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Does the Animal Origin Influence the Calcification of Xenograft Tissue Heart Valve Substitutes? Comparison between Bovine and Camel Pericardium in a Subcutaneous Rat Model

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International Journal of Clinical Medicine 2015年第9期6卷 700-709页

作者： fatima al harmoodi Salah al Shafy Michel Guichardant Jean-Jacques Lebrun Francoise Thivolet Olivier Jegaden Department of biomedical engineering Khalifa University Abu Dhabi UAE Department of cardiac surgery Zayed Military Hospital Abu Dhabi UAE Chemistry-Biology Health Area Institut Multidisciplinaire de Biochimie des lipides Institut National des Sciences Appliquées Lyon France Institute of Analytic Sciences Centre National de la Recherche Scientifique Villeurbanne France Department of Biology Hospices Civils de Lyon Claude Bernard University Lyon1 Lyon France Department of Cardiac Surgery Cleveland Clinic Abu Dhabi Abu Dhabi UAE Claude Bernard University Lyon1 Lyon France Cleveland Clinic Lerner College of Medicine—Case Western Reserve University Cleveland Ohio USA

Objective: To validate the hypothesis that camel pericardium could be more protected than bovine pericardium against calcification process according to the huge difference in their respective lifestyle and lifetime. Methods: Glutaraldehyde (GA) fixed bovine and camel pericardium samples (BP and CP respectively) were both implanted in 30 New Zealand white rats (2 BP and 2 CP matched specimens in each animal) and explanted after 60 days. Unimplanted GA-fixed samples of both species served as control. Matched implanted samples and unimplanted samples were randomly submitted to elemental analysis by spectroscopy, phospholipid extraction, macroscopic and X-ray examination and histology. Results: At 60 days, calcium and phosphorus content were respectively 9.54% ± 3.1% and 4.79% ± 1.4% of tissue dry weight in BP, and 12.52% ± 2.7% and 6.14% ± 1.3% of tissue dry weight in CP (ns). In X-ray analysis, the calcification score was 1.28 ± 0.45 and 2.14 ± 0.98 in BP and CP samples respectively without significant difference (p alcifications were lower in BP than in CP: 1.37 ± 0.85 vs 2.28 ± 0.83 (ns);collagen fibers were better conserved in BP than in CP: 2.4 ± 0.48 vs 1.87 ± 0.78 (ns), and less disoriented: 25% vs 62% (ns). In unimplanted samples, there was a higher but not significant rate of extracted lipids in CP: 5.7 ± 1.8 vs 9.5 ± 3.8 nanomoles in PS fraction and 11.3 ± 3.7 vs 19 ± 7.7 nanomoles in total fatty acids, in BP and CP samples respectively. all results were in conjunction and demonstrated a higher but not significant rate of mineralization in camel pericardium after implantation, which could be related to a higher but not significant basic rate of phospholipid and fatty acids. Conclusion: This experiment study in a subcutaneous rat model has failed to valid our hypothesis. Because the differences observed between bovine and camel pericardium did not reach the significance, at the best, there is no difference between both species and at th

关键词： Pericardium Calcification Bovine Camel Xenograft Tissue Heart Valve Substitutes

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