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Chinese Chemical Letters 2010年第12期21卷 1430-1434页

作者： Ardeshir Khazaei Amin Rostami fatemeh Mantashlo Faculty of Chemistry Bu-Ali Sina UniversityHamedan ***Iran Department of Chemistry Faculty of ScienceUniversity of KurdistanSanandaj 66135Iran

The catalytic application of p-toluenesulfonyl chloride for efficient acetylation of various types of alcohols and phenols with acetic anhydride in solvent-free conditions is *** structurally diverse alcohols were formylated using formic acid based on the use of catalytic amount of p-toluenesulfonyl chloride under solvent-free *** reactions were carried out in short reaction time and in good to excellent yields at room temperature.

关键词： p-Toluenesulfonyl chloride Hydroxyl compounds Acetylation Forrnylation

Measurement and calculation of solubility of quinine in supercritical carbon dioxide

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Chinese Journal of Chemical Engineering 2017年第5期25卷 641-645页

作者： fatemeh Zabihi Mehrdad Mirzajanzadeh Jingfu Jia Yaping Zhao Department of Chemical Engineering Islamic Azad UniversityAyatollah Amoli Branch Amol Department of Chemical Engineering Islamic Azad UniversityTehran Science and Research Branch School of Chemistry & Chemical Engineering Shanghai Jiaotong University

Solubility of quinine in supercritical carbon dioxide(SCCO_2) was experimentally measured in the pressure range of 8 to 24 MPa, at three constant temperatures: 308.15 K, 318.15 K and 328.15 K. Measurement was carried out in a semi-dynamic system. Experimental data were correlated by iso-fugacity model(based on cubic equations of state, CEOS), Modified Mendez–Santiago–Teja(MST) and Modified Bartle semi-empirical models. Two cubic equations of state: Peng–Robinson(PR) and Dashtizadeh–Pazuki–Ghotbi–Taghikhani(DPTG) were adopted for calculation of equilibrium parameters in CEOS modeling. Interaction coefficients(k_(ij)& l_(ij)) of van der Waals(vdW) mixing rules were considered as the correlation parameters in CEOS-based modeling and their contribution to the accuracy of model was investigated. Average Absolute Relative Deviation(AARD) between correlated and experimental data was calculated and compared as the index of validity and accuracy for different modeling systems. In this basis it was realized that the semi-empirical equations especially Modified MST can accurately support the theoretical studies on phase equilibrium behavior of quinine–SCCO_2 media. Among the cubic equations of state DPGT within two-parametric vd W mixing rules provided the best data fitting and PR within one-parametric vd W mixing rules demonstrated the highest deviation respecting to the experimental data. Overall, in each individual modeling system the best fitting was observed on the data points attained at 318 K, which could be perhaps due to the moderate thermodynamic state of supercritical phase.

关键词： Supercritical fluid Solubility Semi-empirical model Iso-fugacity Quinine

CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?

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Frontiers of Medicine 2022年第3期16卷 322-338页

作者： Pooria Safarzadeh Kozani Pouya Safarzadeh Kozani fatemeh Rahbarizadeh Department of Medical Biotechnology Faculty of Medical SciencesTarbiat Modares UniversityTehranP.O.Box 14115/111Iran Department of Medical Biotechnology Faculty of ParamedicineGuilan University of Medical SciencesRashtP.O.Box 44771/66595Iran Research and Development Center of Biotechnology Tarbiat Modares UniversityTehranP.O.Box 14115/111Iran

Immune-based therapies have experienced a pronounced breakthrough in the past decades as they acquired multiple US Food and Drug Administration(FDA)approvals for various *** date,six chimeric antigen receptor T cell(CAR-T)therapies have been permitted for the treatment of certain patients with relapsed/refractory hematologic ***,several clinical trials of solid tumor CAR-T therapies were prematurely terminated,or they reported life-threatening treatment-related damages to healthy *** simultaneous expression of target antigens by healthy organs and tumor cells is partly responsible for such *** targeting tumor-specific antigens,targeting the aberrantly glycosylated glycoforms of tumor-associated antigens can also minimize the off-tumor effects of CAR-T ***,T,and sialyl-Tn antigens have been reported to be involved in tumor progression and metastasis,and their expression results from the dysregulation of a series of glycosyltransferases and the endoplasmic reticulum protein chaperone,***,these glycoforms have been associated with various types of cancers,including prostate,breast,colon,gastric,and lung ***,we discuss how underglycosylated antigens emerge and then detail the latest advances in the development of CAR-T-based immunotherapies that target some of such antigens.

关键词： cancer immunotherapy chimeric antigen receptor solid tumors tumor-associated antigen glycosylation O-glycans adoptive cell therapy

Calculation of the structural properties of a strange quark star in the presence of a strong magnetic field using a density dependent bag constant

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Research in Astronomy and Astrophysics 2012年第9期12卷 1280-1290页

作者： Gholam Hossein Bordbar Hajar Bahri fatemeh Kayanikhoo Department of Physics Shiraz University Shiraz 71454 Iran Research Institute for Astronomy and Astrophysics of Maragha P.O. Box 55134-441 Maragha Iran

We have calculated the structural properties of a strange quark star with a static model in the presence of a strong magnetic field. To this end, we use the MIT bag model with a density dependent bag constant. To parameterize the density dependence of the bag constant, we have used our results for the lowest order constrained variational calculation of the asymmetric nuclear matter. By calculating the equation of state of strange quark matter, we have shown that the pressure of this system increases by increasing both density and magnetic field. Finally, we have investigated the effect of density dependence of the bag constant on the structural properties of a strange quark star.

关键词： stars: dense matter — equation of state — ISM: structure — supernova remnants

Persian medicine non-pharmacological therapies for headache：phlebotomy and wet cupping

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Journal of Traditional Chinese Medicine 2018年第3期38卷 457-464页

作者： Akramo Sadat Atyabi fatemeh Nejatbakhsh Hoorie Mohammadi Kenari fatemeh Eghbalian Mohammad Hos-sein Ayati Laila Shirbeigi Department of Traditional Medicine School of Traditional Medicine Tehran University of Medical Sciences Tehran *** Iran Research Institute for Islamicand Complementary Medicine School of Traditional Medicine Iran University of Medical Sciences Tehran*** Iran Department of History of Medicine School of Traditional Medicine Tehran University of Medical Sciences Tehran *** Iran

OBJECTIVE: To describe the common causes of headache as well as the different methods of Phlebotomy(Fasd) and wet Cupping(Hijamat) based on Persian ***: In this study, we searched Google Scholar, Science Direct, Pub Med and Scopus to get any in vitro or clinical evidence of the efficacy and possible mechanisms of phlebotomy or wet cupping on different types of headaches. Also different types of headaches, according to PM, under the title of "Sodaa"; extracted from famous Persian medical text books with key words including "Sodaa","Bayze" and "Shaqiqe".RESULTS: According to PM, diseases(dystemperament) are created by abnormal alteration in temperament. Temperament is a monolithic quality yielded by interaction between opposing qualities of four elements that are coldness, hotness, dryness and wetness. Headaches are caused by dystemperament(sue-Mizaj) in brain or in total body that are divided into simple and corporal. Common forms of the latter type are Vaporal and Migrant headache(Bokhari and Rihi). Each of these headaches is treated either through phlebotomy or wet ***: In Persian Medicine, Fasd and Hijamat are easy and economical methods for treatment of headache with reasonable results. By describing the precise areas and indications of phlebotomy and wet cupping, this study provides the first step for future clinical trials in this field.

关键词： Headache Phlebotomy Cupping thera-py Sodaa Persian Medicine

Synthesis of TiO_2 nanoparticles in different thermal conditions and modeling its photocatalytic activity with artificial neural network

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Journal of Environmental Sciences 2012年第4期24卷 750-756页

作者： fatemeh Ghanbary Nasser Modirshahla Morteza Khosravi Mohammad Ali Behnajady Department of Applied Chemistry Faculty of ChemistryNorth Tehran BranchIslamic Azad UniversityTehran***Islamic Republic of Iran Research Laboratory Department of Applied ChemistryTabriz BranchIslamic Azad UniversityTabriz1655Islamic Republic of Iran

Titanium dioxide （TiO2） nanoparticles were prepared by sol gel route. The preparation parameters were optimized in the removal of 4-nitropbenol （4-NP）. All catalysts were analyzed by X-ray diffraction （XRD） and scanning electron microscopy （SEM）. An artificial neural network model （ANN） was developed to predict the photocatalytic removal of 4-NP in the presence of TiOz nanoparticles prepared under desired conditions. The comparison between the predicted results by designed ANN model and the experimental data proved that modeling of the removal process of 4-NP using artificial neural network was a precise method to predict the extent of 4-NP removal under different conditions.

关键词： nanoparticle TiO2 4-nitrophenol photocatalysis neural network modeling

A Cu-Cr alloy with nano and microscale Cr particles produced in a water-cooled copper mold

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International Journal of Minerals,Metallurgy and Materials 2010年第5期17卷 629-634页

作者： Seyyed Mohammd Hossein Hejazi fatemeh Majidi Gholam Hossein Akbari Mining Industries Research Center Shahid Bahonar University of Kerman Department of Material Science and Engineering Faculty of Engineering Shahid Bahonar University of Kerman

Microstructures have profound effects on the hardness and strength of Cu-Cr alloys. The microstructures of a Cu-Cr alloy cast in a water-cooled copper mold were studied in the present work. The scanning electron microscopy （SEM） results show that there are the copper matrix saturated with chromium, spherical precipitates of chromium separated from liquid phase during cooling before the initiation of so- lidification, and a eutectic phase in grain boundary areas. To investigate the effect of age-hardening treatment on the microstructures and properties of the material, some samples were subsequently age-hardened in a salt bath and investigated by transmission electron microscopy （TEM）. The results show that coherent precipitates with the diameter of 11 nm are detectable in the samples before and after the age-hardening stage. Of course, the volume fraction of coherent precipitates is higher after the aging process.

关键词： copper alloys chromium molding precipitation hardening nanoparticles

Investigation of the degradation rate of electron beam processed and friction stir processed biocompatible ZKX50 magnesium alloy

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Journal of Magnesium and Alloys 2022年第3期10卷 768-781页

作者： fatemeh Iranshahi Mohammad Bagher Nasiri Fernando Gustavo Warchomicka Christof Sommitsch Joining and Forming Institute of Materials ScienceGraz University of TechnologyKopernikusgasse 24/IGraz 8010Austria

Together with the mechanical properties,the degradation rate is an important factor for biodegradable *** ZKX50 Mg alloy is a suitable candidate to be used as a biodegradable implant due to its favorable biocompatibility and mechanical *** research investigates the degradation rate and corrosion behavior of the ZKX50 as a function of the microstructure constituents and their *** grain refinement is the main strengthening mechanism for the ZKX50,the effect of the microstructure refinement on the corrosion rate was studied by applying electron beam processing(EBP)and friction stir processing(FSP)on the ZKX50 cast *** study the effect of the microstructure constituents and their morphology a subsequent solution heat treatment(HT)was applied to the processed *** results show that the EBP and FSP lead to a uniform and remarkably refined microstructure of the ZKX50 alloy and homogeneous distribution of the intermetallic *** results of electrochemical corrosion tests together with the microstructure characterization show that microgalvanic corrosion is the predominant mechanism that occurs between the Ca2Mg6Zn3 intermetallic phase andα-Mg *** to the results attained through the electrochemical tests,the EBPed-HT ZKX50 alloy shows higher corrosion resistance compared to all other conditions immersed in 0.5 wt.%NaCl *** dissolution and spheroidizing of Ca2Mg6Zn3 particles during the solution heat treatment provides higher corrosion resistance mainly by decreasing the microgalvanic *** microstructure of the heat-treated samples does not show a significant grain coarsening which can degrade the enhancement of the mechanical properties achieved by the EBP and FSP.

关键词： Magnesium alloys Electron beam processing Friction stir processing Corrosion Biodegradable metals.

Hydrothermal synthesis and structural studies of a new coordination polymer of lanthanum(Ⅲ) with benzene-1,2,4,5-tetracarboxylic acid and 4,4′-bipyridine

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Journal of Rare Earths 2009年第3期27卷 357-362页

作者： Masoumeh Tabatabaee Mahboubeh A. Sharif fatemeh Vakili Saina Saheli Department of Chemistry Islamic Azad University Yazd Branch Department of Chemistry Islamic Azad University Qom Branch

A new lanthanum complex formulated as {（bpyH2）[La（btc）（H2O）4（NO3）]·2H2O}n （1）（btcH4=benzene-1,2,4,5-tetracarboxylic acid; bpy=4,4＇-bipyridine） was hydrothermally synthesized. The complex was characterized by FT-IR spectroscopy, elemental analysis and X-ray diffraction. X-ray crystal structural analysis revealed that the compound belonged to the monoclinic space group C2/c with cell parameters a= 1.42806（7） nm, b=1.10258（5） nm, c=1.60333（8） nm and β=101.9400（10）°. The complex was polymeric with La^III atoms linked by four O atoms from two carboxylate groups of one benzene-1,2,4,5-tetracarboxylate. The LaIn atom was ten coordinated in a distorted tetracapped trigonal prism. In the crystal structure, a wide range of noncovalent interactions consisting of hydrogen bonding （of the types of O-H…O, N-H…O and C-H…O） and ion pairing interactions connected the various components into a supramolecular structure.

关键词： lanthanum(III) complex hydrothermal synthesis coordination polymer hydrogen bonding benzene-1,2,4,5-tetracarboxylic acid rare earths

Inhibitory effect of gold nanoparticles conjugated with interferon gamma and methionine on breast cancer cell line

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Asian Pacific Journal of Tropical Biomedicine 2016年第2期6卷 173-178页

作者： Nastaran Mohseni fatemeh Salehi Sarvestani Mehdi Shafiee Ardestani fatemeh Kazemi-Lomedasht Masoud Ghorbani Biotechnology Research Center Biotechnology Department Venom and Biotherapeutics Molecules Laboratory Pasteur Institute of Iran Department of Biology Science and Research Branch Islamic Azad University Department of Radiopharmacy Faculty of Pharmacy Tehran University of Medical Sciences Research and Development Department Pasteur Institute of Iran Department of Virology University of Ottawa

Objective: To develop a gold nanoparticles complex conjugated with interferon-gamma(IFN-g) and methionine along with application of hyperthermia using near-infrared laser beams for the treatment of cancer ***: Gold nanorods(10 nm) were conjugated with IFN-g and methionine using carbodiimide family and characterized after purification by dialysis bags. Breast cancer cells were cultured and incubated with gold nanorods at different concentrations followed by irradiation with near-infrared laser beam. Samples were then evaluated for their viability in order to determine the effect of treatment and variables by MTT ***: Zetasizer results confirmed the conjugation of gold nanorods with methionine and IFN-g. The median percentage of cell viability in 0.30 mg/m L concentration of gold nanorods was 82%. The cell viability reached to 85% at the same concentration of gold nanorods, which existed in the assayed complex. The results of MTT assay showed that the 0.60 mg/m L concentration of gold nanoparticles complex was toxic on tumor cells(P < 0.05). After exposure to hyperthermia, the viability of cells at 6 min decreased to77% in 0.30 mg/m L concentration of gold nanorods ***: The size and concentration of gold nanorods was not cytotoxic. However,their presence during irradiation near-infrared laser increased the number of dead cells during the treatment of cells.

关键词： Gold nanorods Breast cancer cell line Interferon gamma Near-infrared laser