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Production and activity of matrix metalloproteinases during liver fibrosis progression of chronic hepatitis C patients

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World Journal of Hepatology 2021年第2期13卷 218-232页

作者： Moises Martinez-Castillo Abigail Hernandez-Barragan Ivonne Flores-Vasconcelos Marina Galicia-Moreno Dorothy Rosique-Oramas Jose Luis Perez-Hernandez fatima higuera-de la tijera Eduardo E Montalvo-Jave Aldo Torre-delgadillo Paula Cordero-Perez Linda Muñoz-Espinosa David Kershenobich Gabriela Gutierrez-Reyes Liver Pancreas and Motility LaboratoryUnit of Experimental MedicineSchool of MedicineGeneral Hospital of MexicoUniversidad Nacional Autonoma de MexicoMexico City 06726Mexico department of Molecular Biology and Genomics Institute of Molecular Biology in Medicine and Gene TherapyHealth Science University CenterUniversity of GuadalajaraGuadalajara 06726Mexico department of Gastroenterology General Hospital of Mexico“Dr.Eduardo Liceaga”Mexico City 06726Mexico department of General Surgery General Hospital of Mexico“Dr.Eduardo Liceaga”School of MedicineUniversidad Nacional Autonoma de MexicoMexico City 06726Mexico Hepatology and Liver Transplant National Institute of Medical Sciences and Nutrition“Salvador Zubirán”Mexico City 06726Mexico University Hospital“Dr.JoséEleuterio González ”Autonomous University of Nuevo LeonMonterrey 06726Mexico

BACKGROUND Matrix metalloproteinases(MMPs)participate in the degradation of extracellular matrix compounds,maintaining the homeostasis between fibrogenesis and fibrolytic processes in the ***,there are few studies on the regulation of liver MMPs in fibrosis progression in *** To assess the production activity and regulation of matrix metalloproteinases in liver fibrosis stages in chronic hepatitis C(CHC).METHODS A prospective,cross-sectional,multicenter study was *** patients were categorized in fibrosis grades through FibroTest®and/or FibroScan®.Serum MMP-2,-7,and-9 were determined by western blot and multiplex suspension array *** were validated by the Kruskal-Wallis and Mann-Whitney U *** Spearman correlation coefficient and area under the receiver operating characteristic curve were *** and gelatinase activity was determined through the Azocoll substrate and zymogram test,whereas tissue inhibitor of metalloproteinase-1 production was determined by dot blot *** Serum concentrations of the MMPs evaluated were higher in CHC patients than in healthy ***-7 distinguished early and advanced stages,with a correlation of 0.32(Pder the receiver operating characteristic displayed moderate sensitivity and specificity for MMP-7 in F4(area under the receiver operating characteristic,0.705;95%confidence interval:0.605-0.805;Plagenolytic activity was detected at F0 and F1,whereas gelatinase activity was not detected at any fibrosis *** inhibitor of metalloproteinase-1 determination showed upregulation in F0 and F1 but downregulation in F2(P<0.001).CONCLUSION High concentrations of inactive MMPs were present in the serum of CHC patients,reflecting the impossibility to restrain liver fibrosis *** could be good diagnostic candidates and therapeutic targets for improving novel strategies to reverse liver fibrosis in CHC.

关键词： Extracellular matrix Matrix metalloproteinases Liver fibrosis Chronic hepatitis C Fibrogenesis Fibrolysis

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Pathophysiological mechanisms involved in non-alcoholic steatohepatitis and novel potential therapeutic targets

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World Journal of Hepatology 2015年第10期7卷 1297-1301页

作者： fatima higuera-de la tijera Alfredo I Servin-Caamano Liver Clinic Gastroenterology DepartmentMexico’s General Hospital "Dr. Eduardo Liceaga" Diabetes Obesity and Metabolic Syndrome ClinicInternal Medicine DepartmentMexico’s General Hospital "Dr. Eduardo Liceaga"

Non-alcoholic fatty liver disease(NAFLD) is a major health care problem and represents the hepatic expression of the metabolic syndrome. NAFLD is classified as nonalcoholic fatty liver(NAFL) or simple steatosis,and non-alcoholic steatohepatitis(NASH). NASH is characterized by the presence of steatosis and inflammation with or without fibrosis. The physiopathology of NAFL and NASH and their progression to cirrhosis involve several parallel and interrelated mechanisms,such as,insulin resistance(IR),lipotoxicity,inflammation,oxidative stress,and recently the gut-liver axis interaction has been described. Incretin-based therapies could play a role in the treatment of NAFLD. Glucagon-like peptide-1(GLP-1) is an intestinal mucosa-derived hormone which is secreted into the bloodstream in response to nutrient ingestion; it favors glucose-stimulated insulin secretion,inhibition of postprandial glucagon secretion and delayed gastric emptying. It also promotes weight loss and is involved in lipid metabolism. Once secreted,GLP-1 is quickly degraded by dipeptidyl peptidase-4(DPP-4). Therefore,DPP-4 inhibitors are able to extend the activity of GLP-1. Currently,GLP-1 agonists and DPP-4 inhibitors represent attractive options for the treatment of NAFLD and NASH. The modulation of lipid and glucose metabolism through nuclear receptors,such as the farsenoid X receptor,also constitutes an attractive therapeutic target. Obeticholic acid is a potent activator of the farnesoid X nuclear receptor and reduces liver fat content and fibrosis in animal models. Ursodeoxycholic acid(UDCA) is a hydrophilic bile acid with immunomodulatory,antiinflammatory,antiapoptotic,antioxidant and antifibrotic properties. UDCA can improve IR and modulate lipid metabolism through its interaction with nuclear receptors such as,TGR5,farnesoid X receptor-a,or the small heterodimeric partner. Finally,pharmacologic modulation of the gut microbiota could have a role in the therapy of NAFLD and NASH. Probiotics prev

关键词： Insulin resistance Lipotoxicity Non-alcoholic steatohepatitis Physiopathology Therapeutic targets

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Mean platelet volume as a novel predictor of systematic inflammatory response in cirrhotic patients with culturenegative neutrocytic ascites

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World Journal of Hepatology 2015年第7期7卷 1001-1006页

作者： Marisol Galvez-Martinez Alfredo I Servin-Caamano Eduardo Perez-Torres Francisco Salas-Gordillo Xaira Rivera-Gutierrez fatima higuera-de la tijera Gastroenterology department Hospital General de México "Dr. Eduardo Liceaga" Internal Medicine department Hospital General de México "Dr. Eduardo Liceaga" Faculty of Medicine "Universidad Veracruzana"

AIM: To identify a mean platelet volume(MPV) cutoff value which should be able to predict the presence of bacterial ***: An observational, analytic, retrospective study. We evaluated medical records of cirrhotic patients who were hospitalized from January 2012 to January 2014 at the Gastroenterology department of "Hospital General de México Dr. Eduardo Liceaga", we included 51 cirrhotic patients with ascites fluid infection(AFI), and 50 non-infected cirrhotic patients as control group. Receiver operator characteristic curves were used to identify the best cutoff value of several parameters from hematic cytometry, including MPV, to predict the presence of ascites fluid ***: Of the 51 cases with AFI, 48 patients(94.1%) had culture-negative neutrocytic ascites(CNNA), 2(3.9%) had bacterial ascites, and one(2%)had spontaneous bacterial peritonitis. Infected patients had greater count of leucocytes and polymorphonuclear cells, greater levels of MPV and cardiac frequency(P der the receiving operating characteristic > 0.80). A cutoff MPV value of 8.3 fl was the best to discriminate between cirrhotic patients with AFI and those without infection. CONCLUSION: Our results support that MPV can be an useful predictor of systemic inflammatory response syndrome in cirrhotic patients with AFI, particularly CNNA.

关键词： Mean platelet volume Cirrhosis Ascites fluid infection Culture negative neutrocytic ascites Systemic inflammatory response

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Progress and challenges in the comprehensive management of chronic viral hepatitis: Key ways to achieve the elimination

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World Journal of Gastroenterology 2021年第26期27卷 4004-4017页

作者： Fátima higuera-de la tijera Alfredo Servín-Caamaño Luis Servín-Abad department of Gastroenterology and Hepatology Hospital General de MéxicoMexico City 06726Mexico department of Internal Medicine Hospital General de MéxicoMexico City 06726Mexico department of Gastroenterology Saint Cloud HospitalSaint CloudMN 56303United States

Chronic viral hepatitis is a significant health problem throughout the world,which already represents high annual *** 2040,chronic viral hepatitis due to virus B and virus C and their complications cirrhosis and hepatocellular carcinoma will be more deadly than malaria,vitellogenesis-inhibiting hormone,and tuberculosis *** this review,we analyze the global impact of chronic viral hepatitis with a focus on the most vulnerable groups,the goals set by the World Health Organization for the year 2030,and the key points to achieve them,such as timely access to antiviral treatment of direct-acting antiviral,which represents the key to achieving hepatitis C virus ***,we review the strategies to prevent transmission and achieve control of hepatitis B ***,we address the impact that the coronavirus disease 2019 pandemic has had on implementing elimination strategies and the advantages of implementing telemedicine programs.

关键词： Hepatitis C Hepatitis B Vaccination Elimination program Telemedicine Direct antiviral agents

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Impact of liver enzymes on SARS-CoV-2 infection and the severity of clinical course of COVID-19

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Liver Research 2021年第1期5卷 21-27页

作者： Fátima higuera-de la tijera Alfredo Servín-Caamaño Daniel Reyes-Herrera Argelia Flores-López Enrique J.A.Robiou-Vivero Felipe Martínez-Rivera Victor Galindo-Hernández Oscar Chapa-Azuela Alfonso Chávez-Morales Victor H.Rosales-Salyano Multidisciplinary Team for the Attention and Care of Patients with COVID-19 Hospital General de México Dr.Eduardo LiceagaMexico CityMexico Gastroenterology and Hepatology department Hospital General de México Dr.Eduardo LiceagaMexico CityMexico Internal Medicine department Hospital General de México Dr.Eduardo LiceagaMexico CityMexico Hepatobiliary and Pancreatology Clinic Surgery DepartmentHospital General de México Dr.Eduardo LiceagaMexico CityMexico Intensive Care Unit Hospital General de México Dr.Eduardo LiceagaMexico CityMexico

Background and aim Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the virus responsible for the current pandemic,can have multi-organ *** studies show that liver injury could be a manifestation of the disease,and that liver disease could also be related to a worse *** aim was to compare the characteristics of patients with severe coronavirus disease 2019(COVID-19)due to SARS-CoV-2 who required intubation versus stable hospitalized patients to identify the early biochemical predictive factors of a severe course of COVID-19 and subsequent requirement for intubation,specifically in *** This was an observational case-control study nested in a cohort *** medical records of patients admitted for confirmed COVID-19 at a tertiary level center in Mexico City were *** and biochemical data were collected,and the characteristics of patients who required invasive mechanical ventilation(IMV)(cases)were compared with stable hospitalized patients without ventilation(controls).Results We evaluated 166 patients with COVID-19 due to SARS-CoV-2 infection;114(68.7%)were men,the mean age was 50.6±13.3 years,and 27(16.3%)required *** comparative analysis between cases and controls showed(respectively)significantly lower blood oxygen saturation(SpO_(2))(73.5±12.0%vs.83.0±6.8%,Planine aminotransferase(ALT)(128(14–1123)IU/L vs.33(8–453)IU/L,P=0.003),aspartate aminotransferase(AST)(214(17–1247)vs.44(12–498)IU/L,P=0.001),lactic dehydrogenase(LDH)(764.6±401.9 IU/L vs.461.0±185.6 IU/L,P=0.001),and D-dimer(3463(524–34,227)ng/mL vs.829(152–41,923)ng/mL,P=0.003)*** in the cases group were older(58.6±12.7 years vs.49.1±12.8 years,P=0.001).Multivariate analysis showed that important factors at admission predicting the requirement for IMV during hospitalization for COVID-19 were AST≥250 IU/L(odds ratio(OR)=64.8,95%confidence interval(CI)7.5–560.3,P<0.0001)and D-dimer≥3500 ng/mL(OR=4.1,95

关键词： Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) Liver enzymes D-dimer Disease severity Invasive mechanical ventilation(IMV) Multi-organ failure

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Optical and magnetic properties of perovskite materials:Ba_(0.3)la_(0.7)Ti_(0.3)Fe_(0.7)O_(3) and Ba_(0.1)la_(0.9)Ti_(0.1)Fe_(0.9)O_(3)

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Journal of Rare Earths 2022年第4期40卷 652-659,I0005页

作者： fatima El Bachraoui Zakaria Chchiyai Youssef Tamraoui Hassan El Moussaoui Jones Alami Bouchaib Manoun Materials Science Energy and Nano-engineering Department(MSN)University Mohammed VI Polytechnic43150BenguerirMorocco Hassan First University of Settat FSTRayonnement-Matière et InstrumentationS3M26000SettatMorocco Materials and Nanomaterials Center Moroccan Foundation for Advanced ScienceInnovation and Research10100RabatMorocco

Structural,optical and magnetic properties are reported for new synthesized perovskite ***_(0.3)la_(0.7)Ti_(0.3)Fe_(0.7)O_(3) and Ba_(0.1)la_(0.9)Ti_(0.1)Fe_(0.9)O_(3) compositions were prepared via solid state reaction.X-ray analysis confirms that both compositions show feature of perovskite *** refinement method was used to confirm the phase formation and investigate the structure and space *** study demonstrates the formation of orthorhombic structure with Pnma space group for Ba_(0.3)la_(0.7)Ti_(0.3)Fe_(0.7)O_(3) while the composition Ba_(0.1)la_(0.9)Ti_(0.1)Fe_(0.9)O_(3) structure adopts Pbnm ***–vis spectroscopy measurements show very broad and intense UV–visible light absorption,the estimated band gap ranges between 2.07 and 2.15 *** measurements were carried out for the compositions Ba_(0.3)la_(0.7)Ti_(0.3)Fe_(0.7)O_(3) and Ba_(0.1)la_(0.9)Ti_(0.1)Fe_(0.9)O_(3).The hysteresis loops of both samples at 300 and 10 K show a strong ferromagnetic *** temperature dependent magnetization at 0.05 T under field-cooled(FC)and zero field cooled(ZFC)modes shows magnetic frustration or spin glass-like behavior.

关键词： Perovskites Co-substitution effect Phase transition Band gap Ferromagnetic Visible light absorption

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Propranolol hydrochloride degradation using la@TiO_(2) functionalized with CMCD

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Journal of Rare Earths 2022年第4期40卷 579-585,I0003页

作者： Gustavo Lopes Colpani Vitor Follmann Santos Rubieli Carla Frezza Zeferino Micheli Zanetti Josiane Maria Muneron de Mello Luciano Luiz Silva Natan Padoin Regina de fatima Peralta Muniz Moreira Márcio Antônio Fiori Cíntia Soaresc Post-Graduate Program in Technology and Innovation Management Community University of ChapecóRegionChapecó89809-900Brazil department of Chemical Engineering Community University of ChapecóRegionChapecó89809-900Brazil laboratory of Materials and Scientific Computing(labMAC) Department of Chemical and Food EngineeringFederal University of Santa CatarinaFlorianópolis88040-900Brazil

Propranolol hydrochloride can be considered a persistent and bioaccumulative pharmaceutical in the *** drug and its by-products are potentially toxic and have adverse effects,since these compounds have been associated with endocrine-disrupting effects,reproductive deficiencies,embryo abnormalities and pericardial ***_(2)–la 0.05%–carboxymethyl-β-cyclodextrin(CMCD)nanoparticles were successfully prepared by a simple two-step method,which consists of sonification and *** characterization analyses reveal that lanthanum is dispersed on the semiconductor surface,probably forming Ti–O–la bonds,which can induce oxygen vacancies and surface defects that effectively restrain the recombination of photogenerated electron/holes *** efficiency of TiO_(2)–la 0.05%–CMCD samples in degradation of propranolol under UV-light irradiation is higher than that of pristine TiO_(2) within 20 min reaction,probably due to complex formation between theβ-blocker and the oligosaccharide,which allows us to propose a photocatalytic mechanism based on the formation of intermediates and competition of these compounds to the radicals and CMCD cavities.

关键词： TiO_(2) lanthanum CMCD Propranolol Photocatalysis Functionalization

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Anti-inflammatory and analgesic properties of Moroccan medicinal plants:Phytochemistry,in vitro and in vivo investigations,mechanism insights,clinical evidences and perspectives

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Journal of Pharmaceutical Analysis 2022年第1期12卷 35-57页

作者： Abdelhakim Bouyahya fatima-Ezzahrae Guaouguaou Nasreddine El Omari Naoual El Menyiy Abdelaali Balahbib Mohamed El-Shazly Youssef Bakri laboratory of Human Pathologies Biology Department of BiologyFaculty of Sciencesand Genomic Center of Human PathologiesFaculty of Medicine and PharmacyMohammed Ⅴ University in Rabat4014Morocco Mohammed Ⅴ University in Rabat LPCMIOMaterials Science Center(MSC)Ecole Normale SuperieureRabat1014Morocco laboratory of Histology Embryology and CytogeneticFaculty of Medicine and PharmacyMohammed Ⅴ University in Rabat10100Morocco department of Biology Faculty of Sciences Dhar El MahrazUniversity Sidi Mohamed Ben AbdellahFez30003Morocco laboratory of Zoology and General Biology Faculty of SciencesMohammed Ⅴ University in RabatRabat1014Morocco department of Pharmacognosy Faculty of PharmacyAin-Shams UniversityCairo11566Egypt department of Pharmaceutical Biology Faculty of Pharmacy and BiotechnologyGerman University in CairoCairo11835Egypt

Moroccan medicinal plants exhibit several pharmacological properties such as antimicrobial,anticancer,antidiabetic,analgesic,and anti-inflammatory effects,which are related to the presence of numerous bioactive compounds,including phenolic acids,flavonoids,and *** the present review,we systematically evaluate previously published reports on the anti-inflammatory and analgesic effects of Moroccan medicinal *** in vitro investigations revealed that Moroccan medicinal plants inhibit several enzymes related to inflammatory processes,whereas in vivo studies noted significant anti-inflammatory and analgesic effects as demonstrated using different experimental *** bioactive compounds exhibiting in vitro and in vivo anti-inflammatory and analgesic effects,with diverse mechanisms of action,have been *** plants and their bioactive compounds reveal specific secondary metabolites that possess important anti-inflammatory effects in clinical *** review proposes the potential applications of Moroccan medicinal plants as sources of anti-inflammatory and analgesic agents.

关键词： Inflammation Medicinal plants Bioactive compounds Anti-inflammatory Analgesic

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Malnutrition negatively impacts the quality of life of patients with cirrhosis: An observational study

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World Journal of Hepatology 2017年第5期9卷 263-269页

作者： Gabriela Rojas-Loureiro Alfredo Servín-Caamano Elizabeth Pérez-Reyes Luis Servín-Abad Fátima higuerade la tijera Liver Clinic Gastroenterology DepartmentHospital General de México“Dr.Eduardo Liceaga” Internal Medicine department Hospital General de México“Dr.Eduardo Liceaga” Gastroenterologist at lakeland Regional Medical Center

AIM To verify how malnutrition is related to health-related quality of life(HRQL) impairment in patients with *** Data was retrospectively abstracted from medical records and obtained by direct interview. We included patients with cirrhosis from any etiology, evaluated at the Liver Clinic from Gastroenterology department in a tertiary healthcare center, from June 2014 to June 2016. Child-Pugh score, data about complications, and demographic, clinical and anthropometric characteristics of patients were obtained. Nutritional status was evaluated by the Subjective Global Assessment(SGA). HRQL was evaluated through the Chronic Liver Disease Questionnaire. Patients were requested to assess their global HRQL with the following code: 0 = impairment of HRQL, when it was compared with other healthy subjects; 1 = good HRQL, if it was similar to the quality of life of other healthy subjects. To compare the primary outcome between malnourished and well-nourished groups, the χ~2 test, Fisher's exact test or Student's t-test were used, based on the variable type. Associations between predictor variables and deterioration of HRQL were determined by calculating the hazard ratio and 95% confidence interval using Cox proportional hazards regression. RESULTS A total of 127 patients with cirrhosis were included, and the mean age was 54.1 ± 12.3 years-old. According to Child-Pugh scoring, 25(19.7%) were classified as A(compensated), 76(59.8%) as B, and 26(20.5%) as C(B/C = decompensated). According to SGA, 58(45.7%) patients were classified as well-nourished. Sixty-nine patients identified HRQL as good, and 76 patients(59.8%) perceived impairment of their HRQL. Multivariate analysis to determine associations between predictor variables and self-perception of an impairment of HRQL found strong association with malnutrition(P < 0.0001). The most important impaired characteristics in malnourished patients were: Presence of body pain, dyspnea on exertion with daily activities,

关键词：营养不良主观全球评价生活的健康相关的质量肝硬化长期的肝疾病问询表

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Current trends of liver cirrhosis in Mexico: Similitudes and differences with other world regions

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World Journal of Clinical Cases 2018年第15期6卷 922-930页

作者： Nahum Méndez-Sánchez Felipe Zamarripa-Dorsey Arturo Panduro Emma Purón-González Edgar Ulises Coronado-Alejandro Carlos Alejandro Cortez-Hernández Fátima higuera de la tijera José Luis Pérez-Hernández Eira Cerda-Reyes Heriberto Rodríguez-Hernández Vania César Cruz-Ramón Oscar Lenin Ramírez-Pérez Nancy Edith Aguilar-Olivos Olga Fabiola Rodríguez-Martínez Samantha Cabrera-Palma Guillermo Cabrera-álvarez Liver Research Unit Medica Sur Clinic and Foundation department of Gastroenterology Hospital "Juárez" of México department of Molecular Biology in Me-dicine Civil Hospital of Guadalajara "Fray Antonio Alcalde" department of Internal Medicine "Christus Muguerza "Super Specialty" Hospital" Monterrey department of Gas-troenterology "University Hospital "Jose Eleuterio González" Monterrey department of Gastroenterology "General Hospital of Mexico "Dr.Eduardo Liceaga" department of Gastroenterology "Central Military Hospital" Faculty of Medicine and Nutrition Juárez University of the State of Durango Liver Clinic Regional General Hospital IMSS 1

AIM To investigate the main current etiologies of cirrhosis in *** We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-december 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico.

关键词： Alcoholic liver disease Hepatitis C virus Nonalcoholic steatohepatitis Liver cirrhosis

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