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Nosocomial Klebsiella variicola Infection in Neonatal Intensive Care: A New Emerging Pathogen

Open Journal of Pediatrics 2023年第3期13卷 450-458页

作者： Soraya Hani Abdessamad Lalaoui fatiha bennaoui Nabila Soraa Nadia El Idrissi Slitine Fadl Mrabih Rabou Maoulainine Neonatal Resuscitation Service Mother and Child Hospital CHU Mohamed VI Marrakech Marrakech Morocco Laboratory of Childhood Health and Development Faculty of Medicine and Pharmacy of Marrakech Cadi Ayyad University Marrakech Morocco Microbiology Laboratory Arrazi Hospital CHU Mohammed VI Marrakech Marrakech Morocco

Klebsiella variicola is a human pathogen that has been misidentified as K. pneumoniae. This misidentification has led to a lack of understanding of important clinical and biological aspects of this bacterial species. It is responsible for serious and potentially fatal infections, with a prevalence of multi-resistance to routine antibiotics. We present through three clinical observations, the case of three newborns having been hospitalized in the neonatal intensive care unit and whose evolution was complicated by the occurrence of a nosocomial infection in front of which a blood culture was done on blood agar, with a manual antibiogram on antibiotic disks, isolated the germ Klebsiella variicola. The management of the newborns was initially centered on non-invasive ventilation with a bi-antibiotic therapy based on carbapenem and amikacin for two newborns and switched to colymicin for the third case. Newborn follow-up was based on assessment of general condition, clinical signs of infection, as well as a biological control made of a blood count, a c-reactive protein, a complete ionogram, and a blood culture, every four days or if signs of clinical call. The evolution was favorable for two cases with good clinical and biological improvement, and complicated by death due to alveolar hemorrhage in the third case. Given the high pathogenicity of this germ, and the frequency of misidentification, it is crucial to know the clinical spectrum of Klebsiella variicola infections in neonatal intensive care units, in order to adapt the antibiotic therapy and to mitigate the fulminant evolution of this germ.

关键词： Newborn Nosocomial Infection Klebsiella variicola Neonatal Resuscitation Antibiotic Therapy

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Neonatal Pleuropulmonary Staphylococcal Disease: A Case Report

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Open Journal of Pediatrics 2023年第1期13卷 138-145页

作者： Fatima-Ezzahra Tahiri Oualid Assem fatiha bennaoui Nadia El Idrissi Slitine Nabila Soraa Fadl Marabih Rabou Maoulainine Department of Neonatal Resuscitation University Hospital Center Mohamed VI Marrakech Morocco Health Childhood and Development Research Team Faculty of Medicine Cadi Ayyad University Marrakech Morocco Microbiology Department University Hospital Center Mohamed VI Marrakech Morocco

Staphylococcal pleuropulmonary disease (SPP) is the localization of pathogenic staphylococcal disease in the lung and pleura and its general haematogenic consequences. This location is not primary, but follows a primary skin or mucous infection that may go unnoticed. This is a very rare phenomenon in neonatology and in the various literature reviews. Through our observation we report the clinical diagnosis of a newborn 13-day age with pleuro-pulmonary staphyloccocia point of departure cutaneous, thus the paraclinical explorations performed in our patient therapeutic management and evolutionary profile after a 3-month decline. Note that the problem of resistance of staphylococci to different antibiotics is currently a real public health problem making the choice of treatment very difficult for the clinician.

关键词： Newborn Skin Infection Respiratory Distress Meticillin-Resistant Staphylococcus Aureus Excavation Pneumothorax

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Epidemic to Different Strains of SERRATIA: Experience of Neonatal Intensive Care Unit: About 30 Cases

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Open Journal of Pediatrics 2023年第2期13卷 253-261页

作者： Fatima-Ezzahra Tahiri Abdessamad Lalaoui Hasna Rafi fatiha bennaoui Nadia El Idrissi Slitine Nabila Soraa Fadl Marabih Rabou Maoulainine Neonatal Intensive Care Unit CHU Mohammed VI Marrakech Morocco Health Childhood and Development Faculty of Medicine Research Team Cadi Ayyad University Marrakech Morocco Microbiology Department CHU Mohammed VI Marrakech Morocco

Serratia is an opportunistic pathogenic bacterium of the Enterobacteriaceae family, occasionally responsible for epidemics of nosocomial infections in critical departments;in particular in neonatal intensive care units Enterobacteriaceae form a large family of Gram-negative bacteria, which cause diseases of highly variable severity, due to distinct pathogenic mechanisms. This family is heterogeneous as it consists of about 30 genera of bacteria and more than 100 species. However, all these germs have in common their preferential location in the digestive system, some being part of the normal flora although they are also present in the environment. Several metabolic processes characterize this bacterial family. These include the ability to reduce nitrate to nitrite (for energy generation), ferment glucose, lack cytochrome oxidase, be aerobic or anaerobic, motile or immobile, … Enterobacteriaceae constitute more than 80% of the germs isolated in the laboratory: Escherichia, Salmonella, Shigella, Klebsiella, Enterobacter, Serratia, Proteus, Morganella and Yersinia are the rods most often found. Regarding nosocomial infection to Serratia, this bacterium colonizes the respiratory, digestive and urinary systems of patients, mainly responsible for bacteremia, infections of the lower respiratory tract, urinary and skin infections. Through our work, we report the epidemic experienced in the neonatal intensive care unit MOHAMMED VI university hospital, mother-child hospital MARRAKECH MOROCCO for three months from December at February 2023 interesting 30 newborns whose clinical presentation was different, the positive diagnosis was based on blood and geographical samples taken by the bacteriology department to isolate the offending germs, the therapeutic management of our patients consisted essentially of various hygiene measures in association with dual antibiotic therapy based on meropenem and amikacin. The evolution was marked by the death of 21 patients (70%) and the recov

关键词： Epidemic Neonatal Resuscitation Nosocomial Infection Serratiamarcesens Serratiaureitylica Serratia Nematodiphila Antibiotic Resistance

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Pantoea SPP: A New Nosocomial Infection in the Neonatal Intensive Care Unit

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Open Journal of Pediatrics 2023年第2期13卷 181-188页

作者： Soraya Hani Fatima Ezzahra Tahiri Abdessamad Lalaoui fatiha bennaoui Nabila Soraa Nadia El Idrissi Slitine Fadl Mrabih Rabou Maoulainine Neonatal Resuscitation Service Mother and Child Hospital Mohamed VI University Hospital Marrakech Morocco Laboratory of Childhood Health and Development Faculty of Medicine and Pharmacy of Marrakech Cadi Ayyad University Marrakech Morocco Microbiology Laboratory Arrazi Hospital Mohammed VI University Hospital Marrakech Morocco

Pantoea SPP is a gram-negative bacillus, which usually colonizes plants, soil and water. This pathogen very rarely causes neonatal sepsis. The most common infections caused by Pantoea SPP are septic arthritis or synovitis, meningitis frequently complicated by brain abscess, upper respiratory infections, and peritonitis. We present the case of a premature infant who presented neonatal respiratory distress and whose evolution was complicated by the occurrence of a nosocomial infection for which a blood culture was performed isolating the germ Pantoea SPP. The patient’s management was initially centered on non-invasive ventilation with antibiotherapy based on carbapenem and aminoglycoside. Due to the clinical and biological worsening, the neonate was intubated and sedated and put on colymicin. The evolution was unfavorable marked by a death at 16th days of life. Considering the high pathogenicity of this germ and its multi-resistance to antibiotics, it is crucial to know the clinical spectrum of Panteoa SPP infections in neonatal intensive care units, in order to palliate the fulminant evolution of multifocal attacks due to this germ.

关键词： Newborn Premature Nosocomial Infection Pantoea SPP Neonatal Resuscitation Antibiotic Therapy

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Experimental performance analysis of an installed microgrid-based PV/battery/EV grid-connected system

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Clean Energy 2022年第4期6卷 599-618页

作者： Aziz Haffaf fatiha Lakdja Djaffar Ould Abdeslam Electro-Technical Department Electro-Technical Engineering LaboratoryFaculty of TechnologyTahar Moulay UniversitySaida20000Algeria IRIMAS Laboratory Haute Alsace UniversityMulhouse68093France

Global energy demand,which is largely based on fossil fuels,is expected to increase *** effort must be made to mitigate carbon emissions and climate change to ensure sustainable and clean *** recent years,the increasing share of renewable energy and energy-storage systems,the development of electric vehicles(EVs),promotion of energy efficiency and demand-side management(DSM)have become today’s solution *** microgrid(MG),which involves the interconnection of several generation and storage units capable of operating locally with or without connection to the power grid,is also a very useful emerging *** study allowed the experimental operation and performance analysis of a grid-connected photovoltaic(PV)/battery/EV MG hybrid system,which was used for maximizing PV self-consumption and DSM *** entire MG consisting of two subsystems(polycrystalline PV array of 2.16 kWp for Subsystem 1,monocrystalline PV system of 2.4 kWp for Subsystem 2,EV with lithium-ion battery capacity of 6.1 kWh)was installed under outdoor conditions at the University Institute of Technology in Mulhouse,France in August *** operation and behaviour of the system components,including the inverter,batteries and power grid,were analysed in both scenarios with and without EV *** results shows that the total cumulative energy injected into the grid during the entire system operating cycle is estimated to be 3466.82 and 5836.58 kWh for Subsystems 1 and 2,respect*** addition,the energy produced by Subsystem 2 during its lifetime and the emissions emitted are respectively estimated at 5597.65 kWh and 4.17 *** other results in terms of PV output power,energy yield,feed-in power and self-consumed energy were quantified and analysed in detail.

关键词： microgrid photovoltaic electric vehicle(EV) self-consumption demand-side management(DSM) energy management

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Investigations on the Optimization of Contacts Barrier Height for the Improved Performance of ZnO/CdS/CZTS Solar Cells

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Energy Engineering 2023年第8期120卷 1803-1815页

作者： fatiha Daoudi Abdelkrim Naas Omar Meglali Radia Boudaira Ahmed Gueddim A.M.Saeed Material Science and Informatics Laboratory University of DjelfaDjelfa17000Algeria Faculty of Sciences University of M’silaM’sila28000Algeria Department of Physics University of ConstantineConstantine25000Algeria Department of Physics Division of Science and TechnologyUniversity of EducationLahorePakistan

The numerical simulations were performed using the AMPS-1D simulator to study the effects of the CZTS as an absorber layer and the contacts’barrier height on the performance of four ZnO/CdS/CZTS solar *** obtain the best cell performances,the barrier heights of the back and front contacts were adjusted between 0.01,0.77,0.5,and 1.55 eV,*** simulations,we used the lifetime mode,and the device performances were evaluated under AM1.5 illumination *** found that the efficiency,fill factor,and open-circuit voltage were almost constant at a front contact barrier height of less than 0.31 *** short-current density was not affected by the front contact barrier *** back contact material had a significant impact on the CZTS cells *** best performance was obtained for the CZTS550 cell with JSC=29.53 mA/cm2,VOC=1.07 V,FF=0.88,andη=28.08%at barrier heights of 0.31 and 1.55 eV for front and back contacts,*** conduction band offset at the CZTS550/CdS hetero-junction was found to be spike-like with 0.21 *** obtained conversion efficiency is comparable to those previously reported in the literature.

关键词： CZTS solar cell barrier height AMPS-1D photovoltaic parameters

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Sirtuins and nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2016年第46期22卷 10084-10092页

作者： fatiha Nassir Jamal A Ibdah Research Service Harry S Truman Memorial VA Hospital University of Missouri Department of Medicine Division of Gastroenterology and Hepatology University of Missouri

Mammalian sirtuins are seven members belonging to the silent information regulator 2 family, a group of Class Ⅲ histone/protein deacetylases. Sirtuins(SIRT 1-7) have different subcellular localization and function and they regulate cellular protein function through various posttranslational modifications. SIRT1 and 3, the most studied sirtuins, use the product of cellular metabolism nicotinamide adenine dinucleotide as a cofactor to post-translationally deacetylate cellular proteins and consequently link the metabolic status of the cell to protein function. Sirtuins have been shown to play a key role in the development and rescue of various metabolic diseases including non-alcoholic fatty liver disease(NAFLD). NAFLD is currently the most chronic liver disease due mainly to high-calorie consumption and lower physical activity. No pharmacological approach is available to treat NAFLD, the current recommended treatment are lifestyle modification such as weight loss through calorie restriction and exercise. Recent studies have shown downregulation of sirtuins in human as well as animal models of NAFLD indicating an important role of sirtuins in the dynamic pathophysiology of NAFLD. In this review, we highlight the recent knowledge on sirtuins, their role in NAFLD and their unique potential role as novel therapeutic target for NAFLD treatment.

关键词： SIRT1 SIRT3 Sirtuins 非酒精的脂肪肝疾病

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Non linear modeling of three-dimensional reinforced and fiber concrete structures

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Frontiers of Structural and Civil Engineering 2018年第4期12卷 439-453页

作者： fatiha IGUETOULENE Youcef BOUAFIA Mohand Said KACHI University Mouloud Mammeri of Tizi-Ouzou 15000Algeria

Under the effect of the ascending loading, the behavior of reinforced concrete structures is rather non linear. Research in industry and science aims to extend forward the use of non-linear calculation of fiber concrete for structural parts such as columns, veils and pious, as the fiber concrete is more ductile behavior then the classical concrete behavior. The formulation of the element has been established for modeling the nonlinear behavior of elastic structures in three dimensions, based on the displacement method. For the behavior of concrete and fiber concrete compressive and tensile strength (stress-strain) the uniaxial formulation is used. For steel bi-linear relationship is used. The approach is based on the discretization of the cross section trapezoidal tables. Forming the stiffness matrix of the section, the integral of the surface is calculated as the sum of the integrals on each of the cutting trapezoids. To integrate on the trapeze we have adopted the type of Simpson integration scheme.

关键词： numerical modeling column and beam nonlinear analysis fibers pious reinforcement 3D formulation response load-deflection

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Quantum Secret Sharing with Error Correction

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Communications in Theoretical Physics 2012年第11期58卷 661-671页

作者： Aziz Mouzali fatiha Merazka Damian Markham Electronic Department National Polytechnic SchoolAlgiersAlgeria Electronic Department National Polytechnic SchoolAlgiersAlgeria 2 Electronic and Computer Enginering FacultyUniversity of Scienceand Technology Houari BoumedineAlgiersAlgeria Laboratoire Traitement et Communication de l'Information CNRS-Tlcom Paris Tech France

We investigate in this work a quantum error correction on a five-qubits graph state used for secret sharing through five noisy channels. We describe the procedure for the five, seven and nine qubits codes. It is known that the three codes always allow error recovery if only one among the sent qubits is disturbed in the transmitting channel. However, if two qubits and more are disturbed, then the correction will depend on the used code. We compare in this paper the three codes by computing the average fidelity between the sent secret and that measured by the receivers. We will treat the case where, at most, two qubits are affected in each one of five depolarizing channels.

关键词：量子秘密共享错误修正量子比特噪声信道量子纠错错误恢复代码发送

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Eigenproblem for p-Laplacian and Nonlinear Elliptic Equation with Nonlinear Boundary Conditions

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Acta Mathematica Sinica,English Series 2015年第4期31卷 659-674页

作者： Berrajaa MOHAMMED Chakrone OMAR Diyer fatiha Diyer OKACHA Department of Mathematics Faculty of sciences University Mohamed I

In this article, we study the solvability of nonlinear problem for p-Laplacian with nonlinear boundary conditions. We give some characterization of the first eigenvalue of an intermediary eigenvalne problem as simplicity, isolation and its strict monotonicity. Afterward, we character also the second eigenvalue and its strictly partial monotony. On the other hand, in some sense, we establish the non-resonance below the first and furthermore between the first and second eigenvalues of nonlinear Steklov-Robin.

关键词： Eigenproblem p-Laplacian operator variational method non-resonance problems

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