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Bladder stone due to late clip migration after prostatic urethral lift procedure: A case report

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World Journal of Clinical Cases 2023年第30期11卷 7457-7462页

作者： Ali Seydi Bozkurt Ozgur Ekici Ercüment Keskin fatih Kocoglu Department of Urology Erzincan Binali Yıldırım University School of MedicineErzincan 24000Turkey

BACKGROUND Prostatic urethral lift(PUL)therapy is an alternative to minimally invasive and other surgeries in younger patients who want to preserve their sexual and ejaculatory functions,and in elderly male patients with benign prostatic hyperplasia who cannot be anesthetized because of the risk of *** procedure can be performed as an outpatient and without anesthesia,and complications are few and *** long-term follow-up,encrustations that require retreatment are rarely *** SUmmARY In our case,a 62-year-old prostate patient who had a PUL operation 8 years ago and had a stone on the PUL material near the bladder neck was *** patient’s stone was removed by endoscopic cystolithotripsy using pneumatic *** transurethral resection of the prostate was applied to the patient in the same *** the patient’s 7-year follow-up,the patient’s complaints relapsed,and cystoscopy was performed *** cystoscopy,stone formation adjacent to the wall was observed at the junction of the bladder neck to the left lateral *** stone was fragmented with a pneumatic *** Placing clips too close to bladder neck in the PUL procedure may result in clip migration.

关键词： Endoscopic cystolithotripsy Transurethral resection-P Urolift Bladder Stone Case report

SYK as a New Therapeutic Target in B-Cell Precursor Acute Lymphoblastic Leukemia

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Journal of Cancer Therapy 2014年第1期5卷 124-131页

作者： fatih m. Uckun Sanjive Qazi Children’s Center for Cancer and Blood Diseases CHLA Los Angeles USA Department of Pediatrics Keck School of Medicine University of Southern California Los Angeles USA

The identification of SYK as a master regulator of apoptosis controlling the activation of the PI3-K/AKT, NFκB, and STAT3 pathways—three major anti-apoptotic signaling pathways in B-lineage leukemia/lymphoma cells—prompts the hypothesis that rationally designed inhibitors targeting SYK may overcome the resistance of malignant B-lineage lymphoid cells to apoptosis and thereby provide the foundation for more effective multi-modality treatment regimens for poor prognosis B-precursor acute lymphoblastic leukemia (BPL). In recent preclinical proof-of-concept studies, a liposomal nanoparticle (LNP) formulation of a SYK substrate-binding site inhibitor, known as C61, has been developed as a nanomedicine candidate against poor prognosis and relapsed BPL. This nanoscale formulation of C61 exhibited a uniquely favorable pharmacokinetics and safety profile in mice, induced apoptosis in radiation-resistant primary leukemic cells taken directly from BPL patients as well as in vivo clonogenic BPL xenograft cells, destroyed the leukemic stem cell fraction of BPL blasts, and exhibited potent in vivo anti-leukemic activity in xenograft models of aggressive BPL. Further development of C61-LNP may provide the foundation for new and effective treatment strategies against therapy-refractory BPL.

关键词： STAT3 SYK Kinase Phosphorylation Apoptosis Leukemia Nanomedicine

Effectiveness of Saccharomyces boulardii in a rat model of colitis

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World Journal of Gastroenterology 2012年第44期18卷 6452-6460页

作者： mujde Soyturk Saba mukaddes Saygili Huseyin Baskin Ozgul Sagol Osman Yilmaz fatih Saygili Hale Akpinar Department of Gastroenterology Dokuz Eylul University School of MedicineInciraltiIzmir 35340Turkey Department of Internal medicine Mediguven HospitalSalihli 45300ManisaTurkey Department of Clinical microbiology Dokuz Eylul University School of MedicineInciraltiIzmir 35340Turkey Department of Pathology Dokuz Eylul University School of MedicineInciraltiIzmir 35340Turkey Department of Laboratory Animal Science Dokuz Eylul University School of MedicineInciraltiIzmir 35340Turkey Department of Gastroenterology Pamukkale University School of MedicineDenizli 20070Turkey

AIm:To investigate the effects of Saccharomyces boulardii(***) in an experimental rat model of trinitrobenzene sulfonic acid(TNBS)-induced ***:Thirty-two Wistar albino female rats were categorized into five *** the first day of the study,50 mg TNBS was administered via a rectal catheter in order to induce colitis in all rats,except those in the control *** 14 d,the rats were fed a standard diet,without the administration of any additional supplements to either the control or TNBS groups,in addition to 1 mg/kg per day *** to the *** group,1 mg/kg per day methyl prednisolone(mP) to the mP *** animals in the *** + mP group were coadministered these doses of *** and *** the study,weight loss,stool consistency,and the presence of obvious blood in the stool were evaluated,and the disease activity index(DAI) for colitis was *** intestines were examined and colitis was macro-and microscopically *** serum and tissue levels of tumor necrosis factor-α(TNF-α) and nitric oxide(NO) were determined,and fungemia was evaluated in the blood ***:The mean DAI scores for the mP and *** + mP groups was significantly lower than the TNBS group(3.69 ± 0.61 vs 4.46 ± 0.34,P = 0.018 and 3.77 ± 0.73 vs 4.46 ± 0.34,P = 0.025,respectively).While no significant differences between the TNBS and the *** or mP groups could be determined in terms of serum NO levels,the level of serum NO in the *** + mP group was significantly higher than in the TNBS and *** groups(8.12 ± 4.25 μmol/L vs 3.18 ± 1.19 μmol/L,P = 0.013;8.12 ± 4.25 μmol/L vs 3.47 ± 1.66 μmol/L,P = 0.012,respectively).The tissue NO levels in the ***,mP and *** + mP groups were significantly lower than the TNBS group(16.62 ± 2.27 μmol/L vs 29.72 ± 6.10 μmol/L,P = 0.002;14.66 ± 5.18 μmol/Lvs 29.72 ± 6.10 μmol/L,P = 0.003;11.95 ± 2.34 μmol/Lvs 29.72 ± 6.10 μmol/L,P = 0.002,respectively).The tis

关键词： Saccharomyces boulardii Rat Trinitroben-zene sulfonic acid Tumor necrOsis factor-m Nitric ox-ide Fungemia

Iatrogenic bladder neck rupture due to traumatic urethral catheterization: A case report

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World Journal of Clinical Cases 2023年第30期11卷 7413-7417页

作者： Ozgur Ekici Ercüment Keskin fatih Kocoglu Ali Seydi Bozkurt Department of Urology Faculty of MedicineErzincan Binali Yıldırım UniversityErzincan 24000Turkey

BACKGROUND In this article,we present a case of iatrogenic bladder neck rupture due to catheter insertion in a 94-year-old comorbid male *** SUmmARY The patient,who had a urethral catheter inserted in the palliative service 3 d ago,was consulted because the catheter did not *** the fluid given to the bladder could not be recovered,computed tomography was performed,which revealed that the catheter had passed the bladder neck first into the retrovesical area then into the intraabdominal *** appearance of the anterior urethra and verumontanum was normal at ***,extremely severe stenosis of the bladder neck,and perforated posterior wall of the urethral segment between the prostatic urethra and the bladder neck were *** urethrotomy was applied to the bladder neck with a *** urethral catheter was sent over the guide wire into the *** patient was followed in the palliative care service and the catheter was removed 7 d *** extravasation was observed in the control *** Although catheter insertion is a simple and frequently performed procedure in hospitalized patients,it is necessary to avoid unnecessary extra-indication catheter insertion.

关键词： Bladder neck rupture Uretrhral catheterization Iatrogenic Extravasation False route Case report

An Experimental Investigation on Workability and Bleeding Behaviors of Cement Pastes Doped with Nano Titanium Oxide (n-TiO 2) Nanoparticles and FlyAsh

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Fluid Dynamics & materials Processing 2023年第1期19卷 135-158页

作者： fatihÇelik Oğuzhan Yıldız AndaçBaturÇolak Samet mufit Bozkır Civil Engineering Department NiğdeÖmer Halisdemir UniversityNiğdeTurkey Electric and Energy Department NiğdeÖmer Halisdemir UniversityNiğdeTurkey mechanical Engineering Department NiğdeÖmer Halisdemir UniversityNiğdeTurkey

In this study,the workability of cement-based grouts containing n-TiO 2 nanoparticles and fly ash has been investigated *** characteristic quantities(including,but not limited to,the marsh cone flow time,the mini slump spreading diameter and the plate cohesion meter value)have been measured for different percentages of these *** use of fly ash as a mineral additive has been found to result in improvements in terms of workability behavior as ***,if nano titanium oxide is also used,an improvement can be obtained regarding the bleeding values for the cement-based grout *** such experimental data,a multi-layer perceptron artificial neural network model has been developed(5 neurons in the hidden layer of the network model have been developed using a total of 42 experimental data).70%of the data employed in this model have been used for training,15%for validation and 15%for the test *** results demonstrate that the artificial neural network model can predict marsh cone flow time,mini slump spreading diameter and plate cohesion meter values with an average error of 0.15%.

关键词： Nano titanium oxide fly ash workability of grouts bleeding stability of grouts ANN

Alterations in Growth and Yield of Camelina Induced by Different Planting Densities under Water Deficit Stress

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Phyton-International Journal of Experimental Botany 2020年第3期89卷 587-597页

作者： Ejaz Ahmad Waraich Zeeshan Ahmed Zahoor Ahmad Rashid Ahmad murat Erman fatih Cig Ayman El Sabagh Department of Agronomy University of AgricultureFaisalabad38040Pakistan Institute of Ecology and Geography Chinese Academy of SciencesXinjiang830011China Cele National Station of Observation and Research for Desert-Grassland Ecosystem Institute of Ecology and GeographyChinese Academy of SciencesXinjiang848300China Department of Field Crops Faculty of AgricultureCukurova UniversityAdana1380Turkey Department of Field Crops Faculty of AgricultureSiirt UniversitySiirt56100Turkey Agronomy Department Faculty of AgricultureKafr El Sheikh UniversityKafr Elsheikh33511Egypt

Camelina(Camelina sativa L.)is famous for its oil quality and unique fatty acid *** and yield of crops reduced under water deficit *** threat such as drought or water deficit condition is the emerging problem which creates the negative impact on the growth of *** upon the current situation a pot study was performed in rain out-shelter to explore the effect of different plant densities(15,10 and 5 plants per pot)on growth and seed yield of two camelina genotypes under normal(100%WHC)and water deficit(60%WHC)conditions by using completely randomized design with factorial arrangement having three *** indicated that individual effects of plant densities and water deficit stress levels considerably influenced the growth and seed yield of camelina but interaction effects did not indicate any significant *** values of leaf area index(LAI)and crop growth rate(CGR)were recorded in P_(3) treatment(15 plants per pot).However,maximum values of leaf area duration(LAD),net assimilation rate(NAR),yield and yield components were observed in the treatment P_(1)(5 plants per pot).Water deficit condition(60%WHC)significantly minimized the growth,seed yield(0.82 g/m^(2))and yield components of camelina *** camelina genotypes(611 and 618)did not differ significantly under water deficit conditions.

关键词： Camelina sativa crop growth rate net assimilation rate planting density water stress

Evaluation of Lipid Peroxidation and Some Antioxidant Activities in Patients with Primary and metastatic Liver Cancer

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Journal of Cancer Therapy 2014年第2期5卷 192-197页

作者： Ayse Arslan Halit Demir m. fatih Ozbay Harun Arslan Department of Biochemistry Faculty of Science Yuzuncu Yil University Van Turkey Department of Internal medicine Training and Research Hospital Van Turkey Training and Research Hospital Department of Radiology Van Turkey

Abstract: HCC is the 6th most common cancer in the world. The main risk factors associated with HCC are hepatitis B (HBV) and hepatitis C viral infections and other factors that play a role in HCC development, include aflatoxin B1 (AFB1) cigarette smoking, and chronic inflammation. The aim of this study is to investigate lipid peroxidation and some antioxidant enzyme activities in patients with primary and metastatic liver cancer. For this purpose, 25 primary and metastatic liver cancer patients and 15 healthy controls were included in the study. In blood samples taken from the patient and control groups, the main product of lipid peroxidation mDA and SOD, GSH, GPx activity levels were examined. In result of study serum mDA level is higher and erythrocyte SOD, GSH, and GPx activities were found to be significantly lower in the patient group compared with the control group (p 0.05). As a result, liver cancer is associated with oxidative stress and antioxidant system weakens, which is an important indicator of oxidative stress, lipid peroxidation levels increased and promotes the tissue damage.

关键词： Primary and metastatic Liver Cancer Lipid Peroxidation Antioxidant Enzymes

Portable lensless wide-field microscopy imaging platform based on digital inline holography and multi-frame pixel super-resolution

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Light(Science & Applications) 2015年第1期4卷 152-162页

作者： Antonio C Sobieranski fatih Inci H Cumhur Tekin mehmet Yuksekkaya Eros Comunello Daniel Cobra Aldo von Wangenheim Utkan Demirci Demirci Bio-Acoustic-mEmS in medicine(BAmm)Laboratory Division of Biomedical EngineeringDivision of Renal MedicineDepartment of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Demirci Bio-Acoustic-mEmS in medicine(BAmm)Laboratory Division of Infectious DiseasesBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA INCoD–National Brazilian Institute for Digital Convergence/LAPIX Image Processing and Computer Graphics LabFederal University of Santa CatarinaBrazil Demirci Bio-Acoustic-mEmS in medicine(BAmm)Laboratory Stanford University School of MedicineCanary Center at Stanford for Cancer Early DetectionPalo AltoCAUSA Present Address:Department of Biomedical Engineering Faculty of Engineering Bas¸kent UniversityAnkaraTurkey VisionLab Master in Applied ComputingUniversity of Itajaı´ValleyBrazil CERTI Foundation FlorianopolisBrazil

In this paper,an irregular displacement-based lensless wide-field microscopy imaging platform is presented by combining digital in-line holography and computational pixel super-resolution using multi-frame *** samples are illuminated by a nearly coherent illumination system,where the hologram shadows are projected into a complementary metal-oxide semiconductor-based imaging *** increase the resolution,a multi-frame pixel resolution approach is employed to produce a single holographic image from multiple frame observations of the scene,with small planar *** are resolved by a hybrid approach:(i)alignment of the LR images by a fast feature-based registration method,and(ii)fine adjustment of the sub-pixel information using a continuous optimization approach designed to find the global optimum *** method for phase-retrieval is applied to decode the signal and reconstruct the morphological details of the analyzed *** presented approach was evaluated with various biological samples including sperm and platelets,whose dimensions are in the order of a few *** obtained results demonstrate a spatial resolution of 1.55 μm on a field-of-view ofmm^(2).

关键词： digital in-line holography image registration lensless imaging point-of-care platform pixel super-resolution

Anti-mmP-2 and mmP-9 activity of Salsola komarovii Iljin extract and its solvent fractions

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Asian Pacific Journal of Tropical Biomedicine 2020年第10期10卷 460-469页

作者： Jung-Ha Kil fatih Karadeniz Ga Hyun Yu Hojun Kim Junse Kim Jung Hwan Oh Jung Im Lee Chang-SukKong Youngwan Seo marine Biotechnology Center for Pharmaceuticals and Foods Silla UniversityBaegyang-daero 700 beon-gil 140Sasang-guBusan 46958Korea Department of Food and Nutrition College of Medical and Life SciencesSilla UniversityBaegyang-daero 700 beon-gil 140Sasang-guBusan 46958Korea Division of marine Bioscience Korea Maritime and Ocean UniversityBusan 49112Korea

Objective: To investigate matrix metalloproteinases(mmP)-2 and mmP-9 inhibitory effect of Salsola komarovii Iljin, an edible halophyte with health beneficial ***: Salsola komarovii crude extracts(SKI), and solvent(n-hexane, 85% aq. meOH, n-BuOH, and H2O) fractionated extracts of SKI were prepared. Gelatin zymography was carried out to observe mmP enzymatic activity. The release of the mmP enzymes was measured by enzyme-linked immunosorbent assay. Expression of mmPs in m RNA and protein level were investigated by polymerase chain reaction analysis and immunoblotting, ***: SKI and SKI fractions inhibited active mmP-2 and mmP-9 amount in the treated cell culture medium. Also, SKI suppressed the release of mmP-2 and mmP-9 from stimulated HT1080 human fibrosarcoma cells. Furthermore, SKI suppressed the m RNA and protein expression of mmP-2 and mmP-9. SKI fractions showed parallel effects except for H2O fraction which did not yield any significant mmP inhibitory effect. Among fractions, 85% aq. me OH was the most active fraction to inhibit both the enzymatic effect and expression of mmP-2 and ***: SKI may contain potential mmP release inhibitory compounds. Salsola komarovii is a promising source of compounds against mmP and could be utilized in the development of antitumor agents.

关键词： release utilized effect