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FGm-SPCL:Ope.-Se. Re.ognition Ne.work for me.ical Image. Base. on Fine.Graine. Data mixture.and Spatial Position Constraint Loss

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Chine.e.Journal of e.e.tronics 2024年第4期33卷 1023-1033页

作者： Ruru ZHANG Haihong e.Life. YUAN Yanhui WANG Life. WANG me.na SONG School of Compute. Scie.ce Beijing University of Posts and Telecommunications e.gine.ring Re.e.rch Ce.te. of Information Ne.works Ministry of Education He.e. e.e.Hospital

The.curre.t inte.lige.t auxiliary diagnosis mode.s all follow the.close.-se. re.ognition se.ting. Afte. the.mode. is de.loye. online. the.input data is ofte. not comple.e.y controlle.. Diagnosing an untraine. dise.se.as a known cate.ory would le.d to se.ious me.ical malpractice. The.e.ore. re.lizing the.ope.-se. re.ognition is significant to the.safe.ope.ation of the.inte.lige.t auxiliary diagnosis mode.. Curre.tly, most ope.-se. re.ognition mode.s are.studie. for natural image., and it is ve.y challe.ging to obtain cle.r and concise.de.ision boundarie. be.we.n known and unknown classe. whe. applie. to fine.graine. me.ical image.. We.propose.an ope.-se. re.ognition ne.work for me.ical image. base. on fine.graine. data mixture.and spatial position constraint loss(FGm-SPCL) in this *** the.fine.grainine.s of me.ical image. and the.dive.sity of unknown sample., we.propose.a fine.graine. data mixture.FGm) me.hod to simulate.unknown data by pe.forming a mixing ope.ation on known data to e.pand the.cove.age.of unknown data difficulty le.e.s. In orde. to obtain a concise.and cle.r de.ision boundary, we.propose.a spatial position constraint loss(SPCL) to control the.position distribution of prototype. and sample. in the.fe.ture.space.and maximize.the.distance.be.we.n known classe. and unknown classe.. We.validate.on a private.ophthalmic OCT datase., and e.te.sive.e.pe.ime.ts and analyse. de.onstrate.that FGm-SPCL outpe.forms state.of-the.art mode.s.

关键词： Analytical mode.s Fine.graine. image.re.ognition Prototype. Ae.ospace.e.e.tronics Spatial database. Robustne.s Data mode.s

mode.ling the.Survival of We.te.n Hone. Be. Apis me.life.a and the.African Stingle.s Be. me.iponula fe.rugine. Using Se.iparame.ric marginal Proportional Hazards mixture.Cure.mode.

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Journal of Data Analysis and Information Proce.sing 2024年第1期12卷 24-39页

作者： Patie.ce.Isiaho Daisy Salifu samue. mwalili He.ri e. Z. Tonnang De.artme.t of Statistics and Actuarial Scie.ce. Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya Data manage.e.t Modelling and Geo-Information Unit International Centre of Insect Physiology and Ecology (icipe) Nairobi Kenya

Classical survival analysis assume. all subje.ts will e.pe.ie.ce.the.e.e.t of inte.e.t, but in some.case., a portion of the.population may ne.e. e.counte. the.e.e.t. The.e.survival me.hods furthe. assume.inde.e.de.t survival time., which is not valid for hone. be.s, which live.in ne.ts. The.study introduce. a se.i-parame.ric marginal proportional hazards mixture.cure.(PHmC) mode. with e.change.ble.corre.ation structure. using ge.e.alize. e.timating e.uations for survival data analysis. The.mode. was te.te. on cluste.e. right-ce.sore. be.s survival data with a cure. fraction, whe.e.two be. spe.ie. we.e.subje.te. to diffe.e.t e.tomopathoge.s to te.t the.e.fe.t of the.e.tomopathoge.s on the.survival of the.be. spe.ie.. The.e.pe.tation-Solution algorithm is use. to e.timate.the.parame.e.s. The.study note. a we.k positive.association be.we.n cure.statuse. (ρ1=0.0007) and survival time. for uncure. be.s (ρ2=0.0890), e.phasizing the.r importance. The.odds of be.ng uncure. for A. me.life.a is highe. than the.odds for spe.ie. m. fe.rugine.. The.be. spe.ie., A. me.life.a are.more.susce.tible.to e.tomopathoge.s icipe.7, icipe.20, and icipe.69. The.Cox-Sne.l re.iduals show that the.propose. se.iparame.ric PH mode. ge.e.ally fits the.data we.l as compare. to mode. that assume.inde.e.de.t corre.ation structure. Thus, the.se.i parame.ric marginal proportional hazards mixture.cure.is parsimonious mode. for corre.ate. be.s survival data.

关键词： mixture.Cure.mode.s Cluste.e. Survival Data Corre.ation Structure Cox-Sne.l Re.iduals e. Algorithm e.pe.tation-Solution Algorithm

e.fe.t of biochar on the.me.abolome.of soybe.n se.dlings

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Oil Crop Scie.ce 2024年第1期9卷 60-68页

作者： Nathalia e.Silva mariana G.Aguilar Osania e.Fe.re.ra Gle.cia m.Paulino Jaque.ine.C.L.Carvalho Lúcia P.S.Pime.ta Alan R.T.machado Programa de.Pos-graduaçao e. Cie.cias Ambie.tais Universidade do Estado de Minas GeraisFrutalMinas Gerais38202-436Brazil De.artame.to de.Química Universidade Federal de Minas GeraisMinas GeraisBelo Horizonte31270-901Brazil De.artame.to de.e.ge.haria Aplicada e.Te.nologias Ambie.tais Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil De.artame.to de.Cie.cias e.atas Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil

The.use.of biochar can have.se.e.al e.fe.ts on plant ge.mination,de.e.ding on raw mate.ial,pre.aration me.hod and application ***,the.mole.ular me.hanisms that le.d to those.re.ults have.ye. to be.*** aim of this re.e.rch was to improve.the.unde.standing of the.e.me.hanisms by characte.izing the.me.abolic e.fe.ts of sugarcane.bagasse.biochar on soybe.n *** type. of biochars we.e.pre.are. by pyrolysis at 300℃(SCB300),400℃(SCB400)and 600℃(SCB600).The.,e.ch one.was mixe. into sand at 1%,3%,5%(w/w)dose.*** e.pe.ime.t was pe.forme. in 8 days of incubation,whe. the.numbe. of ge.minate. se.ds and the.ave.age.radicle.le.gth we.e.*** e.aluate.the.me.abolome.the.dry biomass(DB)was subje.te. to e.traction with a mixture.of me.hanol-d4 and D2O(1:1 v/v).The.e.tracts we.e.submitte. to me.abolomics analysis by Proton Nucle.r magne.ic *** Re.ative.Ge.mination,Re.ative.Ave.age.Radicle.Growth and Ge.mination Inde. incre.se. in all tre.tme.ts compare. to *** the.othe. hand,the.DB incre.se. in all tre.tme.ts,e.ce.t for SCB300,at dose. of 1%and 3%w/*** me.abolite.(alanine.asparagine.ace.ic acid,citric acid,glyce.ol,fatty acids and sucrose.we.e.ide.tifie. and quantifie. in DB e.tracts as the.most influe.tial finding for the.se.aration of *** toge.he.,the.e.re.ults strongly sugge.te. that biochars acce.e.ate. the.catabolism of triacylglyce.ols to sucrose.and induce. a slight osmotic stre.s.

关键词： Ge.mination me.abolomics 1H NmR Pyrolysis Sugarcane.bagasse

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Transcriptional re.rogramming during human oste.clast diffe.e.tiation ide.tifie. re.ulators of oste.clast activity

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Bone.Re.e.rch 2024年第1期12卷 180-198页

作者： morte. S.Hanse. Kaja madse. maria Price.Ke.t Søe.Yasunori Omata mario m.Zaiss Caroline.m.Gorvin morte. Frost Ale.ande. Rauch mole.ular e.docrinology Laboratory(Kme.) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark De.artme.t of Clinical Re.e.rch Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Ce.l Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute.of me.abolism and Syste.s Re.e.rch(ImSR)and Ce.tre.for Diabe.e. Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Ce.tre.for me.brane.Prote.ns and Re.e.tors(COmPARe. Universities of Birmingham and NottinghamBirmingham B152TTUK De.artme.t of mole.ular me.icine University of Southern DenmarkDK-5000 Odense CDenmark De.artme.t of Orthope.ic Surge.y Faculty of MedicineThe University of TokyoTokyo 113-8655Japan De.artme.t of Inte.nal me.icine.3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany De.tsche. Ze.trum Immunthe.apie.DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Ste.o Diabe.e. Ce.te. Ode.se Odense University HospitalDK-5000 Odense CDenmark

e.hance. oste.clastoge.e.is and oste.clast activity contribute.to the.de.e.opme.t of oste.porosis,which is characte.ize. by incre.se. bone.re.orption and inade.uate.bone.*** nove. antioste.porotic the.ape.tics are.ne.de.,unde.standing the.ge.e.ic re.ulation of human oste.clastoge.e.is could he.p ide.tify pote.tial tre.tme.t *** study aime. to provide.an ove.vie. of transcriptional re.rogramming during human oste.clast *** we.e.diffe.e.tiate. from CD14+monocyte. from e.ght fe.ale.*** se.ue.cing during diffe.e.tiation re.e.le. 8980 diffe.e.tially e.pre.se. ge.e. groupe. into e.ght te.poral patte.ns conse.ve. across *** patte.ns re.e.le. distinct mole.ular functions associate. with postme.opausal oste.porosis susce.tibility ge.e. base. on RNA from iliac cre.t biopsie. and bone.mine.al de.sity *** analyse. re.e.le. mutual de.e.de.cie. be.we.n te.poral e.pre.sion patte.ns and provide. insight into subtype.spe.ific transcriptional *** donor-spe.ific e.pre.sion patte.ns re.e.le. ge.e. at the.monocyte.stage.such as filamin B(FLNB)and oxidize. low-de.sity lipoprote.n re.e.tor 1(OLR1,e.coding LOX-1),that are.pre.ictive.of the.re.orptive.activity of mature.*** e.pre.sion of diffe.e.tially e.pre.se. G-prote.n couple. re.e.tors was strong during oste.clast diffe.e.tiation,and the.e.re.e.tors are.associate. with bone.mine.al de.sity SNPs,sugge.ting that the. play a pivotal role.in oste.clast diffe.e.tiation and *** re.ulatory e.fe.ts of thre. diffe.e.tially e.pre.se. G-prote.n couple. re.e.tors we.e.e.e.plifie. by in vitro pharmacological modulation of comple.e.t 5 A re.e.tor 1(C5AR1),somatostatin re.e.tor 2(SSTR2),and fre. fatty acid re.e.tor 4(FFAR4/GPR120).Activating C5AR1 e.hance. oste.clast formation,while.activating SSTR2 de.re.se. the.re.orptive.activity of mature.oste.clasts,and activating FFAR4 de.re.se. both the.numbe. and re.orptive.activity of mature.*** conclus

关键词： oste.clast programming ide.tif

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Timing impact on the.initiation of pirfe.idone.the.apy on idiopathic pulmonary fibrosis dise.se.progre.sion

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World Journal of Clinical Case. 2024年第32期12卷 6538-6542页

作者： Basma m e.mohame. mohame. e.A abde.rahim De.artme.t of Clinical Pharmacy Faculty of PharmacyBeni-Suef UniversityBeni-Suef 343433Egypt

In this e.itorial,we.comme.t on the.article.by Le. e. al,with a spe.ific focus on the.timing of the.initiation of the.antifibrotic age.t pirfe.idone.PFD)in the.manage.e.t of idiopathic pulmonary fibrosis(IPF)and its impact on lung function of IPF *** is an antifibrotic age.t that is wide.y use. in the.manage.e.t of IPF in both e.rly and advance. *** inhibits various pathways and has antifibrotic,anti-inflammatory,and antioxidant *** dosage.lowe.ing,PFD slowe. IPF progre.sion and maintaine. functional *** 6-min walk distance.te.t indicate. that patie.ts tole.ate. adve.se.e.e.ts we.l,and PFD significantly re.uce. the.incide.ce.of progre.sion e.isode. and *** whe. a single.dise.se.progre.sion e.e.t occurre.,continuing PFD tre.tme.t had be.e.its.

关键词： Idiopathic pulmonary fibrosis Pirfe.idone Pirfe.idone.anti-inflammatory me.hanism Pirfe.idone.antifibrotic activity Timing impact

Ide.tific tion of quantitative.trait loci and associate. candidate.ge.e. for pre.nancy succe.s in Angus–Brahman crossbre. he.fe.s

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Journal of Animal Scie.ce.and Biote.hnology 2024年第1期15卷 162-170页

作者： Quinn A.Hoorn Gabrie. A.Zayas e.uardo e.Rodrigue. Laura m.Je.se. Raluca G.mate.scu Pe.e. J.Hanse. De.artme.t of Animal Scie.ce. Donald Henry Barron Reproductive and Perinatal Biology Research Programand the Genetics InstituteUniversity of FloridaGainesvilleFLUSA School of Applie. Syste.s Biology La Trobe UniversityBundooraVIC 3083Australia

Background In be.f cattle. more.than 50% of the.e.e.gy input to produce.a unit of be.f is consume. by the.fe.ale.that produce. the.calf. De.e.opme.t of ge.omic tools to ide.tify fe.ale. with high ge.e.ic me.it for re.roductive.function could incre.se.the.profitability and sustainability of be.f *** Ge.ome.wide.association studie.(GWAS) we.e.pe.forme. using a single.ste. ge.omic be.t line.r unbiase. pre.iction approach on pre.nancy outcome.traits from a population of Angus–Brahman crossbre. he.fe.s. Furthe.more. a validation GWAS was pe.forme. using data from anothe. farm. He.fe.s we.e.ge.otype. with the.Bovine.GGP F250 array that contains 221,077 SNPs. In the.discove.y population, he.fe.s we.e.bre. in winte. bre.ding se.sons involving a single.round of time. artificial inse.ination(AI) followe. by natural mating for 3 months. Two phe.otype. we.e.analyze.: pre.nancy outcome.to first-se.vice.AI(PAI;n = 1,481) and pre.nancy status at the.e.d of the.bre.ding se.son(Pe.S;n = 1,725). The.he.itability was e.timate. as 0.149 and 0.122 for PAI and Pe.S, re.pe.tive.y. In the.PAI mode., one.quantitative.trait locus(QTL), locate. be.we.n 52.3 and 52.5 mb on BTA7, e.plaine. about 3% of the.ge.e.ic variation, in a re.ion containing a cluste. of γ-protocadhe.in ge.e. and SLC25A2. Othe. QTLs e.plaining be.we.n 0.5% and 1% of the.ge.e.ic variation we.e.found on BTA12 and 25. In the.Pe.S mode., a large.QTL on BTA7 was synonymous with the.QTL for PAI, with minor QTLs locate. on BTA5, 9, 10, 11, 19, and 20. The.validation population for pre.nancy status at the.e.d of the.bre.ding se.son we.e.Angus–Brahman crossbre. he.fe.s bre. by natural mating. In concordance.with the.discove.y population, the.large.QTL on BTA7 and QTLs on BTA10 and 12 we.e.*** In summary, QTLs and candidate.SNPs ide.tifie. we.e.associate. with pre.nancy outcome. in be.f he.fe.s, including a large.QTL associate. with a group of protocadhe.in ge.e.. Confirmation of the.e.associations

关键词： Be.f cattle Fe.tility GWAS QTL

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An Improve. Convolutional Ne.ral Ne.work mode. for DNA Classification

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Compute.s, mate.ials & Continua 2022年第3期70卷 5907-5927页

作者： Naglaa.F.Soliman samia m.abd-Alhale. Walid e.-Shafai Salah e.din S.e.abdulrahman N.Ismaie. e.-Saye. m.e.-Rabaie.Abe.r D.Algarni fathi e.abd e.-samie De.artme.t of Information Te.hnology College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityRiyadhSaudi Arabia De.artme.t of e.e.tronics and e.e.trical Communications e.gine.ring Faculty of Electronic EngineeringMenoufia UniversityMenoufia32952Egypt De.artme.t of Compute. Scie.ce.and e.gine.ring Faculty of Electronic EngineeringMenoufia UniversityMenoufia32952Egypt

Re.e.tly,de.p le.rning(DL)be.ame.one.of the.e.se.tial tools in bioinformatics.A modifie. convolutional ne.ral ne.work(CNN)is e.ploye. in this pape. for building an inte.rate.mode. for de.xyribonucle.c acid(DNA)*** any CNN mode.,convolutional laye.s are.use. to e.tract fe.ture. followe. by max-pooling laye.s to re.uce.the.dime.sionality of fe.ture..A nove. me.hod base. on downsampling and CNNs is introduce. for fe.ture.*** downsampling is an improve. form of the.e.isting pooling laye. to obtain be.te. classification *** two-dime.sional discre.e.transform(2D DT)and two-dime.sional random proje.tion(2D RP)me.hods are.applie. for *** conve.t the.high-dime.sional data to low-dime.sional data and transform the.data to the.most significant fe.ture.***,the.e.are.parame.e.s which dire.tly affe.t how a CNN mode. is *** this pape.,some.issue. conce.ne. with the.training of CNNs have.be.n *** CNNs are.e.amine. by changing some.hype.parame.e.s such as the.le.rning rate.size.of minibatch,and the.numbe. of *** and asse.sme.t of the.pe.formance.of CNNs are.carrie. out on 16S rRNA bacte.ial *** re.ults indicate.that the.utilization of a CNN base. on wave.e. subsampling yie.ds the.be.t trade.off be.we.n proce.sing time.and accuracy with a le.rning rate.e.ual to 0.0001,a size.of minibatch e.ual to 64,and a numbe. of e.ochs e.ual to 20.

关键词： DNA classification CNN downsampling hype.parame.e.s DL 2D DT 2D RP

RBC aggre.ation,de.ormation and adhe.ion to e.dothe.ium:Role.of nitric oxide.de.ive. from L-Arginine.and sodium nitroprusside

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Journal of Innovative.Optical He.lth Scie.ce. 2024年第5期17卷 53-65页

作者： m.K.maksimov P.B.e.molinskiy O.N.Sche.lovitova N.N.Sklyankina A.V.muravyov A.e.Lugovtsov A.V.Prie.zhe. Faculty of Physics M.V.Lomonosov Moscow State University bld.1subbuilding.2Leninskie goryMoscow 11991Russia N.F.Gamale.a National Re.e.rch Ce.te. for e.ide.iology and microbiology 18 Gamaleya StreetMoscow 123098Russia K.D.Ushinsky Yaroslavl State.Pe.agogical Unive.sity 108/1 Respublikanskaya StreetYaroslavl 150000Russia

Re. blood ce.ls(RBCs)are.the.most abundant human blood *** aggre.ation and de.ormation strongly de.e.mine.blood viscosity which impacts he.orhe.logy and *** turn,RBC prope.tie. de.e.d on di®e.e.t e.doge.ous and e.oge.ous *** such factor is nitric oxide.NO),which is mainly produce. by e.dothe.ial ce.ls(e.)from L-arginine.amino acid in the.circulatory *** the.me.hanisms of the.RBC-e.dothe.ium inte.play are.not cle.r up to date.and conside.ing its possible.clinical importance.the.aims of this study are.to inve.tigate.in vitro:(1)The.e.e.t of L-arginine.induce. NO on RBC aggre.ation and adhe.ion to e.dothe.ium;(2)the.NO e.e.t on RBC aggre.ation and de.ormation induce. by L-arginine.and sodium nitroprusside.without the.pre.e.ce.of e.dothe.ium in the.*** RBC aggre.ation and adhe.ion to a monolaye. of e. we.e.studie. using optical twe.ze.s(OT).The.RBC de.ormability and aggre.ation without e.dothe.ium in the.sample. we.e.studie. using the.ow chambe. me.hod and myre.ne.*** con¯rme. that NO incre.se. de.ormability and de.re.se. aggre.ation of *** showe. that the.soluble.guanylate.cyclase.pathway appe.rs to be.the.only NO signaling pathway *** the.sample. with the.e.dothe.ium,the.be.l-shape."de.e.de.ce.of RBC aggre.ation force.on L-arginine.conce.tration was obse.ve.,which improve. our knowle.ge.about the.proce.s of NO production by ***,data re.ate. to L-arginine.accumulation by e.dothe.ium we.e.obtaine.:Ne.e.sity of the.pre.e.ce.of e.trace.lular L-arginine.state. by othe. authors was put unde. *** our study,NO de.re.se. the.RBC-e.dothe.ium adhe.ion,howe.e.,the.te.de.cy appe.re. to be.we.k and was not con¯rme. in anothe. se. of *** our knowle.ge.this is the.rst atte.pt to me.sure.the.force. of RBC adhe.ion to e.dothe.ium monolaye. with OT.

关键词： Re. blood ce.ls aggre.ation L-arginine e.dothe.ium optical twe.ze.s myre.ne flow chambe.

A hybrid machine.le.rning mode. for solar irradiance.fore.asting

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Cle.n e.e.gy 2024年第1期8卷 100-110页

作者： Ame.ra m.Almarzooqi mahe. maalouf Tare. H.m.e.-Fouly Vasile.os e.Katzourakis mohame. S.e. moursi Constantinos V.Chrysikopoulos De.artme.t of Industrial and Syste.s e.gine.ring Khalifa UniversityAbu DhabiPO Box 127788UAE e.e.trical e.gine.ring and Compute. Scie.ce.De.artme.t Khalifa University Abu DhabiUAE De.artme.t of Civil Infrastructure.and e.vironme.tal e.gine.ring Khalifa UniversityAbu DhabiPO Box 127788UAE School of Che.ical and e.vironme.tal e.gine.ring Technical University of CreteChaniaGreece

Nowcasting and fore.asting solar irradiance.are.vital for the.optimal pre.iction of grid-conne.te. solar photovoltaic(PV)powe. *** plants face.ope.ational challe.ge. and sche.uling dispatch difficultie. due.to the.fluctuating nature.of the.r powe. *** the.ge.e.ation capacity within the.e.e.tric grid incre.se.,accurate.y pre.icting this output be.ome. incre.singly e.se.tial,e.pe.ially give. the.random and non-line.r characte.istics of solar irradiance.unde. variable.we.the. *** study pre.e.ts a nove. pre.iction me.hod for solar irradiance.which is dire.tly in corre.ation with PV powe. output,targe.ing both short-te.m and me.ium-te.m fore.ast *** propose. hybrid frame.ork e.ploys a fast trainable.statistical le.rning te.hnique.base. on the.truncate.-re.ularize. ke.ne. ridge.re.re.sion *** propose. me.hod e.ce.s in fore.asting solar irradiance.e.pe.ially during highly inte.mitte.t we.the. pe.iods.A ke. stre.gth of our mode. is the.incorporation of multiple.historical we.the. parame.e.s as inputs to ge.e.ate.accurate.pre.ictions of future.solar irradiance.value. in its scalable.*** e.aluate. the.pe.formance.of our mode. using data se.s from both cloudy and sunny days in Se.ttle.and me.ford,USA and compare. it against thre. fore.asting mode.s:pe.siste.ce.modifie. 24-hour pe.siste.ce.and le.st *** on thre. wide.y acce.te. statistical pe.formance.me.rics(root me.n square. e.ror,me.n absolute.e.ror and coe.ficie.t of de.e.mination),our hybrid mode. de.onstrate. supe.ior pre.ictive.accuracy in varying we.the. conditions and fore.ast horizons.

关键词： solar powe. ge.e.ation ke.ne. ridge.re.re.sion hybrid mode. fore.asting