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Evaluation of Quantitative Phytochemicals, Liver Enzymes and Histological Changes in Isoniazid Induced Hepatotoxicity in Adult Male Wistar Rats Treated with Aqueous Extracts of <i>Brysocarpus coccineus</i>

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Advances in Enzyme Research 2017年第3期5卷 33-44页

作者： Kashini Andrew Nachamada Solomon Emmanuel Deborah Chioma Ejiogu Chinonso Nicodemus Chima fatima mohammed yahuza Emmanuel Chukwuemeka Umeh Philemon Paul Mshelia Department of Human Physiology Faculty of Basic Medical SciencesCollege of Medical SciencesAhmadu Bello University ZariaNigeria Department of Human Physiology College of Medical SciencesAbubakar Tafawa Balewa UniversityBauchiNigeria

Isoniazid induced hepatotoxicity is a major concern in patients taking anti tuberculosis treatment and prophylaxis. It can result in elevated serum liver enzymes and hepatic failure. The aim of the study was to evaluate the phytochemicals and ameliorative effects of aqueous extracts of Brysocarpus coccineus on serum liver enzymes in isoniazid (INH) induced hepatotoxicity in adult male Wistar rats. Thirty six (36) adult male Wistar rats were divided into six groups of six rats each and were treated orally for 30 days as follows: Group I: 1 ml/kg of distilled water;group II: Isoniazid (27 mg/kg);group III: Isoniazid (27 mg/kg) + Livolin forte (20 mg/kg);group IV: Isoniazid (27 mg/kg) + B. coccineus (200 mg/kg);group V: Isoniazid (27 mg/kg) + B. coccineus (400 mg/kg);group VI: Isoniazid (27 mg/kg) + B. coccineus (800 mg/kg). At the end of the experiments, the Wistar rats were sacrificed and sera obtained for liver enzymes assay, whereas the liver tissue was also harvested and used for histological studies. Tanins, saponins, alkaloids and flavonoids were quantitatively present at 2.29%, 18.05%, 23.24% and 18.99%, respectively. There was an increase in the serum AST and ALT in the isoniazid treated group, which was reversed by livolin forte and the aqueous extracts at a dose of 200 mg/kg, however the extracts increased the serum levels of AST and ALT at higher doses, which was however not significant (p > 0.05) when compared to the controls. There was evidence of a reduction in hepatocytes damage in the extract treated groups when compared to the Isoniazid untreated group. In conclusion, aqueous extracts of B. coccineus shows hepatoprotective effects at 200 mg/kg in isoniazid hepatotoxicity in adult male Wistar rats.

关键词： Brysocarpus coccineus Isoniazid Hepatotoxicity Phytochemicals

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Experimental and numerical study of effecting core configurations on the static and dynamic behavior of honeycomb plate with aluminum material

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Defence Technology（防务技术） 2024年第9期39卷 177-192页

作者： Nehad Abid Allah Hamza fatima mohammed K.AL-Fatlwe Muna Ali Talib Engineering College Al-Qasim Green University51013BabylonIraq Engineering Technical College of Al-Najaf Al-Furat Al-Awsat Technical University(ATU)Najaf54003Iraq

The sandwich panel incorporated a honeycomb core,a widely utilized composite structure recognized as a fundamental classification of composite *** a core resembling a honeycomb,possessing thickness and softness,and is flank by rigid face sheets that sandwich various shapes and *** paper presents an examination of the static and dynamic analysis of lightweight plates made of aluminum honeycomb sandwich *** sandwich plate samples are 300 mm long,and 300 mm wide,the heights of the core have been varied at four values ranging from 10 to 25 *** honeycomb core is manufactured from Aluminum material by using a novel technique namely resistance spot welding(RSW)instead of using adhesive material,which is often used when an industrial flaw is *** optimization based on response surface methodology(RSM)and design of experiment software(DOE)was used to verify the current work.A theoretical examination of the crashworthiness behavior(maximum bending load,maximum deflection)and vibration attributes(natural frequency,damping ratio,transient temporal response)of honeycomb sandwich panels with different design parameters was also carried *** addition,the finite element method-based ANSYS software was used to confirm the theoretical *** findings of the present work showed that the relationship between the natural frequency,core height,and cell size is *** contrast,the relationship between the natural frequency and the thickness of the cell wall is ***,the damping ratio is inversely proportional to the core height and cell size but directly proportional to the thickness of the cell *** study indicates that altering the core height within 10-25 mm leads to a significant increase of 82%in the natural frequency and a notable decrease of 49%in the damping *** findings are based on a specific cell size value of 0.01 m and a cell wall thickness of 0.001 ***,the results indicate

关键词： Honeycomb Load Transient response Free vibration Natural frequency

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Mechanical and Thermal Properties of Polypropylene Reinforced with Almond Shells Particles： Impact of Chemical Treatments

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Journal of Bionic Engineering 2015年第3期12卷 483-494页

作者： fatima Zahra El Mechtali Hamid Essabir Souad Nekhlaoui mohammed Ouadi Bensalah Mohammad Jawaid Rachid Bouhfid AbouEIkacem Qaiss Laboratory of Mechanic and Materials (LMM) Mohammed V-Rabat University Faculty of Science Rabat Morocco Moroccan Foundation for Advanced Science Innovation and Research (MAScIR) Institute of Nanomaterials and Nanotechnology (NANOTECH) Laboratory of Polymer Processing Rabat Morocco Laboratory of Mechanics in Processes Energy and Environment National School of Applied Sciences Ibn Zohr University Agadir Morocco Department of Biocomposite Technology Institute of Tropical Forestry and Forest Products (INTROP) Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia

Polypropylene （PP） matrix composites reinforced with chemically treated Almond Shell （AS） particles with and without compatibilizer （PP-g-MA） was prepared by a twin-screw extrusion at loading of 20 wt.% AS particles. Two types of chemical treatments （alkali treatment with sodium hydroxide and etherification with dodecane bromide） of the particles were carried out to improve the interface adhesion between particles and PP matrix. Results show that chemical modifications of AS particles affect the mechanical and viscoelastic properties of AS/PP composites. The composites reinforced with alkali treated particles and the compatibilized matrix lead to a notable increase in the Young＇s modulus （14%） compared to the composites with untreated AS particles. The ductility of composite was also evaluated by the yield strain, and results show a notable increase （31%） compared to that of composites with untreated particles. The thermal stability increased with the use of etherification （385 ℃）, with gains in the temperature up to 23 ℃ compared to neat PP （362 ℃）. The achieved results show that the AS/PP composites can be used in several applications. A thermoplastic matrix compsite mixed with treated AS particles appears to be a good alternative to obtain environmentally friendly products.

关键词： PP AS chemical treatment composite extrusion injection

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Antioxidant activity profiling by spectrophotometric methods of aqueous methanolic extracts of Helichrysum stoechas subsp. rupestre and Phagnalon saxatile subsp. saxatile

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Chinese Journal of Natural Medicines 2014年第6期12卷 415-422页

作者： Farah Haddouchi Tarik mohammed Chaouche Riadh Ksouri Faten Medini fatima Zohra Sekkal Abdelhafid Benmansour Laboratory of Natural Products Department of Biology Faculty of Sciences Abou Bekr Belkad University Laboratory of Plant Adaptation to Abiotic Stresses Biotechnologic Center in Borj-Cedria Technopol (CBBC) Department of Biotechnology Faculty of Natural Science and Life Abdelel Hamid Ibn Badiss University Mostaganem 27000 Algeria

AIM: The aqueous methanolic extracts of two plants from Algeria, Helichrysum stoechas subsp. rupestre and Phagnalon saxatile subsp. saxatile, were investigated for their antioxidant activity. METHOD: Total phenolics, flavonoids, and tannins were determined by spectrophotometric techniques..In vitro antioxidant and radical scavenging profiling was determined by spectrophotometric methods, through: Total antioxidant capacity, and radical scavenging effects by the DPPH and ABTS methods, reducing and chelating power, and blanching inhibition of the β-carotene. RESULTS: All of the extracts showed interesting antioxidant and radical scavenging activity. The highest contents in phenolics, tannins, and the highest total antioxidant capacity as gallic acid equivalents of 97.5 ± 0.33 mg GAE/g DW was obtained for the flowers of H. stoechas subsp. rupestre extract in the phosphomolybdenum assay. An extract of the leafy stems of P. saxatile subsp. saxatile revealed the highest content of flavonoids, and the highest antioxidant activity by the radical scavenging and β-carotene assays when compared with standards. The best activity was by the scavenging radical DPPH with an IC50 value of 5.65 ± 0.10 μg·mL-1. CONCLUSION: The studied medicinal plants could provide scientific evidence for some traditional uses in the treatment of diseases related to the production of reactive oxygen species(ROS) and oxidative stress.

关键词： Helichrysum stoechas subsp.rupestre Phagnalon saxatile subsp.saxatile Phenolic compounds Antioxidant activity

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Diet fortification for mild and moderate picky eating in typically developed children:Opinion review of Middle East consensus

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World Journal of Clinical Pediatrics 2025年第1期14卷 139-148页

作者： mohammed Al-Beltagi Elie Choueiry Najat Alahmadi Zeinab Demerdash Wafaa Helmi Ayesh Khoula Al-Said fatima Al-Haddad Sanaa Y Shaaban Eslam Tawfik Department of Pediatric Faculty of MedicineTanta UniversityTanta 31511Egypt Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671ManamaBahrain Paediatric Intensive and Critical Care Unit Hospital Hôtel Dieu de FranceBeirut 166830BeyrouthLebanon Department of Pediatric Gastroenterology Hepatology and NutritionMadina Maternity and Children HospitalKing Salman Medical CityAlmadina Almonawarh 41412Almadina AlmonawarhSaudi Arabia Department of Gastroenterology Hepatology and NutritionAl Amiri HospitalKuwait City 999044Kuwait Department of Nutrition Altadawi Speciality HospitalDubai 1853DubayyUnited Arab Emirates Department of Paediatric Gastroenterology Royal HospitalMuscat 1331MuscatOman Department of Dietetic Salmaniya Medical ComplexGovernment HospitalsAl Salmaniya 12ManamaBahrain Department of Pediatrics Faculty of MedicineAin Shams UniversityCairo 11591Egypt Department of Paediatric Faculty of MedicineSuez UniversitySuez 41522Egypt Department of Paediatric Sheikh Khalifa Medical CityAbu Dhabi 00000Abu DhabiUnited Arab Emirates

BACKGROUND Picky eating is a commonly observed behavior among children globally,negatively impacting their physical and mental *** common characteristics distinguish peaky eaters,including food selectivity,food neophobia,and food avoidance,there is no clear definition to assess this *** to the unavailability of data regarding picky eating,it wasn’t easy to estimate its *** To develop a regional protocol to help healthcare professionals identify and manage mild and moderate picky eating *** A virtual roundtable discussion was held in April 2021 to gather the opinions of seven pediatricians and two pediatric dietitians from eight Middle Eastern countries who had great experience in the management of picky *** discussion covered different topics,including clearly defining mild and moderate picky eating,identifying the role of diet fortification in these cases,and the possibility of developing a systematic approach to diet *** The panel identified picky eating as consuming an inadequate amount and variety of foods by rejecting familiar and unfamiliar *** of the time,moderate picky eating cases had micronutrient deficiencies with over-or undernutrition;the mild cases only showed inadequate food consumption and/or poor diet *** attention to the organic red flags like growth faltering and development delay and behavioral red flags,including food fixation and anticipatory gagging,will help healthcare professionals evaluate the picky eaters and the caregivers to care for their *** dietary supplementation and commercial food fortification play an important role in picky eating,they were no benefit in the Middle *** The panel agreed that food fortification through a food-first approach and oral nutritional supplements would be the best for Middle Eastern *** recommendations would facilitate identifying and managing picky-eating children in the Middle East.

关键词： Picky eating Diet fortification Children Protocol Roundtable discussion Middle East

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Comparative Study of Entanglement and Wigner Function for Multi-Qubit GHZ-Squeezed State

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Communications in Theoretical Physics 2017年第12期67卷 729-734页

作者： fatima-Zahra Siyouri Laboratoire de Physique Thèorique Département de Physique Faculté des Sciences Université Mohammed Ⅴ-Agdal

In this paper we address the possibility of using the Wigner function to capture the quantum entanglement present in a multi-qubit system. For that purpose, we calculate both the degree of entanglement and the Wigner function for mixed tripartite squeezed states of Greenberger–Horne–Zeilinger(GHZ) type then we compare their behaviors. We show that the role of Wigner function in detecting and quantifying bipartite quantum correlation [Int. J. Mod. Phys. B30(2016) 1650187] may be generalized to the multipartite case.

关键词： negativity of Wigner function entanglement squeezed states tripartite GHZ non-classicality

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The Floristic Diversity of the Tlemcen Southern Slope Scrublands （Western Algeria）

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Journal of Life Sciences 2012年第10期6卷 1167-1173页

作者： Belhacini fatima Bouazza mohammed Laboratory of Ecology and Management of the Natural Ecosystems Department of Ecology and Environment University Abou BakrBelkaid Tlemcen 13000 Algeria

This work was completed on the study of the southern slope scrublands （matorrals） of Tlemcen region in the northwest of Algeria （Western Algeria）. These scrublands are under various states of degradation, made up of Quercus ilex, Juniperus oxycedrus, Thymus ciliatus, Rosmarinus officinalis. The problems sought in this study are to give the actual position of vegetable cover and in particular that of the formations to matorrals currently existing in the southern slope of the area of Tlemcen, while being based on the phytoecological aspect of the vegetable groupings which constitute this inheritance. Sampling is the first phase of work based on the analysis of the spatial variations of the structure and composition floristic and considering the nature of the problem to be treated, the authors considered to be useful to use the method Zuricho Montpeli6raine developed at the point by Braun-Blanquet, the method usually used consists to collect all the plant species and to make the list of the species on a small square of surface 100 m2 （have it minimal）. The floristic readings （150 on the whole） were taken according to the method of Braun-Blanquet. Our results show that there exists a therophytisation marked by a general invasion of annual species as show us as the synergistic action of the aridity and the anthropic action generated important modifications on the level of the vegetation in the dynamic direction. This advanced degradation leads a steppisation which results in a substitution of the elements of the matorrals by species more adapted much the xericity.

关键词： Scrublands floristic diversity phanerophyte chamaephyte anthropical Tlemcen Algeria.

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Antioxidant and antihyperlipidemic activity of Costus speciosus against atherogenic diet-induced hyperlipidemia in rabbits

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Journal of Integrative Medicine 2019年第3期17卷 181-191页

作者： Fatma Mohamed Hussein Shediwah Khalid mohammed Naji Hussein Saleh Gumaih fatima A Alhadi Amani Lutf Al-Hammami Myrene Roselyn D'Souza Department of Biology Faculty of ScienceSana'a University Department of Chemistry Faculty of ScienceSana'a University Chemical Ecology Department of BiologyUniversity of Konstanz Department of Biochemistry Mount Carmel College

Objective: An extract of Costus speciosus(CSE), a herb widely used in folk medicine, was evaluated for its antioxidant, antihyperlipidemic and ameliorating effects on histopathological changes in atherogenic ***: Twenty-four male rabbits(Oryctolagus cuniculus) were divided into 4 groups. Three groups were fed a diet containing 3% saturated fat and 1.3% cholesterol for 40 d. One of these was sacrificed on the 40 th day and was called the pathogenic(P) group; the other two groups received treatment for another 30 d as follows: one received 0.8 g/(kgád) of CSE and the other was given 0.01 g/(kgád) of simvastatin. The normal group was sacrificed on the 70 th day and used as a ***: CSE showed radical-scavenging ability. Administration of CSE for a 30-day period resulted in a significant decrease in total cholesterol, triacylglycerol, low-density lipoprotein and aspartate aminotransferase compared to the P group, while levels of hemoglobin, packed corpuscular volume and red blood cells were elevated. With respect to studies performed on the heart, a decrease in malondialdehyde and an increase in reduced glutathione were noted. Total protein increased in the liver, heart and aorta after treatment with CSE and also a marked improvement in histopathological parameters was ***: The present findings indicate that the C. speciosus rhizome possesses antiatherogenic and antioxidant properties which may provide protective effects against oxidative stress in atherosclerotic rabbits.

关键词： Antioxidants Atherosclerosis Costus speciosus Lipid profile Myocardial infraction Simvastatin

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A Novel Human Interaction Framework Using Quadratic Discriminant Analysis with HMM

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Computers, Materials & Continua 2023年第11期77卷 1557-1573页

作者： Tanvir fatima Naik Bukht Naif Al Mudawi Saud S.Alotaibi Abdulwahab Alazeb mohammed Alonazi Aisha Ahmed AlArfaj Ahmad Jalal Jaekwang Kim Department of Computer Science Air UniversityIslamabad44000Pakistan Department of Computer Science College of Computer Science and Information SystemNajran UniversityNajran55461Saudi Arabia Information Systems Department Umm Al-Qura UniversityMakkahSaudi Arabia Department of Information Systems College of Computer Engineering and SciencesPrince Sattam bin Abdulaziz UniversityAl-Kharj16273Saudi Arabia Department of Information Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Convergence Program for Social Innovation Sungkyunkwan UniversitySuwon03063Korea

Human-human interaction recognition is crucial in computer vision fields like surveillance,human-computer interaction,and social *** enhances systems’ability to interpret and respond to human behavior *** research focuses on recognizing human interaction behaviors using a static image,which is challenging due to the complexity of diverse *** overall purpose of this study is to develop a robust and accurate system for human interaction *** research presents a novel image-based human interaction recognition method using a Hidden Markov Model(HMM).The technique employs hue,saturation,and intensity(HSI)color transformation to enhance colors in video frames,making them more vibrant and visually appealing,especially in low-contrast or washed-out *** filters reduce noise and smooth imperfections followed by silhouette extraction using a statistical *** extraction uses the features from Accelerated Segment Test(FAST),Oriented FAST,and Rotated BRIEF(ORB)*** application of Quadratic Discriminant Analysis(QDA)for feature fusion and discrimination enables high-dimensional data to be effectively analyzed,thus further enhancing the classification *** ensures that the final features loaded into the HMM classifier accurately represent the relevant human *** impressive accuracy rates of 93%and 94.6%achieved in the BIT-Interaction and UT-Interaction datasets respectively,highlight the success and reliability of the proposed *** proposed approach addresses challenges in various domains by focusing on frame improvement,silhouette and feature extraction,feature fusion,and HMM *** enhances data quality,accuracy,adaptability,reliability,and reduction of errors.

关键词： Human interaction recognition HMM classification quadratic discriminant analysis dimensionality reduction

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Interleukin-28 and hepatitis C virus genotype-4:Treatment-induced clearance and liver fibrosis

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World Journal of Gastroenterology 2012年第47期18卷 7003-7008页

作者： Moutaz Derbala Nasser Rizk fatima Shebl Saad Alkaabi Nazeeh Eldweik Anil John Manik Sharma Rafie Yaqoob Muneera Almohanadi mohammed Butt Khaled Alejji Department of Gastroenterology and Hepatology Hamad HospitalDoha 3050Qatar Department of Gastroenterology and Hepatology Weill Cornell Medical CollegeDoha 3050Qatar Department of Health Sciences Qatar UniversityDoha 2713Qatar Chronic Disease Epidemiology Division Yale School of Public HealthNew HavenCT 06520United States

AIM:To investigate the association between interleukin-28B(IL28B) genotype and response to treatment and hepatic fibrosis in patients with hepatitis C virus(HCV) genotype ***:Two hundred and one HCV-genotype 4 patients were *** patients were treated with Peginterferon alph2a/Ribavirin for 48 *** of treatment response(ETR) was defined as loss of detectable serum HCV RNA at the end of *** viral response(SVR) was defined as loss of detectable serum HCV RNA at the end of 24 wk follow *** of IL28B rs12979860 was performed using the TaqMan *** used logistic regression to estimate the adjusted odds ratio(aOR) and 95%***:The study included 201 HCV-genotype 4 *** majority of patients were men(89.6%),with a median age of 47 years,inter-quartile range(40-51).Approximately 62.5% of patients had ETR,and 49.6% had *** who achieved SVR were more likely to be younger(χ 2 = 4.91,P = 0.027),and less likely to have fibrosis(χ 2 = 15.54,P < 0.0001),or inflammation(χ 2 = 7.58,P = 0.006).The genotype distribution of rs12979860 was 36.2%,49.0% and 14.8% for genotypes CC,CT,and TT,*** these participants,rs12979860 genotype distribution did not differ by gender(P = 0.466),pretreatment viral load(P = 0.600),inflammation(P = 0.435),or fibrosis(P = 0.291).The frequencies of IL28B rs12979860 genotypes were TT(14.8%),CT(49.0%),and CC(36.2%).Compared to rs12979860 genotype TT,aORs(95%CI) for ETR and SVR were:CC genotype,[17.55(5.34-57.69) and 5.92(2.09-16.76),respectively];CT genotype,[5.15(1.80-14.78) and 2.48(0.94-6.52),respectively].In the current study,the patients who did not achieve ETR or SVR had a lower prevalence of rs12979860 CC(17.4% and 23.3%,respectively) than individuals who had ETR or SVR(47.9% and 47.2%,respectively).Individuals with rs12979860 CC genotype had approximately 6 times the odds of SVR compared to individuals with TT genotype(aOR = 5.92;95%CI:2.09-16.76).Similarly,patients with CT

关键词： Genotype 4 Hepatic fibrosis Hepatitis C virus Interleukin-28B rs12979860

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