检索结果-南通市图书馆

Isolation and structural elucidation of cytotoxic compounds from the root bark of Diospyros quercina (Baill.) endemic to Madagascar

引用

Asian Pacific Journal of Tropical Biomedicine 2014年第3期4卷 169-175页

作者： fatiany pierre ruphin Robijaona Baholy Randrianarivo Emmanuel Raharisololalao Amelie Marie-Therese Martin Ngbolua Koto-te-Nyiwa Department of Organic Chemistry Faculty of SciencesP.O.Box 187University of Toliara601 ToliaraMadagascar Malagasy Institute of Applied Research Avarabohitra Itaosy lot AVB 77.P.OBOX 3833.102 AntananarivoMadagascar Antananarivo Poly-technique High School University of Antananarivo101 AntananarivoMadagascar Department of Organic Chemistry Faculty of SciencesP.O.Box 906 University of Antananarivo101 AntananarivoMadagascar Institute of Natural Products Chemistry National Centrefor Scientific Research CNRS 91198Gif Sur Yvette-ParisFrance Department of Biology Faculty of ScienceUniversity of KinshasaP.OBOX 190 Kinshasa XI.Democratic Republic of the Congo

Objective:To isolate and characterize the cytotoxic compounds from Diospyros quercina(Baill.)***&Lowry(Ebenaceae).Methods:An ethno-botanical survey was conducted in the south of Madagascar from July to August ***-guided fractionation assay was carried out on the root bark of Diospyros quercina,using cytotoxicity bioassay on murine P388 leukemia cell lines as *** structures of the cytotoxic compounds were elucidated by 1D and 2D NMR spectroscopy and mass ***:Biological experiments resulted in the isolation of three bioactive pure compounds(named TR-21,TR-22,and TR-23)which exhibited very good in vitro cytotoxic activities with the IC_(50)values of(0.017 5±0.0060)μg/mL,(0.089±0.005)μg/mL and(1.027±0.070)μg/mL ***,they support the claims of traditional healers and suggest the possible correlation between the chemical composition of this plant and its wide use in Malagasy folk medicine to treat ***:The ability of isolated compounds in this study to inhibit cell growth may represent a rational explanation for the use of Diospyros quercina root bark in treating cancer by Malagasy traditional *** studies are,therefore,necessary to evaluate the in vivo antineoplastic activity of these cytotoxic compounds as effective anticancer drugs.

关键词： Diospyros quercinia Cytotoxic activities Isodiospyrin 6’-Ethoxy-1’ 3’-dihydroxy-4 6-dimethyl-1,2’-binaphthyl-2,5’3,8’tetraones (E)-5,6-Dimethyl-2-(2-methyl-3-(prop-1-enyl) phenyl)-2H-Chromene Madagascar

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Antiplasmodial,cytotoxic activities and characterization of a new naturally occurring quinone methide pentacyclic triterpenoid derivative isolated from Salacia leptoclada Tul.(Celastraceae)originated from Madagascar

引用

Asian Pacific Journal of Tropical Biomedicine 2013年第10期3卷 780-784页

作者： fatiany pierre ruphin Robijaona Baholy Randrianarivo Emmanuel Raharisololalao Amelie Marie-Therese Martin Ngbolua Koto-te-Nyiwa Department of Organic Chemistry Faculty of SciencesP.O.Box 187.University of Toliara601 Toliara Madagascar Malagasy Institute of Applied Research Avarabohitra Itaosy lot AVB 77.P.O.BOX 3833102 Antananarivo Madagascar Department of Organic Chemistry Faculty of SciencesP.O.Box 906 University of Antananarivo101 AntananarivoMadagascar Institute of Natural Products Chemistry National Centre for Scientific Research CNRS 91198Gif Sur Yvette-ParisFrance Department of Biology Faculty of ScienceUniversity of KinshasaP.O.BOX 190 Kinshasa XIDemocratic.Republic of the Congo

Objective:To validate scientifically the traditional use of Salacia leptoclada Tul.(Celastraceae)(***)and to isolate and elucidate the structure of the biologically active ***:Bioassay-guided fractionation of the acetonic extract of the stem barks of *** was carried out by a combination of chromatography technique and biological experiments in viro using Plasmodium falciparum and P388 leukemia cell lines as *** structure of the biologically active pure compound was elucidated by 1D and 2D NMR spectroscopy and mass ***:Biological screening of *** extracts resulted in the isolation of a pentacyclic triterpenic quinone *** pure compound exhibited both in vitro a cytotoxic effect on murine P388 leukemia cells with IC_(50)value of(0.041±0.020)μg/mL and an antiplasmodial activity against the chloroquine-resistant strain FC29 of Plasmodium falciparum with an IC_(50)value of(0.052±0.030)μg/*** this interesting anti-malarial property of the lead compound,the therapeutic index was weak(0.788).In the best of our knowledge,the quinone methide pentacyclic triterpenoid derivative compound is reported for the first time in ***:The results suggest that furthers studies involving antineoplastic activity is needed for the development of this lead compound as anticancer drug.

关键词： Salacia leptoclada Quinone methide Malaria Therapeutic index Cancer Madagascar

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：