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Transgenic mouse models for studying adult neurogenesis

Frontiers in Biology 2016年第3期11卷 151-167页

作者： fatih semerci Mirjana Maletic-Savatic Program in Developmental Biology Baylor College of Medicine Houston TX 77030 USA Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital Houston TX 77030 USA Department of Pediatrics-Neurology Department of Neuroscience and Structural and Computational Biology and Molecular Biophysics Baylor College of Medicine Houston TX 77030 USA

The mammalian hippocampus shows a remarkable capacity for continued neurogenesis throughout life. Newborn neurons, generated by the radial neural stem cells （NSCs）, are important for learning and memory as well as mood control. During aging, the number and responses of NSCs to neurogenic stimuli diminish, leading to decreased neurogenesis and age-associatedcognitive decline and psychiatric disorders. Thus, adult hippocampal neurogenesis has garnered significant interest because targeting it could be a novel potential therapeutic strategy for these disorders. However, if we are to use nenrogenesis to halt or reverse hippocampal-related pathology, we need to understand better the core molecular machinery that governs NSC and their progeny. In this review, we summarize a wide variety of mouse models used in adult neurogenesis field, present their advantages and disadvantages based on specificity and efficiency of labeling of different cell types, and review their contribution to our understanding of the biology and the heterogeneity of different cell types found in adult neurogenic niches.

关键词： adult neurogenesis mouse models neural stem cells neuroprogenitors lineage tracing

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