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Nephritis Syndrome Tubulo-Intertitial and Uveitis (Tinu Syndrome): About 2 Cases

Open Journal of Nephrology 2021年第1期11卷 21-33页

作者： Hiba El Oury fatim.Zahra Jabrane kenza Bouyad Université m.ham.ed VI des sciences de la santé Casablanca Maroc Université Hassan II faculté de médecine et de pharmacie Casablanca Maroc

Introduction: Tubular and interstitial nephropathy syndrome with uveitis or TINU syndrome is a rare association. Patients and methods: We have listed cases in which the clinical-biological picture and histology were consistent with this syndrome. Results: Two cases were retained: These were two female patients whose mean age at diagnosis was 16 years. The inaugural symptoms were bilateral anterior uveitis in two cases. The time to onset of renal signs: was 4 to 2 weeks months. Acute kidney failure was reported in both cases with a mean creatinine of 36.4 mg/l. An average proteinuria of 1.1 g/24 h associated with aseptic leukocyturia in one case/2 and glycosuria normoglycemic in 1 case/2. Non inflammatory syndrome specific with inflammatory anemia is reported in both cases. kidney puncture biopsy confirmed the diagnosis with nephropathy diffuse polymorphic tubulointerstitial and immunofluorescence negative in both cases. Oral corticosteroid therapy (1 mg/kg per day) was started for 4 to 6 months. Both patients received initial local corticosteroid therapy for uveitis. The outcome was favorable under treatment with remission complete. kidney function recovered after 6 months with an average serum creatinine of 6 mg/l. Discussion: The incidence of TINU syndrome appears to be underestimated in the literature. It is believed to be an autoimmune disease. The positive diagnosis is based on clinical, biological and histological. An etiological investigation in search of disease systemic is necessary before making the diagnosis. There is no codified treatment. The prognosis is favorable in the majority of cases. Conclusion: Investigation of renal function is necessary for any patient.

关键词： Nephritis Syndrome Tubulo-Intertitial Uveitis Tinu Syndrome

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A Severe COVID-19 Infection in Neonates: A Case Report

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Journal of Biosciences and medicines 2021年第12期9卷 118-123页

作者： Idrissa Demba Ba mohameth mbodj fatim.Tall Serigne T. Ndiaye Safietou Dieye mouhamed Fattah Amadou Sow Ndeye F. Sow Awa kane Aita Seck Aminata mbaye alioune m. Coundoul khadim Bop Pape S. Sow Amadou L. Fall Papa m. Faye Ousmane Ndiaye albert Royer National Children Hospital Dakar Senegal Cheikh Anta DIOP University Dakar Senegal Abass Ndao Hospital Center Dakar Senegal

Coronavirus disease (COVID-19) is a highly contagious infectious disease. First case was reported at the end of 2019 in China. Children and neonate population appears to be relatively free of the virus. We reported a severe and fatal neonate case of COVID-19 in a 22 days old neonate female due to the delta variant strain during the third wave outbreak. She presented with fever, cough, grunting and diarrhea started 5 days before admission. Physical exam’s revealed severe respiratory distress, hypoxia and bilateral pulmonary condensation. PCR test for COVID-19 was positive. Chest X-ray found bilateral infiltrates. Chest CT showed diffuse ground glass images with 75% of lung parenchymal involvement. She was treated with antibiotics, corticostoid, respiratory support (CPAP and oxygen). Death occurred after 15 days of hospitalization in the context of multiple organ failure and pulmonary hypertension.

关键词： COVID-19 Hypoxia Newborn Variant Delta Senegal

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