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Effectiveness of Saccharomyces boulardii in a rat model of colitis

World Journal of Gastroenterology 2012年第44期18卷 6452-6460页

作者： Mujde Soyturk Saba Mukaddes saygili Huseyin Baskin Ozgul Sagol Osman Yilmaz fatih saygili Hale Akpinar Department of Gastroenterology Dokuz Eylul University School of MedicineInciraltiIzmir 35340Turkey Department of Internal Medicine Mediguven HospitalSalihli 45300ManisaTurkey Department of Clinical Microbiology Dokuz Eylul University School of MedicineInciraltiIzmir 35340Turkey Department of Pathology Dokuz Eylul University School of MedicineInciraltiIzmir 35340Turkey Department of Laboratory Animal Science Dokuz Eylul University School of MedicineInciraltiIzmir 35340Turkey Department of Gastroenterology Pamukkale University School of MedicineDenizli 20070Turkey

AIM:To investigate the effects of Saccharomyces boulardii(***) in an experimental rat model of trinitrobenzene sulfonic acid(TNBS)-induced ***:Thirty-two Wistar albino female rats were categorized into five *** the first day of the study,50 mg TNBS was administered via a rectal catheter in order to induce colitis in all rats,except those in the control *** 14 d,the rats were fed a standard diet,without the administration of any additional supplements to either the control or TNBS groups,in addition to 1 mg/kg per day *** to the *** group,1 mg/kg per day methyl prednisolone(MP) to the MP *** animals in the *** + MP group were coadministered these doses of *** and *** the study,weight loss,stool consistency,and the presence of obvious blood in the stool were evaluated,and the disease activity index(DAI) for colitis was *** intestines were examined and colitis was macro-and microscopically *** serum and tissue levels of tumor necrosis factor-α(TNF-α) and nitric oxide(NO) were determined,and fungemia was evaluated in the blood ***:The mean DAI scores for the MP and *** + MP groups was significantly lower than the TNBS group(3.69 ± 0.61 vs 4.46 ± 0.34,P = 0.018 and 3.77 ± 0.73 vs 4.46 ± 0.34,P = 0.025,respectively).While no significant differences between the TNBS and the *** or MP groups could be determined in terms of serum NO levels,the level of serum NO in the *** + MP group was significantly higher than in the TNBS and *** groups(8.12 ± 4.25 μmol/L vs 3.18 ± 1.19 μmol/L,P = 0.013;8.12 ± 4.25 μmol/L vs 3.47 ± 1.66 μmol/L,P = 0.012,respectively).The tissue NO levels in the ***,MP and *** + MP groups were significantly lower than the TNBS group(16.62 ± 2.27 μmol/L vs 29.72 ± 6.10 μmol/L,P = 0.002;14.66 ± 5.18 μmol/Lvs 29.72 ± 6.10 μmol/L,P = 0.003;11.95 ± 2.34 μmol/Lvs 29.72 ± 6.10 μmol/L,P = 0.002,respectively).The tis

关键词：酿酒酵母菌大鼠模型结肠炎肿瘤坏死因子-α Wistar 甲基强的松龙硝基苯磺酸啤酒酵母菌

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Treatment of Crohn's disease and familial Mediterranean fever by leukopheresis:Single shot for two targets

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World Journal of Gastroenterology 2015年第13期21卷 4078-4081页

作者： Mahmut Yuksel fatih saygili Orhan Coskun Nuretdin Suna Mustafa Kaplan Ufuk Baris Kuzu Zeki Mesut Yalin Kilic Yasemin Ozderin Ozin Ertugrul Kayacetin Department of Gastroenterology Turkiye Yuksek Ihtisas Training and Education HospitalAnkara 06230Turkey

Coexistence of Crohn's disease(CD) and familial Mediterranean fever(FMF) is a rare condition and knowledge about this clinical situation is limited with a few case reports in the literature. The treatment of both diseases depends on their individual therapies. However, it is very hard to deal with this coexistence when CD is refractory to standard therapies. Ongoing activity of CD triggers the clinical attacks of FMF and the symptoms like abdominal pain interfere with both disease presentations which can cause problems about diagnostic and therapeutic approach. The main therapeutic agent for FMF is colchicine and diarrhea is the most common side effect of this drug. This side effect also causes problems about management of these diseases when both of them are clinically active. Here we report probably the first case in the literature with coexisting CD and FMF who was successfully treated by leukopheresis since he was refractory to conventional therapies for CD.

关键词： Crohn’s disease Familial Mediterranean fever Leuko

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Examining the whole bowel, double balloon enteroscopy: Indications, diagnostic yield and complications

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World Journal of Gastrointestinal Endoscopy 2015年第3期7卷 247-252页

作者： fatih saygili Saba Mukaddes saygili Erkin Oztas Department of Gastroenterology Turkiye Yuksek Ihtisas Education and Research Hospital Department of Intensive Care Ankara University

Double balloon enteroscopy(DBE) is an advanced type of endoscopic procedure which brings the advantage of reaching the whole small bowel using anterograde or the retrograde route. This procedure is both diagnostic and interventional for a variety of small intestinal diseases, such as vascular lesions, tumors, polyps and involvement of inflammatory bowel *** indication is the diagnosis and treatment of mid-gastrointestinal bleeding according to the recent published data all over the world. The complication rates seem to be higher than conventional procedures but growing experience is lowering them and improving the procedure to be safe and well tolerated. This review is about the technique, indications, diagnostic importance and complications of DBE according to the literature growing since 2001.

关键词： Endoscopy Small bowel Double balloonenteroscopy

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