra Lahmamssi Sana Abourazzak Laila Bouguenouch Moustapha Hida Endocrinology Unit of the Pediatrics Department Hassan II University Hospital Fez Morocco

47XYY syndrome is a rare sex chromosome variant with an extra Y chromosome. Most patients with a 47XYY karyotype have a normal phenotype. This disorder seems to be associated with a higher risk of developing behavior and cognitive problems, tall stature and infertility in adulthood. We report here a rare case of 47, XYY syndrome associated with an 11-beta-hydroxylase deficiency revealed by a stature advance along with precocious puberty after obtaining informed consent from parents. To our knowledge, this is the first case reported in the literature.

关键词： Jacob’s Syndrome 47XYY Syndrome 11-Beta-Hydroxylase Deficiency

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